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Fermented Lentinus edodes extract containingα-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice

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Food Science and Human Wellness 2024年第4期13卷 2102-2115页

作者： Xin Hu dan cheng Yingxia Zhang Po Li Xiaoping Wu Junsheng Fu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China Mycological Research Center Fujian Agriculture and Forestry UniversityFuzhou 350002China Shanghai Lithy One-Health Group Technology Co. Ltd.Shanghai 200235China

Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health *** aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-glucan(FLA),in a concanavalin A(Con A)-induced AIH mouse model and to determine the underlying liver-protective *** results showed that compared with the model group,the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased,and the degree of inflammatory cell infiltration in liver,thymus and spleen was significantly *** polymerase chain reaction,immunohistochemistry,and Western blotting showed that FLA pre-treatment inhibited the Con A-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of *** research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling ***,FLA may improve liver injury in mice by shifting gut microbial composition to reduce the release of inflammatory cytokines in the serum and prevent the necrosis of ***-regulation of NRF2 signaling pathway,down-regulation of TRAF6/NF-κB signaling pathway,and an increase in the relative abundance of Lactobacillus_johnsonii and Ligilactobacillus_murinus play a protective role in liver.

关键词： Autoimmune hepatitis Concanavalin A Lentinus edodes TRAF6/NF-κB NRF2

Transcriptomic analysis identifies the S100 calcium-binding protein β subunit(S100B)and intercellular adhesion molecule-1(ICAM-1)as potential diagnostic biomarkers for acute cerebral infarction

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Genes & Diseases 2024年第1期11卷 46-48页

作者： dan cheng Yushuo Wang Jingna Li Yulan Yao Simiao Zhang Yunliang Wang Department of Neurology Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450014China School of Medicine Medical Sciences and Nutrition University of AberdeenAberdeen AB252ZDUK Department of Neurology The 960th Hospital of PLAZiboShandong 255300China

Due to its high mortality,disability,and recurrence rates,cerebral infarction has a serious impact on the economy and is a physical and psychological burden on patients.1 There is a huge unmet medical need for biomarkers to predict acute cerebral *** have shown that the ischemic damage to neurons,myelin,and glia caused by a stroke leads to the release of the S100 calcium-binding protein beta subunit(S100B)through the blood-brain barrier into the systemic circulation,resulting in an increase in the level of S100B in the peripheral blood.

关键词： S100B cerebral infarction

Factors affecting meibomian gland area loss in symptomatic adults

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1036-1041页

作者： Si-cheng Ding Jing-Jing Su Qing Zhan Jiao-Man Wang Fang Zheng Xu-Xuan Fang dan cheng Ping Guo The Second Clinical Medical College Jinan UniversityShenzhen 518000Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

AIM:To characterize the distribution of meibomian gland(MG)area loss(MGL)and its relationship with demographic characteristics,mites,and ***:This retrospective observational study included patients who visited the Dry Eye Clinic of Shenzhen Eye Hospital between June 2020 and August *** patient characteristics,ocular symptoms,Demodex test results of the eyelid edges,and the results of a comprehensive ocular surface analysis were *** was analyzed using Image J ***:This study enrolled 1204 outpatients aged 20-80(40.70±13.44)y,including 357 males(29.65%)and 847 females(70.35%).The patients were classified into mild(n=155;12.87%),moderate(n=795;66.03%),severe(n=206;17.11%),and extremely severe(n=48;3.99%)MGL *** was significantly larger in female than in male(P=0.006).The degree of MGL also significantly differed in age(P<0.001)and the more numbers of mites with severity(P<0.001).Multivariate disordered multinomial logistic regression analysis identified that female sex,older age,secretory symptoms,and a large number of mites were risk factors for MGL(P<0.05).CONCLUSION:Patients with MGL are more likely to be older,female,more numbers of mites,and increased secretion.

关键词： meibomianglands aging sex symptomatology Demodex

Clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： Jun Zhu dan cheng Xue-Ying Zhu Fen-Fen Li Ye Yang Yu-Feng Ye National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surgery and were divided into the low(<250μm)and normal(250-1000μm)vault groups based on the postoperative vault at *** preoperative biometric parameters and clinical outcomes were compared between the two *** relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating ***:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

STING signaling in islet macrophages impairs insulin secretion in obesity

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Science China(Life Sciences) 2024年第2期67卷 345-359页

作者： Ze Hong Saihua Chen Jing Sun dan cheng Hanli Guo Jiahao Mei Xiang Zhang Munire Maimaiti Haiping Hao Peng Cao Haiyang Hu Chen Wang School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Natural Medicines Department of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 211198China School of Life Sciences Westlake UniversityHangzhou 310012China

The innate immune regulator stimulator of interferon genes(STING)mediates self-DNA sensing and leads to the induction of type I interferons and inflammatory cytokines,which promotes the progression of various inflammatory and autoimmune *** immune system plays a critical role in regulating obesity-induced islet dysfunction,whereas the potential effect of STING signaling is not fully ***,we demonstrate that STING is mainly expressed and activated in islet macrophages upon high-fat diet(HFD)***^(-/-)alleviates HFD-induced islet inflammation by inhibiting the expression of pro-inflammatory cytokines and the infiltration of ***,palmitic acid incubation promotes mitochondrial DNA leakage into the cytosol and subsequently activates STING pathway in ***,STING activation in macrophages impairs glucose-stimulated insulin secretion by mediating the engulfment ofβcell insulin secretory *** inhibiting STING activation enhances insulin secretion to control ***,our results reveal a regulatory mechanism in controlling the islet inflammation and insulin secretion in dietinduced obesity and suggest that selective blocking of the STING activation may be a promising strategy for treating type 2 diabetes.

关键词： STING obesity type 2 diabetes insulin macrophages islet

Modified Xiaoyao powder for postpartum depression:A systematic review and meta-analysis

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 120-130页

作者： Mengyuan Hu Xiaowen Zhang Xuya Zhang dan cheng Yali Zhang Xinyu Zhang Lingling Li Xinjie Li Xue Li Yi Lu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Centre for Evidence Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Chinese Medicine The University of Hong KongHong KongChina

Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,Google Scholar,the SinoMed,Embase,Cochrane Library,and PubMed databases were searched from their inception to April 25,*** Cochrane Risk of Bias tool was used to assess the quality of the *** applied the risk ratio to present dichotomous data and the mean difference to present continuous *** with similar characteristics were pooled for meta-analysis and heterogeneity was assessed using ***:This review included 35 trials involving 2848 *** quality of the included studies was low(unclear randomization processes and insufficient reporting of blinding).Participants treated with modified Xiaoyao powder plus Western medicine showed lower Hamilton Depression Scale(HAMD)depression score than those who used Western medicine alone(mean difference=-2.15;95%confidence interval:-2.52 to 1.78;P<.00001),and higher effective rate(relative risk=1.19;95%confidence interval:1.15 to 1.24;P<.00001),When comparing modified Xiaoyao alone with Western medicine,the HAMD depression score remained low,however,the efficacy rate was higher in the modified Xiaoyao *** adverse events,the modified Xiaoyao group reported weight gain,nausea,and diarrhea,but no severe adverse events were ***:Modified Xiaoyao may help relieve depression in PPD when used alone or in combination with Western medicine,with minor side ***,future high-quality,large-sample size RCTs are warranted.

关键词： Postpartum depression Modified Xiaoyao Chinese medicine Systematic review Meta-analysis

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湖北烤烟低温连阴雨灾害时空分布特征

华中农业大学学报 2024年第5期43卷 140-148页

作者：刘静刘璐成丹湖北省气象服务中心/湖北省烟草气象研究重点实验室武汉430205 恩施土家族苗族自治州气象局恩施445000

为更好地防御低温连阴雨灾害对湖北烤烟的产量与品质带来的不利影响,构建烤烟不同生育期的低温连阴雨判别指标,并利用湖北烤烟种植区32个国家气象观测站1975—2020年逐日气象数据,深入分析湖北烟区低温连阴雨7项灾害指标的时空分布特征... 详细信息

为更好地防御低温连阴雨灾害对湖北烤烟的产量与品质带来的不利影响,构建烤烟不同生育期的低温连阴雨判别指标,并利用湖北烤烟种植区32个国家气象观测站1975—2020年逐日气象数据,深入分析湖北烟区低温连阴雨7项灾害指标的时空分布特征。结果表明:(1)时间上,过程平均气温、日平均降水量及平均总降水量等3项指标均为低—高—低演变过程,以成熟前期最高、伸根期最低,过程平均日数均在5d左右,而年平均过程次数、年平均过程日数、灾害频率均以成熟后期最多、旺长期最少,其中灾害频率在这2个时期分别为每10a发生6、1次;(2)空间上,气温、降水在不同生育期南北差异一致,北部烟区气温低,南部烟区降水多、强度大,而过程平均日数在伸根期、旺长期南部大于北部,成熟后期则相反;(3)灾害频率空间差异显著,前3个生育期,南部烟区较北部烟区发生频率更高,成熟后期南北相当,灾害频率均高达56%以上,过程平均持续5.7d。

关键词：烤烟低温连阴雨生育期灾害频率时空分布

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新媒体环境下高职院校影视制作课程的探索与实践——以安徽警官职业学院新闻采编与制作专业为例

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安徽电气工程职业技术学院学报 2024年第2期29卷 109-115页

作者：程丹安徽警官职业学院信息管理系安徽合肥230031

随着社交媒体、移动互联网、虚拟现实等新兴媒体技术的迅速发展,传媒行业正经历着深刻的变革,市场需要更富创意、更具技术娴熟度的影视制作人才来适应和引领这一变革,这对高职院校影视制作专业人才培养提出了更高的要求。文章在分析新... 详细信息

随着社交媒体、移动互联网、虚拟现实等新兴媒体技术的迅速发展,传媒行业正经历着深刻的变革,市场需要更富创意、更具技术娴熟度的影视制作人才来适应和引领这一变革,这对高职院校影视制作专业人才培养提出了更高的要求。文章在分析新媒体环境下影视制作行业人才需求和高职院校影视制作课程教学现状的基础上,以安徽警官职业学院新闻采编与制作专业为实践案例,从专业课程设置、实践教学手段、师资队伍建设三个方面对高职院校影视制作课程进行探索,以期全面提高高职院校人才培养质量,满足传媒行业的人才需求。

关键词：影视制作课程设置实践教学师资队伍建设

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媒体融合背景下高职传媒人才培养策略探索

安徽警官职业学院学报 2024年第2期23卷 116-119页

作者：程丹安徽警官职业学院安徽合肥230031

伴随着媒体融合向纵深推进,人才供给侧正面临着全新的挑战。培养复合型全媒体人才,既是传媒行业的诉求,也是业界的共识。尽管部分高职院校对全媒体人才培养模式进行了有益的探索与创新,但是在课程设置、实践教学等方面仍存在较大问题。... 详细信息

伴随着媒体融合向纵深推进,人才供给侧正面临着全新的挑战。培养复合型全媒体人才,既是传媒行业的诉求,也是业界的共识。尽管部分高职院校对全媒体人才培养模式进行了有益的探索与创新,但是在课程设置、实践教学等方面仍存在较大问题。在媒体融合背景下,通过实地调研,采用文献研究法和案例分析探讨高职传媒人才的培养,既有助于对内优化课程体系、健全校内实践平台、完善以赛促学机制,更有利于对外搭建媒校协同育人平台,合力提升高职全媒体人才的培养质量。

关键词：媒体融合全媒体人才人才需求培养策略