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Effect of Boron on Morphology of Inclusions in Tire Cord Steel

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Journal of Iron and Steel Research International 2012年第4期19卷 22-27页

作者： CUI Huai-zhou chen wei-qing State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Metallurgical Process Research Institute CentralIron and Steel Research Institute Beijing 100083 China

B2O3 was added to tire cord steel during refining in a carbon tube *** influence of boron on the deformability of oxide inclusions was studied by metallographic and scanning electron microscope（SEM） *** melting points of boron-bearing compound oxide inclusions were calculated using Factsage *** results showed that the main inclusion was a boron-bearing compound oxide and the deformation properties of the inclusions were clearly improved by adding *** the boron content was increased from 0.0046% to 0.039%,the proportion of long strip type inclusions changed slightly and the number of inclusions *** low-melting point areas of the MnO-SiO2-Al2O3 and CaO-SiO2-Al2O3 ternary system increased with the addition of ***,the area increased with the increase of B2O3 *** improvements in the deformation ability of the inclusions occurred when the B2O3 mass percent rose to 5% in the CaO-SiO2-Al2O3 inclusion system and to 10% in the MnO-SiO2-Al2O3 inclusion system

关键词： boron tire cord steel inclusions morphology

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing chen wei-qing chen Fei-hua GONG Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain

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Neuroscience Bulletin 2012年第1期28卷 61-68页

作者： Wen-Zhen Shi Chun-Zhen Zhao Bing Zhao Xiao-Liang Zheng San-Hua Fang Yun-Bi Lu wei-Ping Zhang Zhong chen Er-qing wei Department of Pharmacology and Institute of Neurobiology School of Medicine Zhejiang University Hangzhou 310058China

Objective To determine whether aquaporin-4 （AQP4） regulates acute lesions, delayed lesions, and the associated microglial activation after cryoinjury to the brain. Methods Brain cryoinjury was applied to AQP4 knockout （KO） and wild-type mice. At 24 h and on days 7 and 14 after cryoinjury, lesion volume, neuronal loss, and densities of microglia and astrocytes were determined, and their changes were compared between AQP4 KO and wild-type mice. Results Lesion volume and neuronal loss in AQP4 KO mice were milder at 24 h following cryoinjury, but worsened on days 7 and 14, compared to those in wild-type mice. Besides, microglial density increased more, and astrocyte proliferation and glial scar formation were attenuated on days 7 and 14 in AQP4 KO mice. Conclusion AQP4 deficiency ameliorates acute lesions, but worsens delayed lesions, perhaps due to the microgliosis in the late phase.

关键词： aquaporin-4 gene deficiency cryoinjury microglia astrocyte

A meta-analysis of relationship between β-fibrinogen gene-148C/T polymorphism and susceptibility to cerebral infarction in Han Chinese

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Chinese Medical Journal 2007年第13期120卷 1198-1202页

作者： chen Xiao-chao XU Ming-tong ZHOU Wu HAN Chun-li chen wei-qing Department of Cardiology.Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000 Guangdong Province China Department of Endocrinology.Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000 Guangdong Province China Department of Neurology.Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000 Guangdong Province China Department of Epidemiology Public Health College Sun Yat-sen University Guangzhou 510080 China

Objective The results of studies on association between -148C/T polymorphism in promoter region of β3-fibrinogen gene and susceptibility to cerebral infarction in Chinese population are controversial. In this study, we summarize the results of published works in this field by a meta-analysis. Data sources Genetic association studies evaluating the β-fibdnogen gene -148C/T polymorphisms and cerebral infarction involving Chinese population published before December 2005 were collected from PubMed, EMBASE and CNKI. Study selection Case control studies involving unrelated, Han subjects aged from 18 to 80 years, and the internationally recognized diagnostic standard of cerebral infarction and genotype frequencies in control group consistent with Hardy-weinberg equilibrium were used. Publication bias was tested by funnel plot and the odds ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager （Version 4.2） was used for meta-analysis. Results Eleven studies including 1223 patients and 1433 controls met the selection criteria. There was no heterogeneity among the odds ratios （ORs） of individual studies （Х^2=17.82, P=0.06）. The combined OFt of susceptibility to cerebral infarction in -148T allele carriers compared to the wild homozygote was 1.32 （95%CI 1.12 to 1.55, P=-0.0008）. In the patients with cerebral infarction, the average plasma fibrinogen level of allele T carrier was 0.42 g/L （95% CI 0.29 to 0.54, P〈0.001）, higher than that of -148C/C homozygous ones. Conclusions β3-fibrinogen gene -148C/T polymorphism might contribute to susceptibility to cerebral infarction in Han Chinese. To reach a definitive conclusion, further gene to gene and gene to environment interactions studies on β3-fibrinogen polymorphisms and cerebral infarction with large sample size are required.

关键词： β-fibrinogen gene polymorphism cerebral infarction meta-analysis

输出重定义方法设计垂直/短距起降飞机高度控制器

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控制理论与应用 2019年第6期36卷 1009-1016页

作者：朱斌陈庆伟南京理工大学自动化学院

垂直/短距起降飞机是一类典型的非最小相位系统.系统的负调特性使得飞机高度响应比较缓慢,并且会在初始阶段响应为负,从而出现不期望的掉高现象.针对该问题,本文设计了新的最小相位输出预估控制器,通过调节近似输出零点的方法提高系统... 详细信息

垂直/短距起降飞机是一类典型的非最小相位系统.系统的负调特性使得飞机高度响应比较缓慢,并且会在初始阶段响应为负,从而出现不期望的掉高现象.针对该问题,本文设计了新的最小相位输出预估控制器,通过调节近似输出零点的方法提高系统的动态响应;对于负调部分,采用两步参数整定的方法设计PID控制器,达到抑制负调的作用.最后,对飞机的高度俯仰控制进行了仿真验证,结果表明设计的控制器对飞机高度初始负调具有明显的抑制作用,并且缩短了回复上升所需的时间.

关键词：非最小相位系统输出重定义 Smith预估控制器两步参数整定

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垂直/短距起降飞机的轨迹跟踪控制器设计

自动化学报 2019年第6期45卷 1166-1176页

作者：朱斌陈庆伟南京理工大学自动化学院

针对垂直/短距起降飞行器在悬停状态下滚转力矩与横侧向推力存在强耦合、系统具有非最小相位特性的问题,本文设计了轨迹跟踪控制器.首先利用坐标变换和输入输出线性化将系统分解成最小相位子系统和非最小相位子系统.对非最小相位子系统... 详细信息

针对垂直/短距起降飞行器在悬停状态下滚转力矩与横侧向推力存在强耦合、系统具有非最小相位特性的问题,本文设计了轨迹跟踪控制器.首先利用坐标变换和输入输出线性化将系统分解成最小相位子系统和非最小相位子系统.对非最小相位子系统,采用稳态系统中心的方法求解理想内部动态,并跟踪系统理想内模设计了LQR控制器,使得内部动态有界;对最小相位子系统设计了高增益控制器使得外部动态渐进稳定.仿真结果表明本文设计的控制器对给定轨迹和飞行器机动轨迹都有较好的跟踪效果,验证了控制器的有效性.

关键词：非最小相位系统理想内模轨迹跟踪垂直/短距起降飞行器

基于QPSO和拥挤距离排序的多目标量子粒子群优化算法

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控制与决策 2011年第4期26卷 540-547页

作者：施展陈庆伟南京理工大学自动化学院南京210094

为了提高多目标优化算法的收敛性、分布性和减少算法的计算代价,提出一种基于量子行为特性的粒子群优化(QPSO)和拥挤距离排序的多目标量子粒子群优化(MOQPSO-CD)算法.MOQPSO-CD利用QPSO快速接近真实的Pareto最优解,同时引入高斯变异算... 详细信息

为了提高多目标优化算法的收敛性、分布性和减少算法的计算代价,提出一种基于量子行为特性的粒子群优化(QPSO)和拥挤距离排序的多目标量子粒子群优化(MOQPSO-CD)算法.MOQPSO-CD利用QPSO快速接近真实的Pareto最优解,同时引入高斯变异算子以增强解的多样性.采用拥挤距离排序的方法对外部存储器中最优解进行更新和维护,使得从中选择的具有全局最优的领导粒子能够引导粒子群最终找到真实的Pareto最优解.仿真结果表明,MOQPSO-CD具有更好的收敛性和更均匀的分布性.

关键词：多目标优化量子行为特性粒子群优化拥挤距离 Pareto最优解

超声波作用下不同添加剂对高碳钢凝固组织的影响

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钢铁 2008年第9期43卷 63-66页

作者：李杰陈伟庆安徽工业大学冶金与资源学院安徽马鞍山243002 北京科技大学冶金与生态工程学院北京100083

主要研究了在超声波作用下不同添加剂对高碳钢凝固组织的影响。结果表明:在超声波作用下,高碳钢液中添加钛铁、铈可以明显细化其凝固组织,但是添加铝对其凝固组织的细化作用不明显。高碳钢凝固组织的细化是由于Ti(C,N)可以作为非均质形... 详细信息

主要研究了在超声波作用下不同添加剂对高碳钢凝固组织的影响。结果表明:在超声波作用下,高碳钢液中添加钛铁、铈可以明显细化其凝固组织,但是添加铝对其凝固组织的细化作用不明显。高碳钢凝固组织的细化是由于Ti(C,N)可以作为非均质形核的核心,促进高碳钢液凝固过程的形核,Ti(C,N)有效的钉扎晶界作用,阻止初生奥氏体晶粒的长大;超声空化作用下稀土氧化物、氧硫化物数量的增多,增加了高碳钢液凝固过程中非均质形核核心的数量。

关键词：超声波高碳钢凝固组织添加剂

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井眼轨迹测斜计算方法误差分析

中国石油大学学报（自然科学版） 2006年第6期30卷 42-45页

作者：陈炜卿管志川中国石油大学石油工程学院山东东营257061

通过数值方法构造了用于井眼轨迹测斜计算方法对比分析的参考曲线,获得了测斜计算误差分析的参考条件。在此基础上对常用的平均角法、校正平均角法、平衡正切法、最小曲率法、弦步法以及它们的平均井眼位置的误差进行了对比分析。结果表... 详细信息

通过数值方法构造了用于井眼轨迹测斜计算方法对比分析的参考曲线,获得了测斜计算误差分析的参考条件。在此基础上对常用的平均角法、校正平均角法、平衡正切法、最小曲率法、弦步法以及它们的平均井眼位置的误差进行了对比分析。结果表明,无论哪种测斜计算方法,所表现出来的误差特性都很相似,均遵循随测深增加而线性增加的变化趋势。误差散点图表现出的分散性不强,与典型的随机误差的散点图相比,更偏向于系统误差的分布。由于井眼轨迹测斜计算方法误差对轨迹综合误差分析影响较小,因此,经过较大样本空间的分析,几种测斜计算方法所产生的误差概率密度函数均可用统一的解析式表示,通过最小二乘法拟合得到了该解析式的参数值。

关键词：井眼轨迹测斜计算误差分析拟合最小二乘法