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Hypericin: chemical synthesis and biosynthesis

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Chinese Journal of Natural Medicines 2014年第2期12卷 81-88页

作者： HUANG lin-Fang WANG Zeng-Hui chen shi-lin Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College

Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hypericum belonging to the sections Euhypericum and Campylosporus of Keller's classification. Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of this unique compound. However, the synthetic strategies are challenging for organic and biological chemists. In this review, specific significant advances in total synthesis, semi-synthesis, and biosynthesis in the past decades are summarized.

关键词： Hypericin Total synthesis Semi-synthesis Biosynthesis

Synthesis of Nitroanilines Catalyzed by Horseradish Peroxidase in the Presence of NaNO2 and H2O2

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Chemical Research in Chinese Universities 2013年第6期29卷 1164-1166页

作者： LIU Cong DAI Rong-ji lin Jie SUN Jian-hua chen shi DENG Yu-lin School of Life Science Beijing Institute of Technology Beijing 100081 P.R.China

The synthesis of nitroanilines catalyzed by horseradish peroxidase（HRP） in the presence of sodium nitrite and hydrogen peroxide was investigated, o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.

关键词： Nitroaniline Horseradish peroxidase Phenylamine Nitration Enzyme

Survey of traditional Dai medicine reveals species confusion and potential safety concerns: a case study on Radix Clerodendri Japonicum

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Chinese Journal of Natural Medicines 2017年第6期15卷 417-426页

作者： DUAN Bao-Zhong FANG Hai-Lan LI Xi-Wen HUANG lin-Fang WANG Ping chen shi-lin College of Pharmaceutical Sciences Hubei University of Chinese Medicine Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences College of Pharmaceutical Sciences Dali University Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College

The adulteration of herbal products is a threat to consumer safety. In the present study, we surveyed the species composition of commercial Radix Clerodendri Japonicum products using DNA barcoding as a supervisory method. A reference database for plant-material DNA-barcode was successfully constructed with 48 voucher samples from 12 Clerodendrum species. The database was used to identify 27 Radix Clerodendri Japonicum decoction piece samples purchased from drug stores and hospitals. The DNA sequencing results revealed that only 1 decoction piece(3.70%) was authentic C. japonicum, as recorded in the Dai Pharmacopeia, whereas the other samples were all adulterants, indicating a potential safety issue. The results indicate that decoction pieces that are available in the market have complex origins and that DNA barcoding is a suitable tool for regulation of Dai medicines.

关键词： Dai medicine DNA barcode Radix Clerodendri Japonicum Adulterants ITS 2

DNA barcoding and rapid identification of the precious herb Herba Anoectochili

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Chinese Journal of Natural Medicines 2019年第10期17卷 738-745页

作者： HU Shuai-Jun HU Hao-Yu GAO Han LIU Xia chen shi-lin School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China

Herba Anoectochili is a commonly used medicinal material. However, its adulteration is a serious concern. Due to the similar morphological characteristics of Herba Anoectochili and its adulterants, traditional identification techniques often fail to distinguish between them accurately, which is not conducive to the circulation management and safety of the medicinal materials. To improve the distinction between Herba Anoectochili and its adulterants accurately, this study identified 41 Herba Anoectochili and its adulterant samples based on the ITS2 sequence. Sequence characteristics, Basic Local Alignment Search Tool(BLAST) application, genetic distance, construction of phylogenetic tree, secondary structure prediction, and other methods showed the ITS2 sequence to accurately identify Herba Anoectochili from its adulterants. Furthermore, in this study, we designed a specific primer, based on the ITS2 sequence, and established a real-time PCR detection system for the rapid, sensitive, and specific identification of the original plant of Herba Anoectochili. Compared to DNA barcoding technology, this method has shorter detection time, stronger specificity, and higher sensitivity, which lays the foundation for the rapid identification of Herba Anoectochili.

关键词： Herba Anoectochili ITS2 DNA barcode Real-time PCR Rapid identification

Complete chloroplast genome of Salvia plebeia:organization, specific barcode and phylogenetic analysis

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Chinese Journal of Natural Medicines 2020年第8期18卷 563-572页

作者： CUI Ning LIAO Bao-Sheng LIANG Cong-Lian LI shi-Feng ZHANG Hao XU Jiang LI Xi-Wen chen shi-lin College of Pharmacy Shandong University of Traditional Chinese MedicineJi’nan 250300China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Central Laboratory Shandong Academy of Chinese MedicineJi’nan 250014China

Salvia plebeia has been in use as traditional Chinese medicine(TCM)for more than 500 *** this study,the complete chloroplast(cp)genome of *** was sequenced,assembled and compared to those of other five published Salvia cp *** was found that the cp genome structure of *** was well conserved and had a total size of 151062 *** parameters were used to display the usage conditions of the codons of the amino acids in Salvia *** the number of protein-coding genes in each species was the same,the total number of codons was *** for amino acids Trp and Met whose Relative Synonymous Codon Usage(RSCU)value of one condon was equal to 1,the remaining 19 amino acids had 1-3 preferred *** preferred codon names of each amino acid were *** period size for the tandem repeats of six species ranged from 9 to 410 *** cp genomes mainly possessed tandem repeats with a copy number less than or equal to *** sequence length of tandem repeats of the six species ranged from 25 to 824 *** viarable regions including four intergenic spacers and six partial genes were discovered as potential specific barcodes for Salvia species through cp genome-wide ***,we performed phylogenetic analyses based on the complete cp genome and coding sequences *** results provide information to help construct the cp genome library for Salvia,which may support studies of phylogenetics,DNA barcoding,population and transplastomics.

关键词： Simple sequence repeat Chloroplast Tandem repeats Microsatellites Barcode

Covariant Anomaly and Hawking Radiation from Kerr-Newman Black Hole in Dragging Coordinates Frame

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Communications in Theoretical Physics 2008年第8期50卷 541-544页

作者： LIU Xiong-Wei ZENG Xiao-Xiong chen shi-Wu lin Kai YANG Shu-Zheng Institute of Theoretical Physics China West Normal University Nanchong 637002 China

In the light of Robinson and Wilczek's new idea,and motivated by Banerjee and Kulkarni's simplified method of using only the covariant anomaly to derive Hawking radiation from a black hole,we generally extend the work to Kerr-Newman black hole in dragging coordinates *** is shown that the flows introduced to cancel the anomaly at the event horizon are equal to the corresponding Hawking radiation in dragging coordinates frame,which supports and extends Robinson and Wilczek's opinion.

关键词： Hawking radiation anomaly dragging coordinates frame Kerr-Newman black hole

Megastigmane Glycosides from Polygala hongkongensis Hemsl

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Chemical Research in Chinese Universities 2007年第5期23卷 530-532页

作者： WU Jian-feng chen Si-bao GAO Jing-chun WU Li-jun chen shi-lin TU Peng-fei School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 P. R. China School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100083 P. R. China State Key Laboratory of Chinese Medicine and Molecular Pharmacology Department of Applied Biology and Chemical Technology College of Medicine Foshan University Foshan 528000 P. R. China Institute of Medicinal Plant Development Chinese Academy of Medical Science Peking Union Medical College Beijing 100094 P. R. China

Two new megastigmane glycosides,7Z-roseoside,and 7Z-trifostigmanoside Ⅰ,as well as,four known compounds,trifostigmanoside Ⅱ,epimedin C,3＇,7-dihydroxy-4＇-methoxyisoflavone-7-D-glucopyranoside,and formenonetin,were isolated from Polygala hongkongensis *** structures of the isolated compounds were established on the basis of UV,IR,NMR,and MS spectral *** glycosides（1-3）were isolated from the family Polygalaceae for the first time.

关键词： Poiygala hongkongensis Polygalaceae Megastigmane glycosides 7Z-Roseoside 7Z-Trifostigmanoside I

Prediction of the globally ecological suitability of Panax quinquefolius by the geographic information system for global medicinal plants(GMPGIS)

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Chinese Journal of Natural Medicines 2019年第7期17卷 481-489页

作者： SHEN Liang LI Xi-Wen MENG Xiang-Xiao WU Jie TANG Huan HUANG lin-Fang XIAO Shui-Ming XU Jiang chen shi-lin Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences (CAMS) Peking Union Medical College (PUMC) Beijing 100193 China

American ginseng(Panax quinquefolius L.) is a well-known Asian traditional herbal medicine with a large market demand. The plant is native to eastern North America, and its main producing areas worldwide are decreasing due to continuous cropping obstacles and environmental changes. Therefore, the identification of maximum similarities of new ecological distribution of ***, and prediction of its response to climate change in the future are necessary for plant introduction and cultivation. In this study, the areas with potential ecological suitability for P. quinquefolius were predicted using the geographic information system for global medicinal plants(GMPGIS) based on 476 occurrence points and 19 bioclimatic variables. The results indicate that the new ecologically suitable areas for P. quinquefolius are East Asia and the mid-eastern Europe, which are mainly distributed in China, Russia, Japan, Ukraine, Belarus, North Korean, South Korea, and Romania. Under global climate change scenarios, the suitable planting areas for P. quinquefolius would be increased by 9.16%–30.97%, and expanding north and west over the current ecologically suitable areas by 2070. The potential increased areas that are ecologically suitable include northern Canada, Eastern Europe, and the Lesser Khingan Mountains of China, and reduced regions are mainly in central China, the southern U.S., and southern Europe. Jackknife tests indicate that the precipitation of the warmest quarter was the important climatic factor controlling the distribution of P. *** findings can be used as a useful guide for P. quinquefolius introduction and cultivation in ecologically suitable areas.

关键词： American ginseng Panax quinquefolius Ecological suitable area Climate change GMPGIS Jackknife test

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si chen Fang Huang Lijie Mao Zhimin Zhang Han lin Qixin Yan Xiangyu Lu Jianlin shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis