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Interaction of Wnt/β-catenin and Nrf2 pathways in cigarette smoke-induced inflammation and emphysema

中国药理学与毒理学杂志 2016年第10期30卷 1035-1036页

作者： cui wen-hui MO Xiao-ting ZHOU wen-cheng ZHANG Zhi-hui GAO Jian School of Pharmacy Anhui Medical University The First Affiliated Hospital of Anhui Medical University The Second Affiliated Hospital of Dalian Medical University

OBJECTIVE The present study aimed to investigate the relationship between Wnt/β-catenin and Nrf2 signaling pathways,and understanding the mechanisms underlying the process of inflammatory in chronic obstructive pulmonary disease(COPD),which was a serious disease of respiratory *** We duplicate the emphysema model with porcine pancreatic elastase(PPE)in Nrf2-/-and WT mouse for 21d,and intraperitoneal injection of Li Cl,the activator of Wnt/β-catenin signaling pathway from 14 d to the *** and eosin(H&E)staining was performed to assess the histopathologic level,and immunohistochemistry(IHC)for Mac-3(the marker of macrophagocyte)and Ly6G(the marker of neutrophil)was used to observe the inflammatory infiltrate,while the levels of Wnt/β-catenin and Nrf2 signaling pathways related proteins heme oxygenase-1(HO-1),NAD(P)H:quinone oxidoreductase 1(NQO1),and the expression of inflammatory cytokine interleukin-6(IL-6)were detected by Western blotting of lung *** vitro,cigarette smoke extract(CSE)-treated normal human bronchial epithelial(NHBE)cells,cell viability was examined by MTT assay,and then we treated recombinant human Wnt3a,si Nrf2 and si Wnt3a to measure the expression of Wnt3a,β-catenin,Nrf2,HO-1,NQO-1,and *** immunofluorescence staining was employed to identify the nuclear translocation of *** We found that the Li Cl-treated group has markedly decreased the damage of alveolar structure and inflammatory signs than the model group of WT mice rather than Nrf2-/-*** also seen that Li Cl not only increasedβ-catenin,but it also led to a comparable increase in Nrf2,HO-1,NQO1,and decrease of IL-6 compared with WT model groups but except to Nrf2-/-group in *** it showed that Wnt3atreatment has significantly increased the nuclear translocation of Nrf2 and the expression of HO-1 and NQO1,reduced the IL-6 release,while there has no significance when Nrf2 was blocked in CSE-induced NHBE *** Our results demons

关键词： chronic obstructive pulmonary disease emphysema interleukin-6 inflammation nuclear factor erythroid-2-related factor-2 Wnt/β-catenin

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Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

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中国药理学与毒理学杂志 2016年第10期30卷 1036-1036页

作者： ZHOU wen-cheng MO Xiao-ting ZHANG Zhi-hui cui wen-hui GAO Jian School of Pharmacy Anhui Medical University The First Affiliated Hospital of Anhui Medical University The Second Hospital of Dalian Medical University

OBJECTIVE Epithelial-mesenchymal transition(EMT)is a phenotype conversion that plays a critical role in the development of pulmonary fibrosis(PF).It is known that a transcription factor snail could regulate the progression of *** factor erythroid 2 related factor 2(Nrf2),a key regulator of antioxidant defense system,protects cells and tissues against oxidative ***,it is not known whether Nrf2 regulates snail thereby modulating the development of *** Bleomycin(BLM)was intratracheally injected into both Nrf2-knockout(Nrf2-/-)and wild-type mice to compare the development of *** type II alveolar epithelial cells(AECs)RLE-6TN were treated with a specific Nrf2activator sulforaphane,or transfected with Nrf2 and snail si RNAs to determine their effects on transforming growth factorβ1(TGF-β1)-induced *** BLM-induced EMT and lung fibrosis were more severe in Nrf2-/-mice compared to wild-type *** vitro,sulforaphane treatment attenuated TGF-β1-induced EMT,accompanied by the down-regulation of ***,silencing Nrf2 by si RNA enhanced TGF-β1-induced EMT along with the expression of ***,silencing snail by si RNA reduced TGF-β1-induced EMT even in the presence of sulforaphane in RLE-6TN *** These findings suggested that Nrf2 may attenuate EMT and fibrosis process through regulating the expression of snail in PF.

关键词： nuclear factor erythroid 2-related factor2 snail epithelial-mesenchymaltransition pulmonaryfibrosis

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硝基苯还原反应的机理探讨

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化学教育 2016年第24期37卷 66-73页

作者：崔文辉陇南师范高等专科学校化学系

硝基苯在不同的还原剂及不同的介质中可以被还原成亚硝基苯、苯胲、偶氮苯、氧化偶氮苯、氢化偶氮苯等不同产物.这一性质深刻揭示了还原剂的还原能力除了与本身的性质有关之外,还与反应介质密切相关.由于这些还原产物结构复杂,相应反应... 详细信息

硝基苯在不同的还原剂及不同的介质中可以被还原成亚硝基苯、苯胲、偶氮苯、氧化偶氮苯、氢化偶氮苯等不同产物.这一性质深刻揭示了还原剂的还原能力除了与本身的性质有关之外,还与反应介质密切相关.由于这些还原产物结构复杂,相应反应的机理在国内外常见经典有机化学教科书中鲜有描述,给初学者的学习理解造成了困难.本文从氧化还原反应中电子守恒原理出发,探讨了这一组还原反应的可能机理,并导出了完整的化学反应方程式.

关键词：硝基苯还原反应机理总反应

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-cui Mao hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Research on the balance optimization algorithm of image recognition accuracy and speed based on autocollimator measurement

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Optoelectronics Letters 2025年第2期21卷 121-128页

作者： LI Renpu MA Long cui Jiwen GUO Junqi Andrei KULIKOV wen Dandan Chongqing Engineering Research Center of Intelligent Sensing Technology and Microsystem Chongqing University of Post and Telecommunications School of Instrumentation Science and Engineering Harbin Institute of Technology Higher School of Engineering and Technology ITMO University

The autocollimator is an important device for achieving precise,small-angle,non-contact *** primarily obtains angular parameters of a plane target mirror indirectly by detecting the position of the imaging *** is limited report on the core algorithmic techniques in current commercial products and recent scientific *** paper addresses the performance requirements of coordinate reading accuracy and operational speed in autocollimator image *** proposes a cross-image center recognition scheme based on the Hough transform and another based on Zernike moments and the least squares *** experimental evaluation of the accuracy and speed of both schemes,the optimal image recognition scheme balancing measurement accuracy and speed for the autocollimator is *** these,the center recognition method based on Zernike moments and the least squares method offers higher measurement accuracy and stability,while the Hough transform-based method provides faster measurement speed.

关键词： Least squares approximations

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微波辐射下2-芳氧甲基苯并咪唑类化合物的合成

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有机化学 2007年第7期27卷 893-897页

作者：张有明崔文辉魏太保西北师范大学化学化工学院甘肃省高分子材料重点实验室兰州730070

以多聚磷酸和4mol/L盐酸(PPA-HCl)作催化剂,在微波辐射条件下合成了13种2-芳氧甲基苯并咪唑类化合物,其中6种尚未见报道.其结构经元素分析,IR,1H NMR,13C NMR及MS确证.与经典方法相比,微波条件下的反应具有时间短、收率高等优点.反应物... 详细信息

以多聚磷酸和4mol/L盐酸(PPA-HCl)作催化剂,在微波辐射条件下合成了13种2-芳氧甲基苯并咪唑类化合物,其中6种尚未见报道.其结构经元素分析,IR,1H NMR,13C NMR及MS确证.与经典方法相比,微波条件下的反应具有时间短、收率高等优点.反应物邻苯二胺与芳氧基乙酸的物质的量比为1∶1.1,催化剂PPA与HCl的最佳比例为1∶1(体积比),最适宜的微波辐射功率为650～850W,反应时间为10～15min.

关键词： PPA-HCl催化剂微波辐射 2-芳氧甲基苯并咪唑合成

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需求市场规模变化条件下四维驱动CE测量模型

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哈尔滨工业大学学报 2011年第5期43卷 79-83,148页

作者：邵景波吴晓静崔文慧付铭哈尔滨工业大学经济与管理学院哈尔滨150001

为了解决现有顾客资产(CE)测量模型均假设需求市场规模不变且不适用于多品牌企业的局限性,在充分考虑交叉购买和口碑宣传等对CE有重要影响却被其现有测量模型所忽视的因素的基础上,运用马尔科夫矩阵模拟了企业间的竞争和顾客的品牌转换... 详细信息

为了解决现有顾客资产(CE)测量模型均假设需求市场规模不变且不适用于多品牌企业的局限性,在充分考虑交叉购买和口碑宣传等对CE有重要影响却被其现有测量模型所忽视的因素的基础上,运用马尔科夫矩阵模拟了企业间的竞争和顾客的品牌转换,并采用趋势预测法将需求市场规模的变化因素引入CE测量模型,最终构建了需求市场规模变化条件下的四维驱动CE测量模型.在此基础上运用线性回归分析、主成分分析以及Logit回归分析等统计方法对模型进行了应用.研究结果发现,顾客数量变化引起了CE价值的显著变化,需求市场规模的变化因素是测量CE时不可忽视的因素.此模型能更准确的测量CE并具有很强的可操作性和实践指导性.

关键词：市场规模顾客终身价值顾客资产趋势预测主成分分析

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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非线性高双折射阶跃光纤中单一频率传输区域调制不稳定性

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光学技术 2006年第5期32卷 698-701页

作者：贾维国耿小涛崔雯辉樊国梁内蒙古大学物理系呼和浩特010021 辽宁农业职业技术学院辽宁营口115214

利用光脉冲在高双折射非线性光纤中传播时所遵守的相干耦合非线性薛定谔方程,研究了单一频率的线偏振光,当偏振方向沿两个双折射轴的分量强度相等时,其在阶跃式光纤中反常色散区和正常色散区所产生的调制不稳定性。结果表明,调制不稳定... 详细信息

利用光脉冲在高双折射非线性光纤中传播时所遵守的相干耦合非线性薛定谔方程,研究了单一频率的线偏振光,当偏振方向沿两个双折射轴的分量强度相等时,其在阶跃式光纤中反常色散区和正常色散区所产生的调制不稳定性。结果表明,调制不稳定性这一过程不仅产生在反常色散区,而且产生在正常色散区,对于阶跃式光纤,矢量调制不稳定性还随级数不同发生变化。并且,反常色散区产生的增益谱不同于正常色散区,较之多一个增益谱区域。

关键词：双折射调制不稳定性单一频率传输区域阶跃式光纤(SWDF) 增益谱

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预成纤维桩在口腔修复治疗中的应用效果分析

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中国现代药物应用 2024年第9期18卷 18-22页

作者：崔惠文临沂市康复医院 276000

目的探讨预成纤维桩在口腔修复治疗中的效果。方法78例进行口腔修复治疗的患者,随机分为观察组和对照组,各39例。观察组应用预成纤维桩修复术,对照组应用可塑纤维桩修复术。比较两组不同时间[术前(T0)、术后3个月(T1)、术后6个月(T2)]... 详细信息

目的探讨预成纤维桩在口腔修复治疗中的效果。方法78例进行口腔修复治疗的患者,随机分为观察组和对照组,各39例。观察组应用预成纤维桩修复术,对照组应用可塑纤维桩修复术。比较两组不同时间[术前(T0)、术后3个月(T1)、术后6个月(T2)]牙周健康指标[菌斑指数(PLI)、出血指数(BI)、牙周袋探诊深度(PD)]、咬合力、咀嚼效率,修复成功率、修复时间及修复前后炎症因子[白细胞介素-17(IL-17)、白细胞介素-23(IL-23)]水平,并发症发生情况。结果①T1时,观察组PLI(1.90±0.22)分、BI(2.01±0.33)分、PD(1.21±0.45)mm明显低于对照组的(2.11±0.26)分、(2.86±0.32)分、(1.51±0.53)mm(t=3.851、11.548、2.695,P<0.05);T2时,观察组PLI(0.83±0.23)分、BI(0.87±0.34)分、PD(0.55±0.49)mm显著低于对照组的(1.65±0.29)分、(1.55±0.35)分、(1.05±0.30)mm(t=13.835、8.703、5.435,P<0.05)。②观察组并发症发生率2.56%低于对照组的17.95%(P<0.05)。③T1时,观察组咬合力(111.51±7.14)lbs、咀嚼效率(73.35±5.01)%明显高于对照组的(94.01±7.46)lbs、(65.35±4.96)%(t=10.583、7.087,P<0.05);T2时,观察组咬合力(133.35±10.01)lbs、咀嚼效率(88.86±7.53)%显著高于对照组的(114.53±18.46)lbs、(77.01±8.02)%(t=5.597、6.727,P<0.05)。④修复后,观察组IL-17(300.84±13.73)ng/L、IL-23(6.29±2.16)μg/L低于对照组的(353.26±10.47)ng/L、(7.65±2.47)μg/L(t=18.959、2.588,P<0.05);观察组修复时间(65.28±3.51)min/颗短于对照组的(100.24±6.61)min/颗(t=29.172,P<0.05)。观察组修复成功率97.44%高于对照组的79.49%(χ^(2)=6.155,P<0.05)。结论预成纤维桩在口腔修复治疗中具有良好的效果,应用价值较高。

关键词：口腔修复预成纤维桩牙周健康炎症因子可塑纤维桩修复时间

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