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Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease Risk among Chinese Adults

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Biomedical and Environmental Sciences 2023年第1期36卷 1-9页

作者： ZHAO Hui QIU Xia LI Hua Zi cui jia jia SUN Yong Ye Department of Nutrition and Food Hygiene School of Public HealthQingdao UniversityQingdao 266071ShandongChina State Key Laboratory of Bioactive Seaweed Substances Qingdao Bright moon Seaweed Group Co.LtdQingdao 266400ShandongChina Department of Medical Imaging Haici Hospital Affiliated to Medical College of Qingdao UniversityQingdao 266071ShandongChina

Objective The aim of this case-control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio(UHR) and the risk of nonalcoholic fatty liver disease(NAFLD) in Chinese *** A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD *** The multivariable adjusted odds ratio(95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888(2.324–6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index(BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m2. Our dose-response analysis indicated a linear positive correlation between UHR and the risk of *** UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.

关键词： Serum uric acid HDL-cholesterol The UHR index Inflammation Nonalcoholic fatty liver disease

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Synthesis, Structure and Decarboxylative Behavior of a Nitro-coordinated Potassium Compound

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Chinese Journal of Structural Chemistry 2019年第3期38卷 362-368页

作者： LI Dong-Mi cui jia-jia YAO jia-Xin LI Zhao-Hao ZHAO Bang-Tun College of Chemistry and Chemical Engineering and Henan Key Laboratory of Function-oriented Porous Materials Luoyang Normal University

A novel nitro-coordinated potassium compound [K(Htdc)(H_2O)]_n(tdc = 3-nitro-thiophene-2,5-dicarboxylate), has been synthesized and characterized. The complex with a two-dimensional(2D) layer structure contains an infinite K-O ladder-shaped chain, which is connected through carboxyl and unusual nitro-coordination of Htdc– anion. Then the 2D layers are further extended by intermolecular hydrogen-bonding to form a three-dimensional(3D) supramoleculalr network. Variable temperature powder X-ray diffractions, thermogravimetric analysis and nuclear magnetic resonance studies exhibit that the compound has a thermal-induced decarboxylative behavior.

关键词： crystal structure coordination mode two-dimensional compound decarboxylative behaviour

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Translational regulation of DNA repair systems by eIF3a in cancer chemotherapeutic response

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中国药理学与毒理学杂志 2016年第10期30卷 1050-1051页

作者： CHEN Juan cui jia-jia ZHANG jian-ting ZHOU Hong-hao LIU Zhao-qian YIN Ji-ye Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Central South University Hunan Key Laboratory of Pharmacogenetics Department of Pharmacology and Toxicology Indiana University School of Medicine IU Simon Cancer Center Indiana University School of Medicine

OBJECTIVE To investigate the role of e IF3a in the regulation of DNA repair pathways in cancer chemotherapeutic *** Immunohistochemistry was used to determine the expression of e IF3a in lung and breast cancer tissues followed by association analysis of e IF3a expression with patient′s response to *** overexpression and RNA interference knockdown of e IF3a were carried out in NIH3T3and H1299 cell lines,respectively,to determine the effect of altered e IF3a expression on cellular response to chemotherapeutic drugs by using MTT *** DNA repair capacity of these cells was evaluated by using host-cell reactivation,NHEJ and HR ***-time reverse transcriptase PCR and Western Blot analyses were carried out to determine the effect of e IF3a on the DNA repair genes by using cells with altered e IF3a *** e IF3a expression associates with response of lung and breast cancer patients to platinum and anthracycline.e IF3a knockdown or overexpression,respectively,increased and decreased the cellular resistance to cisplatin and anthracycline anticancer drugs,DNA repair activity,and expression of NER and NHEJ DNA repair *** e IF3a plays an important role in regulating the expression of NER and NHEJ DNA repair proteins which,in turn,contributes to cellular response to DNA-damaging anticancer drugs and patients′response to platinum and anthracycline chemotherapy.

关键词： eIF3a DNA repair translation regulation platinum anthracycline cancer chemotherapy

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基于改进MFCC和3D-CNN的变压器铁心松动故障声纹识别模型

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电机与控制学报 2022年第12期26卷 150-160页

作者：崔佳嘉马宏忠河海大学能源与电气学院江苏南京211100

为了准确提取变压器铁心松动故障时的声纹特征,提出一种基于改进的梅尔频率倒谱系数(MFCC)和三维卷积神经网络(3D-CNN)的变压器声纹识别模型。首先对变压器噪声信号进行分帧加窗处理,提取梅尔频率倒谱系数(MFCC);然后运用局部线性嵌入算... 详细信息

为了准确提取变压器铁心松动故障时的声纹特征,提出一种基于改进的梅尔频率倒谱系数(MFCC)和三维卷积神经网络(3D-CNN)的变压器声纹识别模型。首先对变压器噪声信号进行分帧加窗处理,提取梅尔频率倒谱系数(MFCC);然后运用局部线性嵌入算法(LLE)对现有的MFCC特征向量降维改进;最后使用三维卷积神经网络对变压器铁心松动故障进行识别。以某10 kV变压器为对象进行空载试验,采集铁心在不同松动程度下的声纹信号。计算结果表明,使用改进后的MFCC特征向量提取算法及3D-CNN模型具有良好的识别效果,准确率可达到98.33%,且平均迭代的时间可降至8.511 26 s。最终研究结果可为变压器的噪声治理提供依据。

关键词：变压器声纹铁心松动梅尔倒谱系数局部线性嵌入算法降维三维卷积神经网络

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang Yang jianfeng Zheng Guoyu Wang Yifei Gao Yatao Yang jia Li Xiaojin Han Yan cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

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Translational regulation of RPA2 via IRES by UNR and e IF3a

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中国药理学与毒理学杂志 2016年第10期30卷 1046-1046页

作者： cui jia-jia WANG Lei-yun YIN Ji-ye Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Central South University Hunan Key Laboratory of Pharmacogenetics

OBJECTIVE To explore the mechanism of translation initiation regulation of RPA2 via IRES by UNR and e *** Biotin pull down assay was taken to study the binding of RPA2 IRES and *** was knocked down and overexpressed in H1299,A549 and SK-MES cell *** blotting and real-time PCR were used to detect protein level and m RNA level ***-IP assay was conducted for the interaction of e IF3a and *** pul down assay was carried out to explore the exact *** the domains of e IF3a and UNR binding to RPA2 IRES were explored with EMSA *** NUR protein can bind to RPA2 IRES as well as e *** regulated the protein expression of RPA2 in H1299,A549 and SK-MES cells,and there was no change in RPA2 m *** combined with e IF3a via the first domain of UNR and the first domain of e *** bound to RPA2 IRES with the first *** there was no sufficient evidence for the binding domain of e IF3a with RPA2 IRES *** UNR worked with eI F3a and co-regulate the RPA2 IRES activity and further regulate the expression of *** is the possible regulation mechanisms of cellular internal ribosomal entry site affect translation initiation.

关键词： IRES RPA2 UNR eIF3a

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外商直接投资对中部六省产业结构调整的影响

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山西大学学报(哲学社会科学版) 2011年第1期34卷 121-126页

作者：史星际崔佳佳山西大学经济与工商管理学院

随着经济全球化的发展,现代国际投资特别是外商直接投资(FDI)已经成为影响一国或地区产业结构变动的重要因素。文章通过分析我国中部六省产业结构现状和演进过程以及FDI在中部六省三次产业的分布特征,采用面板数据重点对1987-2004年间... 详细信息

随着经济全球化的发展,现代国际投资特别是外商直接投资(FDI)已经成为影响一国或地区产业结构变动的重要因素。文章通过分析我国中部六省产业结构现状和演进过程以及FDI在中部六省三次产业的分布特征,采用面板数据重点对1987-2004年间产业结构的合理性,特别是FDI与促进产业结构调整变动的关联性进行了实证分析,借助回归模型估计检验了FDI对三次产业的贡献度并对二者之间的因果关系作了格兰杰(Granger)检验,最后就如何利用FDI更好地推动中部六省产业结构升级问题展开讨论,提出相关建议。

关键词： FDI 中部六省产业结构影响分析

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大兴安岭北部森林群落结构及植物多样性特征研究

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西北林学院学报 2021年第2期36卷 24-30页

作者：崔佳佳铁牛内蒙古农业大学林学院内蒙古呼和浩特010019

探究大兴安岭北部群落结构及植物多样性有助于了解当地森林稳定性,对该地区兴安落叶松林树种结构调整及科学经营提供理论依据。以大兴安岭北部过伐林与原始林为研究对象,分析过伐林与原始林不同的植物多样性特征及群落构建机制。结果表... 详细信息

探究大兴安岭北部群落结构及植物多样性有助于了解当地森林稳定性,对该地区兴安落叶松林树种结构调整及科学经营提供理论依据。以大兴安岭北部过伐林与原始林为研究对象,分析过伐林与原始林不同的植物多样性特征及群落构建机制。结果表明:1)大兴安岭北部的过伐林共有20科31属36种植物,原始林共16科24属27种植物,过伐林的植物物种数量高于原始林。Shannon-Wiener多样性及Margalef丰富度指数原始林多于过伐林,Pielou均匀度和Simpson优势度在过伐林和原始林表现基本一致。2)大兴安岭北部过伐林在群落构建过程中环境过滤起主导作用,原始林研究区域内各物种在初期经历了环境过滤,后期经历了负密度制约。大兴安岭北部原始林的植物多样性和群落构建在目前的环境背景下随时间逐步趋于单一化,应对该群落进行适当采伐来引进聚集度高(同一属)的植物以增加群落的稳定性,采伐原始林胸径和冠幅较大的老龄化乔木来调节林木间的关系及改变群落的动态变化。

关键词：过伐林原始林群落结构植物多样性特征

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3-叔丁氧羰基氨甲基苯甲酰胺的合成

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化学试剂 2015年第6期37卷 564-566页

作者：洪伟崔嘉佳王昊北方民族大学化学与化学工程学院宁夏银川750021 宁夏医科大学药学院宁夏银川750004

采用一锅法,以3-甲基苯甲酸为原料,经溴取代、酰胺化及Gabriel还原3步反应合成了标题化合物。其结构经1HNMR和MS表征,总收率35%。

关键词： 3-甲基苯甲酸 Gabriel还原反应合成

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邓肯-张非线性模型研究及其在ANSYS中的实现

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中国农村水利水电 2010年第3期 76-79页

作者：宿辉党承华崔佳佳北京科技大学土木与环境学院北京100083 河北工程大学水电学院河北邯郸056021

对工程领域使用广泛的邓肯-张非线性本构模型进行了研究,总结了国内外的研究现状及理论成果,针对其无法判定因结压力降低时的加载情况,提出了相应的变形模量的计算方法,同时考虑中主应力、土体抗拉强度的影响对模型进行了修正。利用APD... 详细信息

对工程领域使用广泛的邓肯-张非线性本构模型进行了研究,总结了国内外的研究现状及理论成果,针对其无法判定因结压力降低时的加载情况,提出了相应的变形模量的计算方法,同时考虑中主应力、土体抗拉强度的影响对模型进行了修正。利用APDL编写程序实现了ANSYS的材料本构模型的二次开发,运用重启动方法实现单元应力修正后数据重写入数据库,通过试验模拟对比分析验证了模型的适用性。

关键词：邓肯-张模型抗拉强度中主应力应力分析

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