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TRPV4-induced Neurofilament Injury Contributes to Memory Impairment after High Intensity and Low Frequency Noise Exposures

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Biomedical and Environmental Sciences 2023年第1期36卷 50-59页

作者： YANG Yang WANG Ju QUAN Yu Lian YANG Chuan Yan chen Xue Zhu LEI Xue Jiao TAN Liang FENG Hua LI Fei chen tu nan Department of Neurosurgery and Key Laboratory of Neurotrauma Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Neurosurgery The 904h Hospital of PLASchool of Medicine of Anhui Medical UniversityWuxi 214044JiangsuChina

Objective Exposure to high intensity, low frequency noise(HI-LFN) causes vibroacoustic disease(VAD),with memory deficit as a primary non-auditory symptomatic effect of VAD. However, the underlying mechanism of the memory deficit is unknown. This study aimed to characterize potential mechanisms involving morphological changes of neurons and nerve fibers in the hippocampus, after exposure to HILFN.Methods Adult wild-type and transient receptor potential vanilloid subtype 4 knockout(TRPV4^(-/-)) mice were used for construction of the HI-LFN injury model. The new object recognition task and the Morris water maze test were used to measure the memory of these animals. Hemoxylin and eosin and immunofluorescence staining were used to examine morphological changes of the hippocampus after exposure to HI-LFN.Results The expression of TRPV4 was significantly upregulated in the hippocampus after HI-LFN exposure. Furthermore, memory deficits correlated with lower densities of neurons and neurofilamentpositive nerve fibers in the cornu ammonis 1(CA1) and dentate gyrus(DG) hippocampal areas in wildtype mice. However, TRPV4^(-/-)mice showed better performance in memory tests and more integrated neurofilament-positive nerve fibers in the CA1 and DG areas after HI-LFN exposure.Conclusion TRPV4 up-regulation induced neurofilament positive nerve fiber injury in the hippocampus,which was a possible mechanism for memory impairment and cognitive decline resulting from HI-LFN exposure. Together, these results identified a promising therapeutic target for treating cognitive dysfunction in VAD patients.

关键词： Low frequency noise Memory impairment TRPV4 Neurofilament Nerve fibers HippocampusLow frequency noise Memory impairment TRPV4 Neurofilament Nerve fibers Hippocampus

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A Novel Defender-Attacker-Defender Model for Resilient Distributed Generator Planning with Network Reconfiguration and Demand Response

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Energy Engineering 2024年第5期121卷 1223-1243页

作者： Wenlu Ji Teng tu nan Ma nanjing Power Supply Company State Grid Jiangsu Electric Power Co.Ltd.Nanjing210019China

To improve the resilience of a distribution system against extreme weather,a fuel-based distributed generator(DG)allocation model is proposed in this study.In this model,the DGs are placed at the planning stage.When an extreme event occurs,the controllable generators form temporary microgrids(MGs)to restore the load maximally.Simultaneously,a demand response program(DRP)mitigates the imbalance between the power supply and demand during extreme events.To cope with the fault uncertainty,a robust optimization(RO)method is applied to reduce the long-term investment and short-term operation costs.The optimization is formulated as a tri-level defenderattacker-defender(DAD)framework.At the first level,decision-makers work out the DG allocation scheme;at the second level,the attacker finds the optimal attack strategy with maximum damage;and at the third level,restoration measures,namely distribution network reconfiguration(DNR)and demand response are performed.The problem is solved by the nested column and constraint generation(NC&CG)method and the model is validated using an IEEE 33-node system.Case studies validate the effectiveness and superiority of the proposed model according to the enhanced resilience and reduced cost.

关键词： Distribution system resilience defender-attacker-defender distributed generator demand response microgrids formation

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Towards efficient generative AI and beyond-AI computing:New trends on ISSCC 2024 machine learning accelerators

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Journal of Semiconductors 2024年第4期45卷 12-15页

作者： Bohan Yang Jia chen Fengbin tu Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong KongChina AI Chip Center for Emerging Smart Systems The Hong Kong University of Science and TechnologyHong KongChina School of the Gifted Young University of Science and Technology of ChinaHefei 230026Chin

Compared to the last decade when the convolution neu-ral network(CNN)dominated the research field,machine learn-ing(ML)algorithms have reached a pivotal moment called the generative artificial intelligence(AI)era.With the emer-gence of large-scale foundation models[1],such as large multi-modal model(LMM)GPT-4[2]and text-to-image generative model DALL·E[3].

关键词： ISSCC beyond AI

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Atomically Dispersed Ruthenium Catalysts with Open Hollow Structure for Lithium-Oxygen Batteries

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nano-Micro Letters 2024年第2期16卷 154-164页

作者： Xin chen Yu Zhang Chang chen Huinan Li Yuran Lin Ke Yu Caiyun nan chen chen Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Solid State ChemistryUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875People’s Republic of China

Lithium–oxygen battery with ultrahigh theoretical energy density is considered a highly competitive next-generation energy storage device,but its practical application is severely hindered by issues such as difficult decomposition of discharge products at present.Here,we have developed N-doped carbon anchored atomically dispersed Ru sites cathode catalyst with open hollow structure(h-RuNC)for Lithium–oxygen battery.On one hand,the abundance of atomically dispersed Ru sites can effectively catalyze the formation and decomposition of discharge products,thereby greatly enhancing the redox kinetics.On the other hand,the open hollow structure not only enhances the mass activity of atomically dispersed Ru sites but also improves the diffusion efficiency of catalytic molecules.Therefore,the excellent activity from atomically dispersed Ru sites and the enhanced diffusion from open hollow structure respectively improve the redox kinetics and cycling stability,ultimately achieving a high-performance lithium–oxygen battery.

关键词： Atomically dispersed Open hollow structure Discharge product Lithium Oxygen battery

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A passive sampler for synchronously measuring inorganic and organic pollutants in sediment porewater:Configuration and field application

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Journal of Environmental Sciences 2024年第2期136卷 201-212页

作者： Pei Lei Mingying chen nan Rong Wenzhong Tang Hong Zhang School of Environment Nanjing Normal UniversityNanjing 210023China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510530China State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control Guangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China

In situ measurement of multiple pollutants coexisting in sediment porewater is an essential step in comprehensively assessing the bioavailability and risk of pollutants,but to date,this needs to be better developed.In this study,a passive sampler,consisting of an“I-shaped”supporting frame and inorganic/organic sampling units,incorporating equilibrium dialysis theory and kinetic/equilibrium sorption principle,was developed for the synchronous measurement of inorganic(e.g.,phosphorus and metal(loid)s)and organic pollutants(e.g.,parent and substituted PAHs).The equilibrium time and sampling rates were explored in laboratory tests to support in situ application.Profiles of pollutants in porewater within a vertical resolution of centimeters,i.e.,1 cm and 2 cm for inorganic and organic pollutants,respectively,were obtained by field deployment of the sampler for further estimation of diffusive fluxes across the sediment-water interface.The results suggested that the role of sediments for a specific pollutant may change(e.g.,from“sink”to“source”)during the sampling time.This study demonstrated the feasibility of synchronous measurement of inorganic and organic pollutants in sediment porewater by the passive sampler.In addition,it provided new insight for further investigation into the combined pollution effects of various pollutants in sediments.

关键词： Passive sampling Bioavailability Polycyclic aromatic hydrocarbons Combined pollution Diffusive flux

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Fine-grained grid computing model for Wi-Fi indoor localization in complex environments

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Journal of Electronic Science and Technology 2024年第1期22卷 42-52页

作者： Yan Liang Song chen Xin Dong tu Liu School of Computer Engineering Chengdu Technological UniversityChengdu611730China HAN Networks Corporation Limited Beijing100094China

The fingerprinting-based approach using the wireless local area network(WLAN)is widely used for indoor localization.However,the construction of the fingerprint database is quite time-consuming.Especially when the position of the access point(AP)or wall changes,updating the fingerprint database in real-time is difficult.An appropriate indoor localization approach,which has a low implementation cost,excellent real-time performance,and high localization accuracy and fully considers complex indoor environment factors,is preferred in location-based services(LBSs)applications.In this paper,we proposed a fine-grained grid computing(FGGC)model to achieve decimeter-level localization accuracy.Reference points(RPs)are generated in the grid by the FGGC model.Then,the received signal strength(RSS)values at each RP are calculated with the attenuation factors,such as the frequency band,three-dimensional propagation distance,and walls in complex environments.As a result,the fingerprint database can be established automatically without manual measurement,and the efficiency and cost that the FGGC model takes for the fingerprint database are superior to previous methods.The proposed indoor localization approach,which estimates the position step by step from the approximate grid location to the fine-grained location,can achieve higher real-time performance and localization accuracy simultaneously.The mean error of the proposed model is 0.36 m,far lower than that of previous approaches.Thus,the proposed model is feasible to improve the efficiency and accuracy of Wi-Fi indoor localization.It also shows high-accuracy performance with a fast running speed even under a large-size grid.The results indicate that the proposed method can also be suitable for precise marketing,indoor navigation,and emergency rescue.

关键词： Fine-grained grid computing (FGGC) Indoor localization Path loss Random forest Reference points(RPs)

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Experimental study on effects of gas flow rate on soot characteristics in diffusion flames coupled with plasma

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Science China(Technological Sciences) 2024年第2期67卷 475-485页

作者： QI DanDan chen MingXiao tu Xin LIU Dong MIIT Key Laboratory of Thermal Control of Electronic Equipment School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Advanced Combustion Laboratory School of Energy and Power EngineeringNanjing University of Science and TechnologyNanjing 210094China Department of Electrical Engineering and Electronics University of LiverpoolLiverpool L693GJUK

This study examined the evolution of morphology and nanostructure of soot particles from the plasma-flame interaction for various gas flow rates.The current study used both optical diagnostic and sampling methods to explore the soot production and combustion characteristics.Soot particles were characterized at the same positions downstream from the flame zone by thermophoretic sampling and transmission electron microscopy.Moreover,X-ray diffraction analysis,and thermogravimetric analysis were performed to study the nanostructure and oxidation reactivity of soot.A reduction in soot concentration was found with the plasma addition,which illustrated an inhibition effect of plasma on soot emission.The increased gas flow rate promoted soot concentration since a growing number of carbons participated in the combustion process.Depending on the gas flow rate(carbon content)variation and plasma activation,either liquid-like soot material with irregularly shaped protrusions or chain-like structure,or a mixture of both,were generated from the diffusion flames.The soot produced by plasma-flame interaction also demonstrated a high correlation between nanostructure and reactivity.The soot from lower carbon content with plasma activation had a shorter fringe length and larger fringe tortuosity related to higher oxidation reactivity.On the contrary,soot from the highest carbon content without plasma-flame interaction exhibited prevalent fullerene-like nanostructures with evident large or small shells and also had a higher carbonization degree resulting in lower oxidation reactivity.

关键词： soot characteristics gas flow rate plasma diffusion flames

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Unveiling the mechanisms of Fe(Ⅲ)-loaded chitosan composite(CTS-Fe)in enhancing anaerobic digestion of waste activated sludge

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Journal of Environmental Sciences 2024年第4期138卷 200-211页

作者： Boaiqi Zhang Ziwen Zhao RuiMa nan chen Zhe Kong Zhongfang Lei Zhenya Zhang Graduate School of Life and Environmental Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8572Japan The Key Laboratory of Water and Sediment Sciences Ministry of Education/State Environmental Protection Key Laboratory of All Material Fluxes in River Ecosystems/College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510345China School of Water Resources and Environment China University of Geosciences(Beijing)Beijing 100083China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China

Anaerobic digestion(AD)of waste activated sludge(WAS)is usually limited by the low generation efficiency of methane.Fe(Ⅲ)-loaded chitosan composite(CTS-Fe)have been reported to effectively enhanced the digestion of WAS,but its role in promoting anaerobic sludge digestion remains unclear.In present study,the effects of CTS-Fe on the hydrolysis and methanogenesis stages of WAS anaerobic digestion were investigated.The addition of CTSFe increased methane production potential by 8%-23%under the tested conditions with the addition of 5-20 g/L CTS-Fe.Besides,the results demonstrate that the addition of CTS-Fe could effectively promote the hydrolysis of WAS,evidenced by lower protein or polysaccharides concentration,higher soluble organic carbon in rector adding CTS-Fe,as well as the increased activity of extracellular hydrolase with higher CTS-Fe concentration.Meanwhile,the enrichment of Clostridia abundance(iron-reducing bacteria(IRBs))was observed in CTS-Fe adding reactor(8.9%-13.8%),which was higher than that in the control reactor(7.9%).The observation further suggesting the acceleration of hydrolysis through dissimilatory iron reduction(DIR)process,thus providing abundant substrates for methanogenesis.However,the presence of CTS-Fe was inhibited the acetoclastic and hydrogenotrophic methanogenesis process,which could be ascribed to the Fe(Ⅲ)act as electron acceptor coupled to methane for anaerobic oxidation.Furthermore,coenzyme F420 activity in the CTS-Fe added reactor was 34.9% lower than in the blank,also abundance of microorganisms involved in hydrogenotrophic methanogenesis was decreased.Results from this study could provide theoretical support for the practical applications of CTS-Fe.

关键词： Chitosan-Fe(Ⅲ)composite Methanogenesis Dissimilatory iron reduction Enzyme activity Microbial community structure

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Non-cooperative Game Based Optimal Dispatch Model for Integrated Energy Systems

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1195-1207页

作者： Jiandong Duan Qian Sun chen Wu Yao Yang Siyu tu School of Electrical Engineering Xi’an University of TechnologyXi’an710056China IEEE CSEE

In order to improve the efficiency of energy utilization,the integrated energy system(IES)has emerged.The IES typically acts as a whole system during operations,the subsystems are separated,and the interests of each system are independent.In this paper,considering the relationship between the various energy systems,non-cooperative game theory is used to establish the optimal dispatch model.The proposed model mainly relies on the relationship between the cooperation and competition among various subsystems to obtain the maximum benefit they can accept.Furthermore,the basic definition is combined with the particle swarm optimization algorithm to solve the problem.The results show that the optimization strategy proposed in this paper can operate safely and reliably,and effectively distribute the benefits of each energy system.

关键词： Integrated energy system multi-energy complimentarily non-cooperative game theory

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Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

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Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： Cao Dai Lin Peng Yanjie Li Zhendong Li Da chen Fei Wang nan Lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or humans.However,data on clinical epidemiology are very limited.In this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood samples.Besides,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers levels.For example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with age.In addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(pture study on the potential clinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) Liver cancer Serum Blood Urine Liver function biomarkers

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