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Design,synthesis and antitumor evaluation of a new series of N-substi-tuted-thiourea derivatives

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Acta Pharmacologica Sinica 2006年第9期27卷 1259-1271页

作者： Jian li~2 Jin-zhi TAN~2 li-li chen~2 Jian ZHANG~2 xu shen~(2,3.Chang-lin MEI~(4,6)li-li FU~4 li-ping liN~5 Jian DING~5 Bing {3.ONG~2 {3.-shan {3.ONG~4 Hong liU~(2,6){3.ao-min LUO~(2,6)Hua-liang JIANG~(2,3.2 Drug Discovery and Design Centre,State Key Laboratory of Drug Research,shanghai Institute of Materia Medica,shanghai Institutes for Biological sciences,chinese academy of sciences,shanghai 201203.china 3.School of Pharmacy.East china University of Science and Technology,shanghai 20023.,china 4 Division of Nephrology,Department of Internal Medicine,Changzheng Hospital,Second Military Medical University,shanghai 200003.china 5 Division of Antitumor Pharmacology,shanghai Institute of Materia Medica,shanghai 201203.china 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 3.chool of Pharmacy East China University of Science and Technology Shanghai 200237 China 3.chool of Pharmacy East China University of Science and Technology Shanghai 200237 China 4Division of Nephrology Department of Internal Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China 5Division of Antitumor Pharmacology Shanghai Institute of Materia Medica Shanghai 201203 China 5Division of Antitumor Pharmacology Shanghai Institute of Materia Medica Shanghai 201203 China 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 4Division of Nephrology Department of Internal Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 201203 China 2Drug Discovery and Design Centre State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Bi

Aim:To design and synthesize a novel class of protein tyrosine kinase inhibitors,featuring the N-(2-oxo-1.2-dihydroquinolin-{1.yl-methyl)-thiourea ***:First,compounds 1.and 2 were identified using the virtual screeningapproach in conjunction with binding assay based on surface plasmon ***,{1.regions of compounds 1.and 2 were selected for chemical *** compounds were characterized potent inhibitory activities toward thehuman lung adenocarcinoma cell line SPAC ***:Forty new compounds(1.2,{1.-g,4a-w,and 5a-l)were designed,synthesized and *** com-pounds(1.{1.,41.4w,5a,and 5b)were found to show promising inhibitory activityagainst the SPAC1.tumor cell *** inhibitory activity of compound 5aincreases approximately 1. times more than that of the original compound ***:This study provides a promising new template with potential antitu-mot activity.

关键词： N-substituted-thiourea derivatives antitumor SPAC1 tyrosine kinase inhibitor virtual screening

A 95 GHz methanol emission survey toward eight small supernova remnants

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Research in Astronomy and Astrophysics 2017年第12期17卷 65-76页

作者： Ying-Jie li {1. xu xi {3. Deng-Rong Lu Yan Sun xin-Yu Du Zhi-Qiang shen Purple Mountain observatory Chinese Academy of SciencesNanjing 210008China University of Science and Technology of china Chinese Academy of SciencesHefei 230026China Center for Astrophysics Guangzhou UniversityGuangzhou 51006China shanghai {1. observatory Chinese Academy of SciencesShanghai 200030China University of the chinese academy of sciences Beijing 100049China

We report on a 95 GHz（80-71.＋） methanol（CH3.H） emission survey with the Purple Mountain {1. Delingha 1.0}7 m telescope. Eight supernova remnants（SNRs） with angular size〈1.′ were observed, but emission was only detected in three SNRs near the Galactic center（Sgr A East,G 0.1.0.1.and G 3.9.92–0.09）. CH3.H emission mainly surrounds the SNRs and can be decomposed into nine spatial peaks with the velocity range of eight peaks being（-3., 70） km s-1. and the other is（70, 1.0） km s-1. They are probably excited by interaction with these SNRs and adjacent molecular gas in the central molecular zone（CMZ）, although star formation may play an important role in exciting CH3.H emission in some regions of CMZ. We infer that tidal action is unlikely to be an excitation source for CH3.H emission.

关键词： ISM:molecules ISM:supernova remnants Galaxy:center ISM:kinematics and dynamics ISM:clouds

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Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

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Science china(Physics,Mechanics & Astronomy) 2024年

作者： Wenda Zhang Weimin Yuan Zhixing {1.ng Yong chen Nanda Rea Arne Rau Zhiming Cai Huaqing cheng Francesco Coti Zelati {1.xin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue {1. Paul O’Brien Rongfeng shen xinwen Shu sheng{1. Sun xiaojin Sun xiaofeng Wang Lei Yang Bing Zhang chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier {1.ming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P. U. Fynbo Lluis Galbany Saurabh W. Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong {1. Bifang {1.u Mingjun {1.u xing {1.u Yuan {1.u Zhu {1.u Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria {1.an Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu xuefeng Wu Dong xu Yanjun xu Suijian xue Yongquan xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng chen Houlei chen Tianxiang chen Wei chen yehai chen Yifan chen chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin chengkui {1. Junfei {1. Longhui {1. Maoshun {1. Wei {1. Zhengda {1. Tianying {1.an Congzhan {1.u Heyang {1.u Huaqiu {1.u Fangjun Lu Laidan Luo Jia Ma xuan Mao Haiwu Pan xin Pan {1.ming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao xu jingjing xu xinpeng xu Yunfei xu Zhao xu Changbin xue Yulong xue Ai{1.ang Yan Haonan Yang xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Zi{1.ang Zhang Donghua Zhao Haisheng Zhao xiaofan Zhao Zijian Zhao Hongyan Zhou Yi{1.n Zhou Yuxuan Zhu Zhencai Zhu Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation academy for Microsatel{1.tes chinese {1. of sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University National astronomical Observatories Department of Physics Anhui Normal University shanghai Institute of Technical Physics chinese {1. of sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas chinese {1. of sciences South African astronomical {1. Department of Astronomy University of Cape Town Department of Physics University of the Free State Universite' Paris Cite' CNRS Astroparticule et Cosmologie Universite' Paris Cite' CEA Paris-Saclay School of Astronomy and Space sciences IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research University of chinese academy of sciences The University of Tokyo ESA/ESTEC Noordwijk 2201.AZ The Netherlands Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics Key Laboratory of Particle Astrophysics The University of Sydney Department of Astronomy xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology Hefei School of Astronomy and Space sciences University of Science and Technology of china Institute of High Energy Physics Institute of Deep Space sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University shanghai {1. observatory chinese {1. of Science

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense {1.t brief X-ray flare lasting for *** flare reached a peak flux of 3.9×1.-9erg cm-2s-1.n 0.5-4 keV,3.0 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-1. keV,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for4d,followed by a steep decay till becoming undetectable1. d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23.d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 1. h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of1. *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词：

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen xiang chen xiaoyu chen xin chen xun chen xurong chen ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china {1. of engineering physics MianyangSichuan china building materials {1. Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Ji{1.ang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geo{1. Beijing china University of Geo{1. WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by{1.,fostered through extensive collaboration with international *** complex comprises four accelerators:a 3. GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 3. MW per beam,it can achieve a luminosity of 5×1.^(3.)cm^(-2)s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1.2}ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,201.)and the Conceptual Design Report(CDR,201.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-203.s.

关键词： initiated exceeding precise

STCF conceptual design report (Volume 1.: Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.chen H.chen H.X.chen J.F.chen K.chen L.L.chen P.chen S.L.chen S.M.chen S.chen S.P.chen W.chen X.chen X.F.chen X.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal University Wuhan 430079China Central South University Changsha 410083China china University of Geo{1. Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 1. Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×1.^(3.) cm^(–2)·s^(–1. or *** STCF will produce a data sample about a factor of 1.0 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

ACE2-independent infection of T lymphocytes by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1232-1242页

作者： xu-Rui {1. Rong Geng Qian li Ying chen Shu-Fen li Qi Wang Juan Min Yong Yang Bei li Ren-Di Jiang {3. Wang {3.ao-Shuang Zheng Yan Zhu Jing-Kun Jia {3.ng-Lou Yang Mei-Qin liu Qian-Chun Gong Yu-Lan Zhang Zhen-Qiong Guan Hui-ling li Zhen-Hua Zheng Zheng-li Shi Hui-Lan Zhang Ke Peng Peng Zhou CAS Key Laboratory of Special Pathogens&State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhanPeople’s Republic of China University of chinese academy of sciences BeijingPeople’s Republic of China State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan University200438 ShanghaiChina Center for Organoid and Regenerative Medicine Greater Bay Area Institute of Precision Medicine(Guangzhou)511462 GuangzhouChina Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyJie Fang RoadHan Kou District430030 WuhanChina

SARS-CoV-2 induced marked lymphopenia in severe patients with ***,whether lymphocytes are targets of viral infection is yet to be determined,although SARS-CoV-2 RNA or antigen has been identified in T cells from ***,we confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells(PBCs)or postmortem lung T cells,and the infectious virus could also be detected from viral antigen-positive *** next prove that SARS-CoV-2 infects T lymphocytes,preferably activated CD4+T cells in *** infection,viral RNA,subgenomic RNA,viral protein or viral particle can be detected in the T ***,we show that the infection is spike-ACE2/TMPRSS2-independent through using ACE2 knockdown or receptor blocking ***,we demonstrate that viral antigen-positive T cells from patient undergone pronounced *** vitro infection of T cells induced cell death that is {1.kely in mitochondria ROS-HIF-1.-dependent ***,we demonstrated that LFA-1.the protein exclusively expresses in multiple leukocytes,is more {1.kely the entry molecule that mediated SARS-CoV-2 infection in T cells,compared to a {1.st of other known ***,this work confirmed a SARS-CoV-2 infection of T cells,in a spike-ACE2-independent manner,which shed novel insights into the underlying mechanisms of SARS-CoV2-induced lymphopenia in COVID-1. patients.

关键词： ACE2 lymphocytes infection

Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-1. outbreak in{1.:a nation-wide study

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Science china({1.fe sciences) 2022年第9期65卷 1855-1865页

作者： Jianping li Nan Zhang Ziyi Zhou {1.ao Huang Weiyi Fang Hongbing Yan Jiyan chen Weimin Wang Dingcheng {1.ang {1. Su Bo Yu Yan Wang Yawei xu Lefeng Wang Chunjie li Kai Huang {1.aobin Wang Yong Huo Junbo Ge Department of Cardiology Peking University First HospitalBeijing 100044China Key Laboratory of Precision Nutrition and Food Quality Ministry of EducationDepartment of Nutrition and HealthCollege of Food Sciences and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Institute of Biomedicine Anhui Medical UniversityHefei 230032China Department of Cardiovascular Medicine Second Affiliated Hospital of Nanchang UniversityNanchang 330008China Department of Cardiology Huadong Hospital Affiliated to Fudan UniversityShanghai 200050China Department of Cardiology Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China Department of Cardiology Guangdong Provincial People’s HospitalGuangzhou 510080China Department of Cardiology Peking University People’s HospitalBeijing 100044China Department of Cardiology General Hospital of Southern Theatre CommandGuangzhou 510010China Department of Cardiology Wuhan ASIA Heart HospitalWuhan 430010China Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Cardiology Xiamen Cardiovascular Hospital Xiamen UniversityXiamen 361004China Department of Cardiology Shanghai Tenth People’s HospitalShanghai 200072China Department of Cardiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Tianjin Chest HospitalTianjin 300074China Department of Cardiology Union Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore 21218USA Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China

Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-1. *** studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction(STEMI),a life-threatening condition that requires emergency medical *** nation-wide data before,during and after the Wuhan lockdown,we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in china across five time periods of the COVID-1. *** analyzed the data of 283.661.STEMI patients who were admitted to 4,487 chest-pain-centers across china,from January 1.201. to May 3.,*** with the period before the lockdown,STEMI in-hospital mortality increased by 25%(OR 1.25,95%CI 1.1.–1.3.)during Early Lockdown,by 1.%(OR 1.1.,95%CI 1.03.1.22)during Later Lockdown,by 3.%(OR 1.3.,95%CI 1.21.1.50)during Early lift,and returned to pre-COVID risk(OR 1.04,95%CI 0.95–1.1.)during Later *** each time-period,we observed a clear mortality gradient by timing and types of revascularization *** conclusion,the COVID-1. epidemic had a significant adverse impact on STEMI in-hospital mortality,with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure,independent of the time periods.

关键词： COVID-1. STEMI mortality lockdown re-opening

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chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

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Journal of Geriatric Cardiology 2018年第1期15卷 30-40页

作者： Yun-Dai chen Wei-Yi FANG Ji-Yan chen Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-xiang HE Yong HUO Lang li Si-Jin li xi-lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI Zhu-Jun shen Jing WANG Yi-Ning WANG Lei xu li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG xiao-li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI chinese PLA General Hospital Beijing China shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Guangdong General Hospital Guangzhou China Beijing Anzhen Hospital Capital Medical University Beijing China Henan Provincial People's Hospital Zhengzhou China Zhongshan Hospital Fudan University Shanghai China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China The First Hospital of Peking University Beijing China The First Affiliated Hospital of Guang{1. Medical University Nanning China The First Affiliated Hospital of Shan{1. Medical University Taiyuan China Peking Union Medical College Hospital Beijing China The 2^nd Affiliated Hospital of Harbin Medical University Harbin China Qilu Hospital of Shandong University Jinan China The First Bethune Hospital of Jilin University Changchun China University of Pennsylvania United States

1.Introduction Early detection and diagnosis of stable coronary artery disease （SCAD） is essential for proactive secondary prevention of myocardial infarction （MI）, control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 201. ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association （AHA）. European Society of Cardiology （ESC） has issued 201.3}ESC guidelines on the management of stable coronary artery disease.

关键词： Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities

Outcomes of a single-step endoscopic ultrasound-guided drainage of pancreatic-fluid collections using an electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent with and without fluoroscopy

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Gastroenterology Report 2020年第6期8卷 425-430,I0001页

作者： Babatunde Olaiya Parit Mekaroonkamol Bai-Wen li Julia Massaad Cicily TVachaparambil Jennifer xu Vladamir Lamm Hui Luo Shan-Shan shen Hui-Min chen Steve Keilin Field FWillingham Qiang Cai Department of Internal Medicine Marshfield ClinicMarshfieldWIUSA Division of Digestive Diseases Emory University School of MedicineAtlantaGAUSA Division of Gastroenterology King Chulalongkorn Memorial HospitalChulalongkorn University and Thai Red CrossBangkokThailand Department of Gastroenterology Shanghai General HospitalShanghai Jiaotong UniversityShanghaiP.R.China Department of Gastroenterology Xijing HospitalXi’anShaanxiP.R.China Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangshuP.R.China Department of Gastroenterology Renji HospitalShanghai Jiaotong UniversityShanghaiP.R.China

Background:Fluoroscopy is often used during the endoscopic drainage of pancreatic-fluid collections(PFCs).An electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent(ELAMS)faci{1.tates a single-step procedure and may avoid the need for *** study compares the treatment outcomes using ELAMS with and without ***:Patients with PFCs who had cystogastrostomy from January 201. to February 201. were *** groups were studied based on fluoroscopy *** success was defined as uneventful insertion of ELAMS at time of *** success was defined as(i)c{1.nical resolution of symptoms after the procedure and(ii)>75%reduction in cyst size on computed tomography 8 weeks after stent *** events including bleeding,stent migration,and infection were ***:A total of 21.patients(1.3}males)had PFCs drainage with ELAMS in the study *** mean age was 51.661..2 *** patients had walled-off necrosis while eight had a pancreatic *** mean size of the PFCs was 1..3.3.3.*** was used in seven cases(3.%)and was associated with a longer procedure time compared to non-fluoroscopy(43.1.1..4 vs 3..3.1..5 min,P=0.025).This association was independent of the size,location,or type of *** had no effect on the technical success *** fluoroless procedures,the c{1.nical resolution was 91.as compared to 71.in fluoroscopy procedures(P=0.52)and the radiologic resolution was 57%as compared to 71.in fluoroscopy procedures(P=0.65).Three cases of stent migration/displacement occurred in the fluoroless ***:ELAMS may avoid the need for fluoroscopy during *** without fluoroscopy were significantly shorter and fluoroscopy use had no impact on the technical or c{1.nical success rates.

关键词： pancreatic-fluid collections electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent(ELAMS) fluoroscopy endoscopic ultrasound