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Reevaluating health metrics:Unraveling the limitations of disabilityadjusted life years as an indicator in disease burden assessment

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World Journal of Methodology 2025年第1期15卷 14-19页

作者： ariel Beresniak Dominique Bremond-Gignac Danielle Dupont Gerard Duru Data Mining International Geneva 1216Switzerland Department of Ophtalmology Necker-Enfants Malades University HospitalAP-HPParis-CitéUniversityINSERMUMRS1138Team 17From Physiopathology of Ocular Diseases to Clinical DevelopmentSorbonne Paris CitéUniversityCentre de Recherche des CordeliersParis 75015France Data Mining America Montreal H2YCanada

In 1993,the World Bank released a global report on the efficacy of health promotion,introducing the disability-adjusted life years(DALY)as a novel *** DALY,a composite metric incorporating temporal and qualitative data,is grounded in preferences regarding disability *** review delineates the algorithm used to calculate the value of the proposed DALY synthetic indicator and elucidates key methodological challenges associated with its *** contrast to the quality-adjusted life years approach,derived from multi-attribute utility theory,the DALY stands as an independent synthetic indicator that adopts the assumptions of the Time Trade Off utility technique to define Disability *** to rely on no mathematical or economic theory,DALY users appear to have exempted themselves from verifying whether this indicator meets the classical properties required of all indicators,notably content validity,reliability,specificity,and *** DALY concept emerged primarily to facilitate comparisons of the health impacts of various diseases globally within the framework of the Global Burden of Disease initiative,leading to numerous publications in international *** widespread adoption,the DALY synthetic indicator has prompted significant methodological concerns since its inception,manifesting in inconsistent and non-reproducible *** the substantial diffusion of the DALY indicator and its critical role in health impact assessments,a reassessment is *** reconsideration is imperative for enhancing the robustness and reliability of public health decisionmaking processes.

关键词： Disability adjusted life years Cost-utility analyses Outcome research Public health Burden of disease

Waveform LiDAR concepts and applications for potential vegetation phenology monitoring and modeling:a comprehensive review

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Geo-Spatial Information Science 2021年第2期24卷 179-200,I0001页

作者： Eric ariel L Salas Agricultural Research Development Program(ARDP) Central State UniversityWilberforceUSA

Researchers continually demonstrated through published literature how LiDAR could create unparalleled measurements of ecosystem structure and forest *** are a number of studies conducted utilizing waveform LiDAR products for terrestrial monitoring,but those that deal specifically with the assessment of space-borne waveform LiDAR for monitoring and modeling of phenology is very *** review highlights the waveform LiDAR system and looks into satellite sensors that could link waveform LiDAR and vegetation phenology,such as the proposed NASA’s Global Ecosystem Dynamics Investigation(GEDI)and the Japanese Experimental Module(JEM)-borne LiDAR sensor named MOLI(Multi-footprint Observation LIDAR and Imager).Further,this work examines the richness and utility of the waveform returns and proposes a spline-function-derived model that could be exploited for estimating the leaf-shooting *** new approach may be utilized for ecosystem-level phenological studies.

关键词： Ecosystems gedi moli phenology vegetation modeling waveform LiDAR

^(40)Ar/^(39)Ar Age and Geological Significance of Lamprophyres in Pishan on the SW Margin of the Tarim Terrane, NW China

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Acta Geologica Sinica(English Edition) 2003年第1期77卷 36-43页

作者： ariel BOVEN Laboratory of Geochronology Vrije Universiteit Brussel Pleinlaan 2 1050 Brussels Belgium

The dike swarm of lamprophyres at Pishan on the SW margin of the Tarimterrane is composed of ultra-potassic lamprophyres that have intruded into the Proterozoichornblende schists. ^(40)Ar/^(39)Ar dating data suggest that the isochron ages for phlogopite andwhole rock separates of the lamprophyres are 231.7+-0.3 Ma and 228.5+-0.3 Ma, *** data indicate that the dikes were derived from a subduction-related or metasomatizedmantle. During the Middle-Late Triassic the western Kunlun area entered the post-orogeny period, andthus the occurrence of the dike swarm in the study area may have been controlled by underplating.

关键词： Tarim western Kunlun Triassic lamprophyre Ar-Ar age

The Healthcare of the Final Frontier- Comprehensive Epidemiological Approach to the Future of Human Space Exploration and Travel

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Space(Science & Technology) 2023年第1期3卷 256-258页

作者： ariel Braverman Clalit Health Services Tel AvivIsrael Ben Gurion University of The Negev BeershebaIsrael

Today,the discussion about colonizing different planets has shifted from the"IF"mode to the"WHEN"mode,and the substantial large group of humans living for a long time in an isolated,hostile,and enclosed environment is about to become a ***,the space-related healthcare methodologies should shift as well from a small number of selected persons to much more extensive groups with much less health ***,the development of human colonies,first on the Moon and later on Mars,will be a game changer in allthat we know and use to see in space travel and eventually in space *** will leave Earth but will carry human society's health patterns,adjusted to the *** foundation for space epidemiology modeling can be set today and should attract the attention of the epidemiological and space research communities.

关键词： eventually Human planet

On the role of geometry in geo-localization

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Computational Visual Media 2021年第1期7卷 103-113页

作者： Moti Kadosh Yael Moses ariel Shamir Department of Electrical Engineering Tel-Aviv UniversityTel-AvivIsrael The Efi Arazi School of Computer Science The Interdisciplinary Center HerzliyaHerzliyaIsrael

Consider the geo-localization task of finding the pose of a camera in a large 3 D scene from a single *** existing CNN-based methods use as input textured *** aim to experimentally explore whether texture and correlation between nearby images are necessary in a CNN-based solution for the geo-localization *** do so,we consider lean images,textureless projections of a simple 3 D model of a *** only contain information related to the geometry of the scene viewed(edges,faces,and relative depth).The main contributions of this paper are:(i)to demonstrate the ability of CNNs to recover camera pose using lean images;and(ii)to provide insight into the role of geometry in the CNN learning process.

关键词： geo-localization geometry CNN-based solutions synthetic lean images

JMJD3 regulates diabetic wound repair in a STINGy fashion

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Cellular & Molecular Immunology 2023年第1期20卷 110-111页

作者： Amiram ariel Departments of Biology and Human Biology University of HaifaHaifaIsrael

skin wound repair is a multifactorial process involving immune and nonimmune cells,such as mast cells,neutrophils,lymphocytes,monocytes,macrophages,keratinocytes,fibroblasts,and endothelial *** diabetic patients,this process is significantly hindered,resulting in chronic complications,such as diabetic foot,which is typically associated with difficult-to-heal ***,the roles of monocytes,their derived macrophages,and skin-resident macrophages in cutaneous wound repair have gained significant *** conversion of macrophages from M1-like inflammatory cells to M2-like reparative cells has been associated with metabolic dysregulation under diabetic *** cytokines,angiogenic factors,and growth factors released by M2 macrophages are believed to be key contributors to proper wound *** persistence of M1 macrophages and the inflammatory state during diabetes or in response to a high-fat diet results in nonhealing wounds.

关键词： wound diabetic healing

Biofiltration of the antibacterial drug sulfamethazine by the species Chenopodium quinoa and its further biodegradation through anaerobic digestion

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Journal of Environmental Sciences 2019年第1期31卷 54-63页

作者： ariel E.Turcios Jutta Papenbrock Institute of Botany Leibniz University Hannover

The biofiltering capacity, distribution patterns and degradation of the antimicrobial sulfamethazine(SMT) by halophyte Chenopodium quinoa under hydroponic conditions and its further biodegradation through anaerobic digestion were evaluated. C. quinoa was cultivated for a complete life cycle under different concentrations of SMT(0, 2 and 5 mg/L) and sodium chloride(0 and 15 g/L). C. quinoa is able to uptake and partially degrade SMT. The higher the SMT concentration in the culture medium, the higher the SMT content in the plant tissue. SMT has different distribution patterns within the plant organs, and no SMT is found in the *** crop residues containing SMT have a great potential to produce methane through anaerobic digestion and, in addition, SMT is further biodegraded. The highest specific methane yields are obtained using crop residues of the plants cultivated in the presence of salt and SMT with concentrations between 0 and 2 mg/L.

关键词： Anaerobic digestion Chenopodium quinoa FISH analysis Phytoremediation Sulfamethazine biodegradation

Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain

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Neural Regeneration Research 2018年第2期13卷 232-233页

作者： ariel diaz manuel yepes department of neurology and center for neurodegenerative disease emory university school of medicineAtlantaGAUSA division of neuropharmacology and neurologic diseases yerkes national primate research centerAtlantaGAUSA department of neurology veterans affairs medical centerAtlantaGAUSA

The central nervous system has a very high energy requirement. Accord- ingly, despite representing only 2% of the body＇s mass, the brain uses 20% of the total oxygen consumption. Importantly, because most of this energy is used to maintain synaptic activity, even a mild decrease in its supply to the brain has deleterious implications for synaptic function.

关键词： Urokinase-type plasminogen activator promotes synaptic repair in the ischemic brain AR TSP OGD LRP

Harnessing class II histone deacetylases in macrophages to combat breast cancer

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Cellular & Molecular Immunology 2017年第7期14卷 575-577页

作者： Hadar Reichman ariel Munitz Department of Clinical Microbiology and Immunology The Sackler School of MedicineTel-Aviv UniversityRamat Aviv69978Israel

Viewing the tumor microenvironment(TME)as a critical factor in cancer biology has been a central paradigm shift in the field in the past two decades.1 During this time,the roles of tumor-infiltrating immune cells have... 详细信息

关键词： cancer breast tumor