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PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling

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Genes & Diseases 2022年第6期9卷 1650-1661页

作者： sicheng chen Mengjun Bie Xiaowen Wang Mengtian Fan Bin chen Qiong Shi Yingjiu Jiang Department of Cardiothoracic Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Ministry of Education Key Laboratory of Diagnostic Medicine School of Laboratory MedicineChongqing Medical UniversityChongqing 400016PR China

Progranulin(PGRN)is a growth factor that is involved in the progression of multiple ***,the effects and molecular mechanisms by which PGRN induces lung cancer remain *** expression level of PGRN was analyzed by conducting immunohistochemistry of the histological sections of lung tissues from non-small-cell lung carcinoma(NSCLC)*** proliferation,apoptosis,migration,and invasion of NSCLC cells were assessed by the MTT assay,Western blot,degree of wound healing,and Transwell assays.A nude mouse xenograft model was used to validate the role of PGRN in *** expression level of PGRN was higher in male patients with lung adenocarcinoma than in those with lung squamous cell carcinoma;by contrast,no difference was observed in female *** overexpression of PGRN promoted the proliferation and anti-apoptosis of H520(derived from lung squamous cell carcinoma)cells,whereas knockdown of PGRN inhibited the proliferation and anti-apoptosis of A549(derived from lung adenocarcinoma)***(targeting PI3K)inhibited the increase in the expression of cell anti-apoptosis marker Bcl-2 induced by rhPGRN protein;the PI3K agonist 740 YeP partially reversed the decrease in Bcl-2 expression induced by PGRN deficiency in both A549 and H520 *** increased the expression of Ki-67,PCNA,and Bcl-2 in *** inhibited cell apoptosis depending on the PI3K/Akt/Bcl-2 signaling axis;PGRN positivity correlated with lung *** is a potential biomarker for the treatment and diagnosis of NSCLC,especially in lung adenocarcinoma.

关键词： Bcl-2 Cell apoptosis NSCLC PGRN PI3K/Akt

Plasma Treatment Induced Chemical Changes of Alkali Lignin to Enhance the Performances of Lignin-Phenol-Formaldehyde Resin Adhesive

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Journal of Renewable Materials 2021年第11期9卷 1959-1972页

作者： Zhigang Wu sicheng chen Jiankun Liang Lifen Li Xuedong Xi Xue Deng Bengang Zhang Hong Lei College of Forestry Guizhou UniversityGuiyang550025China Kaili University Qiandongnan556011China ENSTIB-LERMAB University of LorraineEpinal88051France Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products Southwest Forestry UniversityKunming650224China

Alkali lignin was processed by plasma and then used in modification of phenol formaldehyde resin in this *** structural changes of lignin which was processed by plasma as well as bonding strength,tensile property,curing performance and thermal property of the prepared phenol formaldehyde resin which was modified by the plasma processed lignin were *** demonstrated that:(1)Alkali lignin was degraded after the plasma *** original groups were destroyed,and the aromatic rings collected abundant free radicals and oxygen-containing functional groups like hydroxyls,carbonyls,carboxyls and acyls were introduced into increase the reaction activity of lignin significantly.(2)The introduction of alkali lignin decreased the free formaldehyde content and increased bonding strength and toughness of the prepared phenol formaldehyde resin,especially after the introduction of lignin treated with plasma.(3)The introduction of alkali lignin led to high curing temperature for the prepared phenol formaldehyde resin,but that was reduced by the plasma processed alkali lignin.(4)The introduction of alkali lignin could also increase thermal stability of phenol formaldehyde resin,but that was modified by plasma processed alkali lignin was better than the unprocessed *** on the results,the plasma processed lignin was used to modify phenol formaldehyde resin,which could increase the strength and toughness of phenol formaldehyde resin significantly.

关键词： Alkali lignin plasma phenol formaldehyde resin bonding performance tensile property

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思变·至诚:成为电影人陈思诚

当代电影 2021年第7期 26-36页

作者：陈思诚饶曙光刘婉瑶(整理) 不详中国电影评论学会上海戏剧学院中国艺术研究院

时间:2021年3月11日下午地点:陈思诚导演公司跨越个人标签饶曙光(以下简称饶):首先,非常感谢陈思诚导演来接受我们的访谈。本次访谈是人物栏目的定位,因此,希望你能打开自己,跟我们聊聊关于职业和生命的感悟。恭喜你在电影业已经有了这... 详细信息

时间:2021年3月11日下午地点:陈思诚导演公司跨越个人标签饶曙光(以下简称饶):首先,非常感谢陈思诚导演来接受我们的访谈。本次访谈是人物栏目的定位,因此,希望你能打开自己,跟我们聊聊关于职业和生命的感悟。恭喜你在电影业已经有了这么大的影响力,《唐人街探案3》(以下简称《唐探3》)在2021年春节档的表现也不错。那么,今天的访谈主要从你的整个创作经历来介入。

关键词：创作经历春节档电影业思变思诚唐人街访谈

Study on Camellia Oleifera Protein based Wood Adhesive by Epoxy Resin and Its Crosslinking Mechanism

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Journal of Wuhan University of Technology(Materials Science) 2021年第4期36卷 607-613页

作者： chen sicheng LIANG Jiankun ZHANG Bengang WU Zhigang LEI Hong LI Lifen YANG Shoulu College of Forestry Guizhou UniversityGuiyang 550025China School of Architectural Engineering Kaili UniversityQiandongnan 556011China Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products Southwest Forestry UniversityKunming 650224China Guizhou Academy of Forestry Guiyang 550005China

Epoxy resin (EPR) was used to crosslink with Camellia oleifera *** to prepare wood adhesive,and the bonding performance and curing characteristics of which were mainly investigated,and the synthesis mechanism was also discussed by using model *** experimental results show that EPR can significantly improve the bonding performance of Camellia oleifera ***-based adhesive,and the maximum of which reaches 0.72 MPa satisfies the strength requirement of Type II plywood in GB/T *** alkali treatment,the protein can more easily crosslink with EPR at low curing temperature,and the adhesive has high degree of crystallinity of curing products,high degree of crosslinking reaction,and high bonding *** reaction mechanism of EPR-modified Camellia oleifera *** adhesive can be divided into resinification phase and curing phase.

关键词： Camellia oleifera protein epoxy resin crosslinking wood adhesive

Mathematical modeling of variable pitched electric power system on UAV

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Mathematical modeling of variable pitched electric power sys...

第三十九届中国控制会议

作者： chen sicheng chen Shuxian An Siqi Civil Aviation Flight University of China

In order to carry out the research on precise kinetic performance and improved control regulation, a modeling method of variable pitched electrical power system equipped on UAV is presented. Firstly, the white box model of variable pitched electric power system is built based on component analysis. Secondly, a number of experiments are performed by the ground testbench to identify parameters of model. According to the results of identification, the simulation model of system is built. From the output comparison of simulation and the physical device, the accuracy of the established mathematical model in this paper is verified.

关键词： modeling identification simulation variable pitched electric power system UAV

来源： cnki会议评论

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政府条块差异与纵向创新扩散

社会学研究 2020年第2期35卷 146-169,M0005,M0006页

作者：陈思丞清华大学公共管理学院清华大学中国农村研究院

通过考察其地方政府生态环境修复政策十余年的历史演变,本文发现,上级条块部门分别主导的纵向创新扩散模式在运作机制、持续条件与政策效果上有着显著的差异,呈现出“条条创新、块块扩散”的有趣现象。上级条条部门主导的纵向创新扩散... 详细信息

通过考察其地方政府生态环境修复政策十余年的历史演变,本文发现,上级条块部门分别主导的纵向创新扩散模式在运作机制、持续条件与政策效果上有着显著的差异,呈现出“条条创新、块块扩散”的有趣现象。上级条条部门主导的纵向创新扩散模式主要以项目制实现,其影响主要在项目期内有效且效果较弱,但是这一弱影响往往为政策创新提供了空间;上级块块部门主导的纵向创新扩散模式可以通过人事任免等多种机制对下级施加影响,其影响常规有效且效果较强,但是这一强影响往往会抑制基层的政策创新。本文试图运用组织社会学拓展创新扩散理论,展现不同纵向创新扩散模式差异背后的组织根源。

关键词：政府组织条块差异纵向创新扩散项目制

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微射流作用下的超声速流场控制机理研究

北京航空航天大学学报 2017年第7期43卷 1491-1500页

作者：刘平超刘艳明陈思成秦洋北京理工大学宇航学院北京100081

以24°压缩拐角为流场模型,针对不同注入总压微射流作用下来流马赫数为2.9的超声速压缩拐角流场进行了数值研究,喷射方向与来流垂直。研究表明,微射流阻挡作用下,其下游速度被减小,而减弱了分离激波强度。此外,微射流与来流耦合会产生... 详细信息

以24°压缩拐角为流场模型,针对不同注入总压微射流作用下来流马赫数为2.9的超声速压缩拐角流场进行了数值研究,喷射方向与来流垂直。研究表明,微射流阻挡作用下,其下游速度被减小,而减弱了分离激波强度。此外,微射流与来流耦合会产生正反向旋转流向涡对,在其下洗作用下,高能量流体被带入到边界层底部近壁面处,使此处低能流体被激活,进而增强了边界层的抗逆压能力不易发生分离,且这种激活能力会随注入总压的增加而增强。权衡控制效果和注入能量认为,注入压比(注入总压/来流总压)为0.60的微射流为最优方案,在其作用下,拐角区分离面积被减小了近70%、激波交汇点与壁面的距离被降低了近37%、分离激波强度被削弱近12%。

关键词：微射流边界层注入总压涡对分离

官员更替、中央环保督察与地方环境监管实施——基于南方A省18945家企业样本的实证研究

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经济社会体制比较 2023年第4期 112-122页

作者：王鸿儒陈思丞国家发展和改革委员会价格成本调查中心清华大学公共管理学院清华大学计算社会科学与国家治理实验室

官员更替作为中央政府“隐性治理”的重要工具,其对地方环境监管实施的影响亟待实证研究。文章基于南方A省2011~2018年18945家民营企业样本数据,定量分析了近年来在中央政府高度重视生态文明建设的背景下,官员更替制度对辖区内民营企业... 详细信息

官员更替作为中央政府“隐性治理”的重要工具,其对地方环境监管实施的影响亟待实证研究。文章基于南方A省2011~2018年18945家民营企业样本数据,定量分析了近年来在中央政府高度重视生态文明建设的背景下,官员更替制度对辖区内民营企业污染排放规模的影响,并利用中央环保督察的准自然实验探讨了中央政府的信号机制对于官员更替影响的调节效应。研究发现,近年来官员更替制度对于加强地方环境监管实施、减轻企业排污具有积极作用。在中央政府借助环保督察传递明确的环境治理信号后,官员更替对民营企业污染排放的抑制程度将进一步加强。文章揭示了官员更替制度作为环境治理工具的内在影响机制,并强调具有明确信号机制的中央环保督察是优化“环境监管分权+官员更替”设计的有效制度安排。本文研究结论为进一步推动环境监管的有效实施提供了理论依据和实践参考。

关键词：官员更替中央环保督察信号机制环境监管实施

Anisotropic metal–insulator transition in strained VO_(2)(B) single crystal

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Chinese Physics B 2024年第6期33卷 56-61页

作者：马泽成闫胜楠刘增霖徐涛陈繁强陈思成曹天俊孙立涛程斌梁世军缪峰 Institute of Brain-Inspired Intelligence National Laboratory of Solid State MicrostructuresSchool of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096China Institute of Interdisciplinary of Physical Sciences School of ScienceNanjing University of Science and TechnologyNanjing 210094China

Mechanical strain can induce noteworthy structural and electronic changes in vanadium dioxide, imparting substantial scientific importance to both the exploration of phase transitions and the development of potential technological applications. Unlike the traditional rutile(R) phase, bronze-phase vanadium dioxide [VO_(2)(B)] exhibits an in-plane anisotropic structure. When subjected to stretching along distinct crystallographic axes, VO_(2)(B) may further manifest the axial dependence in lattice–electron interactions, which is beneficial for gaining insights into the anisotropy of electronic ***, we report an anisotropic room-temperature metal–insulator transition in single-crystal VO_(2)(B) by applying in-situ uniaxial tensile strain. This material exhibits significantly different electromechanical responses along two anisotropic *** reveal that such an anisotropic electromechanical response mainly arises from the preferential arrangement of a straininduced unidirectional stripe state in the conductive channel. This insulating stripe state could be attributed to the in-plane dimerization within the distorted zigzag chains of vanadium atoms, evidenced by strain-modulated Raman spectra. Our work may open up a promising avenue for exploiting the anisotropy of metal–insulator transition in vanadium dioxide for potential technological applications.

关键词： vanadium dioxide strain anisotropy electrical transport