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Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing Dong-Hui Wang hai-Feng Zhang Li-Dan Liu cheng-Ce Li Chao Wei Jun-Yu Liu Nai-Jian Ge Xuan-Yong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer

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吸气模式激光推进空气等离子体光谱

推进技术 2007年第5期28卷 546-549页

作者：余亮英程祖海左都罗陈钰琦曹华梁华中科技大学光电子科学与工程学院湖北武汉430074

利用实验室自行研制的紫外预电离CO2激光器进行了激光等离子体实验,实验采用底面直径均为60mm,焦距分别为5 mm和10 mm的两种抛物面光船。介绍了激光等离子体光谱和明显的特征谱线,以及激光等离子体温度估计模型;分析了两种光船对激光等... 详细信息

利用实验室自行研制的紫外预电离CO2激光器进行了激光等离子体实验,实验采用底面直径均为60mm,焦距分别为5 mm和10 mm的两种抛物面光船。介绍了激光等离子体光谱和明显的特征谱线,以及激光等离子体温度估计模型;分析了两种光船对激光等离子体的影响。实验表明:相同底面直径10 mm焦距光船产生的等离子体信号峰值和持续时间均略大于5 mm焦距光船;10 mm焦距光船产生的等离子体温度明显高于5 mm的,最大温度产生时间比5 mm光船要晚一些。

关键词：二氧化碳激光器激光等离子体光谱

高能CO_2激光腔镜高反介质薄膜的传输特性

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推进技术 2007年第5期28卷 555-557页

作者：彭玉峰程祖海崔金玲张毅张虎余文峰华中科技大学光电子科学与工程学院湖北武汉430074 河南师范大学物理与信息工程学院河南新乡453007

为了获得适用于高能CO2激光器的高抗破坏阈值高反薄膜,以10.6μm高反膜ZnSe/YbF3,PbTe/BaF2膜系为例,数值模拟了激光在高反介质膜中的传输的场特性;给出了激光在多层介质膜中的场强分布、温度场分布及热应力分布。结果表明硅镜基体上的P... 详细信息

为了获得适用于高能CO2激光器的高抗破坏阈值高反薄膜,以10.6μm高反膜ZnSe/YbF3,PbTe/BaF2膜系为例,数值模拟了激光在高反介质膜中的传输的场特性;给出了激光在多层介质膜中的场强分布、温度场分布及热应力分布。结果表明硅镜基体上的PbTe/BaF2膜系所需膜层厚度小、膜层数少,反射率可高达99.98%。

关键词：二氧化碳激光器反射镜介质薄膜激光损伤^+

Network Pharmacology of Xian-Lian-Jie-Du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： Ming-Xia Zhao cheng-Lin Song Qin-Chang Zhang Hao-Jie Du Shu-Qiong Zhang Yu-Xian Shen Yang Sun hai-Bo cheng Wen Lv Department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina Department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina Department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the Xian-Lian-Jie-Du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology Xian-Lian-Jie-Du decoction

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脉冲激光输出模式对介质薄膜损伤的影响

推进技术 2007年第5期28卷 558-560页

作者：曹华梁程祖海叶克飞余亮英陈佳元华中科技大学武汉光电国家实验室湖北武汉430074

采用单横模(TEM01)和多模横向激励高气压(TEA)脉冲二氧化碳激光器和不同焦距的透镜对10.6μm的增透膜进行了破坏实验,对破坏样品进行了显微分析,研究了不同激光模式和不同焦距透镜对薄膜破坏的影响。实验结果表明,在短焦距透镜聚焦时,... 详细信息

采用单横模(TEM01)和多模横向激励高气压(TEA)脉冲二氧化碳激光器和不同焦距的透镜对10.6μm的增透膜进行了破坏实验,对破坏样品进行了显微分析,研究了不同激光模式和不同焦距透镜对薄膜破坏的影响。实验结果表明,在短焦距透镜聚焦时,相同能量密度的单横模激光脉冲焦距前比焦距后更容易造成薄膜的损伤,破坏阈值相差5 J/cm2;使用长焦距透镜聚焦时,在单模激光脉冲和多模激光脉冲幅照下薄膜的损伤阈值基本相同,但比使用短焦距单模激光测量到的损伤阈值高。

关键词：激光损伤^+ 介质薄膜破坏阈值激光模式

TEACO_2激光器涡流管同轴非稳腔光束质量

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强激光与粒子束 2007年第7期19卷 1057-1060页

作者：陈佳元余文峰杨峰邬思明左都罗程祖海华中科技大学光电子科学与工程学院武汉430074

为改善TEA CO2同轴非稳腔激光器输出光束质量,采用涡流管低温气流冷却窗口及凸镜,实验实时测量了单脉冲平均能量18.3 J、在不同工作频率下及是否采用涡流管冷却情况下的光束模式,并计算出衍射极限倍数因子值。激光器工作频率3 Hz,连续运... 详细信息

为改善TEA CO2同轴非稳腔激光器输出光束质量,采用涡流管低温气流冷却窗口及凸镜,实验实时测量了单脉冲平均能量18.3 J、在不同工作频率下及是否采用涡流管冷却情况下的光束模式,并计算出衍射极限倍数因子值。激光器工作频率3 Hz,连续运行300 s,没有涡流管冷却时衍射极限倍数因子值由3.52变化到6.94;采用涡流管冷却后,该值仅由3.50变化到3.88。

关键词： TEA CO2激光器同轴非稳腔涡流管光束质量

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强激光作用下单晶硅的热畸变特性研究

河南师范大学学报（自然科学版） 2005年第3期33卷 36-38页

作者：崔金玲彭玉峰程祖海河南师范大学物理与信息工程学院河南新乡453007 华中科技大学激光技术与工程研究院武汉430074

高功率激光已经广泛应用于核聚变、激光加工、激光化学以及材料处理等领域.在强激光的辐照下,由于大量光子进入材料体内被吸收,局部蓄热,因而形成较大的温度场梯度.考虑到有限厚介质的表面热对流,利用格林函数方法理论计算了硅基板的三... 详细信息

高功率激光已经广泛应用于核聚变、激光加工、激光化学以及材料处理等领域.在强激光的辐照下,由于大量光子进入材料体内被吸收,局部蓄热,因而形成较大的温度场梯度.考虑到有限厚介质的表面热对流,利用格林函数方法理论计算了硅基板的三维温度分布和热变形,给出了硅基板温度分布和热变形跟基片半径和厚度的关系表示式以及关系曲线图.计算结果表明:温升不仅与介质的吸收系数密切相关,而且与对流换热系数有关.在激光照射的初始阶段,基片热变形量迅速增加;其后,随着激光照射时间的增加,热变形增加量逐步变缓.

关键词：强激光温度场热效应单晶硅

New First-line Immunotherapy-based Therapies for Unresectable Hepatocellular Carcinoma: A Living Network Meta-analysis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 15-24页

作者： Jian-Jian Chen Zhi-cheng Jin Biao Luo Yu-Qing Wang Rui Li hai-Dong Zhu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjingJiangsuChina

Background and Aims:Several first-line immune checkpoint inhibitor(ICI)-based combination therapies have been identified for unresectable hepatocellular carcinoma(uHCC).This network meta-analysis(NMA)aimed to provide the most updated evidence about the preferred first-line ICI-based regimens for ***:A comprehensive literature search was performed in various databases from database inception to May *** phase 3 trials evaluating first-line single-agent ICIs,molecular-target agents(MTAs),or their combinations in uHCC were *** main endpoints were overall survival(OS)and progression-free survival(PFS).Pooled effect estimates were calculated using a random effects model within the frequentist *** analyses based on etiology were also ***:Twelve trials at low risk of bias with 8,275 patients comparing 13 treatments were *** with atezolizumab plus bevacizumab was comparable to sintilimab plus IBI305[hazard ratio(HR):1.16;95%confidence interval(CI):0.80–1.68]and camrelizumab plus apatinib(HR:1.06;95%CI:0.75–1.51).The combination therapies,apart from atezolizumab plus cabozantinib in OS and durvalumab plus tremelimumab in PFS,had higher P-score than single-agent MTAs or *** survival benefits were associated with a high risk of adverse events leading to treatment *** proportion of patients with hepatitis B virus-related HCC receiving ICIs combinations might positively correlate with survival advantages(R2=0.8039,p=0.0155).Conclusion:This NMA demonstrated that atezolizumab plus bevacizumab remains the stand of care and confers comparable survival benefits to sintilimab plus IBI305 and camrelizumab plus apatinib in first-line therapy for *** optimal treatment algorithms should consider efficacy,safety,and etiology.

关键词： Hepatocellular carcinoma Systemic therapy Immunotherapy Molecular targeted therapy Tyrosine protein kinase inhibitors Overall survival

CD3ε of a pan T cell marker involved in mouse Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 616-624页

作者： Wen-Hao Shi Li-Mei Wang hai-Jing Yan Shi-Long Liu Xian Yang Xue-JiaoYang cheng-Ye Che Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Weifang Medical University Weifang 261053Shandong ProvinceChina Eye Hospital of Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Department of Medical Engineering the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To explore whether CD3ε is involved in the adaptive immunity of Aspergillus fumigatus(***)keratitis in mice and the role of innate and adaptive immunity in ***:Mice models of *** keratitis were established by intra-stromal injection and corneal epithelial *** injections of natamycin,wedelolactone,LOX-1 inhibitor(poly I)or Dectin-1 inhibitor(laminarin)were used to treat mice with *** *** were pretreated by intraperitoneal injection of anti-mouse CD3ε.We observed the corneal infection of mice under the slit lamp microscope and made a clinical *** protein expression of CD3ε and interleukin-10(IL-10)was determined by Western ***:With the disease progresses,the degree of corneal opacity and edema *** the intrastromal injection models,CD3εprotein expression began to increase significantly on the 2^(nd) ***,in the scraping epithelial method models,CD3ε only began to increase on the 3^(rd) *** natamycin treatment,the degree of corneal inflammation in mice was significantly attenuated on the 3^(rd) *** wedelolactone treatment,the severity of keratitis *** the amount of CD3ε protein was also reduced,compared with the control *** inhibiting LOX-1 and Dectin-1,there was no significant difference in CD3ε production compared with the control *** inhibiting CD3ε,corneal ulcer area and clinical score increased,and IL-10 expression was ***:As a pan T cell marker,CD3ε participate in the adaptive immunity of *** keratitis in *** our mice models,the corneas will enter the adaptive immune stage *** regulating IL-10,CD3ε exerts antiinflammatory and repairs effects in the adaptive immune stage.

关键词： CD3ε adaptive immunity Aspergillus fumigatus keratitis interleukin-10