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Anal cancer screening in women with a history of human papillomavirusrelated lower genital tract cancers:a pilot study

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Gynecology and Obstetrics clinical Medicine 2024年第2期4卷 88-93页

作者： Isobel Mary Poynten Fengyi Jin Rhonda Farrell Trevor Tejada-Berges Carmella law Richard Hillman Jennifer Roberts Andrew Grulich The Kirby Institute University of New South WalesSydneyNew South WalesAustralia Chris O'Brien Lifehouse SydneyNew South WalesAustralia Prince of Wales Private Hospital RandwickNew South WalesAustralia Dysplasia and Anal Cancer Services St Vincent's Hospital SydneyDarlinghurstNewSouthWalesAustralia Douglass Hanly Moir Pathology SydneyNew South WalesAustralia

Objectives Women diagnosed with a history of lower genital tract cancer(LGTC)and precancer are at increased risk of anal *** for anal cancer in a manner analogous to cervical cancer may detect precursor anal high-grade squamous intraepithelial lesions(HSILs)and prevent progression to *** In a pilot study of anal cancer screening,women with previous LGTC and aged≥18 years in Sydney,Australia underwent a digital anorectal examination,anal swab for human papillomavirus(HPV)and p16/Ki67 testing and completeda *** with positive HPV and/or p16/Ki67 results were referred for a high-resolution anoscopy(HRA)and evaluation of their *** Of 52 participants,46 agreed to screening and 6 provided demographic information *** age was 46.5 years(IQR:36.059.0).Anal high-risk HPV(HRHPV)was detected in only seven(15.2%)participants(three HPV16).Eight(17.4%)had positive p16/Ki67 dual staining,with invalid results for 25(54.4%).0f 10 women referred for HRA,9 attended and 3 had HSILs,representing 6.5%of the screened *** were completed by 41 participants(89.1%).The majority reported that being screenedwas reassuring(97.5%)and was positive for their health(95.1%).Conclusion This pilot study demonstrated a lower-than-expected prevalence of anal *** with HRHPV and p16/Ki67 staining identified anal HSILs in 6.5%of ***,screeningwas viewed as beneficial by almost all *** utility of p16/Ki67dual staining was low,suggesting it may not be a suitable anal cancer screening methodology.

关键词： pilot Sydney screening

乡村振兴促进法实施机制的理论重述与制度表达

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学习与探索 2024年第5期 60-69页

作者：耿卓王洪广广东外语外贸大学法学院

《乡村振兴促进法》是持续推进乡村全面振兴的法治依托,但其面临执法规范不够具体、难以司法适用和法律监督效果有限等实施困境。困境的根源在于该法由自治范式向回应范式转化过程中,为获得更强的回应能力转变了限制自由裁量权的思路、... 详细信息

《乡村振兴促进法》是持续推进乡村全面振兴的法治依托,但其面临执法规范不够具体、难以司法适用和法律监督效果有限等实施困境。困境的根源在于该法由自治范式向回应范式转化过程中,为获得更强的回应能力转变了限制自由裁量权的思路、预留了创新法律强制手段的空间,实质上外化了该法的实施机制。国家土地督察作为本土化制度,与回应型法的发展趋势和政策性法律的实施特点相契合,对困境破解具有启示作用。破解困境的关键在于顺应《乡村振兴促进法》的法律发展范式转变,遵循政策与法律互动、中央地方权责划分的实践逻辑,构建与之相协调的法律实施机制。为此,应坚持问题导向、人民至上和系统观念,以《乡村振兴促进法》为基础,创制主体权责有力、对象明确具体、内容全面科学、手段丰富有效、制度协调配合的乡村振兴法律实施督察机制,强化法律实施以保障乡村全面振兴持续推进。

关键词：《乡村振兴促进法》回应型法法律实施督察制度

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香港前肠外科现状

中华普通外科杂志 2024年第6期39卷 418-422页

作者：黄宇匡罗英杰香港大学临床医学院外科学系中国

前肠是指胚胎时期的消化道上部,进一步发育成为食管、肺、胃、肝脏、胰腺及部分十二指肠等器官.在中国香港,针对治疗和研究前肠相关良性疾病的前肠外科已经拥有相对成熟的技术和先进仪器配合,包括采用一系列的辅助检查方法,率先开展新... 详细信息

前肠是指胚胎时期的消化道上部,进一步发育成为食管、肺、胃、肝脏、胰腺及部分十二指肠等器官.在中国香港,针对治疗和研究前肠相关良性疾病的前肠外科已经拥有相对成熟的技术和先进仪器配合,包括采用一系列的辅助检查方法,率先开展新颖的抗反流手术方式,如机器人辅助下食管裂孔疝修补、磁珠环括约肌增强术等.目前亚洲各地学者开始越来越重视前肠相关疾病,本文通过介绍中国香港前肠外科情况促进与国际进行学术交流合作,谋求与亚太地区进一步共同建设亚洲前肠相关协会,分享诊治经验和学术成果.

关键词：胃食管反流疝,食管裂孔肥胖症机器人贲门失驰缓症前肠外科

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Osmotic concentration of succinic acid by forward osmosis:Influence of feed solution pH and evaluation of seawater as draw solution

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Chinese Journal of Chemical Engineering 2018年第5期26卷 976-983页

作者： Jeng Yih law Abdul Wahab Mohammad Department of Chemical and Process Engineering Faculty of Engineering and Built Environment Universiti Kebangsaan Malaysia Section of Chemical Engineering Technology Universiti Kuala Lumpur Malaysian Institute of Chemical & Bioengineering Technology

In this study, we investigated the essential role of feed solution pH so as to gain insights into the transport mechanisms of succinic acid concentration by osmotically-driven forward osmosis （FO） process. FO performances including water flux and bidirectional transport of succinate and chloride anions were systematically examined using cellulose triacetate-based FO membrane. Additionally, real seawater was explored as draw solution. Experimental results revealed that the pH-dependent speciation of succinic acid can affect the FO performances. Ionization of succinic acid at higher solution pH enhanced the osmotic pressure of feed solution, thus leading to lower water flux performance. A strong effect was pointed out on the succinate rejection for which nearly 100% rejections were achieved at pH above its pKa2 value. The rejection of succinate increased in the following order of chemical form： C2H4C2O4H2 〈 C2H4C2OH- 〈 C2H4C2O24-. With real seawater as the draw solution, low to moderate water fluxes （〈4 L. m- 2. h- 1 ） were observed. The divalent succinate anion was highly retained in the feed side despite differences in the succinic acid feed concentration at pH of approximately 6.90.

关键词： Forward osmosis Succinic acid pH Transport mechanism Seawater

Stem Cell Niche,the Microenvironment and Immunological Crosstalk

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Cellular & Molecular Immunology 2008年第2期5卷 107-112页

作者： law Sujata S.Chaudhuri Stem Cell Research and Application Unit Department of Biochemistry and Medical BiotechnologySchool of Tropical MedicineC R AvenueKolkata 700073India

The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, ＇how compatible these cells are immunologically？＇ Indeed, the medical aspects of stem cells are dependent on a large number of queries based on the basic properties of the cells. It has greatly been emphasized to probe into the basic research on stem cells before any successful therapeutic attempts are made. One of the intricate aspects of the adult stem cells is its immunological behavior in relation to the microenvironmental associates, the stromal cells in the presence of a suitable target. Cellular ＆ Molecular Immunology.

关键词： stem cell niche stromal immunology

Historical imaginaries, historic urban branding, and the local state in China: rejuvenation discourse, manufactured heritage and simulacrascapes

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Built Heritage 2023年第1期7卷 76-87页

作者： Andrew Malcolm law School of Architecture Planning and LandscapeNewcastle UniversityNewcastleUK

This intervention examines the extant literature on historical imaginaries and historic urban branding in *** suggests that while research in this field has increasingly moved away from an economic(or an implicit neo-Marxist)model,there is still a lack of research on the role of broader cultural and state led discourses of nationalism in the construction of historic urban imaginaries and historic urban branding within Chinese *** unpacking one nationalistic discourse a-narrative of rejuvenation-this article argues that more needs to be done to examine the role of these themes in the construction of historical imaginaries at the level of the local state(including related state networks of developers,retailers,tourist officials,town planners,architects,and designers).It is suggested that an analysis of these discourses and imaginaries is important if we are:1)to appreciate the role of these themes in the construction and/or the reconfiguration of existing or emerging historic brands within Chinese cities;2)to comprehend the construction of'authorised heritage discourses,(AHDs)practices and materialities at the level of the local state;3)to understand the politics of the past(including the uses of history,memory,nostalgia,and heritage)at the level of the local state;4)to be aware of the way in which these themes inform the preservation,conservation,and/or the demolition of heritage space at the level of the local state;5)to recognise the manufacture of'heritage'or simulacrascapes within Chinese cities.

关键词： rejuvenation historical urban imaginaries historical urban branding built heritage simulacrascapes

The dispersion of surface contaminants by Stokes drift in random waves

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Acta Oceanologica Sinica 2018年第7期37卷 55-61页

作者： HUANG Guoxing law Wing-Keung Adrian State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China State Key Laboratory of Hydrology Water Resources and Hydraulics Engineering Nanjing 210029 China School of Civil and Environmental Engineering Nanyang Technological University Singapore 639798 Singapore

Contaminants that are floating on the surface of the ocean are subjected to the action of random *** the literature,it has been asserted by researchers that the random wave action will lead to a dispersion mechanism through the induced Stokes drift,and that this dispersion mechanism may have the same order of significance comparable with the others means due to tidal currents and *** is investigated whether or not surface floating substances will disperse in the random wave environment due to the induced Stokes *** analytical derivation is first performed to obtain the drift velocity under the random *** the analysis,it is shown that the drift velocity is a time-independent value that does not possess any fluctuation given a specific wave energy ***,the random wave drift by itself should not have a dispersive effect on the surface floating *** were then conducted with small floating objects subjected to P-M spectral waves in a laboratory wave flume,and the experimental results reinforced the conclusion drawn.

关键词： dispersion surface contaminants random wave Stokes drift

Dispersion in oscillatory electro-osmotic flow through a parallel-plate channel with kinetic sorptive exchange at walls

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Journal of Hydrodynamics 2014年第3期26卷 363-373页

作者： SONG Jie 吴朝安 law Wing-Keung Adrian School of Civil and Environmental Engineering Nanyang Technological University Department of Mechanical Engineering The University of Hong Kong

Dispersion in time-oscillatory electro-osmotic flows in a slit micro-channel under the effect of kinetic sorptive exchange at walls is theoretically investigated using the homogenization method. The two walls of the channel are considered to be made up of different materials, and therefore have different zeta potentials and sorption coefficients. A general expression for the Taylor dispersion coefficient under different zeta potentials as well as various sorption conditions at the walls is derived analytically. The dispersion coefficient is found to be dependent on the oscillation frequency, the Debye parameter, the species partition coefficient, the reaction kinetics and the ratio of the wall potentials. The results demonstrate that the presence of wall sorption tends to enhance the dispersion when the oscillation frequency is low, but the effect is negligible in high-frequency oscillatory flows. Moreover, it is found that the dispersion coefficient could be significantly changed by adjusting the relative wall potentials for low-frequency flows.

关键词： oscillatory electro-osmotic flows dispersion sorptive walls homogenization method