检索结果-南通市图书馆

Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Frontiers of Medicine 2024年第3期18卷 538-557页

作者： Yue Yuan Jiaxuan Li Xun Lu Min chen Huifang Liang xiao-ping chen Xin Long Bixiang Zhang Song Gong xiaowei Huang Jianping Zhao Qian chen Division of Gastroenterology Department of Internal Medicine at Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Hepato–Pancreato–Biliary Diseases Wuhan430030China Department of Trauma Surgery Tongji Trauma CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Schistosoma infection is one of the major causes of liver *** roles of hepatic progenitor cells(HPCs)in the pathogenesis of liver fibrosis have been ***,the precise mechanism underlying the role of HPCs in liver fibrosis in schistosomiasis remains *** study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulating exosomal *** activation of HPCs was verified by immunohistochemistry(IHC)and immunofluorescence(IF)staining in fibrotic liver from patients and mice with Schistosoma japonicum *** coculturing HPCs with hepatic stellate cells(HSCs)and assessing the autophagy level in HPCs by proteomic analysis and in vitro phenotypic assays,we found that impaired autophagy degradation in these activated HPCs was mediated by lysosomal *** autophagy by the autophagy inhibitor chloroquine(CQ)significantly diminished liver fibrosis and granuloma formation in ***-infected ***-secreted extracellular vehicles(EVs)were further isolated and studied by miRNA ***-1306-3p,miR-493-3p,and miR-34a-5p were identified,and their distribution into EVs was inhibited due to impaired autophagy in HPCs,which contributed to suppressing HSC *** conclusion,we showed that the altered autophagy process upon HPC activation may prevent liver fibrosis by modulating exosomal miRNA release and inhibiting HSC activation in *** the autophagy degradation process may be a therapeutic strategy for liver fibrosis during Schistosoma infection.

关键词： schistosomiasis hepatic progenitor cell autophagy extracellular vesicle fibrosis miRNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma pharmacological study on Da Huang Zhe Chong capsule on platelet aggregation of normal person

引用

Journal of Central South University of Technology 2005年第Z1期12卷 326-330页

作者： WANG Dong-sheng chen Fang-ping xiao Chang-jiang HE Shi-lin FU Bin LI Xin CAO Xing-yu chen Yan XIE Qin-zhi Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China

Objective To develop a plasma pharmacological method evaluates the effect of Da Huang Zhe Chong capsule on platelet aggregation and its mechanism, which is a representative Traditional Chinese Medicine Patent Prescription Promoting blood circulation by removing blood stasis. Methods Platelets specimens from healthy volunteers made serum and plasma with medicine, while platelet PRP were separated, which were divided into 8groups,i.e. auto-serum, allo-serum, serum with Da Huang Zhe Chong capsule , serum with aspirin, auto-plasma, plasma with Da Huang Zhe Chong capsule, plasma with aspirin, every group added to serum and plasma to hatch. After ADP and adrenalin were added into the specimens and hatched, the effects of specimens on platelet aggregation were observed. Results After ADP adrenalin were added, all the serum groups did not present platelet aggregation,while all the plasma group presented platelet aggregation. P1, P5, Pmax, t and TM have no significant difference (P＞0. 05) between auto-plasma group and allo-plasma group induced by ADP and adrenalin. P1, P5, t and Pmax have significant differences (P＜0. 01) and TM decreased significantly (P＜0. 05) comparing plasma group with Da Huang Zhe Chong capsule and plasma group of aspirin to allo-plasma group. P1, t and Pmax have significant difference (P＜0.05), and P5 and TM are simulate comparing plasma group with Da Huang Zhe Chong capsule to plasma group of aspirin. P1, P5, t and Pmax have significant differences (P＜0. 01), P1, TM have also significant(P＜0. 05), comparing plasma group of Da Huang Zhe Chong capsule with plasma of aspirin to allo-plasma group induced by adrenalin. P1 ,P5 and Pmax have significant differences (P＜0.05), and t and Pmax are simulate comparing plasma group with Da Huang Zhe Chong capsule with plasma group of aspirin. Conclusion The serum pharmacological study is inappropriate to study platelet aggregation in vitro. The plasma pharmacological study is inappropriate to study platelet aggrega

关键词： Da Huang Zhe Chong capsule plasma pharmacology platelet aggregation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

幽门螺杆菌诱导HepG2细胞损害的研究

引用

南方医科大学学报 2006年第8期26卷 1219-1221页

作者：陈仁陈小苹广东省人民医院感染科广东广州510080

目的探讨幽门螺杆菌对HepG2细胞杀伤和凋亡的作用。方法应用MTT比色法和Hoechst33258细胞核荧光染色等技术检测不同浓度的cagA(+)Hp和cagA(-)Hp对HepG2细胞杀伤和凋亡的作用。结果HepG2杀伤率和凋亡率随着cagA(+)Hp菌液浓度的增加而升高... 详细信息

目的探讨幽门螺杆菌对HepG2细胞杀伤和凋亡的作用。方法应用MTT比色法和Hoechst33258细胞核荧光染色等技术检测不同浓度的cagA(+)Hp和cagA(-)Hp对HepG2细胞杀伤和凋亡的作用。结果HepG2杀伤率和凋亡率随着cagA(+)Hp菌液浓度的增加而升高,且呈剂量依赖性。结论cagA(+)Hp对HepG2细胞具有明显的细胞杀伤和凋亡作用。

关键词：幽门螺杆菌 HepG2细胞凋亡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

杂合启发式在线POMDP规划

引用

软件学报 2013年第7期24卷 1589-1600页

作者：章宗长陈小平中国科学技术大学计算机科学与技术学院安徽合肥230027

许多不确定环境下的自主机器人规划任务都可以用部分可观察的马氏决策过程(partially observableMarkov decision process,简称POMDP)建模.尽管研究者们在近似求解技术的设计方面已经取得了显著的进展,开发高效的POMDP规划算法依然是一... 详细信息

许多不确定环境下的自主机器人规划任务都可以用部分可观察的马氏决策过程(partially observableMarkov decision process,简称POMDP)建模.尽管研究者们在近似求解技术的设计方面已经取得了显著的进展,开发高效的POMDP规划算法依然是一个具有挑战性的问题.以前的研究结果表明:在线规划方法能够高效地处理大规模的POMDP问题,因而是一类具有研究前景的近似求解方法.这归因于它们采取的是"按需"作决策而不是预前对整个状态空间作决策的方式.旨在通过设计一个新颖的杂合启发式函数来进一步加速POMDP在线规划过程,该函数能够充分利用现有算法里一些被忽略掉的启发式信息.实现了一个新的杂合启发式在线规划(hybrid heuristiconline planning,简称HHOP)算法.在一组POMDP基准问题上,HHOP有明显优于现有在线启发式搜索算法的实验性能.

关键词：部分可观察的马氏决策过程在线规划杂合启发法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in noble metal-modified g-C_(3)N_(4) heterostructures toward enhanced photocatalytic redox ability

引用

International Journal of Minerals,Metallurgy and Materials 2024年第11期31卷 2368-2389页

作者： xiao Zhang ping Yang Faculty of Chemical Engineering and Technology Cracow University of TechnologyKrakow 31-155Poland School of Material Science&Engineering University of JinanJinan 250022China

The photocatalytic activity of catalysts depends on the energy-harvesting ability and the separation or transport of photogenerated *** light absorption capacity of graphitic carbon nitride(g-C_(3)N_(4))-based composites can be enhanced by adjusting the surface plasmon resonance(SPR)of noble metal nanoparticles(e.g.,Cu,Au,and Pd)in the entire visible *** can be carried out by varying the nanocomponents of the *** SPR of noble metals can enhance the local electromagnetic field and improve interband transition,and resonant energy transfer occurs from plasmonic dipoles to electron-hole pairs via near-field electromagnetic ***,noble metals have emerged as relevant nanocomponents for g-C_(3)N_(4) used in CO_(2) photoreduction and water ***,recent key advances in noble metals(either in single atom,cluster,or nanoparticle forms)and composite photocatalysts based on inorganic or organic nanocomponent-incorporated g-C_(3)N_(4) nanosheets are systematically discussed,including the applications of these photocatalysts,which exhibit improved photoinduced charge mobility in CO_(2) photoconversion and H2 *** related to the different types of multi-nanocomponent heterostructures(involving Schottky junctions,Z-/S-scheme heterostructures,noble metals,and additional semiconductor nanocomponents)and the adjustment of dimensionality of heterostructures(by incorporating noble metal nanoplates on g-C_(3)N_(4) forming 2D/2D heterostructures)are *** current prospects and possible challenges of g-C_(3)N_(4) composite photocatalysts incorporated with noble metals(e.g.,Au,Pt,Pd,and Cu),particularly in water splitting,CO_(2) reduction,pollution degradation,and chemical conversion applications,are summarized.

关键词： g-C_(3)N_(4) heterostructure noble metal photocatalysis H_(2)generation CO_(2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Construction of Genetic Linkage Map Based on SSR Markers in Peanut(Arachis hypogaea L.)

引用

Agricultural Sciences in China 2008年第8期7卷 915-921页

作者： HONG Yan-bin LIANG Xuan-qiang chen xiao-ping LIU Hai-yan ZHOU Gui-yuan LI Shao-xiong WEN Shi-jie Crops Research Institute Guangdong Academy of Agricultural Sciences Guangzhou 510640 P.R.China

Molecular genetic maps of crop species can be used in a variety of ways in breeding and genomic research such as identification and mapping of genes and quantitative trait loci （QTLs） for morphological, physiological and economic traits of crop species. However, a comprehensive genetic linkage map for cultivated peanut has not yet been developed due to the extremely low frequency of DNA polymorphism in cultivated peanut. In this study, 142 recombinant inbred lines （RILs） derived from a cross between Yueyou 13 and Zhenzhuhei were used as mapping population in peanut （Arachis hypogaea L.）. A total 652 pairs of genomic-SSR primer and 392 pairs of EST-SSR primer were used to detect the polymorphisms between the two parents. 141 SSR primer pairs, 127 genomic-SSR and 14 EST-SSR ones, which can be used to detect polymorphisms between the two parents, were selected to analyze the RILs population. Thus, a linkage genetic map which consists of 131 SSR loci in 20 linkage groups, with a coverage of 679 cM and an average of 6.12 cM of inter-maker distance was constructed. The putative functions of 12 EST-SSR markers located on the map were analyzed. Eleven showed homology to gene sequences deposited in GenBank. This is the first report of construction of a comprehensive genetic map with SSR markers in peanut （Arachis hypogaea L.）. The map presented here will provide a genetic framework for mapping the qualitative and quantitative trait in peanut.

关键词： peanut (Arachis hypogaea L.) SSR genetic linkage map

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D robust anisotropic diffusion filtering algorithm for sparse view neutron computed tomography 3D image reconstruction

引用

Nuclear Science and Techniques 2024年第3期35卷 13-29页

作者： Yang Liu Teng-Fei Zhu Zhi Luo xiao-ping Ouyang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China

The most critical part of a neutron computed tomography(NCT) system is the image processing algorithm,which directly affects the quality and speed of the reconstructed *** types of noise in the system can degrade the quality of the reconstructed ***,to improve the quality of the reconstructed images of NCT systems,efficient image processing algorithms must be *** anisotropic diffusion filtering(ADF) algorithm can not only effectively suppress the noise in the projection data,but also preserve the image edge structure information by reducing the diffusion at the image ***,we propose the application of the ADF algorithm for NCT image *** compare the performance of different algorithms in NCT systems,we reconstructed images using the ordered subset simultaneous algebraic reconstruction technique(OS-SART) algorithm with different regular terms as image processing *** the iterative reconstruction,we selected two image processing algorithms,the Total Variation and split Bregman solved total variation algorithms,for comparison with the performance of the ADF ***,the filtered back-projection algorithm was used for comparison with an iterative *** reconstructing the projection data of the numerical and clock models,we compared and analyzed the effects of each algorithm applied in the NCT *** on the reconstruction results,OS-SART-ADF outperformed the other algorithms in terms of denoising,preserving the edge structure,and suppressing *** example,when the 3D Shepp–Logan was reconstructed at 25 views,the root mean square error of OS-SART-ADF was the smallest among the four iterative algorithms,at only *** universal quality index,mean structural similarity,and correlation coefficient of the reconstructed image were the largest among all algorithms,with values of 0.9877,0.9878,and 0.9887,respectively.

关键词： NCT OS-SART Sparse-view Anisotropic diffusion filtering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Muscovite^(40)Ar/^(39)Ar isotopic dating of pegmatite veins in the Bieyesamas rare metal deposit in the Altay Mountain,Xinjiang,northwestern China

引用

China Geology 2024年第3期7卷 589-591页

作者： Geng-biao Qiao ping Wang xiao-hong Wang Jun-lu chen Key Laboratory for the Study of Focused Magmatism and Giant Ore Deposits Ministry of Natural ResourcesXi’an 710119China Northwest China Center for Geoscience Innovation Xi’an Center of China Geological SurveyXi’an 710119China Petroleum Exploration and Development Research Institute of PetroChina Changqing Oilfield Company Xi’an 710086China

*** The Altay Orogenic Belt in Xinjiang,China is located in the west of the Central Asian Orogenic Belt and in the transition zone between the Siberian Plate and the Kazakhstan-Junggar Plate,extending approximately 500 km in northern Xinjiang,China(Fig.1a).The Altay Orogenic Belt has undergone two-way accretion of the Paleozoic crust and the Meso-Cenozoic intracontinental orogeny,leading to the formation of large numbers of intermediate-acid *** than 100000 pegmatite veins have been discovered in the intermediate-acid intrusions,and they constitute an important rare metal metallogenic belt of China(Fig.1b).

关键词： Xinjiang dating isotopic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Fluctuation Test for Structural Change Detection in Heterogeneous Panel Data Models

引用

Journal of Systems Science & Complexity 2024年第3期37卷 1184-1208页

作者： LI Fuxiao xiao Yanting chen Zhanshou Department of Applied Mathematics Xi'an University of TechnologyXi'an 710048China School of Mathematics and Statistics Qinghai Normal UniversityXining 810008China Academy of Plateau Science and Sustainability Xining 810008China

Structural change in panel data is a widespread phenomena. This paper proposes a fluctuation test to detect a structural change at an unknown date in heterogeneous panel data models with or without common correlated effects. The asymptotic properties of the fluctuation statistics in two cases are developed under the null and local alternative hypothesis. Furthermore, the consistency of the change point estimator is proven. Monte Carlo simulation shows that the fluctuation test can control the probability of type I error in most cases, and the empirical power is high in case of small and moderate sample sizes. An application of the procedure to a real data is presented.

关键词： Common correlated effects fuctuation test heterogeneous panel data models structural change detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

引用

Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 385-392页

作者： Min-Zhi chen ping Xie xiao-Chang Wu Zhen-Hua Tan Hai Qian Zhi-Hong Ma Xing Yao Department of Hepatopancreatobiliary Surgery Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China Huzhou Key Laboratory of Molecular Medicine Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China

Background: Obesity is a common public health issue and is currently deemed a disease. Research has shown that the risk of gallstones in individuals with obesity is elevated. This study aimed to explore the bile proteomics differences between cholelithiasis patients with obesity and normal body weight. Methods: Bile samples from 20 patients(10 with obesity and 10 with normal body weight) who underwent laparoscopic cholecystectomy at our center were subjected to tandem mass tag labeling(TMT) and liquid chromatography-tandem mass spectrometry(LC-MS/MS), followed by further bioinformatic analysis. Results: Among the differentially expressed proteins, 23 were upregulated and 67 were downregulated. Bioinformatic analysis indicated that these differentially expressed proteins were mainly involved in cell development, inflammatory responses, glycerolipid metabolic processes, and protein activation cascades. In addition, the activity of the peroxisome proliferator-activated receptor(PPAR, a subfamily of nuclear receptors) signaling pathway was decreased in the Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Two downregulated proteins in the PPAR signaling pathway, APO A-Ⅰ and APO A-Ⅱ, were confirmed using enzyme-linked immunosorbent assay. Conclusions: The PPAR signaling pathway may play a crucial role in the development of cholelithiasis among patients with obesity. Furthermore, biliary proteomics profiling of gallstones patients with obesity is revealed, providing a reference for future research.

关键词： Proteome profiling Gallstones Obesity-associated gallstones Tandem mass tag labeling PPAR signaling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：