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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1223-1228页

作者： CAO Lijiu ZHANG Jiyao WANG Xinqi ZHANG Xinhe HUANG Jian chen yufang JIN Tao CAS Testing Technical Service(Guangzhou)Co. Ltd.Guangzhou 510650China Xuefeng Innovation(Beijing)Technology Co. Ltd.Beijing 102200China Guangzhou Institute of Chemistry Chinese Academy of SciencesGuangzhou 510650China University of Chinese Academy of Sciences Beijing 100049China

Through exploring the effects of low pH on the composite system of desulfurization gypsum(DG)enhanced by melamine-formaldehyde resin(MF),it is found that the inducing of sulfate-ion,in contrast to chloride and oxalate ions,favors the longitudinal growth of the crystalline form of the hydration product,which was relatively simple and had the highest length to width(L/D)*** the same time,MF can also improve L/D ratio of gypsum hydration products,which favors the formation of hydrated ***,in a composite system composed of hemihydrate gypsum,MF,and glass fibers,when dilute sulfuric acid was used to regulate pH=3-4,the tight binding formed among the components of the composite system compared to pH=*** hydration product of gypsum adheres tightly to glass fiber surface and produces a good cross-linking and binding effect with *** flexural strength,compressive strength,elastic modulus,and water absorption of the desulphurized gypsum composite board is 22.7 MPa,39.8 MPa,5608 MPa,and 1.8%,respectively.

关键词： MF-reinforced desulphurized gypsum board composite forming system low pH condition hydration process aspect ratio synergistic effect

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明清时期对违规传教士的惩处与安置

古代文明（中英文） 2024年第2期18卷 109-120,M0006页

作者：陈玉芳吉林大学文学院中国史系吉林长春130012

明清时期发生过多起涉及天主教和传教士的案件。朝廷在处理相关案件时,“化外人有犯,依律拟断”的司法原则始终是基本参照。与此同时,司法权与行政权的混合运用,法条、历史经验、国家安全、对天主教的政策、贸易关系、传教士与朝廷的关... 详细信息

明清时期发生过多起涉及天主教和传教士的案件。朝廷在处理相关案件时,“化外人有犯,依律拟断”的司法原则始终是基本参照。与此同时,司法权与行政权的混合运用,法条、历史经验、国家安全、对天主教的政策、贸易关系、传教士与朝廷的关系、朝廷对特殊地区的政策与管理,以及最高统治者的态度等等,都是关联因素。具体来看,从晚明到清嘉庆时期,朝廷对京城违规传教士的惩处有别于地方传教士,对所有违规的在华传教士的处置总体上趋于严厉,其间“禁教”政策是变化的关键。与“禁教”趋于严厉相关,朝廷对中国澳门天主教的管治渐与内地接近。

关键词：明清禁教司法传教士怀柔远人

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结节样色素型基底细胞癌

临床皮肤科杂志 2024年第9期53卷 513-514页

作者：陈俊均陈玉芳李明常州市肿瘤医院皮肤科江苏常州213000 常州市肿瘤医院病理科江苏常州213000 复旦大学附属中山医院皮肤科上海200032

患者男,74岁主诉:左侧下眼睑结节3年。现病史:患者3年前左侧眼睑下方出现一半透明结节,无自觉症状,未予治疗。病程中结节缓慢增大,2023年9月1日至常州市肿瘤医院皮肤科就诊。患者病程中饮食、睡眠及大小便均正常,体重无明显变化。既往... 详细信息

患者男,74岁主诉:左侧下眼睑结节3年。现病史:患者3年前左侧眼睑下方出现一半透明结节,无自觉症状,未予治疗。病程中结节缓慢增大,2023年9月1日至常州市肿瘤医院皮肤科就诊。患者病程中饮食、睡眠及大小便均正常,体重无明显变化。既往史、个人史及家族史:既往体健。否认面部外伤史、面部囊肿史及其他面部感染性疾病史。个人史及家庭史无特殊。体格检查:系统检查无异常。皮肤科检查:左侧眼睑下方见一半透明结节,约1.5 cm×2.0 cm,界限较清楚,表面光滑,质地韧,表面可见粗大的分支状毛细血管扩张,透过表皮可见多个大小不一的蓝灰色结节(图1)。皮肤镜检查:皮损表面见粗大的分支状毛细血管扩张、蓝灰色卵圆形巢及界限不清的点状色素沉着(图2)。

关键词：基底细胞癌色素型结节样

基于PDMS增敏空芯微瓶谐振腔的高灵敏温度传感器

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中国激光 2024年第5期51卷 174-181页

作者：梁中伟陈彧芳鹿姚陈新玉汪静丽万洪丹南京邮电大学电子与光学工程学院柔性电子(未来技术)学院江苏南京210023

提出并实现了一种基于聚二甲基硅氧烷(PDMS)增敏空芯微瓶谐振腔(PS-HCMR)的高灵敏温度传感器。采用提拉镀膜法在高Q值(~7.83×10^(7))PS-HCMR表面均匀涂敷一层PDMS薄膜以实现热敏功能化,基于PS-HCMR回音壁模共振谱的热敏感性以及PDMS的... 详细信息

提出并实现了一种基于聚二甲基硅氧烷(PDMS)增敏空芯微瓶谐振腔(PS-HCMR)的高灵敏温度传感器。采用提拉镀膜法在高Q值(~7.83×10^(7))PS-HCMR表面均匀涂敷一层PDMS薄膜以实现热敏功能化,基于PS-HCMR回音壁模共振谱的热敏感性以及PDMS的高热光效应和热膨胀效应,实现了对温度信号的高灵敏度感知与测量。实验结果表明:当膜层厚度为150μm时,温度灵敏度可达0.127 nm·℃^(-1),相比于纯SiO_(2)HCMR提高了32倍。所提出的PS-HCMR的温度传感器具有灵敏度高、制备简单、结构紧凑等优势,在工业化控制、电力系统、环境监测等领域中具有良好的应用前景。

关键词：传感器微腔聚二甲基硅氧烷增敏空芯微瓶谐振腔回音壁模式热光效应温度灵敏度

“三全三融”模式在护理技能大赛选手选拔和培训中的应用

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卫生职业教育 2024年第17期42卷 73-77页

作者：吕海琴陈玉芳黄丽王艾青河南护理职业学院河南安阳455000

护理技能大赛是护理职业教育改革的风向标,引领护理职业教育发展。通过“全员参与、全程关注、全方位考量”(“三全”)的选拔机制,能够全面挖掘和选拔出具有潜力的优秀参赛选手;通过“临床思维融入理论知识、人文关怀融入技能操作、心... 详细信息

护理技能大赛是护理职业教育改革的风向标,引领护理职业教育发展。通过“全员参与、全程关注、全方位考量”(“三全”)的选拔机制,能够全面挖掘和选拔出具有潜力的优秀参赛选手;通过“临床思维融入理论知识、人文关怀融入技能操作、心理调节融入模拟考核”(“三融”)的综合培训,能够全面提升参赛选手的综合能力。“三全三融”选拔和培训模式助力选手荣获2023年全国职业院校高职组护理技能大赛一等奖,能为职业院校和选手备赛提供参考。

关键词：护理技能大赛选手选拔培训

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Review of regulating Zn^(2+) solvation structures in aqueous zinc-ion batteries

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Materials Futures 2023年第4期2卷 34-51页

作者： Wanyao Zhang yufang chen Hongjing Gao Wei Xie Peng Gao Chunman Zheng Peitao Xiao College of Aerospace Science and Engineering National University of Defense TechnologyChangshaHunan 410073People’s Republic of China College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology of Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangsha 410082People’s Republic of China

Aqueous zinc-ion batteries,due to their high power density,intrinsic safety,low cost,and environmental benign,have attracted tremendous attentions ***,their application is severely plagued by the inferior energy density and short cycling life,which was mainly ascribed to zinc dendrites,and interfacial side reactions,narrow potential window induced by water decomposition,all of which are highly related with the Zn^(2+)solvation structures in the aqueous ***,in this review,we comprehensively summarized the recent development of strategies of regulating Zn^(2+)solvation structures,specially,the effect of zinc salts,nonaqueous co-solvents,and functional additives on the Zn^(2+)solvation structures and the corresponding electrochemical performance of aqueous zinc-ion ***,future perspectives focused on the challenges and possible solutions for design and commercialization of aqueous electrolytes with unique solvation structures are provided.

关键词： solvation structure aqueous electrolyte zinc-ion batteries zinc dendrites

Multistep continuous flow synthesis of Erlotinib

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Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： Hui Jin Qin Cai Peiwen Liu Yan chen Derong Wang Weiping Zhu yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

Design,synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells

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Chinese Chemical Letters 2024年第5期35卷 287-289页

作者： Wenyi Mei Lijuan Xie Xiaodong Zhang Cunjian Shi Fengzhi Wang Qiqi Fu Zhenjiang Zhao Honglin Li yufang Xu Zhuo chen Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Ursolic acid(UA)is a naturally occurring ursane triterpenoid,which exhibits a wide range of unique biological *** clarify its mechanism of action(MOA),a series of fluorescent derivatives of UA(5a-c)were designed and synthesized by conjugation with 7-nitrobenzo-2-oxa-1,3-diazole(NBD)*** them,5c exhibited similar anti-proliferative activity with UA against HCT116 cells(half maximal inhibitory concentration(IC_(50))=9.21±0.50μmol/L).Cell imaging experiment indicated that 5c was rapidly taken up in HCT116 cells in a dose and time-dependent ***,5c was found to localize in endoplasmic reticulum(ER),lysosomes,and mitochondria,but not in nucleus of HCT116 cells by confocal microscopy *** MOA proved that UA induced autophagy with a unique intracellular distribution mechanism involving ER and *** all,our work provides new clues for revealing the molecular mechanism of UA as an antitumor agent.

关键词： Pentacyclic triterpenoid Ursolic acid Fluorescent derivatives Autophagy Apoptosis

Temperature-sensitive splicing is an important molecular regulation mechanism of thermosensitive genic male sterility in rice

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Chinese Science Bulletin 2009年第14期54卷 2354-2362页

作者： chen RongZhi PAN yufang WANG Yang ZHU LiLi HE GuangCun Key Laboratory of Ministry of Education for Plant Developmental Biology College of Life Sciences Wuhan University Wuhan 430072 China

Photoperiod and temperature-sensitive genetic male sterility (PGMS and TGMS) plants have a number of desirable characteristics for hybrid production. Two-line hybrids developed using the PGMS/TGMS system now account for a large proportion of rice production in China. In this paper, we summarize recent advances on molecular regulation mechanisms and genetics of PGMS/TGMS in rice. We suggest that temperature-sensitive splicing, an important posttranscriptional regulatory mechanism in modulating gene expression and eventually development and differentiation, is also an important molecular regulation mechanism of TGMS in rice. We review those factors involved in temperature-sensitive splicing like cis splice site, snRNA, trans premRNA splicing protein and SR proteins, and delineate that splicing could be regulated by a complex cell signaling pathway. These might shed light on other unknown molecular PGMS/TGMS mechanisms.

关键词：温敏核不育水稻分子调节机制雄性不育基因剪接位点温度敏感分子调控机制信号转导通路 SR蛋白

自拟灌肠方辅助治疗对脓毒症胃肠功能障碍患者胃肠功能及炎症因子的影响

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中国中医急症 2024年第1期33卷 53-56页

作者：胡乃强唐秋莲卢同兴陈玉芳欧日英余梅平黄盛海何雪明广西中医药大学附属国际壮医医院广西南宁530021

目的观察自拟灌肠方灌肠辅助治疗对脓毒症胃肠功能障碍患者的临床疗效。方法选取脓毒症胃肠功能障碍患者100例,随机分为两组各50例,均给予西医常规治疗。对照组加用0.9%氯化钠注射液灌肠,治疗组加用自拟灌肠方灌肠,疗程均为7 d。结果... 详细信息

目的观察自拟灌肠方灌肠辅助治疗对脓毒症胃肠功能障碍患者的临床疗效。方法选取脓毒症胃肠功能障碍患者100例,随机分为两组各50例,均给予西医常规治疗。对照组加用0.9%氯化钠注射液灌肠,治疗组加用自拟灌肠方灌肠,疗程均为7 d。结果治疗组总有效率明显高于对照组(P0.05)。结论运用自拟灌肠方辅助治疗方案,可改善脓毒症胃肠功能障碍患者胃肠症状,恢复胃肠功能,降低炎症因子水平,降低MODS发生率,改善患者预后。

关键词：脓毒症胃肠功能障碍灌肠方随机对照试验