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Prophylactic effects of sialylated glycopeptides from edible bird’s nest on neuroinflammation in lipopolysaccharide-treated mice via the gut-brain axis

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Food Science and Human Wellness 2024年

作者： Xiang-Rong cheng chen-Xi zhang Xiao-Yi Zhao Qiu-Shi Li Yu Song Lan zhang Jia-Hui Ma Yu-Yao chen Man Yuan Dong-Liang Wang School of Food Science and Technology， Jiangnan University State Key Laboratory of Food Science and Resources， Jiangnan University Central Nervous System Drug Key Laboratory of Sichuan Province Luzhou Hebei Edible Bird's Nest Fresh Stew Technology Innovation Center

Edible bird’s nest (EBN)， abundant in sialic acid (SA) has been recognized as a natural substance beneficial to brain development and cognitive ability. In order to investigate active component of EBN， sialylated glycopeptides (SCP) were extracted from EBN by 60% ethanol after trypsin hydrolysis and its effects on central nervous system was evaluated in lipopolysaccharide (LPS)-induced neuroinflammation mice. EBN， SCP， and SA pretreatment and intervention reduced IL-1β， TNF-α， and IL-6 levels in hippocampus and cortex， meanwhile inhibited the activation of microglia， astrogliosis and neuron apoptosis， which were consistent with the learning and memory improvement and anti-depression effects in behavioral tests. The counts of leukocytes， neutrophils and monocytes， as well as IL-1β， TNF-α， and IL-6 levels in peripheral circulation were significantly reduced by SCP. Results of plasma metabolomics suggested SCP up-regulated energy metabolism， promoted the recovery of primary and secondary bile acid metabolism and indole metabolism， where microbiota may involve. 16S rDNA sequencing of colonic contents showed EBN， SCP and SA repaired dysbacteriosis in LPS-treated mice by significantly up-regulating the anti-inflammatory Muribaculaceae and inhibiting pro-inflammatory related Desulfovibrio and Candidatus＿Saccharimonas. In addition， both EBN and SCP could significantly enrich ***， while SA could specifically enrich Prevotellaceae＿UCG＿001. The gut-brain axis was preliminarily established， and SCP may have the potential to be a functional factor for neuroprotection applied in EBN industry.

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Marginal zone lymphoma with severe rashes: A case report

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World Journal of Clinical Cases 2024年第3期12卷 565-574页

作者： Si-Jun Bai Ye Geng Yi-Nan Gao Cai-Xia zhang Qian Mi chen zhang Jia-Ling Yang Si-Jie He Zhen-YingYan Jian-Xia He Department of Hematology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial *** SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent ***-line treatment with rituximab combined with zanubrutinib had poor ***,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes *** For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be *** approach may provide a new perspective in the treatment of MZL.

关键词： Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab,Obinutuzumab Zanubrutinib Case report

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Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1437-1452页

作者： Bin-Sheng Wang chen-Li zhang Xiang Cui Qiang Li Lei Yang Zhi-Yun He Ze Yang Miao-Miao Zeng Nong Cao Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Third Department of General Surgery First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer,characterized by a multifactorial etiology and high heterogeneity,continues to confound researchers in terms of its ***,a natural anticancer agent,exhibits therapeutic promise in gastric *** effects include promoting cell apoptosis,curtailing tumor angiogenesis,and enhancing sensitivity to radiation and *** noncoding RNAs(lncRNAs)have garnered significant attention as biomarkers for early screening,diagnosis,treatment,and drug response because of their remarkable specificity and *** investigations have revealed an association between aberrant lncRNA expression and early diagnosis,clinical staging,metastasis,drug sensitivity,and prognosis in gastric cancer.A profound understanding of the intricate mechanisms through which lncRNAs influence gastric cancer develop-ment can provide novel insights for precision treatment and tailored management of patients with gastric *** study aimed to unravel the potential of curcumin in suppressing the malignant behavior of gastric cancer cells by upregu-lating specific lncRNAs and modulating gastric cancer onset and *** To identify lncRNAs associated with curcumin treatment and investigate the role of lncRNA AC022424.2 in the effects of curcumin on gastric cancer cell apoptosis,proliferation,and ***,these findings were validated in clinical *** The study employed CCK-8 assays to assess the impact of curcumin on gastric cancer cell proliferation,flow cytometry to investigate its effects on apoptosis,and scratch and Transwell assays to evaluate its influence on the migration and invasion of BGC-823 and MGC-803 *** blotting was used to gauge changes in the protein expression levels of CDK6,CDK4,Bax,Bcl-2,caspase-3,P65,and the PI3K/Akt/mTOR pathway in gastric cancer cell lines after curcumin *** expression of lncRNAs before and after curcumin treatment was assessed using lncRNA seq

关键词： Gastric cancer Curcumin Long noncoding RNA AC022424.2 Apoptosis Akt/PI3K pathway Lymph metastasis

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《乐书》纸背明代所司细务揭帖的性质、特点及文本价值

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河南师范大学学报（哲学社会科学版） 2024年第4期51卷 95-102页

作者：张琛河南师范大学历史文化学院河南新乡453007

公文纸本《乐书》纸背揭帖是最新发现的文书原件,内容集束于明成化九年南京仓场细务,属所司细务揭帖,据钤印不同,可分为朱印揭帖和无印揭帖两种,二者在发文者、流转地、功用、内容上多有差异,在南京仓场日常活动管理中承担着不同的角色... 详细信息

公文纸本《乐书》纸背揭帖是最新发现的文书原件,内容集束于明成化九年南京仓场细务,属所司细务揭帖,据钤印不同,可分为朱印揭帖和无印揭帖两种,二者在发文者、流转地、功用、内容上多有差异,在南京仓场日常活动管理中承担着不同的角色。传世典籍中所司细务揭帖经后期删汰加工已失去原有的物质形态,内容零星而分散,多流转于中央衙署机关和省级机构,《乐书》纸背揭帖的发现可弥补其多项不足,它是能够反映基层机构运作的公牍实物,具有专于细务、文式简易、使用灵活、时效性强的特点,可实现明代公文在书式、文体、花押、印章、纸张与制度运作方面研究的新突破。在复原揭帖文式的基础上与唐、宋帖式进行对比,考察其来源可视为书式研究的新创获。

关键词：纸背文献揭帖书式明代

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分类分析结果的数据故事化描述模型研究

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情报科学 2024年第2期42卷 165-173,181页

作者：张晨中国人民大学信息资源管理学院北京100872

【目的/意义】分类分析已经在实践生活中应用广泛,构建分类分析结果的数据故事化描述模型,旨在明确数据故事化描述的实现方式,发挥数据故事的解释性功能。【方法/过程】本研究综合应用文献调研法、模型构建法,按照“问题提出-需求识别-... 详细信息

【目的/意义】分类分析已经在实践生活中应用广泛,构建分类分析结果的数据故事化描述模型,旨在明确数据故事化描述的实现方式,发挥数据故事的解释性功能。【方法/过程】本研究综合应用文献调研法、模型构建法,按照“问题提出-需求识别-内容提取-模型设计”的路径展开研究,并采用BPMN方法设计数据故事化描述流程,接着在此基础上逐渐深入,探究数据故事化描述模型构建的内容模块和关键活动,最终形成数据故事化描述模型。【结果/结论】本研究提炼出数据故事化描述的故事情境、数据的描述统计和分析结果的解释需求与内容,并拆分出包含情境模块、描述统计模块和解释模块的数据故事内容模块以及由人物、事件和情节组织起来的描述模型。最后在UCI Breast-Cancer数据集上构建模型实例,实现本研究分类分析结果的数据故事化描述模型的实际应用。【创新/局限】本研究提出了面向分类分析结果的数据故事化描述模型,对数据故事化描述的实现具有理论指导意义,后续要结合其它类型分析结果的特征加强此描述模型的泛化性,并基于此突破数据故事自动生成任务。

关键词：分类分析分类分析结果数据故事化数据故事化描述模型构建

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Prenatal ultrasound diagnosis of fetal maxillofacial teratoma:Two case reports

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World Journal of Clinical Oncology 2024年第9期15卷 1245-1250页

作者： Chuan-Fen Gao Pei Zhou chen zhang Department of Ultrasound The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Prenatal Diagnosis Center The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina School of 1^(st)Clinic Medicine Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND Facial teratoma is a rare benign tumor that accounts for about 1.6%of all teratomas and can be diagnosed by prenatal ultrasound(US).The purpose of this report was to describe our experience with the diagnosis of fetal facial teratoma by prenatal US at second trimester to provide a reference for clinical diagnosis of fetal maxillofacial *** SUMMARY We present two cases of patients with abnormal fetal facial findings on US at second trimester of pregnancy in our *** 1 was a 31-year-old G3 P1+1 female,with US revealing a heterogeneous echogenicity of 32 mm×20 mm×31 mm on the fetal face,most of it located outside the oral cavity and filling the root of the oral *** 2 was a 29-year-old G1P0 female,with fetal head and neck US revealing a cystic-solid echo mass measuring 42 mm×33 mm×44 mm,the upper edge of the lesion reaching the palate and filling the oral *** contours of the lesions were visualized using three-dimensional(3D)US *** patients decided to give up *** of the lesions were performed after induction of labor,and diagnosed as maxillofacial *** Fetal maxillofacial teratomas can be diagnosed by US in early pregnancy,allowing parents to expedite treatment decisions.

关键词： Fetal maxillofacial teratoma Prenatal ultrasound Diagnosis Ultrasound Case report

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精神分裂症患者体质量增加的非药物干预研究进展

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上海交通大学学报（医学版） 2024年第5期44卷 635-640页

作者：陈小畅张晨上海交通大学医学院附属精神卫生中心精神科上海200030

精神分裂症是一种慢性精神障碍,常常伴随着体质量增加问题,从而影响患者服药依从性、症状改善,并增加代谢性和心血管相关疾病的风险。然而,精神分裂症患者体质量增加的具体机制尚未完全明确,可能的原因包括抗精神病药物对多个神经递质... 详细信息

精神分裂症是一种慢性精神障碍,常常伴随着体质量增加问题,从而影响患者服药依从性、症状改善,并增加代谢性和心血管相关疾病的风险。然而,精神分裂症患者体质量增加的具体机制尚未完全明确,可能的原因包括抗精神病药物对多个神经递质受体的作用导致食欲增加和糖脂代谢异常,精神分裂症与肥胖之间的共同发病机制,以及精神分裂症患者不健康的饮食偏好和生活方式等。近年来非药物干预治疗精神分裂症患者体质量增加的研究成果不断更新,干预主要包括3种方式:生活方式干预、减重手术、神经调控技术。生活方式干预包括饮食、运动及认知等方面,目前探究综合性的生活干预模式的成效及患者依从性成为研究的主流;减重手术治疗对满足手术适应证的精神分裂症肥胖患者具有减重的效果,但目前报道的案例总数较少,且需要进一步探究围术期症状管理;神经调控技术治疗中重复经颅磁刺激(repeated transcranial magnetic stimulation,rTMS)对治疗精神分裂症患者的体质量增加具有潜在的前景。该文旨在为治疗精神分裂症患者体质量增加提供更多样化的临床策略参考。

关键词：精神分裂症体质量增加生活方式干预减重手术神经调控技术

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Timp1 Deletion Induces Anxiety-like Behavior in Mice

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Neuroscience Bulletin 2024年第6期40卷 732-742页

作者： Xiaotong Wang Wei Zheng Ziyi Zhu Biyu Xing Weijie Yan Ke Zhu Lingli Xiao Chaojuan Yang Mengping Wei Lei Yang Zi-Bing Jin Xueyun Bi chen zhang State Key Laboratory of Neurology and Oncology Drug Development Nanjing210000China School of Basic Medical Sciences Wenzhou Medical UniversityWenzhou325035China School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and RepairAdvanced Innovation Center for Human Brain ProtectionBeijing Laboratory of Oral HealthCapital Medical UniversityBeijing100069China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing100005China Chinese Institute for Brain Research Beijing102206China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China

The hippocampus is essential for learning and memory,but it also plays an important role in regulating emotional behavior,as hippocampal excitability and plasticity affect anxiety and *** synaptic plasticity may be regulated by tissue inhibitor of matrix metalloproteinase 1(TIMP1),a known protein inhibitor of extracellular matrix(ECM),and the expression of TIMP1 in the hippocampus can be induced by neuronal excitation and various ***,the involvement of Timp1 in fear learning,anxiety,and hippocampal synaptic function remains to be *** study of Timp1 function in vivo revealed that Timp1 knockout mice exhibit anxiety-like behavior but normal fear *** results suggested that Timp1 knockout mice showed hyperactivity in the ventral CA1 region,but the basic synaptic transmission and plasticity were normal in the Schaffer collateral *** together,our results suggest that deletion of Timp1 in vivo leads to the occurrence of anxiety behaviors,but that Timp1 is not crucial for fear learning.

关键词： Timp1 Anxiety Fear Synaptic transmission Synaptic plasticity

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Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer

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Science China Chemistry 2024年第2期67卷 652-663页

作者： Chong Li Minghao Han Ji Gao Shuxian Wang Song-Bo Lu Yaxi Li Zhao Liu chen zhang Zhaojin Wang Fangliang Wang Yuang Sun Chun Loong Ho Kai Wang Yun Shen Kai Li Shenzhen Key Laboratory of Smart Healthcare Engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhen518055China Department of Chemical and Environmental Engineering University of California RiversideRiverside92521USA Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen518055China

The critical factor of spatial constraint,provided by the external confinement(e.g.,matrix),is often overlooked during photodynamic inactivation,despite playing a crucial role in determining the molecular photophysical process and subsequent antipathogen ***,as a proof-of-concept model,we employed two types of polymers with varying interaction energies with dopants to investigate the intrinsic relationship between spatial constraint and the essential excited-state behaviors of doped photosensitizer(4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)ethyl)-1-methylquinolin-1-ium iodine,TPP).Through experimental investigation and theoretical calculations,we found that TPP tends to remain in the excited state for a shorter dwell time under weaker spatial constraints due to less restricted molecular motion in polyurethane(PU) ***,the singlet oxygen(^(1)O_(2)) generated from doped-TPP shows a 9.23-fold enhancement in PU than in the polyvinylchloride(PVC) *** light irradiation,the PU@TPP nanofiber can efficiently eliminate the coronavirus MHV-A59(≥99.9997%) at a 220,000-fold higher concentration than the infected *** antibacterial efficacy has also been demonstrated,with a killing rate of ≥99%.

关键词： photodynamic antibacterial singlet oxygen triphenylamine nanofiber

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Effect of dietary with Zhibai dihuang pills and gonadotropinreleasing-hormone-analogue on girls with precocious and rapidly progressive puberty

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World Journal of Clinical Cases 2024年第24期12卷 5534-5541页

作者： Xue-Mei Wang Wei Li Liu-Qing Yang Rui Luo chen-chen zhang Department of Pediatrics Ma’anshan Maternal and Child Health HospitalMa’anshan 243011Anhui ProvinceChina

BACKGROUND At present,the clinical mechanisms underlying precocious puberty remain unclear,making effective intervention for children experiencing this condition and rapidly progressive puberty *** To explore the effects of Zhibai dihuang pills and gonadotropin-releasing hormone analogue(GnRHa)on growth and ovarian function in girls with precocious *** The clinical data of 84 adolescent girls with precocious puberty and rapidly progressive puberty from February 2017 to August 2023 were retrospectively *** were divided into a control group and an observation group,with 42 cases in each *** control group received diet intervention combined with GnRHa treatment,while the observation group received diet intervention combined with Zhibai dihuang pills+GnRHa *** such as clinical efficacy,growth indicators,ovarian function,and adverse reactions were compared between the two *** The observation group showed superior clinical efficacy compared to the control group(P0.05).Post-intervention,the observation group exhibited significantly lower rates in growth,height,and bone age,along with reduced levels of progesterone,testosterone,estradiol,prolactin,luteinizing hormone,and follicle-stimulating hormone compared to the control group(P0.05).CONCLUSION Combining Zhibai dihuang pills with GnRHa and dietary intervention effectively improves growth,enhances ovarian function,and minimizes adverse reactions in adolescent girls with precocious and rapidly progressive puberty.

关键词： Zhibai dihuang pills Gonadotropin-releasing hormone analogue Dietary intervention Precocious puberty Rapidly progressive puberty Ovarian function

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