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中国环境科学 2024年第4期44卷 1885-1893页

作者：史思捷黎鸿莉姚婧梅韩乐谭秋君刘亚丽韦冰于雪松王程成重庆大学三峡库区生态环境教育部重点实验室重庆400045 重庆市规划设计研究院重庆401147

以具有不同扰动功能的黄色羽摇蚊幼虫(Chironomus flaviplumus)､苏氏尾鳃蚓(Branchiura sowerbyi)和椭圆萝卜螺(Radix swinhoei)为对象,通过微宇宙实验探究不同底栖动物扰动效应下的沉积物界面理化因子演变特性以及对温室气体CO_(2)和CH... 详细信息

以具有不同扰动功能的黄色羽摇蚊幼虫(Chironomus flaviplumus)､苏氏尾鳃蚓(Branchiura sowerbyi)和椭圆萝卜螺(Radix swinhoei)为对象,通过微宇宙实验探究不同底栖动物扰动效应下的沉积物界面理化因子演变特性以及对温室气体CO_(2)和CH_(4)释放的影响规律.结果表明,不同扰动类型的底栖动物对沉积物-水界面的溶氧(DO)特征带来差异化改变,并影响了有机质的好氧/厌氧分解和碳素转化,进而改变了CO_(2)和CH_(4)的产生及释放量:1)3种底栖动物对CO_(2)和CH_(4)释放的影响存在差异:苏氏尾鳃蚓对两种温室气体的释放呈现最强的促进作用(为对照组的1.59和1.64倍),椭圆萝卜螺对两种温室气体释放的影响不显著,而摇蚊幼虫一定程度上抑制了CH_(4)释放.2)尾鳃蚓扰动下更多的碳素被消耗(表层沉积物和上覆水的TC含量减少)并生成CO_(2)和CH_(4)从系统逸出,其最低的DO渗透深度也为有机物厌氧分解产生CH_(4)创造了更有利的条件;萝卜螺仅在沉积物表面活动,对DO渗透深度以及系统TC和TOC改变较小,进而对温室气体释放的影响也最弱;摇蚊幼虫对CH_(4)释放的抑制作用可能是由于其扰动增大了DO渗透深度,抑制了有机物厌氧分解.

关键词：底栖动物扰动功能群河流沉积物温室气体影响

江西嗜酸链霉菌去铁胺E及金属络合物的分离鉴定与生物活性研究

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有机化学 2024年第7期44卷 2377-2380页

作者：李金达程伯涛黄积武刘文上海师范大学化学与材料科学学院中国科学院上海有机化学研究所生命过程小分子调控全国重点实验室

嗜酸链霉菌属细菌的研究主要集中在新物种的分离和鉴定上,而其次级代谢产物的研究则相对较少.从江西嗜酸链霉菌的发酵液中分离得到一个新的铝配合物铝草铵(alumioxamine,3)和两个已知化合物去铁胺E(desferrioxamine E, 1)和铁草铵E (fer... 详细信息

嗜酸链霉菌属细菌的研究主要集中在新物种的分离和鉴定上,而其次级代谢产物的研究则相对较少.从江西嗜酸链霉菌的发酵液中分离得到一个新的铝配合物铝草铵(alumioxamine,3)和两个已知化合物去铁胺E(desferrioxamine E, 1)和铁草铵E (ferrioxamine E, 2),并通过MS、IR、NMR以及单晶X射线衍射技术对其结构进行鉴定.从结构上来看,化合物3以铝为中心,与配体的六个O原子相连,形成六齿配合物.此外,体外细胞毒活性实验表明,在100μmol/L浓度时化合物1对4种人肿瘤细胞(Hela、PANC1、A375和MHCC-97H)均具有一定的抑制活性,细胞存活率为4.8%～66.4%.

关键词：江西嗜酸链霉菌次级代谢产物配合物细胞毒活性晶体结构

胃袖状切除联合双通路术对预防胃袖状切除术后胃食管反流病的价值

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中国实用外科杂志 2024年第8期44卷 880-884页

作者：朱孝成王键洪健姚立彬徐州医科大学附属医院减重代谢外科江苏徐州221006 徐州医科大学国际肥胖及代谢病中心江苏徐州221004

胃袖状切除术(SG)作为目前开展最为广泛的减重代谢手术,虽然效果显著,但术后胃食管反流病(GERD)的发生率较高。胃袖状切除联合双通路术(SG-TB)作为SG联合手术,通过在SG基础上增加一个通道,降低胃内压力,减少食物在胃内滞留时间,从而有... 详细信息

胃袖状切除术(SG)作为目前开展最为广泛的减重代谢手术,虽然效果显著,但术后胃食管反流病(GERD)的发生率较高。胃袖状切除联合双通路术(SG-TB)作为SG联合手术,通过在SG基础上增加一个通道,降低胃内压力,减少食物在胃内滞留时间,从而有效降低GERD的发生风险,同时其减重代谢效果也较好。但是,SG-TB预防SG术后GERD的机制尚未完全明确,仍需要开展更多的基础和临床研究以明确。

关键词：胃袖状切除术胃食管反流病胃袖状切除联合双通路术减重代谢手术

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北京市板栗产业发展问题及对策研究

中国果树 2024年第6期 125-129页

作者：乔艳杰刘巍吴瑞刚胡广隆兰彦平程丽莉程运河毛威涛北京市农林科学院 100093 河北工程大学北京市怀柔区林业工作总站潜江市畜牧技术推广站

我国是世界板栗第一生产大国,也是板栗出口第一大国。板栗产业作为北京市山区农民经济支柱来源之一,发挥着极其重要的作用。从板栗生产、品种选育、贮藏加工和销售4个方面分析了北京市板栗产业发展现状,并对当前北京市板栗产业存在重栽... 详细信息

我国是世界板栗第一生产大国,也是板栗出口第一大国。板栗产业作为北京市山区农民经济支柱来源之一,发挥着极其重要的作用。从板栗生产、品种选育、贮藏加工和销售4个方面分析了北京市板栗产业发展现状,并对当前北京市板栗产业存在重栽轻管、品种良莠不齐、贮藏加工不科学等问题进行了深入分析,提出了良种化、提高贮藏加工水平等对策及建议。

关键词：板栗产业发展趋势

An accurate determination of the Hubble constant from baryon acoustic oscillation datasets

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Science China(Physics,Mechanics & Astronomy) 2015年第9期58卷 103-108页

作者： cheng cheng HUANG QingGuo State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences University of the Chinese Academy of Sciences

Even though the Hubble constant cannot be significantly determined just by the low-redshift Baryon Acoustic Oscillation(BAO)data, it can be tightly constrained once the high-redshift BAO data are combined. We combined BAO data from 6d FGS, BOSS DR11 clustering of galaxies, Wiggle Z and z = 2.34 from BOSS DR11 quasar Lyman-α forest lines to get H0= 68.17+1.55-1.56 km s-1Mpc-1. In addition, we adopted the simultaneous measurements of H(z) and DA(z) from the two-dimensional two-point correlation function from BOSS DR9 CMASS sample and two-dimensional matter power spectrum from SDSS DR7 sample to obtain H0=(68.11±1.69) km s-1Mpc-1. Finally, combining all of the BAO datasets, we conclude that H0=(68.11±0.86) km s-1Mpc-1, a1.3% determination.

关键词： Hubble constant baryon acoustic oscillation large-scale structure

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基于角度交会的二维坐标图像测量系统

应用光学 2024年第2期45卷 438-445页

作者：程瑶许文斌刘云阳重庆理工大学机械工程学院重庆400050

针对基准平面障碍物检测定位问题,设计了一种采用角度交会法测量二维坐标的嵌入式图像检测系统。二维坐标测量系统采用双线法标定线阵CCD图像传感器,并采用角度交会法对被测对象进行坐标计算,从而测得未修正的二维坐标测量结果。采用控... 详细信息

针对基准平面障碍物检测定位问题,设计了一种采用角度交会法测量二维坐标的嵌入式图像检测系统。二维坐标测量系统采用双线法标定线阵CCD图像传感器,并采用角度交会法对被测对象进行坐标计算,从而测得未修正的二维坐标测量结果。采用控制变量法分别测量X轴和Y轴坐标,使用Matlab软件对数据进行处理,并对X轴和Y轴测量误差分别进行多项式线性拟合,进而得到坐标修正公式,修正的二维坐标误差明显变小。实验结果表明:基于角度交会的二维坐标图像测量系统能够实时、准确、快速和可靠地测量二维坐标,为基准平面障碍物二维坐标测量定位提供了一种可行的方案,具有一定的应用价值和意义。

关键词：线阵CCD 二维坐标测量角度交会法 Matlab

CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第2期21卷 166-171页

作者： cheng-ming NI Bing-yu LING Xiang XU He-ping SUN Hui JIN Yu-qiu ZHANG Hong CAO lan XU Department of Endocrinology the Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxi 214023China Department of Translational Neuroscience Jing’an District Centre Hospital of ShanghaiInstitutes of Brain ScienceState Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain ScienceFudan UniversityShanghai 200032China Department of Emergency Northern Jiangsu People’s HospitalYangzhou UniversityYangzhou 225001China Department of Endocrinology the Affiliated Kunshan First People’s Hospital of Jiangsu UniversityKunshan 215300China

Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life(Abbott et al.,2011),by causing sleeping disorders,anxiety,and depression(Dermanovic Dobrota et al.,2014).The primary clinical manifestation of painful diabetic neuropathy(PDN)is mechanical hypersensitivity,also known as mechanical allodynia(MA)(Callaghan et al.,2012).MA’s underlying mechanism remains poorly understood,and so far,based on symptomatic treatment,it has no effective therapy(Moore et al.,2014).

关键词：趋化因子(CX3CL1) 趋化因子受体(CX3CR1) 机械痛链脲佐菌素糖尿病模型

Biomimetic fibril-like injectable hydrogels for wound management

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Biomedical Engineering Communications 2024年第2期3卷 26-27页

作者： Bo-Han Li Jin-Gai Jiang Si-Wen Du Hui-Juan cheng Yan-Ni Song Wei Shi Dong-Liang Yang Key Laboratory of Flexible Electronics and Institute of Advanced Materials School of Physical and Mathematical SciencesNanjing Tech UniversityNanjing 211816China

Soft tissue repair and regeneration present a significant clinical *** hydrogels have emerged as a promising solution for promoting stem cell differentiation and facilitating soft tissue formation[1].Various materials,including synthetic polymers like polydimethyl siloxane and natural polymers like proteins,have been be used as hydrogel matrix for hydrogel preparation[2,3].However,the limited biodegradability,inhomogeneous network structure,and inadequate mechanical properties of these hydrogels hinder their long-term application in complex environments in *** by the nanostructure of collagen fibrils,Li et *** a strategy for creating injectable nanofibrillar hydrogels by combining self-assembly and chemical crosslinking of nanoparticles[4].Moreover,injectable hydrogels offer advantages as implantable materials,including better defect filling and reduced risk of infection compared to prefabricated hydrogels[5].

关键词： hydrogel inhomogeneous crosslinking

Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-269页

作者： Jian Li Ye Xu Aimin Zang Yunong Gao Quanli Gao Yanqiao Zhang Dong Wang Jianming Xu Ying Yuan Haiping Jiang Jieer Ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu Yi Huang Xiaoping Qian Yueyin Pan Ying cheng Sheng Hu Jin Wang Mengyue Shi Ke Wang Han Hu Lin Shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China Department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Hunan Cancer HospitalChangsha 410013China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Immunotherapy Hubei Cancer HospitalWuhan 430079China Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(ORR;primary endpoint),duration of response(DoR),and progression-free survival(PFS)were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1).Results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021;median follow-up 15.2 months),overall ORR[46.7%;95%confidence interval(95%CI),35.1−58.6;one-sided P<0.0001]and ORR across tumor-specific subgroups[colorectal(n=46):39.1%(95%CI,25.1–54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1−80.9)]were significantly greater with tislelizumab vs.a prespecified historical control ORR of 10%;five(6.7%)patients had complete *** DoR,PFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TRAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor

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