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Undifferentiated high-grade pleomorphic sarcoma of the common bile duct:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2253-2260页

作者： Li-Ping Zheng Wen-Yan Shen chun-Dong Hu chun-hua wang Xu-Jian Chen Jing wang Yi-Yu Shen Department of General Surgery The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Pathology The Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Undifferentiated pleomorphic sarcoma(UPS)is a rare malignant mesenchymal tumor with a poor *** mainly occurs in the extremities,trunk,head and neck,and retroperitoneum *** to the lack of specific clinical manifestations and imaging features,UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive *** we report an extremely rare case of high-grade UPS in the common bile duct(CBD).There are limited available data on such *** SUMMARY A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 *** laboratory data suggested significantly elevated hepatorenal function *** imaging data revealed calculous cholecystitis,intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi,and a space-occupying lesion at the distal *** endoscopic biliary stenting and symptomatic support therapy,CBD exploration and biopsy were *** frozen section indicated malignant spindle cell tumor of the CBD mass,and further radical pancreaticoduodenectomy was ***,the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical *** This extremely rare case highlighted the need for increasing physicians'vigilance,reducing the odds of misdiagnosis,and providing appropriate treatment strategies.

关键词： Undifferentiated pleomorphic sarcoma Soft tissue sarcoma Common bile duct Extrahepatic bile duct Immunohistochemistry Case report

Gallbladder carcinosarcoma with a poor prognosis: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1817-1823页

作者： Yi Dai Min Meng Qi-Zhi Luo Yuan-Jun Liu Fan Xiao chun-hua wang Department of Hepatobiliary Surgery Suining Central HospitalSuining 629000Sichuan ProvinceChina The Cancer Center Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Pathology Suining Central HospitalSuining 629000Sichuan ProvinceChina Department of Liver Surgery&Liver Transplantation West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Carcinosarcoma of the gallbladder is a rare malignant tumor with a very poor *** date,only approximately 100 patients have been reported in the English *** prognosis of this tumor type is poor,the preoperative diagnosis is difficult,and there is a possibility of a *** present an unsuccessful case of carcinosarcoma of the gallbladder with a preoperative misdiagnosis and rapid early postoperative ***,we have a deeper understanding of the poor prognosis of gallbladder carcinosarcoma(GBC)*** SUMMARY The patient is a 65-year-old *** was admitted to the hospital because of right upper abdomen distending pain and discomfort for half a *** magnetic resonance imaging revealed a polycystic mass in the right lobe of the liver and the fossa of the *** admission,the patient was diagnosed with a liver abscess,which was treated by abscess puncture ***,this treatment was *** and cholecystectomy were performed one month after the *** pathologic examination revealed carcinosarcoma of the gallbladder,and the resected specimen contained two tumor *** month after surgery,the patient's tumor recurred in situ and started to compress the duodenum,resulting in duodenal obstruction and *** treatment was not *** patient died of gastrointestinal hemorrhage and hypovolemic *** Carcinosarcoma of the gallbladder is a rare malignant tumor that is easily misdiagnosed preoperatively and has a poor prognosis.

关键词： Gallbladder disease Carcinosarcoma Misdiagnosis Poor prognosis Pathological diagnosis Recurrence Case report

Clinical characteristics and analysis of vestibular-evoked myogenic potentials in patients with sudden sensorineural hearing loss in different ages

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World Journal of Clinical Cases 2024年第19期12卷 3760-3766页

作者： Yan-Zhuo Zhang Ya-Bo wang Jing-Lei Fang Yue-Tang wang Gui-Fang Li Ran-Ran Liu Shu-Jing Shi chun-hua wang Yong-Tao Tian Department of Otolaryngology Hebei Provincial Eye HospitalHebei Provincial Key Laboratory of OphthalmologyHebei Provincial Eye InstituteXingtai 054001Hebei ProvinceChina

BACKGROUND Numerous studies have found that patients experiencing sudden sensorineural hearing loss(SSHL),with or without accompanying vertigo,often show impaired vestibular ***,there is a dearth of studies analyzing vestibularevoked myogenic potentials(VEMPs)in SSHL patients across various age *** To investigate vestibular condition in SSHL patients across various age *** Clinical data of 84 SSHL patients were investigated ***,cervical vestibular evoked myogenic potentials(c-VEMPs),and ocular vestibular evoked myogenic potentials(o-VEMPs)were conducted on these *** assessed included the latencies of P1 and N1 waves,as well as the amplitudes of P1–N1 ***,the study evaluated the influence of factors such as sex,affected side,configuration of hearing loss,and presence of accompanying *** Among the 84 SSHL patients,no significant differences were observed among the three groups in terms of gender,affected side,and the presence or absence of *** II(aged 41–60 years)had the highest number of SSHL *** rates of absent o-VEMPs in the affected ears were 20.83%,31.58%,and 22.72%for the three age groups,respectively,with no statistically significant difference among *** rates of absent c-VEMPs in the affected ears were 8.3%,34.21%,and 18.18%for the three age groups,respectively,with significant *** the unaffected ears,there were differences observed in the extraction rates of o-VEMPs in the unaffected ears among the age *** the three age groups,no significant differences were noted in the three age groups in the latencies of P1 and N1 waves or in the amplitude of N1–P1 waves for c-VEMPs and o-VEMPs,either on the affected side or on the unaffected side,across the three age *** The extraction rate of VEMPs is more valuable than *** of the presence of vertigo,vestibular organs are involved in ***,SSHL pat

关键词： Sudden sensorineural hearing loss Cervical vestibular evoked myogenic potential Ocular vestibular evoked myogenic potential Vertigo Pure tone audiometry

Synthesis and Adsorption Properties of Polystyrene-supported Chelating Resins Containing Heterocyclic Functional Groups

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Chinese Chemical Letters 2005年第9期16卷 1193-1196页

作者： chun Nuan JI Rong Jun QU chun hua wang Chang Mei SUN Qing hua TANG School of Chemistry and Materials Science Yantai Normal University Yantai 264025 School of Materials Science and Engineering Tianjin University Tianjin 300072

A series of new chelating resins with incorporating heterocyclic functional groups： pyridine, thiadizole, benzothizole into macroporous chloromethylated polystyrene were synthesized via hydrophilic spacer arm of polyethylene glycol containing sulfur. These chelating resins were found to show high adsorption capacities for Ag^＋, Hg^2＋, Au^3＋ and Pd^2＋, and the presence of spacer arm can enhance adsorption ability due to increase the hydrophilicity of the chelating resins.

关键词： Chelating resins heterocyclic functional groups spacer ann adsorption metal ions

Facile preparation of antibacterial polymer coatings via thiol-yne click photopolymerization

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Chinese Chemical Letters 2016年第5期27卷 681-684页

作者： Chuan Zhou Yi-He Li Zhen-hua Jiang Kwang-Duk Ahn Tian-Jiao Hu Qing-hua wang chun-hua wang Department of Chemistry and Biology College of Science National University of Defense Technology Polymer Research Center Korea Institute of Science and Technology

Novel antibacterial polymer coatings were prepared by a facile thiol-yne click photopolymerization of 1-propargyl-3-allYl-l,3-diazanyl-2,4-cyclopentadiene bromide （[PAIMIBr） and tetra（3-mercapto-pro- pionate）pentaerythritol （PETMP）（2：1 molar ratio） using 2,2-dimethoxy-2-phenylacetophenone （DMPA） as initiator. The antibacterial activity of the coatings was tested against Staphylococcus aureus （ATCC 292130） and Escherichia coli （ATCC 25922） by the dynamic shake method. The evaluation results revealed the antibacterial polymer coatings exhibited excellent inhibitory activity against S. aureus and E. coil, especially for S. aureus.

关键词： Antibacterial polymer Thiol-yneClick chemistry UV-curing Coatings

Poly[(mercaptopropyl)methylsiloxane](PMMS)-based antibacterial polymer coatings prepared by a two-step sequential thiol–ene click chemistry

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Chinese Chemical Letters 2016年第5期27卷 685-688页

作者： Chuan Zhou Yi-He Li Zhen-hua Jiang Kwang-Duk Ahn Tian-Jiao Hu Qing-hua wang chun-hua wang Department of Chemistry and Biology. College of Science National University of Defense Technology Changsha 410073 China State Key Laboratory of NBC Protection for Civilian Beijing 102205 China Polymer Research Center Korea Institute of Science and Technology Seoul 136-791 Republic of Korea

Poly[（mercaptopropyl）methylsiloxane] （PMMS）-based antibacterial polymer coatings have been prepared through a two-step sequential thiol-ene click chemistry utilizing 1-allyl-3-decylimidazolium bromide （ADIm） as antibacterial monomer and triallyl cyanurate （TAC） as the crosslinker. These films with different content of ADIm were characterized by thermogravimetric analysis （TGA）, dynamic mechanical analysis （DMA） and pencil hardness. It was found that the mechanical and thermal properties of these films were largely influenced by the content of ADIm in the films. Films with imidazolium bromide groups displayed excellent antimicrobial activity against Staphylococcus aureus with 100% killing efficiency.

关键词： Antibacterial polymerThiol-ene UV-curing Click chemistry Coatings

Unsymmetric Side Chains of Indacenodithiophene Copolymers Lead to Improved Packing and Device Performance

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高分子科学：英文版 2020年第4期38卷 342-348,I0005页

作者： Ying Yang Tong Shan Jian Cao hua-chun wang Ji-Kang wang Hong-Liang Zhong Yun-Xiang Xu College of Polymer Science&Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Two conjugated polymers(PulDTBD and PulDTQ)with un symmetric side chai ns have been prepared for polymer solar cells using two other polymers(PIDTBD and PIDTQ)with symmetric side chains as control *** combi nation of methyl a nd 4-hexylphenyl side chai ns on the same bridged carb on can en sure good solubility,decrease tt-tt stacking dista nces,and bring proper miscibility with PC71BM ***,the corresp on ding polymer solar cells(PSCs)based on donor polymers with un symmetric side chains exhibited enhanced short-circuit current density(■)and power conversion efficiency(PCE)compared with those of control *** PIDTBD and PIDTQ based devices possessed low PCE of 2.13%and 1.48%,while PCEs of devices based on PulDTBD and PulDTQ were improved to 3.93%and 4.12%,*** results demonstrate that unsymmetric side chain engineering of conjugated polymers is an effective approach to achieve high performance PSCs.

关键词： Polymer solar cell Indacenodithiophene Side-chain engineering Unsymmetric

Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus

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Neural Regeneration Research 2020年第5期15卷 936-943页

作者： Dong-Qi Lin Xin-Ying Cai chun-hua wang Bin Yang Ri-Sheng Liang Department of Cardiothoracic Surgery the Second Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery Union HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Clinical Research Center Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-sen UniversityShantouGuangdong ProvinceChina

Hippocampal neurons undergo various forms of cell death after status ***-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 ***,there are no reports of necroptosis in mouse models of status ***,in this study,we investigated the effects of necrostatin-1 on hippocampal neurons in mice with status epilepticus,and,furthermore,we tested different amounts of the compound to identify the optimal concentration for inhibiting necroptosis and apoptosis.A mouse model of status epilepticus was produced by intraperitoneal injection of kainic acid,12 mg/*** concentrations of necrostatin- 1 (10,20,40,and 80 μM) were administered into the lateral ventricle 15 minutes before kainic acid *** damage was assessed by hematoxylin-eosin staining 24 hours after the model was successfully *** deoxynucleotidyl transferase-mediated dUTP nick end labeling staining,western blot assay and immunohistochemistry were used to evaluate the expression of apoptosis-related and necroptosis-related ***-1 alleviated damage to hippocampal tissue in the mouse model of *** 40 μM concentration of necrostatin-1 significantly decreased the number of apoptotic cells in the hippocampal CA1 ***,necrostatin-1 significantly downregulated necroptosis-related proteins (MLKL,RIP1,and RIP3) and apoptosis-related proteins (cleaved-Caspase-3,Bax),and it upregulated the expression of anti-apoptotic protein *** together,our findings show that necrostatin-1 effectively inhibits necroptosis and apoptosis in mice with status epilepticus,with the 40 μM concentration of the compound having an optimal *** experiments were approved by the Animal Ethics Committee of Fujian Medical University,China (approval No.2016-032) on November 9,2016.

关键词： apoptosis Bax Bcl-2 cleaved-Caspase-3 epilepsy hippocampal neuron MLKL necroptosis necrostatin-1 nerve regeneration neural regeneration RIP1 RIP3

The dynamics of a memristor-based Rulkov neuron with fractional-order difference

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Chinese Physics B 2022年第6期31卷 30-38页

作者： Yan-Mei Lu chun-hua wang Quan-Li Deng Cong Xu College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China

The exploration of the memristor model in the discrete domain is a fascinating *** electromagnetic induction on neurons has also begun to be simulated by some discrete ***,most of the current investigations are based on the integer-order discrete memristor,and there are relatively few studies on the form of fractional *** this paper,a new fractional-order discrete memristor model with prominent nonlinearity is constructed based on the Caputo fractional-order difference ***,the dynamical behaviors of the Rulkov neuron under electromagnetic radiation are simulated by introducing the proposed discrete *** integer-order and fractional-order peculiarities of the system are analyzed through the bifurcation graph,the Lyapunov exponential spectrum,and the iterative *** results demonstrate that the fractional-order system has more abundant dynamics than the integer one,such as hyper-chaos,multi-stable and transient *** addition,the complexity of the system in the fractional form is evaluated by the means of the spectral entropy complexity algorithm and consequences show that it is affected by the order of the fractional *** feature of fractional difference lays the foundation for further research and application of the discrete memristor and the neuron map in the future.

关键词： discrete memristor Rulkov neuron fractional-order difference dynamics