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Application of sustained delivery microsphere of cyclosporine A for preventing posterior capsular opacification in rabbits

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 1-7页

作者： cheng pei Yi Xu Jean Xin.Jiang Li-Jun Cui Li Li Li Qin Department of Ophthalmology the First Affiliated Hospitalof Xi'an Jiaotong University Disease Control Center of Shaanxi Province University of Texas Health Science Center at San Antonio

AIM:To explore the inhibitory effect of a sustained cyclosporin A (CsA) delivery microsphere (CsA-MS) on posterior capsular opacification (PCO) in rabbit eyes after cataract extraction. ·METHODS:Twenty New Zealand white rabbits accepted cataract extraction plus intraocular lens implantation and their left eyes were intraoperatively injected CsA-MS prepared using polymer polylactioglycolic acid (PLGA) as a carrier and their right eyes were injected with empty MS. The changes in cornea, anterior chamber reaction, intraocular pressure, PCO and CsA concentration in aqueous humor were examined postoperatively and all the eyes were enucleated 3 months after surgery for histopathological and morphological examination with light microscopy and electron microscopy. · RESULTS:Conjunctival hyperemia, corneal edema, intraocular pressure and anterior chamber response of experimental and control eyes were similar, while PCO in CsA MS injected eyes was greatly improved compared with that in control eyes. Posterior capsules in CsA-MS injected eyes were smooth and lens epithelial cells (LEC) did not proliferate significantly (P >0.05), while LEC in posterior capsule of control eyes had different degrees of proliferation and cortical regeneration. LEC in CsA-MS injected eyes were not functionally active and underwent apoptosis, whereas LEC in control eyes were functionally active (F-test, P =0.025). In addition, the cornealultrastructure showed no differences between CsA-MS and MS injected eyes. CONCLUSION:CsA-MS has high bioavailability in rabbit eyes and could inhibit postoperative PCO occurrence and development during the study period, suggesting that CsA-MS may be a promising, effective and safe administration route to prevent PCO in clinic.

关键词： sustained cyclosporine A delivery microsphere posterior capsular opacification rabbit eyes

PTA wastewater molecular toxicity detected with gene chip

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Journal of Environmental Sciences 2006年第3期18卷 514-518页

作者： ZHU cheng-jun cheng Shu-pei ZHANG Xu-xiang LANG You-zhe SUN Shi-lei GU Ji-dong ZHAO Da-yong PAN Wen-yang YU Hong-xia State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University Nanjing 210093 China Department of Ecology and Biodiversity University of Hong Kong Hong Kong China

The purified terephthalic acid （PTA） petrochemical wastewater molecular toxicity detected by use of Mouse Genome 430A 2.0 GeneChip was conducted in this research. The toxic dose to male mice was 0.03 g/（kg, d） of PTA in the wastewater. The mice liver total RNA was isolated as the temple for synthesis of eDNA and then the cDNA as the temple for synthesis of cRNA. Hybridizing the cRNA with the target genes on the gene chip, there were 232 genes expression levels up-regulated and 74 genes down-regulated discovered obviously. The foremost 40 genes for both the highest and the lowest expression levels involved endogenetic steroid and hormone metabolism, immune system, the leukocyte activity and inflammation, detoxification in liver, reproduction and growth hormone, regulation immune factors of anti-tumor and anti-infection and cancer to the mice sampled. The data suggest the PTA wastewater contained over 5 aromatics and their toxicities integrated were much higher than the pure chemical PTA. And the pure chemical PTA toxicities data cannot be used to evaluate the toxicity of the PTA wastewater instead.

关键词： gene chip PTA wastewater male mice molecular toxicity predication of security

Mechanism of Oscillation Mark Formation in Continuous Casting of Steel

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International Journal of Minerals,Metallurgy and Materials 2000年第3期14卷 189-192页

作者： Kaitao Bo, Guoguang cheng, Jie Wu, pei Zhao, Jun Wang (Metallurgy School, University of Science and Technology, Beijing, Beijing 100083, China) Metallurgy School University of Science and Technology Beijing Beijing 100083 China

A new mechanism of oscillation mark formation has been suggested based on the deep investigation of meniscus behavior in continuous casting of steel. It's confirmed that the meniscus form is important to oscillation mark formation. The factors related to the formation of oscillation mark are discussed in detail. The longer the solid shell existed at the root of meniscus and the smaller the contact angle between meniscus and mold wall, the deeper the oscillation mark.

关键词： continuous casting oscillation mark meniscus

Five Novel Pterocarpan Derivatives from Sophora flavescens

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Chinese Journal of Chemistry 2021年第10期39卷 2763-2768页

作者： Kai-Zhou Lu Zi-Ming Feng Xiang Yuan Ya-Nan Yang Jian-Shuang Jiang Xu Zhang pei-cheng Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050 China

Main observation and conclusion Five novel pterocarpan derivatives(1—5)and three known pterocarpans were isolated from the roots of Sophora flavescens *** structures were elucidated based on extensive spectroscopic data(UV,IR,1D and 2D NMR,and HR-ESI-MS).Notably,compounds 1—5 were the first reported natural products,which possess unique pterocarpan-glucose-long chain aliphatic acid *** kinds of aliphatic acids were determined by comparison with authentic aliphatic acids using HPLC-ELSD analysis after acid *** absolute configurations of 1—5 were confirmed by analysis of their ECD *** compounds were evaluated against lipopolysaccharide(LPS)-induced TNF-αproduction in RAW264.7 cells,and compound 1 showed significant inhibitory activity with inhibition rate of 86.22%,IC_(50)=0.79μmol/L(dexamethasone as positive control,inhibition rate of 71.38%).

关键词： Sophora flavescens Pterocarpan derivatives Natural products Structure elucidation Biological activity

Groundwater and environmental challenges in Asia

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Journal of Groundwater Science and Engineering 2024年第2期12卷 223-236页

作者： Yan-pei cheng Fa-wang Zhang Hua Dong Xue-ru Wen Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Key Laboratory of Groundwater Sciences and Engineering Ministry of natural ResourcesZhengding 050803HebeiChina Center for Hydrogeology and Environmental Geology Survey China Geological SurveyBaoding 071051HebeiChina

Asia stands out as the most populous and geographically diverse region *** pressing issues of water resource development and the resulting ecological impacts are exacerbated by the region's rapid population growth and economic ***,a vital source of water in Asia,faces significant disparities in distribution and suffers from unsustainable exploitation *** study applies groundwater system theory and categorizes Asia into 11 primary groundwater systems and 36 secondary ones,based on intercontinental geological structures,climate,terrain,and hydrogeological *** of the end of 2010,Asia's assessed groundwater resources totalled 4.677×10^(9) m^(3)/a,with exploitable resources amounting to 3.274×10^(9) m^(3)/*** considering the geological environmental impacts of groundwater development and the distinctive characteristics of terrain and landforms,six categories of effect zones with varying distribution patterns are *** current research on Asia's groundwater resources,environmental dynamics,and human impacts aims to provide a theoretical foundation for sustainable groundwater management and environmental conservation in the region.

关键词： Asia Groundwater resources Groundwater quality Ecological environment Environmental impacts

Ecological function zoning and protection of groundwater in Asia

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Journal of Groundwater Science and Engineering 2021年第4期9卷 359-368页

作者： Xue-ru Wen Yan-pei cheng Jian-kang Zhang Hua Dong Institute of Hydrogeology and Environmental Geology CAGSShijiazhuang 050061China Key Laboratory of Groundwater Sciences and Engineering Ministry of Natural ResourcesShijiazhuang 050061China.

The natural groundwater recharge in Asia is estimated to be 4677.74×10^(9)m^(3)/***,it features extremely uneven spatial-temporal *** is distributed in various natural and geological environments,and it is liable to be affected by numerous factors and possesses different ***,groundwater faces complex ecological *** paper gains a complete understanding of groundwater in Asia in terms of the structure of aquifer systems,the processes of groundwater cycle,and the spatial variation laws of surface *** on this,it proposes the ecological function zoning scheme of groundwater in Asia,aiming to provide guidance for the utilization of regional water resources and the planning for economic and social development,coordinate the relationship between social and economic development and water resource protection,and improve the ecological functions of ***,this paper analyzes the problems with regional groundwater management in Asia and puts forward countermeasures and suggestions,thus providing a theoretical basis for the sustainable development and utilization of regional groundwater and environmental protection.

关键词： Asia Groundwater resources Eco-environment index system Function zoning

A Novel Dihydroflavone from the Roots of Uvaria Macrophylla

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Chinese Chemical Letters 2002年第9期13卷 857-858页

作者： Si WANG pei cheng ZHANG Ruo Yun CHEN Ying Hong WANG Wen Yi HE De Quan YU Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

A new dihydroflavone (1), named macrophyllol A, was isolated from the roots of Uvaria macrophylla. Its structure was elucidated on the basis of spectroscopic evidence.

关键词： Uvaria macrophylla macrophyllol A.

Early outcomes of vision and objective visual quality analysis after cataract surgery with trifocal intraocular lens implantation

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1575-1581页

作者： Mei-Fang Chu Na Hui Cong-Yi Wang Lei Yu Bo Ma Yan Li cheng pei Ophthalmology Department Xi’an Fourth HospitalShaanxiOphthalmological HospitalXi’an710004Shaanxi ProvinceChina Ophthalmology Department First Affiliated Hospital of Xi’anJiaotong UniversityXi’an710061Shaanxi ProvinceChina

AIM: To investigate the early outcomes of vision, objective visual quality and their correlation after cataract surgery with trifocal intraocular lens ***: The visual examination and objective visual quality analysis using Optical Quality Analysis System(OQAS) at 1 mo and 3 mo, and defocus curve examination at 3 mo were performed in 20 patients(27 eyes) after phacoemulsification combined with trifocal intraocular lens implantation ***: The uncorrected distant(UD), intermediate and near visual acuity(VA) were significantly improved after surgery(P<0.001). UDVA at 1 mo after the surgery was slightly better than that after 3 mo(P=0.026). The defocus curve after 3 mo indicated that the peak of distant vision was close to 0 logMAR, and UDVA was lower than 0.3 logMAR in the range of-1.5 D to-3.0 D. The modulation transfer function(MTF) cutoff frequency, strehl ratio(SR), Optical Quality Analysis System values(OVs), includes OV100, OV20 and OV9 after the surgery were significantly better than before surgery(P<0.001), but the objective scattering index(OSI) was significantly decreased(P<0.001). UDVA at 3 mo after the surgery had correlations with MTF cutoff, OSI, OV100 and OV20(r=-0.400, 0.431,-0.437,-0.411, P=0.039, 0.025, 0.023, 0.033). The uncorrected intermediate VA after 3 mo of the surgery had correlations with OSI and OV100(r=0.478,-0.411, P=0.012, 0.033). CONCLUSION: Trifocal intraocular lens implantation can provide good distant, intermediate and near VA, and the vision shows a well correlation with objective visual quality during early surgery.

关键词： visual quality trifocal intraocular lens vision correlation

Tissue distribution of deoxynivalenol in piglets following intravenous administration

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Journal of Integrative Agriculture 2015年第10期14卷 2058-2064页

作者： DENG Xian-bai DIN Huan-zhong HUANG Xian-hui MA Yong-jiang FAN Xiao-long YAN Hai-kuo LU pei-cheng LI Wei-cheng ZENG Zhen-ling College of Veterinary Medicine South China Agricultural University

Contamination of deoxynivalenol（DON） in grains is common worldwide and pigs are particularly susceptible to this mycotoxin. The distribution of DON in porcine tissues following intravenous administration was investigated in this study. Fifteen pigs were randomly divided into three groups. Animals in groups A and B were administrated with DON at the dose of 250 and 750 μg kg–1 body weight, respectively, while group C served as blank control. Plasma, bile and 27 tissues were collected at 30 min post-administration. DON concentrations in all samples were tested using high-performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS）. To observe the distribution of DON in tissues, these samples were further subjected to the immunohistochemical analyses. Totally, the bile and 13 tissues were sampled for DON-based detection, including kidney, mesenteric lymph nodes, muscle, stomach, jejunum, colon, plasma, spleen, rectum, cecum, liver, ileum, and duodenum. No significant difference was observed for the concentrations of DON in duodenum, ileum and liver samples between groups A and B; while the DON concentrations in cecum and rectum of group B were significantly higher（P-value 〈0.05） than those in group A. In addition, the DON concentrations in stomach, jejunum, colon, mesenteric lymph nodes, muscle, kidney, spleen, bile, and plasma of group B were remarkably higher than those of group A（P-value〈0.01）. Levels of DON in other 14 tissues including medulla oblongata, midbrain, diencephalon, pons, tip and tongue body, tongue, soft palate, tonsils, pharyngeal mucosa, oral buccal mucosa, thymus, thyroid, esophagus and adrenal gland were all below the limit of detection. The results of immunohistochemistry showed that 11 tissue samples（medullaoblongata, tonsil, adrenal medulla, thyroid gland, thyroid, stomach, duodenum, jejunum, kidney, spleen, and mesenteric lymph nodes） were positive and DON was mainly distributed around blood vessels in these tissues. Therefore, we be

关键词： deoxynivalenol tissue distribution immunohistochemical staining HPLC-MS/MS swine