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Journal of Hainan Medical University 2018年第7期24卷 1-4页

作者： Shen-qing cui North China Petroleum Administration General Hospital RenqiuHebei062552

Objective: To explore the effect of trimetazidine in combined with Huangqi injection in resisting inflammation and oxygen radicals in patients with acute viral myocarditis (AVMC). Methods: A total of 70 patients with AVMC who were admitted in our hosptial from October, 2015 to September, 2017 were included in the study and randomized into the observation group and the control group with 35 cases in each group. The patients in the control group were orally administrated with trimetazidine. On the above basis, the patients in the observation group were given intravenous injection of Huangqi injection. The patients in the two groups were treated for 4 weeks. The morning fasting peripheral venous blood before and after treatment was collected. The serum TFN-α, IL-6, CRP, MDA, SOD, NO, cTnI, CK, CK-MB, and LDH. Results: CRP, TFN-α, and IL-6 after treatment in the observation group were significantly lower than those in the control group. MDA and NO after treatment in the observation group were significantly lower than those in the control group, while SOD was significantly higher than that in the control group. cTnI, CK, CK-MB, and LDH after treatment in the observation group were significantly lower than those in the control group. Conclusions:Trimetazidine in combined with Huangqi injection in the treatment of AVMC can effectively play the anti-inflammation and anti-OFR effects in order to reduce the myocardial damage, thus, the therapeutic effect is enhanced.

关键词： Trimetazidine Huangqi injection AVMC Anti-inflammation Anti-oxygen radical

Joint training with local soft attention and dual cross-neighbor label smoothing for unsupervised person re-identification

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Computational Visual Media 2024年第3期10卷 543-558页

作者： qing Han Longfei Li Weidong Min Qi Wang qingpeng Zeng Shimiao cui Jiongjin Chen School of Mathematics and Computer Sciences Nanchang UniversityNanchang 330031China Institute of Metaverse Nanchang UniversityNanchang 330031China Jiangxi Key Laboratory of Smart City Nanchang 330031China

Existing unsupervised person re-identification approaches fail to fully capture thefine-grained features of local regions,which can result in people with similar appearances and different identities being assigned the same label after *** identity-independent information contained in different local regions leads to different levels of local *** address these challenges,joint training with local soft attention and dual cross-neighbor label smoothing(DCLS)is proposed in this ***,the joint training is divided into global and local parts,whereby a soft attention mechanism is proposed for the local branch to accurately capture the subtle differences in local regions,which improves the ability of the re-identification model in identifying a person’s local significant ***,DCLS is designed to progressively mitigate label noise in different local *** DCLS uses global and local similarity metrics to semantically align the global and local regions of the person and further determines the proximity association between local regions through the cross information of neighboring regions,thereby achieving label smoothing of the global and local regions throughout the training *** extensive experiments,the proposed method outperformed existing methods under unsupervised settings on several standard person re-identification datasets.

关键词： person re-identification(Re-ID) unsupervised learning(USL) local soft attention joint training dual cross-neighbor label smoothing(DCLS)

Infection and Genomic Characteristics of Campylobacter jejuni from a Patient Without Diarrhea — China, 2018

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China CDC weekly 2024年第33期6卷 846-851,I0001-I0005页

作者： Xiangdong Yang Wen Wang Chajin cui Binbin Yu qing Zhang Yanhua Wang Ecological Medicine Research Center National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Zoonotic Disease Control and Prevention Yunnan Institute of Endemic Diseases Control&PreventionDali Bai Autonomous PrefectureYunnan ProvinceChina Medical Laboratory Department Yunnan Luxi County People’s HospitalHonghe Hani-Yi Autonomous PrefectureYunnan ProvinceChina

Summary What is already known about this topic?A 20-month-old boy was admitted to the hospital with a maximum temperature of 40°C and a single ***,blood culture detected Francisella tularensis(***)using the VITEK 2 Compact *** is added by this report?After incubation of the patient’s blood for 48 hours,the cultured strain was identified as Campylobacter jejuni,named L8,excluding *** the genome sequence of L8,we found a novel Type VI Secretion System(T6SS),of which the conserved C-terminal VgrG domain from positions 561 to 884 showed significant *** are the implications for public health practice?It should be underscored that relying solely on automatic bacterial identification instruments for accurate strain identification is ***,our study suggests that the potential effect of T6SS should be considered when studying the genetic features of a patient’s clinical phenotypes.

关键词： Campylobacter admitted culture

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非线性相关的信号—响应系统稳健性参数设计

计算机集成制造系统 2013年第8期19卷 1957-1966页

作者：崔庆安郑州大学管理工程学院河南郑州450001

针对非线性相关的信号—响应系统的稳健性参数设计,提出一种基于支持向量回归机和遗传算法的实现方法。首先,利用过程方差描述信号—响应之间非线性关系的波动,建立可控因子与过程方差之间的支持向量回归模型,利用遗传算法全局性寻优得... 详细信息

针对非线性相关的信号—响应系统的稳健性参数设计,提出一种基于支持向量回归机和遗传算法的实现方法。首先,利用过程方差描述信号—响应之间非线性关系的波动,建立可控因子与过程方差之间的支持向量回归模型,利用遗传算法全局性寻优得到使非线性关系最稳定的可控因子水平;其次,将噪声因子水平的变化看作重复,建立可控因子、信号因子和响应变量之间的支持向量回归模型,进而预测出最优可控因子水平下信号—响应的样本集;最后,根据此样本集拟合出信号因子与响应变量之间的具体作用关系模型。理论与实证研究表明,与现有信噪比分析和响应建模方法相比,所提方法能够较为真实地反映各类因子与响应变量之间的复杂作用关系,得到波动性更小的稳健性优化解。

关键词：稳健性参数设计信号—响应系统非线性相关支持向量回归机优化设计

The α and β domains of human metallothionein-3 co-operatively protect against Aβ_(1-42)-Cu^(2+) cytotoxicity

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Chinese Chemical Letters 2012年第10期23卷 1193-1196页

作者： Ying Luo Yu Xia Xu Qin Gui Bao Zhi Chun Ding cui qing Zhu Zhong Xian Huang Xiang Shi Tan Institutes of Biomedical Sciences Fudan UniversityShanghai 200433China Department of Chemistry Fudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology Shanghai Medical College of Fudan UniversityChina

Cytotoxicity of Aft with redox active metals in neuronal cells has been implicated in the progression of Alzheimer＇s disease （AD）. Zn7MT-3 protects cell against AβCu2＋ toxicity. The roles of single domain proteins （α/β） and α-β domain-domain interaction of ZnTMT-3 in its anti-Aβ1-42-Cu2＋ toxicity activity were investigated herein. Aβ1-42 and four mutants of human MT3 （α/β domain, β（MT3）--α（MT1） and △31-34） were prepared and characterized. Aβ1-42-Cu2＋ induced hydroxyl radical and ROS production with/without Zn-MTs were measured by fluorescence spectroscopy and DCFH-DA in living cells, respectively. These results indicate that the two domains form a co-operative unit and each of them is indispensable in conducting its bioactivity.

关键词： Aβ1-42 Alzheimer's disease Zn7MT3 ROS Toxicity

儿童照顾者口腔专业知识认知度、需求现状及影响因素的调查研究

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临床口腔医学杂志 2024年第8期40卷 472-476页

作者：王静张航崔雨晴龚静梁天一王春丽北京大学口腔医学院·口腔医院儿童口腔科北京100081 国家口腔医学中心国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·护理部办公室北京100081

目的:分析儿童照顾者对口腔专业知识的认知度及需求,为构建全面、科学、规范的儿童口腔健康教育模式及内容提供参考。方法:采用问卷调查法对2022年4~11月就诊于我院儿童口腔门诊的536名儿童照顾者进行问卷调查,统计照顾者年龄、文化水... 详细信息

目的:分析儿童照顾者对口腔专业知识的认知度及需求,为构建全面、科学、规范的儿童口腔健康教育模式及内容提供参考。方法:采用问卷调查法对2022年4~11月就诊于我院儿童口腔门诊的536名儿童照顾者进行问卷调查,统计照顾者年龄、文化水平、与儿童的关系、对口腔专业知识了解程度及需求等内容,并进行数据分析。结果:92.91%的儿童照顾者认同乳牙龋齿需要治疗,63.43%的儿童照顾者部分了解或了解儿童全身麻醉下口腔治疗的方式;不同年龄段的儿童照顾者对口腔专业知识需求不同,儿童照顾者因照顾的儿童年龄不同需求也有所差别,初诊和复诊的儿童照顾者需求不同,差异有统计学意义(P<0.05)。结论:儿童照顾者对口腔专业知识认知程度低但需求程度较高,探讨科学合理的健康教育模式非常有必要。口腔医护人员应根据儿童照顾者的需求提供个性化的健康指导,以促进儿童照顾者口腔健康意识及行动的形成。

关键词：调查研究照顾者口腔专业知识认知度口腔健康教育

An EMS mutant library for cucumber

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Journal of Integrative Agriculture 2018年第7期17卷 1612-1619页

作者： CHEN Chen cui qing-zhi HUANG San-wen WANG Shen-hao LIU Xiao-hong LU Xiang-yang CHEN Hui-ming TIAN Yun College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha 410128P.R.China Hunan Vegetable Research Institute Hunan Academy of Agricultural SciencesChangsha 410125P.R.China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture/Sino-Dutch Joint Laboratory of Horticultural Genomics Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081P.R.China Key Laboratory for Agricultural Biochemistry and Biotransformation of Hunan Provincial University Changsha 410128P.R.China Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients Changsha 410128P.R.China

Cucumber is an important vegetable crop and a model crop for the study of sex expression in plants. However, the genomic resources and tools for functional genomics studies in cucumber are still limited. In this paper, we conducted ethyl methyl sulfone（EMS） mutagenesis in the northern China ecotype cucumber inbred line 406 to construct a mutant library. We optimized the conditions of EMS mutagenesis on inbred line 406 which included treatment of seeds at 1.5% EMS for 12h. We obtained a number of mutant lines showing inheritable morphological changes in plant architecture, leaves, floral organs, fruits and other traits through M1, M2 and M3 generations. The F2 segregating populations were constructed and *** found that a short fruit mutant and a yellow-green fruit peel mutant were both under the control of a single recessive gene, respectively. These results provide valuable germplasm resources for the improvement of cucumber genetics and functional genomic research.

关键词： cucumber EMS mutant library traits

基于改进成本收入比法的DRG成本核算模式探索与实践

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医院管理论坛 2024年第3期41卷 79-86页

作者：张运奎刘国华庄娟崔宗晴李云霞济南市儿童医院

成本收入比法以病案首页的费用分类划分服务单元,进行成本收入归集,存在一定缺陷,通过对成本收入比法进行优化,将服务单元细化为作业中心,引入作业成本费率作为分摊参数,构建DRG成本核算模型,为DRG成本核算方法的应用提供参考。结果显示... 详细信息

成本收入比法以病案首页的费用分类划分服务单元,进行成本收入归集,存在一定缺陷,通过对成本收入比法进行优化,将服务单元细化为作业中心,引入作业成本费率作为分摊参数,构建DRG成本核算模型,为DRG成本核算方法的应用提供参考。结果显示,改进的成本收入比法可以快速、有效地核算DRG成本,核算结果更为精细,对帮助医院实现多维度精细化管理具有重要作用。

关键词：医院按疾病诊断相关分组成本核算成本收入比法

基于正交试验的修剪施肥组合处理对茶树产量与生化品质的影响

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茶叶学报 2024年第2期65卷 45-53页

作者：梁金波胡双玲姚健姚建军张强赵亮崔清梅陈清华罗鸿向俊恩施土家族苗族自治州农业科学院/国家茶产业技术体系恩施综合试站湖北恩施445000 咸丰县农业农村局湖北咸丰445600

【目的】研究不同修剪施肥处理对茶树产量与品质的影响,为春茶高质量生产提供技术参考。【方法】以茶树品种‘白叶1号’和‘槠叶齐’为试验材料,基于正交试验设计,研究修剪时间、修剪高度、施肥水平对次年春茶产量和生化品质的影响。【... 详细信息

【目的】研究不同修剪施肥处理对茶树产量与品质的影响,为春茶高质量生产提供技术参考。【方法】以茶树品种‘白叶1号’和‘槠叶齐’为试验材料,基于正交试验设计,研究修剪时间、修剪高度、施肥水平对次年春茶产量和生化品质的影响。【结果】提早修剪时间和增加修剪高度显著提高了茶树枝条数量和高度,对枝条茎粗无显著影响;不同修剪时间和修剪高度对春茶产量的影响存在显著差异(P<0.05),修剪时间为5月17日(A1)、修剪高度为55 cm(B3)时春茶产量较高;施肥水平为尿素225 kg·hm^(-2)+磷酸钾复合肥750 kg·hm^(-2)+有机肥3000 kg·hm^(-2)(C3)时,茶叶中茶多酚、儿茶素总量及氨基酸等物质积累较多,春茶鲜叶产量亦较高,故‘白叶1号’和‘槠叶齐’均以处理Ⅲ(A1B3C3)的春茶产量最高,分别为1170.24 kg·hm^(-2)和1261.85 kg·hm^(-2),较对照[10月15日修剪,修剪高度为离地70 cm,施肥水平为C2(尿素150 kg·hm^(-2)+磷酸钾复合肥600 kg·hm^(-2)+有机肥2250 kg·hm^(-2))]分别高36.77%和46.28%。【结论】修剪施肥影响次年春茶产量和生化品质,修剪时间为5月17日、修剪高度为55 cm、施肥水平为C3的处理Ⅲ为适宜的修剪施肥组合。

关键词：修剪施肥水平正交试验产量生化品质

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PS-VA模式预倾角的影响因素研究

河北省科学院学报 2024年第3期41卷 55-58,63页

作者：梁瑞祥徐凯温刚崔青员国良李元元王岩段楠石家庄诚志永华显示材料有限公司河北石家庄050091

TFT-LCD有多种显示模式,其中PS-VA模式以其高透过率、高对比度而被广泛应用。与传统的VA显示模式相比,PS-VA模式不需要通过PI来控制预倾角大小。PS-VA模式是在液晶中添加一定量的可聚合性化合物(RM),通过改变制程条件实现不同的预倾角... 详细信息

TFT-LCD有多种显示模式,其中PS-VA模式以其高透过率、高对比度而被广泛应用。与传统的VA显示模式相比,PS-VA模式不需要通过PI来控制预倾角大小。PS-VA模式是在液晶中添加一定量的可聚合性化合物(RM),通过改变制程条件实现不同的预倾角大小。本文主要研究了RM浓度、UV1加电电压、UV1固化光计量三个条件对预倾角大小的影响。结果表明,预倾角大小和RM浓度、UV1加电电压、UV1固化光计量均有很强的正相关性。在现实生产的过程中,可以根据不同产品的需求来调整相应的影响因素,以达到最佳的预倾角设计。

关键词：可聚合垂直配向预倾角可聚合性化合物