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国外情报科学 1992年第2期10卷 21-26页

作者： cooper,m 薛列栓

Record of Early Tonian mafic magmatism in the central Espinhaco(Brazil):New insights for break-up of the Neoproterozoic landmass ancestor of Sao Francisco-Congo paleocontinent

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Geoscience Frontiers 2020年第6期11卷 2323-2337页

作者： helen F.moreira AndréDanderfer Alice F.O.Costa Samuel m.Bersan Cristiano C.Lana Gláucia N.Queiroga Post Graduate Program of Department of Geology Mine SchoolFederal University of Ouro PretoBrazil Department of Geology Mine SchoolFederal University of Ouro PretoBrazil

Petrological characterization,U-Pb geochronology,Lu-Hf analyses and major and trace element data from mafic intrusions in the Central Espinhaco(central portion of the Brazilian shield)are used here to investigate the geological significance of the Early Neoproterozoic magmatism in the context of the Sao Francisco-Congo *** mafic bodies are represented by medium to coarse-grained metagabbros with plagioclase,amphibole and *** U-Pb isotopic data from two samples yielded weighted mean 206pb/238U ages of 895±3.4 ma(mSWD=1.7)and 896±2.4 ma(mSWD=0.64),regarded as the best estimates for the crystallization age of these mafic *** and trace element data(including REEs)show that the gabbros originated from a subalkaline tholeiitic magma,typical of intraplate *** rocks are slightly enriched in LREEs and LILEs and depleted in *** new isotope and geochemical data,along with regional knowledge,indicate that these metagabbros mark the beginning of an important Tonian-age extensional tectonic event of the landmass of which the Sao Francisco-Congo paleocontinent was part(Rodinia supercontinent or Central African block?).We furthermore suggest that these rocks belong to a prominent suite of Tonian-age mafic rocks that mark a diachronic breakup attempt of this landmass which may have occurred from south to north along the Espinhaco mountain range.

关键词： mafic rocks Espinhaco basin Sao Francisco-Congo paleocontinent Tonian rifting U–Pb geochronology

Evolutionary Algorithm Based Task Scheduling in IoT Enabled Cloud Environment

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Computers, materials & Continua 2022年第4期71卷 1095-1109页

作者： R.Joshua Samuel Raj m.Varalatchoumy V.L.helen Josephine A.Jegatheesan Seifedine Kadry maytham N.meqdad Yunyoung Nam Department of Information Science&Engineering CMR Institute of TechnologyBengaluru560037India Department of Computer Science&Engineering Cambridge Institute of TechnologyBengaluru560036India Department of Computer Applications CMR Institute of TechnologyBengaluru560037India Department of Computer Science&Engineering Swarnandhra College of Engineering and TechnologyNarasapur534280India Department of Applied Data Science Noroff University CollegeKristiansand4612Norway Department of Computer Techniques Engineering Al-Mustaqbal University CollegeHillah51001Iraq Department of Computer Science and Engineering Soonchunhyang University31538Korea

Internet of Things (IoT) is transforming the technical setting ofconventional systems and finds applicability in smart cities, smart healthcare, smart industry, etc. In addition, the application areas relating to theIoT enabled models are resource-limited and necessitate crisp responses, lowlatencies, and high bandwidth, which are beyond their abilities. Cloud computing (CC) is treated as a resource-rich solution to the above mentionedchallenges. But the intrinsic high latency of CC makes it nonviable. The longerlatency degrades the outcome of IoT based smart systems. CC is an emergentdispersed, inexpensive computing pattern with massive assembly of heterogeneous autonomous systems. The effective use of task scheduling minimizes theenergy utilization of the cloud infrastructure and rises the income of serviceproviders by the minimization of the processing time of the user job. Withthis motivation, this paper presents an intelligent Chaotic Artificial ImmuneOptimization Algorithm for Task Scheduling (CAIOA-RS) in IoT enabledcloud environment. The proposed CAIOA-RS algorithm solves the issue ofresource allocation in the IoT enabled cloud environment. It also satisfiesthe makespan by carrying out the optimum task scheduling process with thedistinct strategies of incoming tasks. The design of CAIOA-RS techniqueincorporates the concept of chaotic maps into the conventional AIOA toenhance its performance. A series of experiments were carried out on theCloudSim platform. The simulation results demonstrate that the CAIOA-RStechnique indicates that the proposed model outperforms the original version,as well as other heuristics and metaheuristics.

关键词： Internet of things cloud computing task scheduling metaheuristics resource allocation

Double-blind randomized controlled study of the efficacy, safety and tolerability of eszopiclone vs placebo for the treatment of patients with post-traumatic stress disorder and insomnia

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World Journal of Psychiatry 2020年第3期10卷 21-28页

作者： Sheila m Dowd Alyson K Zalta helen J Burgess Elizabeth C Adkins Zerbrina Valdespino-Hayden mark H Pollack Department of Psychiatry and Behavioral Sciences Rush University Medical CenterChicagoIL 60601United States Department of Psychological Science University of California IrvineIrvineCA 92697United States Sleep and Circadian Research Laboratory Department of PsychiatryUniversity of MichiganAnn ArborMI 48109United States Center for Behavioral Intervention Technologies|Department of Preventive medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Psychology Montclair State UniversityMontclairNJ 07043United States

BACKGROUND Sleep disturbance is a core feature of post-traumatic stress disorder(PTSD).Given the relationship between sleep disturbance and PTSD,there has been a relative paucity of studies examining the potential therapeutic impact of using pharmacotherapy to target sleep disturbance in patients with ***(ESZ)is a non-benzodiazepine y-aminobutyric acid-A receptor agonist indicated for the treatment of sleep and may affect sleep in patients with *** To evaluate the efficacy of ESZ vs placebo(PBO)for patients with PTSD and *** The study was a 12-wk,double blind,randomized controlled trial with 3 mg of ESZ(n=13)or PBO(n=12).RESULTS Patients in both arms experienced significant improvement in PTSD symptoms as assessed by the Clinician-Administered PTSD Scale for DSm-IV(CAPS):ESZ(t11=-3.12,P=0.005)and PBO(t11=-3.5,P=0.002)and by self-report with the Short PTSD Rating Interview(ESZ t11=-3.38,P=0.003 and PBO t11=-4.48,P=0.0005).There were no significant differences between treatments on the CAPS(t22=-0.13,P=0.70)or the Short PTSD Rating Interview(t22=-0.58,P=0.56).Similarly,both treated groups improved on sleep measures as assessed by the Pittsburgh Sleep Quality Index with PTSD Addendum(PSQI)and on total sleep time(TST)and sleep latency assessed by actigraphy with no significant differences between groups(PSQI t22=-0.24,P=0.81;total sleep time t10=0.13,P=0.90 and sleep latency t10=0.68,P=0.50).There was a significant correlation between improvement in sleep and overall improvement in PTSD as measured by change scores on the PSQI and CAPS,r(8)=0.79,P=0.01 for ESZ treated subjects,but not for those treated with PBO r(9)=0.16,P=*** events of ESZ were consistent with the known profile of the medication including dysgeusia(30%,mild),sedation(20%,mild)and headache(20%,moderate to severe).CONCLUSION Results do not support the hypothesis of a specific positive effect of ESZ compared to PBO for measures of PTSD and associated sleep disturban

关键词： Trauma Sleep disturbance Hypnotic Post-traumatic stress disorder

Potential Range Expansion of the Invasive Red Shiner, <i>Cyprinella lutrensis</i>(Teleostei: Cyprinidae), under Future Climatic Change

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Open Journal of Ecology 2014年第9期4卷 554-564页

作者： helen m. Poulos Barry Chernoff College of the Environment Wesleyan University Middletown USA Departments of Biology and Earth and Environmental Studies Wesleyan University Middletown USA

We built climate envelope models under contemporary and future climates to explore potential range shifts of the invasive Red Shiner-Cyprinella lutrensis. Our objective was to estimate aquatic habitat vulnerability to Red Shiner invasion in North America under future climatic change. We used presence records from within the species’ native and invaded distributions, a suite of bioclimatic predictor variables from three climate models (CCCma, CSIRO, and HadCm3), and maximum entropy modeling to generate potential distribution maps for the year 2080. Our model predicted major range expansion by Red Shiner under both low and high carbon emissions scenarios. The models exceeded average area under the receiver operator characteristic curve values of 0.92, indicating good overall model performance. The model predictions fell largely outside of areas of climatic extrapolation (i.e. regions predicted into environments different from training the region) indicating good model performance. The results from this study highlight the large potential range expansion across North America of Red Shiner under future warmer climates.

关键词： Invasive Fishes maxent Climate Envelope model Climate Change Biological Invasions Cyprinella Lutrensis

Chick chorioallantoic membrane model to investigate role of migrasome in angiogenensis

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Biophysics Reports 2023年第5期9卷 241-254页

作者： Cuifang Zhang helen He Shuyao Yin mingyi Gao Li Yu The State Key Laboratory of membrane Biology Tsinghua University-Peking University Joint Centre for Life Sciences Beijing Frontier Research Center for Biological Structure Xiamen Cardiovascular Hospital Xiamen University

The development of the vascular system is essential for embryonic development, including processes such as angiogenesis. Angiogenesis plays a critical role in many normal physiological and pathological processes. It is driven by a set of angiogenic proteins, including angiogenic growth factors, chemokines,and extracellular matrix proteins. Among various animal model systems, the chorioallantoic membrane(CAm), a specialized and highly vascularized tissue of the avian embryo, has proven to be a valuable tool for analyzing the angiogenic potential of candidate cells or factors. In this protocol, we provide detailed procedures for establishing the CAm model to evaluate the function and mechanism of migrasomes in embryonic angiogenesis. This includes the CAm nylon mesh assay and CAm ex vivo sprouting assay to assess CAm angiogenesis, as well as the observation, purification, and delivery of migrasomes. Additionally, we describe the generation of T4-KO-m Cherry-KI embryos using the CRISPR system within the CAm tissue to investigate the role of migrasomes in angiogenesis.

关键词： Angiogenesis Chorioallantoic membrane (CAm) Chick CAm model

万古霉素和Teicoplanin的体外抗生素后效作用的比较

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国外医药（抗生素分册） 1991年第5期12卷 373-374页

作者： cooper m A 黄为

万古霉素被确定用来作为治疗革兰氏阳性菌感染的抗生素,尤其是当菌类对多种抗生素产生耐药性造成治疗上的困难时。Tei-coplanin是由5个结构很相似的糖肽抗生素组成,其基本结构与万古霉素类似,并有类似的抗菌谱和作用方式,但药代动力学... 详细信息

万古霉素被确定用来作为治疗革兰氏阳性菌感染的抗生素,尤其是当菌类对多种抗生素产生耐药性造成治疗上的困难时。Tei-coplanin是由5个结构很相似的糖肽抗生素组成,其基本结构与万古霉素类似,并有类似的抗菌谱和作用方式,但药代动力学不同。Teicoplanin有很长的半衰期和较好的组织渗透力以及可能毒性较低,而且与万古霉素形成对照。

关键词：万古霉素 Teicoplanin 抗生素

Effect of post treatment temperature and humidity conditions onfixation performance of CCA-C treated red pine and southern pine

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Journal of Forestry Research 1999年第3期10卷 141-146页

作者：郭爱龙 P.A.cooper Faculty of Forestry University of Toronto Earth Science Center Toronto Canada

Rates of fixation in chromated copper arsenate (CCA-C) treated red pine (Pinus resinosa Ait.) and southern pine (Pinus spp) sapwood specimens using retention of 1.5, 2.0, 6.4 kg·m?3 are compared at temperature (T) ranging from 70°C to 50°C and 5 different relative humidity (RH) conditions. The samples were investigated using the expressate method to follow chromium fixation. Red pine fixes faster than southern pine under all 11 post treatment schedules. The fixation rates for both species are not significantly different while the blocks were fixed under 6 fixation/drying schedules that differed only in the order of T/RH conditions applied. The rate of fixation of all samples in any fixation stage were reduced when the blocks were fixed under lower humidity conditions in spite of no change in chamber temperature. Some of this influence can be attributed to the effect of humidity on heat transfer into the wood and cooling of the wood surface.

关键词： CCA-c Fixation Post treatment Temperature Relative humidity Red pine Southern pine

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反转构造讨论纪要

地质地球化学 1995年第6期23卷 84-86页

作者： m.A.cooper 王卫贤贵州石油指挥部

介绍了对石油地质具有重要意义的反转构造的不同认识，同时列举了识别反转构造的准则，对正确认识反转构造有所帮助。

关键词：反转构造石油地质油气藏

The Sediment and Hydrographic Characteristics of Three Horseshoe Crab Nursery Beaches in Hong Kong

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Journal of Ocean University of Qingdao 2003年第1期2卷 35-43页

作者： helen m.C. Chiu Brian morton Environmental Resources management (ERm)-Hong Kong Ltd Swire Institute of Marine Science and Department of Ecology and Biodiversity 979 King's Road Taikoo Place Island East Hong Kong University of Hong

Horseshoe crab juveniles have been recorded from sand and sandy-mud nursery beaches at Pak Nai (western New Territories), San Tau and Shui Hau (Lantau Island), Hong Kong. In order to provide a better understanding of these beaches and to identify those plausible factors which have made them preferred by spawning horseshoe crabs, environmental parameters, including temperature, salinity, pH and dissolved oxygen content of the water, and particle size distribution and organic matter content of the sediments at the three sites, were determined and compared. The hydrographic and sediment data obtained for the three study sites have revealed some common environmental features. The three nursery beaches are relatively remote, and far (in Hong Kong terms) from urbanized and densely populated areas. The beaches are generally well sheltered from strong wave action and inundated regularly by estuarine waters. Horseshoe crab adults tend to select these beaches for spawning as their protected features ensures the laid eggs are less likely to be washed out of the sand, and hatched juveniles can feed on the meiofauna and grow. Sediments of the three beaches largely comprise medium-sized sand particles and are moderately sorted, suggesting medium porosity and good water permeability. Such a sand type, with the generally high oxygen levels in incursing waters, may help create a well-oxygenated micro-environment for the normal development of horseshoe crab eggs, larvae and juveniles. Lantau Island beaches at San Tau and Shui Hau are relatively free from organic pollution, as reflected in generally high dissolved oxygen level, and low BOD 5 and ammonia nitrogen values. Pak Nai is, however, more polluted.

关键词： sediment hydrography horseshoe crab nursery beaches Hong Kong