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“澄江针灸学派”第四代传人陆斌教授治疗面瘫30年经验拾粹

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中医康复 2025年第2期2卷 65-69页

作者：周臣旗孙子扬李国薇陆斌南京中医药大学江苏南京210029 南京中医药大学附属医院江苏南京210029

针灸治疗面瘫有着相当长的历史,早在《黄帝内经》中就有记载。针灸操作简便,见效快,经济实用,无毒副作用,面瘫是针灸科常见病和优势病种。现代研究显示针灸能通过刺激特定穴位,改善面部的血液循环,增强神经传导能力,加速神经再生和修复... 详细信息

针灸治疗面瘫有着相当长的历史,早在《黄帝内经》中就有记载。针灸操作简便,见效快,经济实用,无毒副作用,面瘫是针灸科常见病和优势病种。现代研究显示针灸能通过刺激特定穴位,改善面部的血液循环,增强神经传导能力,加速神经再生和修复,促进面部肌肉的收缩和舒张,促进面部神经的再生和恢复功能。陆斌教授在30年临床实践中不断探索总结,形成了对该病的独到见解,首先强调认病识症以正本清源,而后方能实行分期序贯治疗;治疗上坚持以针为主,针药结合,治疗过程中注重动态观察,谨防倒错等后遗症发生,并衷中参西,整体把握病势与转归。此外还总结出一系列注意事项用以患教,助力疾病康复。

关键词：面瘫针灸针灸学派名医经验学术争鸣

Large SYBR Green I fluorescence enhancement for label-free aptamer-based detection of estradiol

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Advanced Agrochem

Advanced Agrochem 2023年第3期2卷 258-263页

作者： Xiaoqin Wang Jiawen Liu chenqi Niu Juewen Liu Department of Chemistry Waterloo Institute for NanotechnologyWater InstituteUniversity of WaterlooWaterlooOntarioN2L 3G1Canada

Estradiol(E2)and related estrogens are emerging environmental contaminants that may adversely affect the health of humans,animals,and *** aptamers have been reported for the detection of E2,and our lab recently selected a series of high-affinity and short DNA aptamers that showed various binding orientations to E2,leading to different selectivity *** this work,we report that using SYBR Green I(SGI)as a fluorescence probe,up to 200%fluorescence increase was achieved upon titration of E2 to these *** enhancement was the highest among all reported small molecule binding aptamers using SGI for signal generation,although some metal-binding DNA can achieve even higher *** gradually shortening the stem region of an E2 binding aptamer,we concluded that the enhanced fluorescence was from the aptamer binding pocket upon target binding instead of from the duplexed stem *** was also made with a few other aptamers including those for caffeine,quinine,uric acid and cortisol,and none of them showed more than 20%fluorescence *** the SGI method,the detection limit was calculated to be 2.4 nM *** attributed the large fluorescence enhancement to the hydrophobic nature of E2 and the high-affinity binding of the *** study provides insights into the aptamers that can use SGI for their binding assays and biosensor development.

关键词： Aptamers Label-free Fluorescence Biosensors Estradiol

LincRNA-1614 coordinates Sox2/PRC2-mediated repression of developmental genes in pluripotency maintenance

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Journal of Molecular Cell Biology 2018年第2期10卷 118-129页

作者： Xudong Guo Zikang Wang chenqi Lu Wujun Hong Guiying Wang Yanxin Xu Zhongmin Liu Jiuhong Kang Clinical and Translational Research Center of Shanghai First Maternity & Infant Health Hospital Shanghai Key Laboratory of Signaling and Disease Research Collaborative Innovation Center for Brain Science School of Life Science and Technology Tongji University Shanghai 200092 China Institute of Regenerative Medicine East Hospital Tongji University School of Medicine Shanghai 200120 China Laboratory of Population and Quantitative Genetics institute of Biostatistics School of Life Sciences Fudan University Shanghai 200433 China

Large-intergenic noncoding RNAs （lincRNAs） cooperate with core transcription factors to coordinate the pluripotency network of embryonic stem cells. The mechanisms by which lincRNAs affect chromatin structure and gene transcription remain mostly unknown. Here, we identified that a UncRNA （linc1614）, occupied by pluripotency factors at its promoter, was indispensable for both maintenance and acquisition of pluripotency. Linc1614 sewed as a specific partner of core factor Sox2 in maintaining pluripotency, primarily by mediating the function of Sox2 in the repression of developmental genes. Moreover, Ezh2, an essential subunit of polycomb repressive complex 2 （PRC2）, physically interacted with linc1614 and contributed to lincRNA-mediated transcriptional silencing. Thus, we propose that the interplay of linc1614 with Sox2 implicates this lincRNA as a recruitment platform that mediates transcriptional silencing by guiding the PRC2 complex to the loci of developmental genes.

关键词： lincRNA Sox2 pluripotency maintenance PRC2 reprogramming

Green Production of Planar Aligned Dense 2D Nano-oxides on CNT Paper by Ultrafast Laser-Induced High-Pressure Photochemistry for Stable High-Rate LIB Anodes

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Energy Material Advances 2023年第1期4卷 67-76页

作者： Jin Xu Sen Xiang chenqi Yi Xingtao Liu Licong An Ziyu Wang Haoqing Jiang Gary J.Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906USA The Institute of Technological Sciences Wuhan UniversityWuhan 430072China

Green production of functional nano-oxides on a large scale is crucial for the modern manufacturing *** hydrothermal methods and ball milling are usually time-consuming and require long-term energy input with undesired ***,an ultrafast laser-induced high-pressure photochemistry manufacturing technique is developed to massively produce planar-aligned graphenecoated two-dimensional(2D)SnO_(2) nanoplatelet on carbon nanotube(CNT)paper under the green chemistry *** unique design of Z-axis confinement added to the ultrafast laser irradiation provides an exceptional high temperature of 1772 K and a high pressure of 24 GPa in the localized laser plasma *** transient nonequilibrium condition controls the formation of 2D SnO_(2),and the ablated C atoms cool down afterward as in-situ“glue”to intactly seal the oxides on the CNT *** resultant hierarchical Graphene@2D SnO_(2)@CNT paper anode for Li-ion battery has an outstanding capacity of 819 mAh g^(−1)(1637 mAh cm^(−3))at 0.5 A g^(−1) and retains 622 mAh g^(−1)(1245 mAh cm^(−3))at 5.0 A g^(−1).The high capacity at 0.5 A g^(−1) has a retention of 92%after 600 *** work provides an environmental-friendly scalable manufacturing technique to produce functional nanocomposites in 1 step.

关键词： oxides exceptional consuming

Phospholipids regulate the structure and function of T-cell receptor

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Phospholipids regulate the structure and function of T-cell ...

A novel gatifloxacin-loaded intraocular lens for prophylaxis of postoperative endophthalmitis

第四届中国结构生物学学术讨论会

作者： chenqi Xu National Center for Protein Science Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

As one of the most complicated multi-subunit membrane receptors, T-cell receptor（TCR） plays a key role in human immune system. TCR recognizes peptide antigens presented by major histocompatibility complex（MHC） molecules and thus initiates the adaptive immune responses against invading pathogens. TCR is composed of four subunits: the antigen recognition subunit TCRab and signaling subunits CD3 ed, eg and zz. Antigen binding on the TCRab subunit generates mechanical force that can be transduced across the membrane and decoded to CD3 tyrosine phosphorylation signal. The molecular mechanism of this physical-to-chemical signal transduction process remains exclusive. Since the membrane environment is crucial for all membrane-related signaling events, we have been studying how phospholipids regulate TCR triggering mainly by NMR and imaging technologies. The cytoplasmic domains of CD3 e and z chains（CD3eCD and CD3zCD） are enriched of basic residues and we found that they can interact with the acidic phospholipids in the inner-leaflet of the plasma membrane via ionic protein-lipid interactions. We solved the NMR structure of the CD3eCD-membrane complex and found that membrane binding induces an amphipathic helix folding of CD3 eCD. The key tyrosine residues were fully embedded in the hydrophobic core of the membrane bilayer, which prevents the spontaneous phosphorylation of CD3 chains in quiescent cells（Xu et al, 2008, Cell）. After T cells are stimulated by antigens, Ca2+ ions locally influx into T cells and generate Ca2+ microdomains proximal to TCRs. We found that Ca2+ ions can directly bind to the acidic phospholipids and neutralize their negative charges, which in turn disrupts the ionic CD3eCD-lipid interaction and lead to the solvent exposure of the key tyrosine residues. Ca2+ can thus help TCR phosphorylation and amplify the weak antigen-stimulating signal to fully activate T cells（Shi et al, 2013, Nature）. These studies demonstrate that membrane lipids can sequester

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Bioactive Materials 2023年第2期20卷 271-285页

作者： Mengna Li Jing-Wei Xu Jiayong Li Wei Wang chenqi Luo Haijie Han Zhi-Kang Xu Ke Yao Eye Center Second Affiliated HospitalZhejiang University School of MedicineHangzhou310009PR China Zhejiang Provincial Key Laboratory of Ophthalmology Hangzhou310009PR China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027PR China

Postoperative endophthalmitis(POE)has been the most threatening complication after cataract surgery,which perhaps can be solved by the antibiotic-loaded intraocular lens(IOL).However,most drug-loaded IOLs demonstrate insufficient drug quantity,short release time,increased implantation-related difficulties or other noticeable *** prevent POE and to address these deficiencies,a drug-loaded copolymer IOL,prepared from poly(urethane acrylate)prepolymer,isobornyl methacrylate(IBOMA),N-vinyl-2-pyrrolidone(NVP),Irgacure 819,RUVA-93,and gatifloxacin(GAT),was rapidly fabricated via photocuring and by using a 3D-printed *** composite displayed an outstanding and controllable GAT release behavior in vitro,a high light transmittance,and a moderate refractive ***,it demonstrated improved strain stress and elongation compared with the reference commercial acrylic IOL *** vivo tests demonstrated satisfying released drug concentration at the early treatment *** vitro and in vivo studies further confirmed the remarkable bacterial inhibition and prevention of POE by the proposed IOL,which also displayed good *** findings suggested that the GAT-loaded IOL could be a promising implant to prevent and cure POE,also the proposed methods could inspire more designs for various medical applications.

关键词： Photocuring Drug delivery intraocular lens 3D printing Postoperative endophthalmitis Gatifloxacin

Albumin-based multidrug delivery system enriched in Golgi apparatus against metastatic breast cancer

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Nano Research 2023年第4期16卷 5640-5652页

作者： chenqi Guo Xiong Peng Ting Zhao Jiaxing Feng Zhaofei Guo Mengying Wu Rongping Zhang Xun Sun Yuan Huang Zhirong Zhang Tao Gong Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Breast cancer and metastasis remain great challenges in clinical *** with monotherapy,combination therapy,especially mediated by nanomedicine delivery strategy,significantly improves the therapeutic efficacy and reduces undesired ***-2(COX-2)inhibitors are widely used for adjuvant chemotherapy because COX-2 is overexpressed in virtually all cancer cell lines to regulate tumor progression by catalyzing prostaglandin E2(PGE2)*** drug combination strategy is still required to be improved due to some unsatisfactory clinical trial *** processes of tumor growth and metastasis are orchestrated by multiple proteins in addition to COX-2,which are modified and transported by Golgi ***,disrupting the structure and function of Golgi apparatus can inhibit the secretion of tumor-related proteins and further suppress carcinoma progression and *** COX-2 is also enriched within Golgi apparatus in tumor cells,COX-2 inhibitors and Golgi disrupting agents can be co-delivered to Golgi apparatus to maximize the *** this work,we developed a human serum albumin(HSA)nanoparticle encapsulating pirarubicin(THP),retinoic acid(RA),and indomethacin(IMC),called TIR-HSA,which was observed to be localized in Golgi complex of 4T1 *** to the synergistic effect of these three drugs,TIR-HSA inhibited the proliferation,migration,and invasion of tumor cells,enhanced the apoptotic rate,and improved the immunosuppressive tumor microenvironment,which remarkably regressed the tumor growth and metastasis and prolonged the survival period of 4T1-bearing mice.

关键词： albumin Golgi apparatus metastatic breast cancer adjuvant chemotherapy cyclooxygenase-2(COX-2)inhibitors

Intrinsic-trap-regulating growth of clean graphene on high-entropy alloy substrate

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Nano Research 2022年第5期15卷 4717-4723页

作者： Xiaofei Hu Jiongzhao Li Zhe Wang Xudong Qian chenqi Zhu Xiaogang Peng Key Laboratory of Excited-State Materials of Zhejiang Province and Department of Chemistry Zhejiang UniversityHangzhou 310027China

A facile way to grow few-layer graphene on high-entropy alloy sheets is presented in this *** systematically investigate the growth mechanism of graphene using the unique properties of FeCoNiCu_(0.25)high-entropy *** intrinsic-trap-regulating growth mechanism derives from the synergistic effect of the multi-metal atoms and sluggish diffusion of high-entropy *** a result,as-obtained few-layer of graphene has the characteristics of wide coverage,large size,good continuity,and high crystallinity with less amorphous carbon and extra *** such as the Cu content,annealing time,growth temperature,growth time,carbon source flow rate,hydrogen flow rate and heat treatment method play a key role in the growth of high-quality graphene,and the best growth parameters have been ***,increasing alloy entropy is found to be responsible for the formation of high-quality graphene.

关键词： high-entropyalloys graphene chemical vapordeposition

Phospholipids regulates membrane receptor activation

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Phospholipids regulates membrane receptor activation