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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

Anticorrosive and antibacterial smart integrated strategy for biomedical magnesium

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Journal of Magnesium and Alloys 2023年第8期11卷 2789-2800页

作者： JianLiang Zhao HanRui cui ZeYu Gao YanZe bi ZhenZhen Dong Yan Li CaiQi Wang School of ChemicalScience University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Engineering Beihang UniversityBeijing 100083China Beijing Advanced Innovation Centre for biomedical Engineering Beihang UniversityBeijing 100191China

biomedical magnesium is an ideal material for hard tissue repair and ***,its rapid degradation and infection after implantation significantly hindersclinical *** overcome these two critical drawbacks,we describe an integrated strategybased on the changes in pH and Mg^(2+)triggered by *** system can simultaneously offer anticorrosion and antibacterial ***,nanoengineered peptide-grafted hyperbranched polymers(NPGHPs)with excellent antibacterial activity were introduced to sodium alginate(SA)to construct a sensitive NPGHPs/SA *** swelling degree,responsiveness,and antibacterial activity were then investigated,indicating that the system can perform dual stimulation of pH and Mg^(2+)with controllable antimicrobial ***,an intelligent platform was constructed by coating hydrogels on magnesium with polydopamine as the transition *** alkaline environment generated by the corrosion of magnesium reduces the swelling degree of the coatingso that the liquid is unfavorable for contacting the substrate,thus exhibiting superior corrosion *** testing shows that the material can effectively fight against bacteria,while hemolytic and cytotoxicity testing suggest that it is highly ***,this work realizes the smart integration of anticorrosion and antibacterial properties of biomedical magnesium,thereby providing broader prospects for the use of magnesium.

关键词： biomedical magnesium Anticorrosion Antibacterial Intelligent Nanoengineered peptide-grafted hyperbranched polymers

Low-complexity method for DOA estimation based on ESPRIT

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Journal of Systems Engineering and Electronics 2010年第5期21卷 729-733页

作者： Xuebin Zhuang Xiaowei cui Mingquan Lu Zhenming feng Department of Electronic Engineering Tsinghua University Beijing 100084 R R. China

A low-complexity method for direction of arrival（DOA） estimation based on estimation signal parameters via rotational invariance technique（ESPRIT） is *** of using the cross-correlation vectors in multistage Wiener filter（MSWF）,the orthogonal residual vectors obtained in conjugate gradient（CG） method span the signal subspace used by *** computational complexity of the proposed method is significantly reduced,since the signal subspace estimation mainly needs two matrixvector complex multiplications at the iteration of data ***,the prior training data are not needed in the proposed *** overcome performance degradation at low signal to noise ratio（SNR）,the expanded signal subspace spanned by more basis vectors is used and simultaneously renders ESPRIT yield redundant DOAs,which can be excluded by performing ESPRIT once more using the unexpanded signal *** with the traditional ESPRIT methods by MSWF and eigenvalue decomposition（EVD）,numerical results demonstrate the satisfactory performance of the proposed method.

关键词： direction of arrival(DOA) multistage Wiener filter(MSWF) conjugate gradient(CG) estimation signal parameters via rotational invariance technique(ESPRIT) eigenvalue decomposition(EVD).

Tearing Toughness of Ductile Metals

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Acta Metallurgica Sinica(English Letters) 2016年第2期29卷 150-155页

作者： cui-Hong Li Qi-Qiang Duan Zhe-feng Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences

A new parameter, i.e., tearing toughness, was employed to characterize the mechanical properties of some ductile metals （Cu, Cu-2 wt% Be, Cu-Al alloys, and some steels） by using three-leg trousers tearing tests. The experi- mental results demonstrate that their tearing toughness is not a physical constant and shows a close relationship with the materials＇ types and microstructures. It can be inferred that the tearing toughness of different ductile metals has their respective variation range, expectantly, and may be represented by the comprehensive mechanical properties of strength and ductility for various ductile materials.

关键词： Ductile metals Strength Ductility Tearing toughness

Parallel Incremental Frequent Itemset Mining for Large Data

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Journal of Computer Science & Technology 2017年第2期32卷 368-385页

作者： Yu-Geng Song Hui-Min cui Xiao-bing feng State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Frequent itemset mining （FIM） is a popular data mining issue adopted in many fields, such as commodity recommendation in the retail industry, log analysis in web searching, and query recommendation （or related search）. A large number of FIM algorithms have been proposed to obtain better performance, including parallelized algorithms for processing large data volumes. Besides, incremental FIM algorithms are also proposed to deal with incremental database updates. However, most of these incremental algorithms have low parallelism, causing low efficiency on huge databases. This paper presents two parallel incremental FIM algorithms called IncMiningPFP and IncBuildingPFP, implemented on the MapReduce framework. IncMiningPFP preserves the FP-tree mining results of the original pass, and utilizes them for incremental calculations. In particular, we propose a method to generate a partial FP-tree in the incremental pass, in order to avoid unnecessary mining work. Further, some of the incremental parallel tasks can be omitted when the inserted transactions include fewer items. IncbuildingPFP preserves the CanTrees built in the original pass, and then adds new transactions to them during the incremental passes. Our experimental results show that IncMiningPFP can achieve significant speedup over PFP （Parallel FPGrowth） and a sequential incremental algorithm （CanTree） in most cases of incremental input database, and in other cases IncBuildingPFP can achieve it.

关键词： incremental parallel FPGrowth data mining frequent itemset mining MapReduce

Repair the faulty TSVs with the improved FNS-CAC codec

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The Journal of China Universities of Posts and Telecommunications 2021年第2期28卷 1-13页

作者： Wei Chen cui Xiaole cui Xiaoxin feng Xu Jin Yufeng Key Laboratory of Integrated Microsystems Peking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Microelectronics Peking UniversityBeijing 100871China Artificial Intelligence Research Center Peng Cheng LaboratoryShenzhen 518055China

Through-silicon via(TSV)is a key enabling technology for the emerging 3-dimension(3 D)integrated circuits(ICs).However,the crosstalk between the neighboring TSVs is one of the important sources of the soft *** suppress the crosstalk,the Fibonacci-numeral-system-based crosstalk avoidance code(FNS-CAC)is an effective ***,the self-repair schemes are often used to deal with the hard faults,but the repaired results may change the mapping between signals to TSVs,thus may reduce the crosstalk suppression ability of FNS-CAC.A TSV self-repair technique with an improved FNS-CAC codec is proposed in this *** codec is designed based on the improved Fibonacci numeral system(FNS)adders,which are adaptive to the health states of *** proposed self-repair technique is able to suppress the crosstalk and repair the faulty TSVs *** simulation and analysis results show that the proposed scheme keeps the crosstalk suppression ability of the original FNS-CAC,and it has higher reparability than the local self-repair schemes,such as the signal-switching-based and the signal-shifting-based counterparts.

关键词： through-silicon via(TSV) build-in self-repair(biSR) crosstalk avoidance code(CAC) Fibonacci number

Revealing the structure design of alloyed based electrodes for alkali metal ion batteries with in situ TEM

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Journal of Energy Chemistry 2021年第8期30卷 405-418,I0009页

作者： Huawen Huang Ran bi Jie cui Ming-Ming Hu Li Tian Xianfeng Yang Lei Zhang School of Chemistry&Chemical Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640China Analytical and Testing Centre South China University of TechnologyGuangzhou 510640China School of Materials Science and Engineering Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and ConversionHunan University of Science and TechnologyXiangtan 411201China

Alloyed based anode materials with high theoretical specific capacity and low reaction potential are considered to be highly potential high-energy density anode materials for alkali metal ion batteries(AMIBs).Thus,the design of alloyed based materials with high electrochemical performance has attracted great *** the numerous characterization methods for guiding electrode materials design,in situ transmission electron microscopy(TEM)gradually plays an irreplaceable role due to its high temporal and spatial resolution in directly observing the change of morphology,crystal structure and element ***,we reviewed the two current research hotspots and mainly focused on the structure design of alloyed based electrode material under the guidance of in situ ***,various nanostructure designs of alloyed based electrode materials with guidance of in situ TEM were employed to solve the key scientific issues of the violent volume change during alloying/dealloying processes for enhanced electrochemical *** through introducing buffer space in the electrode material to reduce volume change to improve structural stability,including porous structure(0 D),nanotube structure(1 D),simple hollow structure,yolk-shell structure and some hybrid hollow structures(3 D).Furthermore,the direct guidance of in situ TEM is expected for creating new opportunities to nextgeneration electrode material design for AMIBs.

关键词： In situ TEM Alloyed based anode Nanostructure design Alkali metal ion batteries

A Piezoelectrically Driven Microrobot Using a Novel Monolithic Spatial Parallel Mechanism as Its Hip Joint

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Journal of bionic Engineering 2024年第2期21卷 803-820页

作者： Guangping Wu Ziyang Wang Jiaxin Zhao feng cui Xinghan Cai National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai200240China Department of Micro-Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Inspired by the fast,agile movements of insects,we present a 1.9 g,4.5 cm in length,piezoelectrically driven,quadrupedal *** microrobot uses a novel spatial parallel mechanism as its hip joint,which consists of two spatially orthogonal slider-crank *** mechanism maps two inputs of two independent actuators to the decoupled swing and lift outputs of a leg,and each leg can produce the closed trajectories in the sagittal plane necessary for robot ***,the kinematics of the transmission are analyzed,and the parameters of the flexure hinges are designed based on geometrical constraints and yield *** hip joints,legs and exoskeletons are integrated into a five-layer standard laminate for monolithic fabrication which is composed of two layers of carbon fiber,two layers of acrylic adhesive and a polyimide *** measured output force(15.97 mN)of each leg is enough to carry half of the robot’s weight,which is necessary for the robot to move *** has been proven that the robot can successfully perform forward and turning *** to the microrobot fabricated with discrete components,the monolithically fabricated microrobot is more capable of maintaining the original direction of locomotion when driven by a forward signal and has a greater speed,whose maximum speed is 25.05 cm/s.

关键词： Insect-like Crawling microrobot Piezoelectric drive Parallel mechanism Monolithic fabrication

Diffusive gradients in thin films using molecularly imprinted polymer binding gels for in situ measurements of antibiotics in urban wastewaters

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Frontiers of Environmental Science & Engineering 2020年第6期14卷 211-222页

作者： Ying cui feng Tan Yan Wang Suyu Ren Jingwen Chen Key Laboratory of Industrial Ecology and Environmental Engineering(MOE) School of Environmental Science and TechnologyDalian University of TechnologyDalian 116024China

Urban wastewater is one of main sources for the introduction of antibiotics into the *** the concentrations of antibiotics in wastewater is necessary for estimating the amount of antibiotics discharged into the environment through urban wastewater treatment *** this study,we report a novel diffusive gradient in thin films(DGT)method based on molecularly imprinted polymers(MIPs)for in situ measurement of two typical antibiotics,fluoroquinolones(FQs)and sulfonamides(SAs)in urban *** show specific adsorption toward their templates and their structural analogs,resulting in the selective uptake of the two target antibiotics during MIP-DGT *** uptake performance of the MIP-DGTs was evaluated in the laboratory and was relatively independent of solution pH(4.0-9.0),ionic strength(1-750 mmol/L),and dissolved organic matter(DOM,0-20 mg/L).MIP-DGT samplers were tested in the effluent of an urban wastewater treatment plant for field trials,where three SA(sulfamethoxazole,sulfapyridine,and trimethoprim)and one FQ(ofloxacin)antibiotics were detected,with concentrations ranging from 25.50 to 117.58 ng/L,which are consistent with the results measured by grab *** total removal efficiency of the antibiotics was 80.1%by the treatment *** study demonstrates that MIP-DGT is an effective tool for in situ monitoring of trace antibiotics in complex urban wastewaters.

关键词： Diffusive gradients in thin films Molecularly imprinted polymers Selective uptake Antibiotics Passive sampling