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Chinese Journal of Mechanical Engineering 2016年第2期29卷 250-259页

作者： LI Shihua LIU Yanmin cui hongliu NIU Yunzhan ZHAO Yanzhi Hebei Provincial Key Laboratory of Parallel Robot and Mechatronic System Yanshan University Qinhuangdao 066004 China Hebei Vocationa & Technical College of Building Materials Qinhuangdao 066004 China

Although it is common to eliminate the singularity of parallel mechanism by adding the branched chain with actuation redundancy, there is no theory and method for the configuration synthesis of the branched chain with actuation redundancy in parallel mechanism. Branched chains with actuation redundancy are synthesized for eliminating interior singularity of 3-translational and 1-rotational（3T1R） parallel mechanisms. Guided by the discriminance method of hybrid screw group according to Grassmann line geometry, all the possibilities are listed for the occurrence of interior singularities in 3T1R parallel mechanism. Based on the linear relevance of screw system and the principles of eliminating parallel mechanism singularity with actuation redundancy, different types of branched chains with actuation redundancy are synthesized systematically to indicate the layout and the number of the branched chainsinterior with actuation redundancy. A general method is proposed for the configuration synthesis of the branched chains with actuation redundancy of the redundant parallel mechanism, and it builds a solid foundation for the subsequent performance optimization of the redundant actuation parallel mechanism.

关键词： parallel mechanism interior singularity hybrid screw group branched chain with actuation redundancy

消除内部奇异的三平移并联机构冗余驱动支链的综合

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机械工程学报 2014年第23期50卷 36-41页

作者：李仕华崔红柳刘艳敏燕山大学河北省并联机器人与机电系统实验室秦皇岛066004 河北建材职业技术学院秦皇岛066004

对三平移并联机构(3T并联机构),提出一种冗余驱动支链的综合方法。采用螺旋理论,分析出3T并联机构发生内部奇异的所有可能情况;根据螺旋系线性相关性和并联机构不发生奇异的条件,系统综合出能消除3T并联机构内部奇异的冗余驱动支链类型... 详细信息

对三平移并联机构(3T并联机构),提出一种冗余驱动支链的综合方法。采用螺旋理论,分析出3T并联机构发生内部奇异的所有可能情况;根据螺旋系线性相关性和并联机构不发生奇异的条件,系统综合出能消除3T并联机构内部奇异的冗余驱动支链类型,并针对不同的支链约束螺旋系和自由度,分别给出相应的冗余驱动支链位置和条数;利用该方法对消除3-RRUR内部奇异的冗余支链进行综合。研究结果表明,该方法简单、有效并可消除3T并联机构内部奇异。

关键词：并联机构内部奇异混合螺旋系冗余驱动支链

Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures

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Neuroscience Bulletin 2022年第11期38卷 1347-1364页

作者： Jie Yu Yao Cheng Yaru cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang hongliu Sun School of Pharmaceutical Sciences Binzhou Medical UniversityYantai 264003China The Sixth Scientifc Research Department Shandong Institute of Nonmetallic MaterialsJinan 250031China

An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic *** reportedly attenuates the apoptosis and injury induced by oxidative ***,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat *** results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and *** treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA ***,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of *** reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin *** findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and ***,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous *** protective effects of irisin may be mediated through the BDNF-mediated UCP2 *** results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures.

关键词： Epilepsy Seizure Irisin Genipin Neuronal injury

Design and performance improvement of SiNPs@graphene@C composite with a popcorn structure

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Journal of Energy Chemistry 2022年第9期31卷 405-415,I0012页

作者： Hong Dong Feifei Zong Jie Wang Hao Ding Peng Wang Ru Song Ningshuang Zhang Xuchun cui Shiyou Li School of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu Province Lanzhou 730050GansuChina Gansu Engineerin Laboratory of Cathode Material for Lithium-ion Battery Baiyin 730900GansuChina

Silicon anodes are considered to be the most promising alternatives owing to their theoretical specific capacity,which is almost 10 times higher than that of graphite ***,huge volume changes during charging and discharging affect their interface stability,which strongly limits their application in commercial ***,a popcorn-structured silicon-carbon composite(SiNPs@graphene@C),composed of silicon nanoparticles(SiNPs),graphene spheres and pitch-based carbon,is prepared by spraydrying followed by a wet *** resulting SiNPs@graphene@C composite has good flexibility and elastic-strain capacity due to the graphene substrate,and it possesses macrostructural integrity and mechanical stability during cycling due to the rigid carbon–carbon chemical *** a result,it shows a discharge-specific capacity of 481.3 mAh g^(-1)and a capacity retention of 82.9%after 500 cycles at 1 A g^(-1).Besides,the initial coulomb efficiency is increased from 65.7%to 86.5%by pre-lithiation,which improves the feasibility of commercialising the SiNPs@graphene@C composite.

关键词： SiNPs@graphene@C Popcorn structure Pre-lithiation

miRNA-126、miRNA-26a在食管癌中的表达及与患者临床特征的关系分析

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癌症进展 2021年第24期19卷 2530-2533页

作者：贺红柳崔美英王丰郑州大学第一附属医院病理科郑州450052

目的检测miRNA-126、miRNA-26a在食管癌患者中的表达水平,并分析miRNA-126、miRNA-26a表达情况与食管癌临床特征的关系。方法收集113例食管癌手术切除患者的食管癌组织和癌旁组织,分析miRNA-126和miRNA-26a在食管癌组织和癌旁组织中的... 详细信息

目的检测miRNA-126、miRNA-26a在食管癌患者中的表达水平,并分析miRNA-126、miRNA-26a表达情况与食管癌临床特征的关系。方法收集113例食管癌手术切除患者的食管癌组织和癌旁组织,分析miRNA-126和miRNA-26a在食管癌组织和癌旁组织中的相对表达量及相关性,采用受试者工作特征(ROC)曲线分析miRNA-126、miRNA-26a的预测价值。结果食管癌组织中miRNA-126和miRNA-26a相对表达量均明显低于癌旁组织,差异均有统计学意义(P﹤0.01)。ROC曲线分析结果显示,当约登指数最大时,对应的miRNA-126和miRNA-26a为0.92和2.03,可作为诊断食管癌的临界值。miRNA-126和miRNA-26a在食管癌组织中的表达水平呈正相关(r=0.757,P﹤0.01)。不同分化程度、TNM分期及淋巴结转移情况的食管癌患者中miRNA-126和miRNA-26a表达情况比较,差异均有统计学意义(P﹤0.01)。结论 miRNA-126、miRNA-26a在食管癌患者中呈低表达,且与食管癌分化程度、TNM分期及淋巴结转移有关,可反映病情严重程度和预后。

关键词： miRNA-126 miRNA-26a 食管癌临床特征

Complete Genome Sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04)

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Genomics, Proteomics & Bioinformatics 2003年第3期1卷 180-192页

作者： ShengliBi E‘deQin ZuyuanXu WeiLi JingWang YongWuHu YongLiu ShuminDuan JianfeiHu YujunHan JingXu YanLi YaoYi YongdongZhou WeiLin1 JieWen HongXu RuanLi ZizhangZhang HaiyanSun JinguiZhu ManYu BaochangFan QingfaWu WeiLin2 LinTang Bao’anYang GuoqingLi WenmingPeng WenjieLi TaoJiang YajunDeng BohuaLiu JianpingShi YongqiangDeng WeiWei hongliu ZongzhongTong FengZhang YuZhang cui‘eWang YuquanLi JiaYe YonghuaGan JiaJi XiaoyuLi XiangjunTian FushuangLu GangTan RuifuYang BinLiu SiqiLiu SonggangLi JunWang JianWang WuchunCao JunYu XiaopingDong HuanmingYang CenterofDiseaseControlandPrevention Beijing100050China InstituteofMicrobiologyandEpidemiology ChineseAcademyofMilitaryMedicalSciencesBeijing100071China JamesD.WatsonInstituteofGenomeSciences ZhijiangCampusZhejiangUniversityandHangzhouGenomicsInstituteHangzhou310008China BeijingGenomicsInstitute ChineseAcademyofSciencesBeijing101300China CollegeofLifeSciences PekingUniversityBeijing100871China WenzhouMedicalCollege Wenzhou325003China PekinaUnionMedicalColleqeHospital ChineseAcademyofMedicalSciencesBeijing100730China CollegeofMaterialsScienceandChemicalEngineering YuquanCampusZhejiangUniversityHangzhou310027China

Beijing has been one of the epicenters attacked most severely by the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) since the first patient was diagnosed in one of the city's hospitals. We now report complete genome sequences of the BJ Group, including four isolates (Isolates BJ01, BJ02, BJ03, and BJ04) of the *** is remarkable that all members of the BJ Group share a common haplotype, consisting of seven loci that differentiate the group from other isolates published to date. Among 42 substitutions uniquely identified from the BJ group, 32 are non-synonymous changes at the amino acid level. Rooted phylogenetic trees, proposed on the basis of haplotypes and other sequence variations of SARS-CoV isolates from Canada, USA, Singapore, and China, gave rise to different paradigms but positioned the BJ Group, together with the newly discovered GD01 (GD-Ins29) in the same clade, followed by the H-U Group (from Hong Kong to USA) and the H-T Group (from Hong Kong to Toronto), leaving the SP Group (Singapore) more distant. This result appears to suggest a possible transmission path from Guangdong to Beijing/Hong Kong, then to other countries and regions.

关键词： SARS SARS-CoV haplotype substitution phylogeny

Adjusting the solvation structure with tris(trimethylsilyl)borate additive to improve the performance of LNCM half cells

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Journal of Energy Chemistry 2022年第4期31卷 55-64页

作者： Jie Wang Hong Dong Peng Wang Xiao-Lan Fu Ning-Shuang Zhang Dong-Ni Zhao Shi-You Li Xiao-Ling cui School of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Gansu Key Laboratory of Low-Carbon Energy and Chemical Engineering Lanzhou 730050GansuChina Gansu Engineering Laboratory of Electrolyte Material for Lithium-ion Battery Lanzhou 730050GansuChina

Tris(trimethylsilyl)borate(TMSB) has been intensively studied to improve the performances of lithiumion batteries. However, it is still an interesting issue needed to be resolved for the research on the Li^(+) solvation structure affected by TMSB additive. Herein, the electrochemical tests, quantum chemistry calculations, potential-resolved in-situ electrochemical impedance spectroscopy measurements and surface analyses were used to explore the effects of Li^(+) solvation structure with TMSB additive on the formation of the cathode electrolyte interface(CEI) film in LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)/Li half cells. The results reveal that the TMSB additive is easy to complex with Li^(+) ion, thus weaken the intermolecular force between Li^(+) ions and ethylene carbonate solvent, which is benefit for the cycle performance. Besides, the changed Li^(+) solvation structure results in a thin and dense CEI film containing compounds with Si–O and B–O bonds which is favorable to the transfer of Li^(+) ions. As a result, the performances of the LNCM811/Li half cells are effectively improved. This research provides a new idea to construct a high-performance CEI film by adjusting the Li^(+) solvation structures.

关键词： Lithium-ion battery Solvation structure Tris(trimethylsilyl)borate Si-containing additive LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) Cathode electrolyte interface film

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生大黄对脓毒症患者肠道屏障功能的影响

中华急诊医学杂志 2006年第10期15卷 927-929页

作者：方雪玲方强崔巍骆建军蔡洪流浙江大学医学院附属第一医院监护室杭州310003 浙江大学医学院附属第二医院监护室

目的观察生大黄对脓毒症患者肠道屏障功能的影响。方法前瞻、随机抽取脓毒症患者40例,随机分为生大黄治疗组(18例)和对照组(22例)。入选的患者于治疗的第1天和第6天测定尿乳果糖和甘露醇的比值(L/M)以及血浆D-乳酸。生大黄治疗组在第1... 详细信息

目的观察生大黄对脓毒症患者肠道屏障功能的影响。方法前瞻、随机抽取脓毒症患者40例,随机分为生大黄治疗组(18例)和对照组(22例)。入选的患者于治疗的第1天和第6天测定尿乳果糖和甘露醇的比值(L/M)以及血浆D-乳酸。生大黄治疗组在第1天留取尿液后即在常规治疗的同时开始给予生大黄治疗,对照组给予常规治疗。结果第1天两组尿L/M比值和血浆D-乳酸差异无统计学意义(P＞0．05)；经生大黄治疗后5d,生大黄治疗组的尿L/M比值(0．0621±0．0128)、血浆D-乳酸水平(0．09±0．03)mmol/L较对照组(0．1674±0．0361、0．24±0．06)mmoL/L明显降低(P＜0．05)。结论生大黄能改善脓毒症患者的肠黏膜屏障功能。

关键词：生大黄脓毒症 D-乳酸乳果糖/甘露醇肠屏障

Superhydrophobic Fe-based amorphous coating fabricated by detonation spraying with excellent anti-corrosion and self-cleaning properties

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Rare Metals 2023年第2期42卷 629-644页

作者： Shuai cui Hai-Min Zhai Wen-Sheng Li Wei Tong Xiao-Song Li An-Hui Cai Xiang-Juan Fan Xu-Qiang Li Dang-Sheng Xiong School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China Hunan Provincial Key Laboratory of Electromagnetic Equipment Design and Manufacturing Hunan Institute of Science and TechnologyYueyang414000China

Amorphous alloys without crystalline defects(dislocation,crystal boundary)are ideal hydrophobic coating materials due to their low surface *** work used a synergistic method of detonation spraying and surface modification to obtain the superhydrophobic Febased amorphous coatings with high hardness and dense structure on the Q 235 *** results showed that the water contact angles(WCA)of the superhydrophobic coating was 160°±3.6°,and water droplets could bounce off the superhydrophobic coating surface,illustrating the excellent self-cleaning performance of ***,the corrosion current density(i_(corr))of the superhydrophobic coating further decreased by 2 orders of magnitude down to8.008×10^(-8)A·cm^(-2)compared to the as-deposited coating with 5.473×10^(-6)A·cm^(-2);the corrosion potential(E_(corr))of the superhydrophobic coating shifted by 34 mV to the positive side compared with that of the as-deposited coating(-310 mV).Likewise,the impedance modulus|Z|values of the superhydrophobic coating increased by nearly2 orders of magnitude up to 1×10^(5.6)compared to the asdeposited coating with 1×10^(3.8).Even through lasting immersion in NaCl for 10 days,|Z|values of the superhydrophobic coating were still much higher than those of the as-deposited *** superhydrophobic Fe-based amorphous coatings could respond to their applications under extreme conditions due to their excellent hydrophobicity and self-cleaning properties,illustrating their promising future in aerospace,automotive,and machinery industries.

关键词： Fe-based amorphous coating Detonation spraying Superhydrophobic Corrosion resistance Self-cleaning

Mechanism of high-concentration electrolyte inhibiting the destructive effect of Mn(Ⅱ)on the performance of lithium-ion batteries

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Journal of Energy Chemistry 2023年第3期78卷 381-392,I0011页

作者： Xiaoling cui Jinlong Sun Dongni Zhao Jingjing Zhang Jie Wang Hong Dong Peng Wang Junwei Zhang Shumin Wu Linhu Song Ningshuang Zhang Chunlei Li Shiyou Li School of Petrochemical Technology Lanzhou University of TechnologyLanzhou 730050GansuChina Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu Province Lanzhou 730050GansuChina Gansu Engineering Laboratory of Electrolyte Material for Lithium-ion Battery Baiyin 730900GansuChina

By optimizing electrolyte formulation to inhibit the deposition of transition metal ions(TMIs) on the surface of the graphite anode is an effective way to improve the electrochemical performance of lithium-ion *** present,it is generally believed the formation of an effective interfacial film on the surface of the anode electrode is the leading factor in reducing the dissolution of TMIs and prevent TMIs from being embedded in the *** ignores the influence of the solvation structures in the electrolyte system with different composition,and is not conducive to the design of the electrolyte formulation from the perspective of changing the concentration and the preferred solvent to inhibit the degradation of battery performance caused by TMIs *** this work,by analyzing the special solvation structures of the high-concentra tion electrolyte,we study the main reason why high-concentration electrolyte inhibits the destructive effect of Mn(Ⅱ) on the electrochemical performance of *** combining the potentialresolved in-situ electrochemical impedance spectroscopy technology(PRIs-EIS) and density functional theory(DFT) calculation,we find that Mn(Ⅱ) mainly exists in the form of contact ions pairs(CIPs) and aggregates(AGGs) in high-concentration *** solvation structures can reduce the destructive effect of Mn(Ⅱ) on battery performance from two aspects:on the one hand,it can rise the lowest unoccupied orbital(LUMO) value of the solvation structures of Mn(Ⅱ),thereby reducing the chance of its reduction;on the other hand,the decrease of Mn2+ions reduction can reduce the deposition of metallic manganese in the solid electrolyte interphase(SEI),thereby avoiding the continuous growth of the *** study can be provided inspiration for the design of electrolytes to inhibit the destructive effect of TMls on LIBs.

关键词： Lithium-ion battery High-concentration electrolyte Manganese deposition Solvation structures