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Predicting portal venous anomalies by left-sided gallbladder or rightsided ligamentum teres hepatis: A large scale, propensity scorematched study

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World Journal of Gastroenterology 2023年第27期29卷 4344-4355页

作者： Hsuan-Yin Lin Rheun-Chuan Lee Jyh-Wen Chai Chiann-Yi Hsu Yen chou Hsuen-En Hwang chien An Liu Nai-Chi Chiu Ho-Hsian Yen Department of Radiology Taichung Veterans General HospitalTaichung 407219Taiwan Department of Radiology Taipei Veterans General HospitalTaipei 11267Taiwan School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112Taiwan Department of Medical Research Taichung Veterans General HospitalTaichung 40705Taiwan Department of Radiology Fu Jen Catholic University HospitalTaipei 24352Taiwan Department of Radiology Far Eastern Memorial HospitalNew Taipei City 220Taiwan

BACKGROUND Right-sided ligamentum teres(RSLT)is often associated with portal venous anomalies(PVA)and is regarded as a concerning feature for hepatobiliary *** studies consider RSLT to be one of the causes of left-sided gallbladder(LGB),leading to the hypothesis that LGB must always be present with ***,some cases have shown that right-sided gallbladder(RGB)can also be present in livers with *** To highlight the rare variation that RSLT may not come with LGB and to determine whether ligamentum teres(LT)or gallbladder location is reliable to predict *** This study retrospectively assessed 8552 contrast-enhanced abdominal computed tomography examinations from 2018 to 2021[4483 men,4069 women;mean age,59.5±16.2(SD)years].We defined the surrogate outcome as major *** cases were divided into 4 subgroups according to gallbladder and LT *** one hand,we analyzed PVA prevalence by LT locations using gallbladder location as a controlled variable(n=36).On the other hand,we controlled LT location and computed PVA prevalence by gallbladder locations(n=34).Finally,we investigated LT location as an independent factor of PVA by using propensity score matching(PSM)and inverse probability of treatment weighting(IPTW).RESULTS We found 9 cases of RSLT present with *** the LGB cases,RSLT is associated with significantly higher PVA prevalence than typical LT[80.0%vs 18.2%,P=0.001;OR=18,95%confidence interval(CI):2.92-110.96].When RSLT is present,we found no statistically significant difference in PVA prevalence for RGB and LGB cases(88.9%vs 80.0%,P>0.99).Both PSM and IPTW yielded balanced cohorts in demographics and gallbladder *** RSLT group had a significantly higher PVA prevalence after adjusted by PSM(77.3%vs 4.5%,P<0.001;OR=16.27,95%CI:2.25-117.53)and IPTW(82.5%vs 4.7%,P<0.001).CONCLUSION RSLT doesn't consistently coexist with *** can predict PVA independently while the gallbladder location does not serve as a suf

关键词： Right-sided ligamentum teres Left-sided gallbladder Portal venous anomalies Inverse probability of treatment weighting Average treatment effect in the treated

Analysis of Core Competency Required for the Managerial Work Force of Small and Medium Enterprises in Taiwan

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Journal of Software Engineering and Applications 2013年第3期6卷 111-113页

作者： chien-Hua Shen Chun-Mei chou Hsi-Chi Hsiao Yu-Je Lee Department of Business Administration TransWorld University Yunlin Taiwan China Graduate Institute of Business and Administration Cheng Shiu University Kaohsiung Taiwan China Institute of Vocational & Technological Education National Yunlin University of Science & Technology Yunlin Taiwan China Takming University of Science & Technology Taipei Taiwan China

This study aims to probe into the core competencies, as should be possessed by the managerial work forces of firms, from the perspective of employers’ in small and medium enterprises. The findings can serve as references for planning core courses of employee training and labor employment. Based on the research purposes, this study adopted revised DACUM, conducted literature review, and applied a questionnaire survey. The subjects were the members of SMEs Honor Instructor Association of Ministry of Economic Affairs, Taiwan, and the Society of Management Science. Random sampling was used, with the number of employees as the units. The valid return rate was 24.2%. After testing goodness of fit of K-S single samples, this study found that a corporate management work force should have 11 items of core competencies, and 35 items of secondary competency.

关键词： Small and Medium Enterprises Enterprise Training Core Competency

The Causes of Conversion from Laparoscopy to Laparotomy in Patients with Laparoscopic Repair of Perforated Peptic Ulcer

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Surgical Science 2015年第2期6卷 75-79页

作者： chien-Hua Lin Der-Ao chou Yueh-Tsung Lee Hurng-Sheng Wu Department of Surgery Chang-Bing Show Chwan Memorial Hospital Changhua Chinese Taipei IRCAD Changhua Chinese Taipei

Purpose: Perforated peptic ulcer is an emergency condition. Laparoscopic ulcer repair is a feasible and safe procedure. The aim of this study was to research the efficacy of laparoscopic repair of peptic ulcer and to discuss the causes of conversion from laparoscopy to laparotomy. Methods: We collected 34 patients with perforated peptic ulcer underwent laparoscopic surgery from October 2003 to October 2008. Thirty four patients with perforated peptic ulcer underwent laparoscopic intervention and 6 cases were converted to laparotomy. The demographics, laboratory data, perioperative data, morbidity and mortality were compared. Results: In demographics of two groups, there were no significant differences in sex, age, location, and mean duration of symptoms of acute abdominal pain. However, there were significant differences in median size of perforation, mean duration of history of peptic ulcer related pain, and the experiences of surgeon. There were no significant differences in the laboratory data and perioperative data of two groups. In morbidity?and mortality of two groups, there were no significant differences in leakage, wound infection, intra-abdominal abscess, ileus, urinary tract infection, pneumonia, and mortality, but there was significant difference in overall morbidity in two groups. Conclusions: Laparoscopic repair of perforated peptic ulcer is safe and could be used in routine clinical practice. However, patients with larger perforations (>10 mm), longer duration of history peptic ulcer related pain (>2 years), and learning curve of surgeon could be associated with conversion rate. It is associated with higher morbidity in patients with conversion from laparoscopy to laparotomy.

关键词： Laparoscopy Perforated Peptic Ulcer Repair Conversion Rate

Insect Flight from the Perspective of a Force Element Theory Using a Simplified Model

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Insect Flight from the Perspective of a Force Element Theory...

Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

2009年度海峡两岸工程力学研讨会

作者： chien C.Chang Chin-chou Chu Cheng-Ta Hsieh Institute of Applied Mechanics National Taiwan University Division of Mechanics Applied SciencesAcademia Sinica

Bird or insect flight has been of great interest to general audience,not only to *** works have been devoted to the study of aerodynamics of insect wings,for example,the hovering *** is generally considered that the lift supporting the insect comes from the unsteadiness of the ***,the term "unsteadiness" itself is loose and imprecise at *** may include several unsteady components:the motion of wing,vortex in the flow as well as the surface *** various contributions are now examined from the perspective of a force element theory to gain more insight into the mechanisms of generating lift.

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World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su Pin-Yu Lai Pei-Hsuan Hu Je-Ming Hu Pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin chien-An Sun Tsan Yang Chih-Hsiung Hsu Hua-Ching Lin Yu-Ching chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

Gene expression profile of peripheral blood in colorectal cancer

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World Journal of Gastroenterology 2014年第39期20卷 14463-14471页

作者： Yu-Tien Chang Chi-Shuan Huang Chung-Tay Yao Sui-Lung Su Harn-Jing Terng Hsiu-Ling chou Yu-Ching chou Kang-Hua Chen Yun-Wen Shih Chian-Yu Lu Ching-Huang Lai Chen-En Jian Chiao-Huang Lin chien-Ting Chen Yi-Syuan Wu Ke-Shin Lin Thomas Wetter Chi-Wen Chang Chi-Ming Chu Division of Biomedical Statistics and Informatics School of Public Health National Defense Medical Center Division of Colorectal Surgery Cheng Hsin Rehabilitation Medical Center Department of Surgery Cathay General Hospital Department of Epidemiology School of Public Health National Defense Medical Center Advpharma Inc. Department of Nursing Far Eastern Memorial Hospital and Oriental Institute of Technology Department of Nursing School of Medicine Chang Gung University Air Force Combatant Command National Defense Ministry Institute of Medical Biometry and Informatics Heidelberg University Germany Department of Biomedical Informatics and Medical Education University of Washington Seattle United States

AIM: Optimal molecular markers for detecting colorectal cancer (CRC) in a blood-based assay were evaluated.

关键词： Colorectal cancer Gene expression Microarray Internet

MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan

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World Journal of Gastroenterology 2021年第34期27卷 5737-5752页

作者： Chia-Cheng Lee Yu-Cheng Kuo Je-Ming Hu Pi-Kai Chang chien-An Sun Tsan Yang Chuan-Wang Li Chao-Yang Chen Fu-Huang Lin Chih-Hsiung Hsu Yu-Ching chou Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Medical Informatics Office Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Health Business Administration Meiho UniversityPingtung 91202TaiwanChina Department and Graduate Institute of Microbiology and Immunology National Defense Medical CenterTaipei 114TaiwanChina Institute of Preventive Medicine National Defense Medical CenterNew Taipei City 237TaiwanChina

BACKGROUND Identifying novel colorectal cancer(CRC)prognostic biomarkers is crucial to helping clinicians make appropriate therapy *** plays a major role in managing the circadian rhythm and exerts oncostatic effects on different kinds of *** To explore the relationship between MTNR1B single-nucleotide polymorphism(SNPs)combined with gene hypermethylation and CRC *** A total of 94 CRC tumour tissues were *** for the four MTNR1B SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)was performed using multiplex polymerase chain *** relationships between the MTNR1B SNPs and CRC 5-year overall survival(OS)was assessed by calculating hazard ratios with 95%*** All SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)were correlated with decreased 5-year *** stratified analysis,rs1387153,rs10830963,and rs1447352 risk genotype combined with CDKN2A and MGMT methylation status were associated with 5-year OS.A strong cumulative effect of the four polymorphisms on CRC prognosis was *** haplotypes of MTNR1B SNPs were also associated with the 5-year ***1B SNPs combined with CDKN2A and MGMT gene methylation status could be used to predict shorter CRC *** The novel genetic biomarkers combined with epigenetic biomarkers may be predictive tool for CRC prognosis and thus could be used to individualise treatment for patients with CRC.

关键词： Colorectal cancer Melatonin Hypermethylation Polymorphism Prognosis Biomarker

The Relations between Elastic Constants and Interatomic Force Constants of Single Crystals

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The Relations between Elastic Constants and Interatomic Forc...

Relationship between severity of venous calcifications and symptoms of phlebosclerotic colitis

2009年度海峡两岸工程力学研讨会

作者： Chia-Ou Chang Chan-Shin chou Po-Chih Chen Wen-Tien Chang chien Institute of Applied mechanics National Taiwan University Degree program of Information Technology Fooyin University

The equations of lattice vibration of a single crystal are needed *** the dispersion curve of acoustic branches at the point where the wavenumber approaches zero,we can match the wave speed of lattice vibration to those obtained from elastic wave theory so that the elastic constants of buck elastic crystals are found to be related to the interatomic force *** concept provides us a technique to determine the microscopic force constants between different atoms once the elastic moduli are known and vice versa.

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World Journal of Gastroenterology 2015年第26期21卷 8148-8155页

作者： Tsung-Shuo Yen chien-An Liu Nai-Chi Chiu Yi-You Chiou Yi-Hong chou Cheng-Yen Chang Department of Radiology Wei Gong Memorial Hospital Department of Radiology Taipei Veterans General Hospital School of Medicine National Yang-Ming University

AIM: To examine the correlation between the severity of venous calcifications and the clinical symptoms of phlebosclerotic ***: This was a retrospective *** data,including the numbers of episodes of active disease,were collected from the medical records at Taipei Veterans General Hospital and Wei Gong Memorial Hospital in Taiwan between January 2005 and December *** computed tomography images with or without contrast enhancement were obtained using a multiple detector computed tomography *** scanning range reached from the dome of the diaphragm to the *** severity of calcification at the tributaries of the portal vein was measured using a four-grade scoring system of the calcification of phlebosclerotic *** episodes of active disease were defined as symptoms of fever,abdominal pain,severe constipation,bowel obstruction,vomiting or diarrhea based on a review of the medical ***'s correlation analysis was used to examine the correlation between the numbers of episodes of active disease and the severity of the calcification of the mesenteric ***: More than 3000 cases were reviewed from 2005 to 2014,and a total of 12 patients from Taipei Veterans General Hospital and Wei Gong Memorial Hospital were enrolled according to our inclusion *** these 12 patients,the mean age of the six males and the six females was 61.8 ± 11.5 *** patients exhibited typical imaging characteristics,consisting of threadlike calcifications and colonic wall thickening in the standard radiographs and calcifications along the colonic and mesenteric vessels or associated with colonic wall thickening and adjacent fat stranding in the computed tomography *** median score of the severity of the venous calcifications was 18 ± 13,and the median number of active disease episodes was 1 ± ***'s correlation analysis revealed that the number of episodes of active phlebosclerotic colitis disease significantly p

关键词： Phlebosclerotic colitis Calcification of themesenteric veins Symptoms of phlebosclerotic colitis Computed tomography Ischemic bowel disease