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Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer malignant behaviors by activation of target of rapamycin kinase/autophagy signaling

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World Journal of Gastroenterology 2024年第26期30卷 3229-3246页

作者： Juan Sun Jin-Xiu Zhang Meng-Shi Li Meng-Bin Qin ruo-Xi cheng Qing-ru Wu Qiu-Ling Chen Dan Yang Cun Liao Shi-Quan Liu Jie-An Huang Department of Gastroenterology The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530007Guangxi Zhuang Autonomous RegionChina Department of Colorectal&Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Monopolar spindle-binding protein 3B(MOB3B)functions as a signal transducer and altered MOB3B expression is associated with the development of human *** To investigate the role of MOB3B in colorectal cancer(CRC).METHODS This study collected 102 CRC tissue samples for immunohistochemical detection of MOB3B expression for association with CRC *** overexpression and knockdown of MOB3B expression were induced in CRC cell lines,changes in cell viability,migration,invasion,and gene expression were *** cell autophagy was detected using transmission electron microscopy,while nude mouse xenograft experiments were performed to confirm the in-vitro *** MOB3B expression was reduced in CRC vs normal tissues and loss of MOB3B expression was associated with poor CRC *** of MOB3B protein in vitro attenuated the cell viability as well as the migration and invasion capacities of CRC cells,whereas knockdown of MOB3B expression had the opposite effects in CRC *** the molecular level,microtubule-associated protein light chain 3 II/I expression was elevated,whereas the expression of matrix metalloproteinase(MMP)2,MMP9,sequestosome 1,and phosphorylated mechanistic target of rapamycin kinase(mTOR)was downregulated in MOB3B-overexpressing RKO *** contrast,the opposite results were observed in tumor cells with MOB3B *** nude mouse data confirmed these in-vitro findings,i.e.,MOB3B expression suppressed CRC cell xenograft growth,whereas knockdown of MOB3B expression promoted the growth of CRC cell *** Loss of MOB3B expression promotes CRC development and malignant behaviors,suggesting a potential tumor suppressive role of MOB3B in CRC by inhibition of mTOR/autophagy signaling.

关键词： Colorectal cancer Monopolar spindle-binding protein 3B Mechanistic target of rapamycin kinase Autophagy Prognosis

The FAST all sky HI survey(FASHI):The first release of catalog

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 112-133页

作者： Chuan-Peng Zhang Ming Zhu Peng Jiang cheng cheng Jing Wang Jie Wang Jin-Long Xu Xiao-Lan Liu Nai-Ping Yu Lei Qian Haiyang Yu Mei Ai Yingjie Jing Chen Xu Ziming Liu Xin Guan chun Sun Qingliang Yang Menglin Huang Qiaoli Hao FAST Collaboration Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China National Astronomical Observatories Chinese Academy of Sciences(CAS)Beijing 100101China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The FAST All Sky HI survey(FASHI)was designed to cover the entire sky observable by the Five-hundred-meter Aperture Spherical radio Telescope(FAST),spanning approximately 22000 square degrees of declination between-14°and+66°,and in the frequency range of 1050-1450 MHz,with the expectation of eventually detecting more than 100000 HI *** August 2020 and June 2023,FASHI had covered more than 7600 square degrees,which is approximately 35%of the total sky observable by *** has a median detection sensitivity of around 0.76 m Jy beam-1and a spectral line velocity resolution of~6.4 km s-1at a frequency of~1.4 *** of now,a total of 41741 extragalactic HI sources have been detected in the frequency range 1305.5-1419.5 MHz,corresponding to a redshift limit of z■*** cross-matching FASHI sources with the Siena Galaxy Atlas(SGA)and the Sloan Digital Sky Survey(SDSS)catalogs,we found that 16972(40.7%)sources have spectroscopic redshifts and 10975(26.3%)sources have only photometric *** of the remaining 13794(33.0%)HI sources are located in the direction of the Galactic plane,making their optical counterparts difficult to identify due to high extinction or high contamination of Galactic stellar *** on current survey results,the FASHI survey is an unprecedented blind extragalactic H I *** has higher spectral and spatial resolution and broader coverage than the Arecibo Legacy Fast ALFA Survey(ALFALFA).When completed,FASHI will provide the largest extragalactic HI catalog and an objective view of HI content and large-scale structure in the local universe.

关键词： surveys redshifts galaxies telescope radio lines HI line

Intervention control of aerobic exercise in maintaining quality of life and pulmonary hypertension in hemodialysis patients

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World Journal of Clinical Cases 2024年第20期12卷 4217-4229页

作者： Dan-Dan Wang Min cheng chun-Ying Chen Department of Rehabilitation Medicine Zhejiang HospitalHangzhou 310012Zhejiang ProvinceChina Blood Purification Center Zhejiang HospitalHangzhou 310012Zhejiang ProvinceChina

BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life ***,treatment and improvement of pulmonary hypertension are of great significance to improve the quality of life of *** To investigate the intervention and control of pedal-powered bicycle in maintaining quality of life and pulmonary hypertension in hemodialysis *** 73 patients with maintenance hemadialysis combined with pulmonary arterial hypertension at a hemodialysis center in a certain hospital from May 2021 to May 2022 are *** are divided into two groups,37 cases in the control group(group C)and 36 cases in the intervention group(group I).Patients are divided into two groups,group C is treated with oral administration of betaglandin sodium combined with routine nursing *** on group C,group I conducts power cycling *** After treatment,group I patients had higher muscle strength,36-Item Short Form Health Survey scores,and Kidney Disease Targets Areas scores;The 6-minute walk distance test index level was higher and the Borg score was lower;The group I had lower systolic blood pressure,greater vital capacity,higher positive emotion,lower systolic pulmonary artery pressure index level,higher arterial partial oxygen pressure level,lower pulmonary vascular resistance index level,and higher blood oxygen saturation level[158.91±11.89 vs 152.56±12.81,1795.01±603.18 vs 1907.20±574.15,24.00(22.00,29.00)vs 24.00(22.00,28.00),P<0.001].CONCLUSION Aerobic exercise combined with Western medicine treatment can effectively improve patients'pulmonary hypertension,alleviate their negative emotions,and enable them to achieve a higher level of quality of life.

关键词： Aerobic exercise Hemodialysis Pulmonary arterial hypertension Cycle ergometer Quality of life

时间轴上具有次线性中立项的二阶动力方程的振动性

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数学的实践与认识 2024年第6期54卷 225-230页

作者：赵春茹梧州学院广西机器视觉与智能控制重点实验室广西高校智能软件重点实验室广西梧州543002

利用时间轴上的微积分理论和广义黎卡提变换以及不等式技巧,研究了一类具有次线性中立项的二阶动力方程的振动性,建立了该类动力方程的一些新的振动准则,推广且丰富了已有文献中的结果,并给出应用实例.

关键词：振动性二阶动力方程次线性中立项时间轴

Is tumor necrosis factor-α monoclonal therapy with proactive therapeutic drug monitoring optimized for inflammatory bowel disease? Network meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 571-584页

作者： Fang-Yuan Zheng Kai-Si Yang Wen-cheng Min Xin-Zhu Li Yu Xing Shuai Wang Ying-Shi Zhang Qing-chun Zhao Teaching Hospital of Shenyang Pharmaceutical University General Hospital of Northern Theater CommandShenyang 110016Liaoning ProvinceChina

BACKGROUND The efficacy and safety of anti-tumor necrosis factor-α(TNF-α)monoclonal antibody therapy[adalimumab(ADA)and infliximab(IFX)]with therapeutic drug monitoring(TDM),which has been proposed for inflammatory bowel disease(IBD)patients,are still *** To determine the efficacy and safety of anti-TNF-αmonoclonal antibody therapy with proactive TDM in patients with IBD and to determine which subtype of IBD patients is most suitable for proactive TDM *** As of July 2023,we searched for randomized controlled trials(RCTs)and observa-tional studies in PubMed,Embase,and the Cochrane Library to compare anti-TNF-αmonoclonal antibody therapy with proactive TDM with therapy with reactive TDM or empiric *** and network meta-analyses were used to determine the IBD patient subtype that achieved clinical remission and to determine the need for *** This systematic review and meta-analysis yielded 13 studies after exclusion,and the baseline indicators were *** found a significant increase in the number of patients who achieved clinical remission in the ADA[odds ratio(OR)=1.416,95%confidence interval(CI):1.196-1.676]and RCT(OR=1.393,95%CI:1.182-1.641)subgroups and a significant decrease in the number of patients who needed surgery in the proactive vs reactive(OR=0.237,95%CI:0.101-0.558)and IFX+ADA(OR=0.137,95%CI:0.032-0.588)subgroups,and the overall risk of adverse events was reduced(OR=0.579,95%CI:0.391-0.858)according to the pairwise ***,the network meta-analysis results suggested that patients with IBD treated with ADA(OR=1.39,95%CI:1.19-1.63)were more likely to undergo TDM,especially in comparison with patients with reactive TDM(OR=1.38,95%CI:1.07-1.77).CONCLUSION Proactive TDM is more suitable for IBD patients treated with ADA and has obvious advantages over reactive *** recommend proactive TDM in IBD patients who are treated with ADA.

关键词： Inflammatory bowel disease Therapeutic drug monitoring Adalimumab Infliximab Network meta-analysis

Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases

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World Journal of Clinical Cases 2024年第1期12卷 188-195页

作者： Shi-Yuan Liu Hao Chen Li-Jia He chun-Kai Huang Pu Wang Zhang-ru rui Jue Wu Yang Yuan Yue Zhang Wen-Ju Wang Xiao-Dan Wang Central Laboratory Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan ProvinceYan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Department of Nephropathy Yan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina

BACKGROUND In this study,we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis(LN)who un-derwent repeated renal *** SUMMARY Clinical data of three diffuse proliferative LN patients with different pathological characteristics(case 1 was LN IV-G(A),case 2 was LN IV-G(A)+V,and case 3 was LN IV-G(A)+thrombotic microangiopathy)were *** patients underwent repeated renal biopsies 6 mo later,and renal biopsy specimens were *** infiltration was assessed by CD68 expression detected by immunohistochemical staining,and an immunofluorescence assay was used to detect podocin expression to assess podocyte *** treatment,Case 1 changed to LN III-(A),Case 2 remained as type V LN lesions,and Case 3,which changed to LN IV-S(A),had the worst *** observed reduced macro-phage infiltration after ***,two of the patients with active lesions after treatment still showed macrophage infiltration in the renal *** treatment,the three patients showed discontinuous expression of ***,the integrity of podocin was restored after treatment in Case *** It may be possible to reverse podocyte damage and decrease the infiltrating ma-crophages in LN patients through effective treatment.

关键词： Lupus nephritis Macrophage Podocyte Repeat renal biopsy Thrombotic microangiopathy Case report

Groundwater and environmental challenges in Asia

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Journal of Groundwater Science and Engineering 2024年第2期12卷 223-236页

作者： Yan-pei cheng Fa-wang Zhang Hua Dong Xue-ru Wen Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Key Laboratory of Groundwater Sciences and Engineering Ministry of natural ResourcesZhengding 050803HebeiChina Center for Hydrogeology and Environmental Geology Survey China Geological SurveyBaoding 071051HebeiChina

Asia stands out as the most populous and geographically diverse region *** pressing issues of water resource development and the resulting ecological impacts are exacerbated by the region's rapid population growth and economic ***,a vital source of water in Asia,faces significant disparities in distribution and suffers from unsustainable exploitation *** study applies groundwater system theory and categorizes Asia into 11 primary groundwater systems and 36 secondary ones,based on intercontinental geological structures,climate,terrain,and hydrogeological *** of the end of 2010,Asia's assessed groundwater resources totalled 4.677×10^(9) m^(3)/a,with exploitable resources amounting to 3.274×10^(9) m^(3)/*** considering the geological environmental impacts of groundwater development and the distinctive characteristics of terrain and landforms,six categories of effect zones with varying distribution patterns are *** current research on Asia's groundwater resources,environmental dynamics,and human impacts aims to provide a theoretical foundation for sustainable groundwater management and environmental conservation in the region.

关键词： Asia Groundwater resources Groundwater quality Ecological environment Environmental impacts

Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway

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Chinese Journal of Integrative Medicine 2024年第10期30卷 906-916页

作者： WANG Ting-ting YU Li-li ZHENG Jun-meng HAN Xin-yi JIN Bo-yuan HUA cheng-jun CHEN Yu-shan SHANG Sha-sha LIANG Ya-zhou WANG Jian-ru Heart Center the First Affiliated Hospital of Henan University of Chinese Medicine

Objective: To investigate potential mechanisms of anti-atherosclerosis by berberine（BBR） using ApoE-/-mice. Methods: Eight 8-week-old C57BL/6J mice were used as a blank control group（normal）, and 56 8-week-old AopE-/-mice were fed a high-fat diet for 12 weeks, according to a completely random method, and were divided into the model group, BBR low-dose group（50 mg/kg, BBRL）, BBR medium-dose group（100 mg/kg, BBRM）, BBR high-dose group（150 mg/kg, BBRH）, BBR+nuclear factor erythroid 2-related factor 2（NRF2） inhibitor group（100 mg/kg BBR+30 mg/kg ML385, BBRM+ML385）, NRF2 inhibitor group（30 mg/kg, ML385）, and positive control group（2.5 mg/kg, atorvastatin）, 8 in each group. After 4 weeks of intragastric administration, samples were collected and serum, aorta, heart and liver tissues were isolated. Biochemical kits were used to detect serum lipid content and the expression levels of malondialdehyde（MDA） and superoxide dismutase（SOD） in all experimental groups. The pathological changes of atherosclerosis（AS） were observed by aorta gross Oil Red O, aortic sinus hematoxylin-eosin（HE） and Masson staining. Liver lipopathy was observed in mice by HE staining. The morphology of mitochondria in aorta cells was observed under transmission electron microscope. Flow cytometry was used to detect reactive oxygen species（ROS） expression in aorta of mice in each group. The content of ferrous ion Fe2+in serum of mice was detected by biochemical kit. The mRNA and protein relative expression levels of NRF2, glutathione peroxidase 4（GPX4） and recombinant solute carrier family 7 member 11（SLC7A11） were detected by quantitative real time polymerase chain reaction（RT-q PCR） and Western blot, respectively. Results: BBRM and BBRH groups delayed the progression of AS and reduced the plaque area（P<0.01）. The characteristic morphological changes of ferroptosis were rarely observed in BBR-treated AS mice, and the content of Fe2+in BBR group was significantly lower than that in the model group（P<0.01）

关键词： ApoE−/− NRF2/SLC7A11/GPX4 pathway atherosclerosis berberine ferroptosis oxidative stress

Unraveling autophagy-related pathogenesis in active ulcerative colitis:A bioinformatics approach

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World Journal of Clinical Cases 2024年第30期12卷 6335-6338页

作者： Wen-rui Hao chun-Yao cheng Ju-Chi Liu Tzu-Hurng cheng Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei City 11002TaiwanChina Department of Medical Education National Taiwan University HospitalTaipei 100225TaiwanChina Department of Ophthalmology Cathay General HospitalTaipei 10633TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404333TaiwanChina

In this editorial,we provide commentary on the study by Gong et *** this original research article,Gong et al employed a bioinformatics approach to investigate the involvement of autophagy in active ulcerative colitis(UC).Through differential gene expression analysis,they identified 58 differentially expressed autophagy-related genes in UC patients compared to healthy ***,HSPA5,CASP1,SERPINA1,CX3CL1,and BAG3,were found to be upregulated in active UC patients,suggesting their significance as core autophagyrelated *** analysis unveiled associations with crucial signaling pathways and diseases such as middle cerebral artery occlusion and ***,immune cell infiltration analysis revealed notable differences in immune cell composition between UC patients and healthy *** findings offer valuable insights into the role of autophagy in UC pathogenesis and potential therapeutic targets.

关键词： Ulcerative colitis Autophagy Bioinformatics Pathogenesis Therapeutic targets