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SPOC教学模式下在“农产品加工与贮藏”课程案例分析

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农产品加工 2024年第15期 123-125,129页

作者：张亮亮刘家乐仝晋昌冯赛赛郭妍崔娜徐建国山西师范大学食品科学学院山西太原030031

“农产品加工与贮藏”是农业方向研究生专业核心课程,包括农产品的开发利用、果蔬贮藏保鲜等专题,对学生基本科学素养养成具有重要地位,旨在探讨基于SPOC(Small private online course)教学模式在农产品加工与贮藏中应用的案例分析。通... 详细信息

“农产品加工与贮藏”是农业方向研究生专业核心课程,包括农产品的开发利用、果蔬贮藏保鲜等专题,对学生基本科学素养养成具有重要地位,旨在探讨基于SPOC(Small private online course)教学模式在农产品加工与贮藏中应用的案例分析。通过在课程中实施基于SPOC的混合式教学,分析课程特点、挖掘课程改革潜力及后续优化方向。同时,通过对具体案例的分析总结课程在实施环节的经验与不足,为更好地满足学生的需求和促进教学质量的提升提供参考依据。

关键词： SPOC 混合式教学农产品加工与贮藏教学改革

脑血管造影术后使用股动脉压迫止血器患者早期活动的循证实践

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护理学报 2024年第15期31卷 29-33页

作者：刘瑶詹欣谢亭平陈炜胡依阳杨翠娜张国忠南方医科大学南方医院血管与介入科广东广州510515 南方医科大学南方医院神经外科广东广州510515

目的基于最佳证据制定脑血管造影术后使用股动脉压迫止血器患者早期活动的循证实践方案,规范临床应用并评价其效果,以提高患者舒适度。方法将最佳证据制定成临床实践的审查指标应用于脑血管造影术后患者,对照组和观察组各48例患者进行审... 详细信息

目的基于最佳证据制定脑血管造影术后使用股动脉压迫止血器患者早期活动的循证实践方案,规范临床应用并评价其效果,以提高患者舒适度。方法将最佳证据制定成临床实践的审查指标应用于脑血管造影术后患者,对照组和观察组各48例患者进行审查,观察比较对照组和观察组患者的舒适度、腰背部疼痛率及术后并发症发生情况。结果证据应用后观察组患者舒适度评分高于对照组,患者腰背部疼痛评分低于对照组,2组比较差异具有统计学意义(P0.05)。结论基于证据制定的脑血管造影术后使用股动脉压迫止血器患者早期活动的循证实践方案可提高护士的循证能力,规范临床工作流程,有效提高患者舒适度,减轻了患者腰酸背痛。

关键词：脑血管造影股动脉压迫止血器早期活动循证实践

The Local Environmental and Conformational Changes of BSA Varied with pH

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生物物理学报 2009年第S1期25卷 367-368页

作者： cui na WU Xue NIU Jianlong SHAN Hong The school of physics, nankai University, Tianjin, 300071,P.R.China

The structure and function of protein are strongly pH-dependence. However, the inonization state of the protein varied with the pH value also depends on the local structure

关键词： BSA The Local Environmental and Conformational Changes of BSA Varied with pH

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头孢他啶/阿维巴坦临床应用中的若干问题

中华医学杂志 2021年第41期101卷 3365-3370页

作者：汤铂崔娜中国医学科学院北京协和医学院北京协和医院重症医学科北京100730

头孢他啶/阿维巴坦是由头孢他啶和阿维巴坦组成的新型酶抑制剂合剂,通过共价结合β-内酰胺酶形成酶-抑制剂复合体,能有效恢复头孢他啶对多种产碳青霉烯酶肠杆菌科菌株的抗菌活性、覆盖产碳青霉烯酶碳青霉烯耐药肺炎克雷伯菌(CRKP)等常... 详细信息

头孢他啶/阿维巴坦是由头孢他啶和阿维巴坦组成的新型酶抑制剂合剂,通过共价结合β-内酰胺酶形成酶-抑制剂复合体,能有效恢复头孢他啶对多种产碳青霉烯酶肠杆菌科菌株的抗菌活性、覆盖产碳青霉烯酶碳青霉烯耐药肺炎克雷伯菌(CRKP)等常见耐药革兰阴性菌感染。本文对头孢他啶/阿维巴坦对肺部感染、腹腔感染、血流感染、尿路感染等不同感染灶的抗感染效果及其涉及的相关问题进行论述。文中亦对头孢他啶/阿维巴坦的适应证及安全性的相关问题进行阐述。

关键词：感染头孢他啶/阿维巴坦多重耐药泛耐药

饮水型地方性砷中毒病区人群砷代谢模式影响因素分析

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中华地方病学杂志 2024年第3期43卷 184-189页

作者：李梦昕李昕晔赵凡刘聪邓丹宇狄震崔娜刘一君孔畅韦炳干李艳红夏雅娟郭志伟内蒙古医科大学公共卫生学院呼和浩特010110 内蒙古自治区疾病预防控制中心(内蒙古自治区预防医学科学院)科研与宣教处呼和浩特010080 杭锦后旗疾病预防控制中心地方病防治科巴彦淖尔015400 内蒙古自治区疾病预防控制中心(内蒙古自治区预防医学科学院)地方病预防控制所呼和浩特010080 中国科学院地理科学与资源研究所陆地表层格局与模拟院重点实验室北京100101

目的探讨饮水型地方性砷中毒(简称饮水型砷中毒)病区人群砷代谢模式及影响因素。方法2004年12月,采用整群抽样方法,选取内蒙古自治区巴彦淖尔市饮水型砷中毒病区内砷中毒人群(砷中毒组)与健康人群(对照组)作为调查对象,对其进行问卷调... 详细信息

目的探讨饮水型地方性砷中毒(简称饮水型砷中毒)病区人群砷代谢模式及影响因素。方法2004年12月,采用整群抽样方法,选取内蒙古自治区巴彦淖尔市饮水型砷中毒病区内砷中毒人群(砷中毒组)与健康人群(对照组)作为调查对象,对其进行问卷调查。采用高效液相色谱-电感耦合等离子体质谱法检测调查对象家中饮用水砷含量,尿砷及其代谢产物[三价砷(As^(Ⅲ))、无机砷(iAs)、一甲基胂酸(五价,MMA^(V))、二甲基胂酸(五价,DMA^(V))、总砷(tAs)、无机砷百分比(iAs%)、一甲基胂酸百分比(MMA%)、二甲基胂酸百分比(DMA%)、一甲基化率(PMI)、二甲基化率(SMI)]水平;采用原子荧光光度计检测指甲砷和指甲硒水平。采用多元线性回归分析砷代谢模式的影响因素。结果共纳入调查对象536人,其中砷中毒组155人、对照组381人,水砷含量范围为0.0~825.7μg/L。与对照组比较,砷中毒组性别、文化程度、氟斑牙患病分布情况,差异均无统计学意义(均P>0.05);而年龄、婚姻状况、吸烟、饮酒、水砷含量分布情况,差异均有统计学意义(均P0.05)。性别、文化程度、水井深度、水砷含量、总井数和指甲砷水平是尿As^(Ⅲ)水平的影响因素(β=-19.82、-23.83、0.61、0.21、7.26、2.98,均P<0.05);年龄、水井深度、水砷含量和指甲砷水平是尿tAs水平的影响因素(β=3.18、3.25、1.31、15.59,均P<0.05);性别、文化程度、水井深度、水砷含量、总井数和指甲砷水平是尿iAs水平的影响因素(β=-20.47、-25.90、0.64、0.25、7.87、3.11,均P<0.05);年龄、性别、文化程度、水砷含量和指甲砷水平是尿MMA^(V)水平的影响因素(β=0.52、-17.07、-21.84、0.22、2.77,均P<0.05);年龄、水井深度、水砷含量和指甲砷水平是尿DMA^(V)水平的影响因素(β=2.35、2.47、0.85、9.22,均P<0.05)。结论与健康人群比较,饮水型砷中毒人群砷代谢模式存在差异,年龄、性别、文化程度、水井深度、水砷含量、总井数以及指甲砷水平可能是不同砷代谢模式的影响因素。

关键词：砷中毒甲基化代谢线性回归分析

The effect of acupuncture at Jǐngjiājǐ(颈夹脊) on the repair and regeneration of cochlear hair cells of rats with sensorineural deafness

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World Journal of Acupuncture-Moxibustion 2018年第1期28卷 55-58,I0008页

作者： Li ZHONG-TAI cui LI-na Department of Acupuncture-Moxibustion Yanbian University Hospital Yanji 133000 Jilin Province China

Objective： To observe the effect of acupuncture at Jǐngjiājǐ（颈夹脊）on the repair and regeneration of cochlear hair cells of guinea pigs with sensorineural ***： Sixty healthy guinea pigs were selected, 20 guinea pigs were randomly assigned to the normal control group（group A）, and other guinea pigs were randomly divided into model control group（group B） and acupuncture treatment group（group C） after injection with gentamicin sulfate in order to induce deafness. No intervention was given to the guinea pigs in group A and group B, and acupuncture at Jǐngjiājǐ was given to the guinea pigs in group C for 30 days. ABR threshold, DPOAE amplitudes and hair cells counting of guinea pigs in each group were recorded after intervention for 30 ***： After intervention for 30 days, ABR threshold in group C was significantly lower than that in group B（38.46 ±7.36 vs 82.94 ±6.47, P〈0.01）. and the DPOAE amplitudes in group C were obviously higher than that in group B（28.06 ±5.64 vs 25.23 ±5.38, P〈0.01）. The number of cochlear hair cells in group C increased significantly, over 50% of the hair cells survived, accounting for 66.67% of the observation cases. The number of cochlear hair cells in the 3 rd and 4 th gyri was close to the normal level, and plenty of proliferous sustentacular cells can be seen. Compared with group B, the number of cochlear outer hair cells in each gyrus in group C significantly increased（36.76 ±1.97 vs 28.59±2.24, P〈0.01）, indicating that acupuncture at Jǐngjiajǐ can promote the repair and regeneration of cochlear hair ***： Acupuncture at Jǐngjiajǐ can promote the repair and regeneration of cochlear hair cells, thus improving the hearing of guinea pigs with deafness.

关键词： Sensorineural deafness Jingjiaji ABR DPOAE Hair cell

Adhesive ileus in pregnant women

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World Journal of Acupuncture-Moxibustion 2018年第4期28卷 297-299,314-315页

作者： Li-na cui Zhong-tai LI Affiliated Hospital of Yanbian University Yanbian 133000JilinChina

A female patient was of the pregnancy for less than 24 weeks and suffered from adhesive ileus. The conservative treatment with acupuncture was selected to keep the fetus alive. A single-used filiform needle,0.30 mm x 40 mm was used. Zúsānlǐ(足三里ST 36), Shàngjùxū(上巨虚 ST 37), Tàichōng(太冲 LR 3) and Zhigōu(支沟TE 6) were selected bilaterally. At each acupoint, the needle was inserted rapidly and manipulated with the twisting, lifting and thrusting techniques to induce mild stimulation. Additionally, the electric stimulation was added at ST 36 and ST 37, with the continuous wave, 60 times per minute in frequency. The needles were retained for 25 min in each treatment. During the hospital stay, the treatment was given once every day and the condition of the disorder was observed carefully. The patient was discharged from the hospital in her 30 weeks of pregnancy. Afterward, acupuncture treatment was given once every one or two days in clinic till the weeks 34 of pregnancy. After acupuncture treatment,the conditions of abdominal distention, enteric flatus and defecation were relieved sustainably through to the cesarean section in weeks 34 of pregnancy. Both the patient and her infant were healthy when discharged. It was proved that acupuncture therapy was applicable and effective in the pregnant patient with ileus.

关键词： Adhesive ileus Second trimester of pregnancy Acupuncture therapy

矿产资源开发效率与经济高质量发展耦合协调关系研究

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矿业研究与开发 2023年第10期43卷 217-224页

作者：崔娜中南林业科技大学经济学院湖南长沙410004 湖南省普通高等学校哲学社会科学重点研究基地产业经济高质量发展研究中心湖南长沙410004

矿产资源开发与经济高质量发展是相互影响相互作用的关系。为高效利用矿产资源、推进经济高质量发展,通过构建矿产资源开发与经济高质量发展评价指标体系,运用SBM模型、熵值法、耦合协调度模型和相对发展度模型,分析2003—2021年我国矿... 详细信息

矿产资源开发与经济高质量发展是相互影响相互作用的关系。为高效利用矿产资源、推进经济高质量发展,通过构建矿产资源开发与经济高质量发展评价指标体系,运用SBM模型、熵值法、耦合协调度模型和相对发展度模型,分析2003—2021年我国矿产资源开发效率与经济高质量发展耦合协调关系与相对发展状况。结果表明,矿产资源开发效率呈波动上升趋势,而经济高质量发展呈稳定上升态势。两者耦合水平已达高度磨合阶段,耦合协调度经历了濒临失调到优质协调的演变过程,但并未实现全程同步发展,矿产资源开发效率超前于经济高质量发展。矿产资源开发为我国经济高质量发展提供了坚实的物质支持与保障。为促进二者的协调发展,需合理配置矿产资源投入,进一步提高矿产资源开发效率,同时多渠道提高经济高质量发展水平。

关键词：矿产资源开发经济高质量发展耦合协调关系

Anti-asthmatic mechanism of the Huashanshen dripping pill via suppressing contraction of the airway smooth muscle

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Traditional Medicine Research 2022年第3期7卷 19-27页

作者： Yu Liu Ni-na cui Xuan-Shuo Liu Peng-Cheng Lin Lorenzo Pecoraro Giuseppe Venturella Shu-Li Man Wen-Yuan Gao The Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(2017-ZJ-Y19) College of pharmacyQinghai Nationalities UniversityXining 810007China State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Department of Agricultural Food and Forest SciencesUniversity of PalermoPalermoItaly

Background:The Huashanshen(HSS)dripping pill has been widely used in asthma for a long time in ***,the relaxant mechanism of HSS is not well ***:In this report,high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify the constituents in rat plasma after oral administration of ***-sensitized allergic asthma and isolated trachea were studied for the anti-asthmatic mechanism of ***:D-anisodamine,L-anisodamine,scopolamine and atropine were detected in the rat plasma containing *** was clear that the HSS inhibited the release of inflammatory mediators,regulated the balance of T-helper 1 and T-helper 2 to reduce the airway inflammation,and relaxed the tracheal smooth muscle by controlling the KCa channel,Ca^(2+)influx and release to reduce the airway ***:Atropine,anisodamine and scopolamine might be active compounds of HSS which inhibited the release of inflammatory mediators,regulated the balance of Th1/Th2,and relaxed the tracheal smooth muscle to reduce airway hyperresponsiveness.

关键词： Huashanshen dripping pill HPLC-QTOF-MS allergic asthma airway remodeling inflammation airway smooth muscle