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IEEE/CAA Journal of Automatica Sinica 2016年第3期3卷 295-303页

作者： xiaojuan chen Jun Zhang Tiedong Ma Department of Automobile Engineering Chongqing College of Electronic Engineering College of Automation Chongqing University

Complex networks have attracted much attention from various fields of sciences and engineering in recent years. However, many complex networks have various uncertain information, such as unknown or uncertain system parameters and topological structure, which greatly affects the system dynamics. Thus, the parameter estimation and structure identification problem has theoretical and practical importance for uncertain complex dynamical networks. This paper investigates identification of unknown system parameters and network topologies in uncertain fractional-order complex network with time delays (including coupling delay and node delay). Based on the stability theorem of fractional-order differential system and the adaptive control technique, a novel and general method is proposed to address this challenge. Finally two representative examples are given to verify the effectiveness of the proposed approach. © 2014 Chinese Association of Automation.

关键词： Adaptive control systems Complex networks Structure (composition) Time delay Topology Uncertainty analysis

Regional Rainfall Damage Functions to Estimate Direct Economic Losses in Rainstorms:A Case Study of the 2016 Extreme Rainfall Event in Hebei Province of China

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International Journal of Disaster Risk Science 2024年第4期15卷 508-520页

作者： xiaojuan chen Yifu Xu Ting Li Jun Wei Jidong Wu China Meteorological Administration Xiong’an Atmospheric Boundary Layer Key Laboratory Xiong’an New Area 071800China Key Laboratory of Meteorology and Ecological Environment of Hebei Province Shijiazhuang 050021China Meteorological Disaster Prevention and Environment Meteorological Center of Hebei Province Shijiazhuang 050021China Joint International Research Laboratory of Catastrophe Simulation and Systemic Risk Governance Beijing Normal University at ZhuhaiZhuhai 519087China

Developing a regional damage function to quickly estimate direct economic losses(DELs) caused by heavy rain and floods is crucial for providing scientific supports in effective disaster response and risk reduction. This study investigated the factors that influence regional rainfall-induced damage and developed a calibrated regional rainfall damage function(RDF) using data from the 2016 extreme rainfall event in Hebei Province, China. The analysis revealed that total precipitation, asset value exposure, per capita GDP, and historical geological disaster density at both the township and county levels significantly affect regional rainfall-induced damage. The coefficients of the calibrated RDF indicate that doubling the values of these factors leads to varying increases or decreases in rainfall-induced damage. Furthermore, the study demonstrated a spatial scale dependency in the coefficients of the RDF, with increased elasticity values for asset value exposure and per capita GDP at the county level compared to the township level. The findings emphasize the challenges of applying RDFs across multiple scales and highlight the importance of considering socioeconomic factors in assessing rainfall-induced damage. Despite the limitations and uncertainties of the RDF developed, this study contributes to our understanding of the relationship between physical and socioeconomic factors and rainfall-induced damage. Future research should prioritize enhancing exposure estimation and calibrating RDFs for various types of rainfall-induced disasters to improve model accuracy and *** study also acknowledges the variation in RDF performance across different physical environments, especially concerning geological disasters and slope stability.

关键词： Regional rainfall damage function Loss attribution Direct economic losses Rainfall intensity Asset value Vulnerability

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3- TBK1 complex

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Protein & Cell 2014年第5期5卷 369-381页

作者： xiaojuan chen Xingxing Yang Yang Zheng Yudong Yang Yaling Xing Zhongbin chen Division of Infection and Immunity Department of Electromagnetic and Laser Biology Beijing Institute of Radiation Medicine_ Beijing 100850 China Anhui Medical University Hefei 230032 China

SARS coronavirus （SARS-CoV） develops an antagonis- tic mechanism by which to evade the antiviral activities of interferon （IFN）. Previous studies suggested that SARS-CoV papain-like protease （PLpro） inhibits activa- tion of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism（s） used by SARS PLpro to inhibit activation of the IRF3 pathway is not fully known. In this study, we uncovered a novel mechanism that may explain how SARS PLpro effi- ciently inhibits activation of the IRF3 pathway. We found that expression of the membrane-anchored PLpro domain （PLpro-TM） from SARS-CoV inhibits STING/ TBKl/IKKE-mediated activation of type I IFNs and dis- rupts the phosphorylation and dimerization of IRF3, which are activated by STING and TBKI. Meanwhile, we showed that PLpro-TM physically interacts with TRAF3, TBK1, IKK~, STING, and IRF3, the key components that assemble the STING-TRAF3-TBK1 complex for activa- tion of IFN expression. However, the interaction between the components in STING-TRAF3-TBK1 complex is dis- rupted by PLpro-TM. Furthermore, SARS PLpro-TM reduces the levels of ubiquitinated forms of RIG-I, STING, TRAF3, TBK1, and IRF3 in the STING-TRAF3- TBK1 complex. These results collectively point to a new mechanism used by SARS-CoV through which PLpro negatively regulates IRF3 activation by interaction withSTING-TRAF3-TBK1 complex, yielding a SARS-CoV countermeasure against host innate immunity.

关键词： SARS coronavirus papain-like protease,interferon deubiquitinase STING-TRAF3-TBK1 complex

X-band AlGaN/GaN HEMTs with high microwave power performance

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Science China(Physics,Mechanics & Astronomy) 2011年第3期54卷 442-445页

作者： PENG MingZeng ZHENG YingKui WEI Ke chen xiaojuan LIU XinYu Key Laboratory of Microelectronics Devices & Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China

An X-band AlGaN/GaN high-electron-mobility transistor (HEMT) on SiC substrate with high microwave power performances has been achieved. Its small-signal characteristics with a gate-length of 0.4 μm showed a unity current gain cut-off frequency (fT) of 22 GHz and a maximum oscillation frequency (fmax) of 65 GHz. The GaN HEMT device with a gate width of 1 mm exhibited a continuous-wave saturated output power of 10.2 W and a linear gain of 14.8 dB at 8 GHz, and successfully achieved the power-added efficiency (PAE) as high as 69.2%, which is very suitable for X-band power applications.

关键词： GaN high-electron-mobility transistor X-band power-added efficiency

Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclinl to negatively regulate antiviral innate immunity

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Protein & Cell 2014年第12期5卷 912-927页

作者： xiaojuan chen Kai Wang Yaling Xing Jian Tu Xingxing Yang Qian Zhao Kui Li Zhongbin chen Division of Infection and Immunity Department of Electromagnetic and Laser Biology Beijing Institute of Radiation Medicine Beijing 100850 China Department of Immunology Bengbu Medical College Bengbu 233030 China Prince of Wales Clinical School The University of New South Wales Sydney NSW 2052 Australia Department of Microbiology Immunology and Biochemistry University of Tennessee Health Science Center Memphis TN 38163 USA

Autophagy plays important roles in modulating viral replication and antiviral immune response. Coronavirus infection is associated with the autophagic process, however, little is known about the mechanisms of autophagy induction and its contribution to coronavirus regulation of host innate responses. Here, we show that the membrane-associated papain-like protease PLP2 （PLP2-TM） of coronaviruses acts as a novel autophagy- inducing protein. Intriguingly, PLP2-TM induces incom- plete autophagy process by increasing the accumula- tion of autophagosomes but blocking the fusion of autophagosomes with lysosomes. Furthermore, PLP2- TM interacts with the key autophagy regulators, LC3 and Beclinl, and promotes Beclinl interaction with STING, the key regulator for antiviral IFN signaling. Finally, knockdown of Beclinl partially reverses PLP2-TM＇s inhibitory effect on innate immunity which resulting in decreased coronavirus replication. These results sug- gested that coronavirus papain-like protease induces incomplete autophagy by interacting with Beclinl, which in turn modulates coronavirus replication and antiviral innate immunity.

关键词： coronavirus papain-like proteaseautophagy antiviral immunity Beclinl STING

Assessment of internal controls for data normalization of gene expression after different bacterial stimulation by quantitative real-time PCR in golden pompano Trachinotus blochii

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Journal of Oceanology and Limnology 2020年第2期38卷 480-489页

作者： chen xiaojuan ZHANG Xiaoqi SUN Yun TU Zhigang CAO Zhenjie WANG Shifeng ZHOU Yongcan State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou 570228China Hainan Academy of Ocean and Fisheries Sciences Haikou 570228China

Trachinotus blochii is one of the important commercial fish *** this study,we aim to confirm the reliability reference genes in *** during different bacterial challenge through quantitative real-time PCR(qRT-PCR).The expression of the seven selected genes in four immune organs(i.e.,spleen,kidney,intestine,and gill)stimulated with Vibrio harveyi,Edwardsiella tarda,and Streptococcus agalactiae were determined by *** PCR data was analyzed using the geNorm and NormFinder *** results showed the selection of the internal controls should be tissue specific when studying gene expression in response to bacterial *** 48 h of stimulation with ***,geNorm ranked EF1 A/Actin,18 S rRNA/B2M,UBCE/B2M,and 18 S rRNA/B2M,as the most stably expressed genes in spleen,kidney,intestine,and gill,*** 48 h of stimulation with ***,geNorm ranked 18 S rRNA/EF1 A,18 S rRNA/B2M,B2M/RPL13,and 18 S rRNA/EF1 A,as the most stably expressed genes in spleen,kidney,intestine,and gill,*** 48 h of stimulation with ***,18 S rRNA/EF1 A,18 S rRNA/B2 M,B2 M/Actin,and 18 S rRNA/B2M were ranked as the most stably expressed genes in spleen,kidney,intestine,and gill,*** to the results analyzed by geNorm,reference genes received similar rankings when using NormFinder *** results showed that the reference genes appeared to be not only tissue specific,but also specific to the infecting species of *** one gene is preferred when *** were infected by bacteria,18 S rRNA,B2M,B2M,18 S rRNA may be used in spleen,kidney,intestine,and gill,respectively.

关键词： Trachinotus blochii housekeeping gene expression stability reference gene

健康意识理论教育干预对脑血管病患者疾病认知水平及康复行为的影响

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中国健康心理学杂志 2025年第1期33卷 56-61页

作者：黄琦尹玉珊梁玮莹陈小娟江慧涛广州医科大学附属第二医院神经内科 510260

目的:探讨健康意识理论教育干预对脑血管病患者疾病认知水平以及康复行为的影响。方法:选取2019年4月至2022年4月期间接受治疗的100例脑血管病患者,按照入院先后顺序将其分为两组:对照组(n=50)和研究组(n=50)。对照组实施常规健康干预,... 详细信息

目的:探讨健康意识理论教育干预对脑血管病患者疾病认知水平以及康复行为的影响。方法:选取2019年4月至2022年4月期间接受治疗的100例脑血管病患者,按照入院先后顺序将其分为两组:对照组(n=50)和研究组(n=50)。对照组实施常规健康干预,研究组则采取基于健康意识理论的教育干预。对比两组在疾病认知、康复行为(合理饮食、用药规范、作息规律、有氧运动)、自我管理能力、生活质量上的差异,并评估患者对干预的满意度。结果:干预后,研究组在疾病认知方面的表现显著优于对照组(Z=4.378,P<0.05);研究组在合理饮食、药物使用规范、作息规律以及有氧运动等多个方面的比例均显著高于对照组(χ^(2)=4.336,7.162,7.862,7.484;P<0.05)。两组在干预后的自我管理能力评分都比干预前有所上升,且研究小组在各个维度的得分显著超过对照组(t=8.309,5.538,8.141,6.025;P<0.05)。此外,干预后,两组的世界卫生组织生活质量测定量表简表(WHOQOL-BREF)评分相比干预前均有改善,而研究小组在所有维度的得分均显著优于对比组(t=6.529,7.406,12.260,4.569;P<0.05)。同时,干预后两组的世界卫生组织生存质量测定量表简表(WHOQOL-BREF)评分均较干预前有所改善,且研究组的得分在所有维度上均明显优于对照组(t=6.529,7.406,12.260,4.569;P<0.05)。此外,研究组的干预满意度也明显高于对照组(χ^(2)=4.332,P<0.05)。结论:相比常规健康教育,基于健康意识理论的干预在提升脑血管病患者的疾病认知水平和康复行为上有显著效果,有助于提高患者的自我效能感和生活质量,且干预满意度较高。

关键词：健康意识理论教育干预脑血管病疾病认知水平康复行为满意度

Selection of the appropriate reference genes by quantitative real-time PCR in leopard coral groupers Plectropomus leopardus

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Journal of Oceanology and Limnology 2023年第3期41卷 1084-1099页

作者： Han ZHANG Haoran YANG Pengsuo LI Na ZHAO xiaojuan chen Yongcan ZHOU Zhenjie CAO Yun SUN State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou 570228China Key Laboratory of Tropical Hydrobiology and Biotechnology of Hainan Province Haikou 570228China Department of Aquaculture College of Marine SciencesHainan UniversityHaikou 570228China

Leopard coral groupers(Plectropomus leopardus),commercially bred in South China,are a significant economical fish *** this study,by means of quantitative real-time PCR(qRT-PCR)technology,we assessed the stability of six common reference genes expression and selected the appropriate reference genes in leopard coral groupers with or without Vibrio harveyi stimulation at different time *** data produced by qRT-PCR was handled via the geNorm,NormFinder,and BestKeeper *** results revealed all the examined reference genes had manifest tissue-specific expression in different *** to *** stimulation,RPL13 gene was the appropriate reference gene among eleven tissue types(blood,spleen,hepatopancreas,kidney,stomach,gill,heart,skin,muscle,intestine,brain)in leopard coral *** *** stimulation,the most reliable reference genes varied from tissue to tissue and were closely hinged upon different time *** 6-h post-bacterial injection,the appropriate reference genes in hepatopancreas,spleen,kidney,and gill were Actin,B2M,UBCE,and Actin,*** 9-and 12-h post-bacterial injection,the appropriate reference genes in hepatopancreas,spleen,kidney,and gill were RPL13,Actin,Actin,and Actin,*** one reference gene was preferable,RPL13,Actin,Actin,and Actin could be selected as the reference gene in hepatopancreas,spleen,kidney,and gill of leopard coral groupers after *** infection,*** profiles of two target genes(IL-6 and NK-lysin)were used to further validate reliability of these selected appropriate *** study will lay a solid foundation for the future research on qRTPCR analysis of gene expression in leopard coral groupers.

关键词： Plectropomus leopardus reference genes Vibrio harveyi stimulation

Screening of stable internal reference genes by quantitative real-time PCR in humpback grouper Cromileptes altivelis

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Journal of Oceanology and Limnology 2021年第5期39卷 1985-1999页

作者： xiaojuan chen Yun SUN Panpan ZHANG Jianlong LI Haiping LI Caoying WEI Zhenjie CAO Yongcan ZHOU State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou 570228China Key Laboratory of Tropical Hydrobiology and Biotechnology of Hainan Province Haikou 570228China Department of Aquaculture College of Marine SciencesHainan UniversityHaikou 570228China

Humpback grouper Cromileptes altivelis is one commercial fish with considerable economic *** determine the expression stabilities of six commonly used internal reference genes in *** challenged by Vibrio harveyi and viral nervous necrosis virus(VNNV)through quantitative real-time PCR(qRT-PCR),the expression levels of selected genes in five immune organs stimulated with pathogenic infection were carefully evaluated using algorithms of geNorm,NormFinder,and *** results show that the expre ssion stabilities of the six candidate inte rnal reference genes were diffe re *** no rmal physiological conditions,RPL13 were identified as the most stably expressed genes among five different immune organs(liver,spleen,kidney,intestine,and gill).After *** stimulation,RPL13,RPL13,EF1 A,RPL13,and EF1 A were identified by geNorm,NormFinder,and BestKeeper as the most stable genes in liver,spleen,kidney,intestine,and gill,*** these three algorithms suggested that under stimulation of VNNV,RPL13,EF1 A,Actin,RPL13,and Actin were as the most stable genes in liver,spleen,kidney,intestine,and gill,*** results suggest that specific experiment conditions and tissue types shall be considered when selecting the reference genes in qRT-PCR *** study provided a solid foundation for future studies on gene expression of *** under different conditions.

关键词： Cromileptes altivelis reference gene expression stability pathogenic infection

Modeling seismic wave propagation in a coal-bearing porous medium by a staggered-grid finite difference method

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Mining Science and Technology 2011年第5期21卷 727-731页

作者： Zou Guangui Peng Suping Yin Caiyun Deng xiaojuan chen Fengying Xu Yanyong State Key Laboratory of Coal Resources and Mine Safety China University of Mining ＆ Technology Beijing 100083 China

A staggered-grid finite difference method is used to model seismic wave records in a coal bearing, porous medium. The variables analyzed include the order of the difference calculations, the use of a perfect match layer to provide absorbing boundary conditions, the source location, the stability conditions, and dispersion in the medium. The results show that the location of the first derivative of the dynamic variable with respect to space is coincident with the location of the first derivative of the kinematic varable with respect to time. Outgoing waves are effectively absorbed and reflection at the boundary is very weak when more than 20 perfect match layer cells are used. Blot theory considers the liquid phase to be homogeneous so the ratio of liquid to solid exposure of the seismic source depends upon the medium porosity. Numerical dispersion and generation of false frequencies is reduced by increasing the accuracy of the difference calculations and by reducing the grid size and time step. Temporal second order accuracy, a tenth order spatial accuracy, and a wavelength over more than ten grid points gave acceptable numerical results. Larger grid step sizes in the lateral direction and smaller grid sizes in the vertical direction allow control of dispersion when the medium is a low speed body. This provides a useful way to simulate seismic waves in a porous coal bearing medium.

关键词： CoalPorous mediaStaggered-grid finite differenceSeismic wave propagation