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Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Clinical Cases 2024年第27期12卷 6057-6069页

作者： Chao-Yu Chen Tzu-Hao Huang Li-Wen Lee Jrhau Lung Yu-Che Ou chien-hui Hung Huei-chieh Chuang min-chi Chen Ting-Yao Wang Department of Obstetrics and Gynecology Chang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Sciences College of MedicineChang Gung UniversityTaoyuan 333Taiwan Department of Early childhood Care and Education Shu-Zen Junior College of Medicine and ManagementKaohsiung 821Taiwan Division of General Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Department of Diagnostic Radiology Chang Gung Memorial HospitalChiayi 613Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Research and Development Chang Gung Memorial HospitalChiayi 613Taiwan Department of Obstetrics and Gynecology Kaohsiung Chang Gung Memorial HospitalKaohsiung 833Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalChiayi 613Taiwan Department of Public Health Chang Gung UniversityTaoyuan 333Taiwan Division of Hematology and Oncology Department of Internal MedicineChang Gung Memorial HospitalChiayi 613Taiwan

BACKGROUND Although cytoreductive surgery(CRS)and hyperthermic intraperitoneal chemotherapy(HIPEC)offer the potential for long-term survival in peritoneal carcinomatosis,outcomes following CRS/HIPEC vary *** To identify the clinical factors associated with progression-free survival(PFS)after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal,ovarian,and gastric *** We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival(OS)in patients recruited between 2015 and *** regression models were used to assess the prognostic factors for the risk of recurrence within 1 ***–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and *** Of the 80 enrolled patients,39 had an unfavorable PFS(chieving CC-0 was the strongest prognostic factor for a favorable PFS(OR=0.131,P=0.005).A peritoneal cancer index score>12 was associated with a lower rate of achieving CC-0(P=0.027).The favorable PFS group had a significantly longer OS(median 81.7 mo vs 17.0 mo,Pchieving CC-0 was associated with a lower early recurrence rate and improved long-term *** study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.

关键词： Peritoneal metastasis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Predictor Recurrence

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Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-ming Zhang Xian Wang Bing-Qian Liu Ling Jin Yi-Nuo Huang Yang-Fan Yang Zi-Dong Chen Da-hui Ma Qing-Shan Chen Chao-Jun Qin Bing-min Feng Zhu-min Yang Xing Huang Cheng-Jie Yang Sheng-hui Liu ming-Xing Wu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

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融合粒子群的改进金豺算法及应用

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计算机集成制造系统 2024年第5期30卷 1733-1744页

作者：回立川曹明远迟一璇辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125105

为了解决传统金豺算法收敛精度低,搜索速度慢等问题,提出一种融合粒子群算法的改进金豺优化算法(PGJO)。首先,采用Chebyshev混沌映射和精英选择策略结合的方式对种群进行初始化,提高初始解质量;然后,结合粒子群优化算法(PSO)思想,提出... 详细信息

为了解决传统金豺算法收敛精度低,搜索速度慢等问题,提出一种融合粒子群算法的改进金豺优化算法(PGJO)。首先,采用Chebyshev混沌映射和精英选择策略结合的方式对种群进行初始化,提高初始解质量;然后,结合粒子群优化算法(PSO)思想,提出一个新的搜索方式。采用动态转换策略,判断PGJO采用原Levy方式搜索还是采用新的搜索方式更新个体位置,以提高算法收敛精度;最后,提出了种群收敛监测策略,帮助算法跳出局部最优。将PGJO与其他智能优化算法经过11个基准测试函数对比实验表明,算法性能均优于其他算法。将PGJO应用于无人机路径规划当中,对比其他算法路径长度下降了3.4%,拐点个数减少了21%,验证了该算法的工程应用能力。

关键词：智能优化算法金豺优化算法种群收敛监测策略 Chebyshev混沌映射三维路径规划

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Reproducibility study of intravoxel incoherent motion and apparent diffusion coefficient parameters in normal pancreas

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2031-2039页

作者： Xiang Liu Yi-Feng Wang Xiao-hui Qi Zhi-Lei Zhang Jiang-Yang Pan Xue-Li Fan Yu Du Ying-min Zhai Qi Wang Department of CT and MRI The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND The consistency of pancreatic apparent diffusion coefficient(ADC)values and intravoxel incoherent motion(IVIM)parameter values across different magnetic resonance imaging(MRI)devices significantly impacts the patient’s diagnosis and *** To explore consistency in image quality,ADC values,and IVIM parameter values among different MRI devices in pancreatic *** This retrospective study was approved by the local ethics committee,and informed consent was obtained from all *** total,22 healthy volunteers(10 males and 12 females)aged 24-61 years(mean,28.9±2.3 years)underwent pancreatic diffusion-weighted imaging using 3.0T MRI equipment from three *** independent observers subjectively scored image quality and measured the pancreas’s overall ADC values and signal-to-noise ratios(SNRs).Subsequently,regions of interest(ROIs)were delineated for the IVIM parameters(true diffusion coefficient,pseudo-diffusion coefficient,and perfusion fraction)using post-processing *** ROIs were on the head,body,and tail of the *** subjective image ratings were assessed using the kappa consistency *** correlation coefficients(ICCs)and mixed linear models were used to evaluate each device’s quantitative parameter ***,a pairwise analysis of IVIM parameter values across each device was performed using Bland-Altman *** The Kappa value for the subjective ratings of the different observers was 0.776(P0.05),and the ICCs for the ADC values from different devices were 0.870,0.707,and 0.808,respectively(P<0.05).Notably,only a few statistically significant inter-device agreements were observed for different IVIM parameters,and among t

关键词： Intravoxel incoherent motion Pancreas Image quality Consistency test

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Predicting hepatocellular carcinoma: A new non-invasive model based on shear wave elastography

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World Journal of Gastroenterology 2024年第25期30卷 3166-3178页

作者： Dong Jiang Yi Qian Yi-Jun Gu Ru Wang Hua Yu hui Dong Dong-Yu Chen Yan Chen Hao-Zheng Jiang Bi-Bo Tan min Peng Yi-Ran Li Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalThird Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of College of Art and Science Case Western Reserve UniversityClevelandOH 44106United States Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China

BACKGROUND Integrating conventional ultrasound features with 2D shear wave elastography(2D-SWE)can potentially enhance preoperative hepatocellular carcinoma(HCC)*** To develop a 2D-SWE-based predictive model for preoperative identification of *** A retrospective analysis of 884 patients who underwent liver resection and pathology evaluation from February 2021 to August 2023 was conducted at the Oriental Hepatobiliary Surgery *** patients were divided into the modeling group(n=720)and the control group(n=164).The study included conventional ultrasound,2D-SWE,and preoperative laboratory *** logistic regression was used to identify independent predictive factors for RESULTS In the modeling group analysis,maximal elasticity(Emax)of tumors and their peripheries,platelet count,cirrhosis,and blood flow were independent risk indicators for *** factors yielded an area under the curve of 0.77(95%confidence interval:0.73-0.81)with 84%sensitivity and 61%*** model demonstrated good calibration in both the construction and validation cohorts,as shown by the calibration graph and Hosmer-Lemeshow test(P=0.683 and P=0.658,respectively).Additionally,the mean elasticity(Emean)of the tumor periphery was identified as a risk factor for microvascular invasion(MVI)in malignant liver tumors(P=0.003).Patients receiving antiviral treatment differed significantly in platelet count(P=0.002),Emax of tumors(P=0.033),Emean of tumors(P=0.042),Emax at tumor periphery(P<0.001),and Emean at tumor periphery(P=0.003).CONCLUSION 2D-SWE’s hardness value serves as a valuable marker for enhancing the preoperative diagnosis of malignant liver lesions,correlating significantly with MVI and antiviral treatment efficacy.

关键词： Shear wave elastography Predicting model Microvascular invasion Antiviral treatment Hepatocellular carcinoma

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Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

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World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu hui-Shu E Yue Yu Shi-Ying Ling Li-Li Liang Wen-Juan Qiu hui-Wen Zhang Rui-Xue Shuai Hai-Yan Wei chi-Ju Yang Peng Xu Xi-Gui Chen hui Zou Ji-Zhen Feng Ting-Ting Niu Hai-Li Hu Kai-Chuang Zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-Fan Gu Yong-Xing Chen Lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric Liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 195 chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2 months to 12 years and 10 *** Among 195 patients carrying the c.482G>A variant,125(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1%),and psychiatric and behavioral disturbances(24.6%).In the 159 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene Newborn screening Outcome Use our pre-submission checklist Avoid common mistakes on your manuscript.

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Effects of fluid therapy combined with a preoperative glucose load regimen on postoperative recovery in patients with rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2662-2670页

作者： Lv-chi Xia Ke Zhang Chuan-Wen Wang Department of Emergency Medicine Jiujiang First People's HospitalJiujiang 332000Jiangxi ProvinceChina

BACKGROUND Patients with rectal cancer undergoing radical resection often have poor post-operative recovery due to preoperative fasting and water deprivation and the removal of diseased tissue,and have a high risk of ***,it is of great significance to apply appropriate rehydration regimens to patients un-dergoing radical resection of rectal cancer during the perioperative period to improve the postoperative outcomes of *** To analyze the effects of goal-directed fluid therapy(GDFT)with a preoperative glucose load regimen on postoperative recovery and complications in patients undergoing radical resection for rectal *** Patients with rectal cancer who underwent radical resection(n=184)between January 2021 and December 2023 at our hospital were randomly divided into either a control group or an observation group(n=92 in each group).Both groups received a preoperative glucose load regimen,and routine fluid replacement and GDFT were additionally implements in the control and observation groups,*** operative conditions,blood levels of lactic acid and inflammatory markers,postoperative recovery,cognitive status,hemodynamic indicators,brain oxygen metabolism,and complication rates were compared between the *** The colloidal fluid dosage,total infusion,and urine volume,as well as time to first exhaust,time to food intake,and postoperative length of hospital stay,were lower in the observation group(P0.05).Compared with the control group,in the ob-servation group the lactic acid level was lower immediately after the surgery(Pmini-Mental State Examination score was higher on postoperative day 3(Pmin after pneumoperitone

关键词： Radical resection of rectal cancer Goal-directed fluid therapy Preoperative glucose load Cognitive condition Complication

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温度对撞击器内颗粒沉积粒径影响的研究

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力学学报 2024年第1期56卷 79-93页

作者：彭慧池辉徐聪尹招琴包福兵凃程旭中国计量大学计量测试工程学院杭州310018 福建省计量科学研究院福州350003

微颗粒的性质几乎与颗粒的粒径紧密相关,为研究气溶胶粒子特性,需获取颗粒粒径分布信息.惯性撞击器是一种基于惯性原理实现大气中不同粒径颗粒沉积分离的装置,在实际使用过程中,经历复杂多变的环境.文章利用拉格朗日多相(LMP)模型对撞... 详细信息

微颗粒的性质几乎与颗粒的粒径紧密相关,为研究气溶胶粒子特性,需获取颗粒粒径分布信息.惯性撞击器是一种基于惯性原理实现大气中不同粒径颗粒沉积分离的装置,在实际使用过程中,经历复杂多变的环境.文章利用拉格朗日多相(LMP)模型对撞击器内的气-固两相流动进行数值模拟,使用有限体积方法(FVM)研究了在绝热和换热两种情况下,气溶胶温度变化(-40℃~60℃)对颗粒沉积率的作用,并分析其对颗粒粒径分离的影响.结果表明:在壁面绝热情况下,随着气溶胶温度的升高,颗粒沉积位置由冲击板中心向边缘发散,颗粒收集效率逐渐降低,颗粒收集数量减少;在气溶胶和壁面换热情况下,随着气溶胶温度的升高,大颗粒沉积位置由冲击板中心向边缘发散,颗粒收集效率降低,小颗粒正好相反.此外,不同气溶胶温度下的颗粒收集效率曲线存在一个交点,交点两侧大小颗粒的收集效率随温度的变化情况相反.通过研究温度对撞击器颗粒收集的影响,可以对颗粒分径结果进行修正,获得更精确的粒径分布.

关键词：惯性撞击器气溶胶温度颗粒沉积颗粒收集效率拉格朗日多相模型

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Progress of International Meridian Circle Program

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空间科学学报 2024年第4期44卷 741-745页

作者： WANG chi BLANC Michel ZHANG Shunrong DENARDINI Clezio Marcos LIU William SHEN Xuhui WU Jian XU Jiyao LI hui ZHANG Qinghe REN Liwen ZHU Yajun LI Guozhu DING Zonghua LIU Zhengkuan YANG Fang National Space Science Center Chinese Academy of SciencesBeijing 100190 IRAP(CNRS-University Toulouse III-CNES) Toulouse 31400 Haystack Observatory Massachusetts Institute of TechnologyMA 01886 Instituto Nacional de Pesquisas Espaciais São Josédos Campos(SP)Brazil 12227-010 china Research Institute of Radio wave Propagation Qingdao 266000 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100083

In 2024,the chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 *** achievement not only provides a robust foundation but also serves as a reference template for the International Meridian Circle Program(IMCP).The IMCP aims to integrate and establish a comprehensive network of ground-based monitoring stations designed to track the propagation of space weather events from the Sun to ***,it monitors various disturbances generated within the Earth system that impact *** the past two years,significant progress has been made on the *** particular,the second phase of construction for the china-Brazil Joint Laboratory for Space Weather has been completed,and the North Pole and Southeast Asia networks are under active *** 2024 IMCP joint observation campaign was successfully *** facilitate these developments,the scientific program committee of IMCP was established,following the success of 2023 IMCP workshop and the space weather school,which was co-hosted with the Asia-Pacific Space Cooperation Organization(APSCO)and sponsored by chinese Academy of Sciences(CAS)and Scientific Committee on Solar-Terrestrial Physics(SCOSTEP).Preparations are now underway for the 2024 workshop in collaboration with the National Institute for Space Research(INPE)in Brazil.

关键词： chinese Meridian Project(CMP) International Meridian Circle Program(IMCP) china-Brazil Joint Laboratory for Space Weather North Pole and Southeast Asia networks

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一种简单实用的新型水驱特征曲线

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新疆石油地质 2011年第4期32卷 376-377页

作者：周志军罗池辉李慧敏于成龙东北石油大学提高油气采收率教育部重点实验室黑龙江大庆163318

在进行水驱特征曲线的拟合过程中发现一种新型水驱特征曲线,通过变形后发现是西帕切夫水驱特征曲线的修正。经过理论推导给出了新型水驱特征曲线预测不同含水率下油田的采油速度以及技术可采储量的计算公式,利用现场的实际数据进行了可... 详细信息

在进行水驱特征曲线的拟合过程中发现一种新型水驱特征曲线,通过变形后发现是西帕切夫水驱特征曲线的修正。经过理论推导给出了新型水驱特征曲线预测不同含水率下油田的采油速度以及技术可采储量的计算公式,利用现场的实际数据进行了可采储量的计算,并与其他5种常用的水驱特征曲线的计算结果进行对比,结果表明,该曲线预测值可达到较高的精度。

关键词：水驱特征曲线累积产油量可采储量含水率

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