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Time-dependent matrix metalloproteinases and tissue inhibitor of metalloproteinases expression change in fusarium solani keratitis

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 512-518页

作者： Qian Li Xin-Rui Gao Hong-Ping cui Li-Li Lang Xiu-Wen Xie qun chen Department of Ophthalmology Shanghai East HospitalTongji University School of Medicine Department of Ophthalmology Shanghai Tenth People's Hospital Tenth People's Hospital of Tongji University Department of Ophthalmology Changzhou Third People's Hospital Department of Ophthalmology Shanghai Pudong New Area Gongli Hospital

AIM： To investigate matrix metalloproteinases（MMPs）and tissue inhibitor of metalloproteinases（TIMPs）expression during the progress of fusarium solani（***） keratitis in a rat model.· METHODS： A rat model of *** keratitis was produced using corneal scarification and a hand-made contact lens. MMPs and TIMPs expressiond were explored in this rat model of *** keratitis using real-time polymerase chain reaction（PCR） and ***6001（400 μmol/m L） was used to treat infected corneas. The keratitis duration, amount and area of corneal neovascularization（CNV） were evaluated.·RESULTS： MMP-3 expression was 66.3 times higher in infected corneas compared to normal corneas. MMP-8,-9,and-13 expressions were significantly upregulated in the mid-period of the infection, with infected- to-normal ratios of 4.03, 39.86, and 5.94, respectively. MMP-2 and-7expressions increased in the late period, with the infected-to-normal ratios of 5.94 and 16.22, ***-1 expression was upregulated in the early period,and it was 43.17 times higher in infected compared to normal corneas, but TIMP-2,-3, and-4 expressions were mildly downregulated or unchanged. The results of DIF were consistent with the result of real-time ***6001, a MMPs inhibitor, decreased the duration of *** infection and the amount and area of CNV.·CONCLUSION： MMPs and TIMPs contributed into the progress of *** keratitis.

关键词： fungal keratitis fusarium solani metalloproteinases tissue inhibitors of metalloproteinases

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Effect of Cooling Rate on the Formation and Morphology of (W,V)Cx in VC-doped WC–Co Cemented Carbide

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Acta Metallurgica Sinica(English Letters) 2017年第2期30卷 146-155页

作者： Xiao-Ou Yi Xiang Huang Chang-Bin Liu Dan-qing Yi Yong Jiang Bin Wang Hui-qun Liu Li-Yong chen school of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China school of Materials Science and Engineering Central South University Changsha 410083 China Key Laboratory of Nonferrous Materials Science and Engineering Ministry of Education Central South University Changsha 410083 China

The grain growth retardation mechanism and the effect of cooling rate on VC-doped WC–Co cemented carbides were investigated in this ***–30Co and WC–30Co–VC were prepared by powder metallurgy,liquid-phase sintering at 1400 ℃ and followed by water quenching（[150 ℃/s） or furnace cooling（＊0.083 ℃/s）.Based on the results of electron probe microanalysis（EPMA）,we found that WC concentration in the Co binder was independent of VC doping during liquid-phase sintering,hence barely contributing to the retardation of WC grain *** contrast,the（W,V）Cx phase formed at the WC/Co interfaces played a major role in retarding WC grain growth during liquid-phase *** effect of cooling rate on the morphology of（W,V）Cxwas revealed by high-resolution transmission electron microscopy（HRTEM） and energy-dispersive spectroscopy（EDS）.In the water-quenched WC–30Co–VC,（W,V）Cxprecipitates were found as thin layers at the WC/Co *** contrast,both thin layers of similar thickness and nanoparticles of（W,V）Cx were observed in the furnace-cooled *** observations listed above suggested that thin（W,V）Cxlayers were stable structures effectively suppressing the growth of WC grains and their thickness remained independent of the cooling ***（W,V）Cxnanoparticles,however,may be inhibited through rapid cooling,ensuring the VC-doped WC–Co cemented carbides desired toughness.

关键词： WC-Co VC doping (W,V)Cx Water-quenched Furnace-cooled

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NiO nanoparticles-decorated ZnO hierarchical structures for isopropanol gas sensing

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Rare Metals 2022年第3期41卷 960-971页

作者： Shi-Chao Wang Xiao-Hu Wang Gao-qun Qiao Xiao-Yan chen Xin-Zhen Wang Nan-Nan Wu Jian Tian Hong-Zhi cui school of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

In this paper,a three-dimensional(3D)hierar-chical ZnO structure consisting of nanosheets modified with ultrafine NiO particles was synthesized via a facile two-step chemical precipitate *** techniques characterized the as-synthesized ZnO/NiO composites and pure *** p-NiO/n-ZnO junctions formed between adjacent ZnO and NiO nanoparticles,improving the gas sensing *** ZnO/NiO composite with the Ni:Zn atomic ratio of 7.42:100 exhibited the best iso-propanol sensing *** to pure ZnO,it showed high selectivity and sensitivity(R_(a)/R_(g)=221.3 toward 400×10^(-6)isopropanol),fast response rate(less than 10 s),short recovery time,and simultaneously low operating ***,the ZnO/NiO composite exhibited a wide sensing range(1×10^(-6)-1000×10^(-6))to isopropanol and processed good long-term *** experimental results suggested the potential application in fabricating efficient isopropanol sensors using this ZnO/NiO *** enhanced isopropanol sensing mech-anism is also discussed in charge transfer between heterojunctions,surface area,and surface defects.

关键词： ZnO NiO Hierarchical structure Gas sensor Isopropanol

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Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation

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World Journal of Gastroenterology 2020年第7期26卷 717-724页

作者： Yi-Chao Zhang Bao-Xiang chen Xiao-Yu Xie Yan Zhou qun Qian Cong-qing Jiang Department of Colorectal and Anal Surgery of Zhongnan Hospital of wuhan university Clinical Center of Intestinal and Colorectal Diseases of Hubei Province Hubei Key Laboratory of Intestinal and Colorectal Diseases (Zhongnan Hospital of Wuhan University) Colorectal and Anal Disease Research Center of Medical School (Zhongnan Hospital of Wuhan University) Quality Control Center of Colorectal and Anal Surgery of Health Commission of Hubei Province

BACKGROUND Chronic constipation is a gastrointestinal functional disease that seriously harms physical and mental health and impacts the quality of life of *** incidence rate is 2%-27%.Slow transit constipation(STC)is a common type of chronic functional constipation,accounting for 10.3%-45.5%of such *** have performed many studies on the pathogenesis of *** studies have indicated that the occurrence of STC may be related to multiple factors,such as dysfunction of the enteric nervous system,interstitial cells of Cajal(ICC)damage,and changes in neurotransmitters regulating intestinal *** To investigate the role of Tenascin-X(TNX)in regulating the TGF-β/Smad signaling pathway in the pathogenesis of *** This study included an experimental group and a control *** experimental group included 28 patients with severe colonic STC,and the control group included 18 patients with normal colon ***(IHC)was used to detect c-Kit,a specific marker of the *** blot,immunofluorescence,and IHC were used to detect the localization and expression of TNX and TGF-β/*** IHC showed that the number of ICC with positive c-Kit expression was significantly reduced in the colon of STC patients(22.17±3.28 vs 28.69±3.53,P2±0.099 vs 0.783±0.178,P1;Smad7:0.626±0.058 vs 0.799±0.03,P1)and that TNX and Smad2/3 levels were higher in the STC group(TNX:0.868±0.028 vs 0.482±0.032,P1).There was no significant difference in TGF-βbetween the two groups(0.476±0.028 vs 0.511±0.044,P=0.272).Pearson correlation analysis showed that the TNX protein exhibited a strong correlation with Smad2/3 and Smad7(P0.8)and TGF-β(P<0.05,|R|=0.7).CONCLUSION The extracellular matrix protein TNX may activate the TGF-β/Smad signaling pathway by upregulat

关键词： Slow transit constipation Tenascin-X Extracellular matrix glycoproteins TGF-β

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The Evolution of Defects in Deformed Cu-Ni-Si Alloys during Isochronal Annealing Studied by Positron Annihilation

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Chinese Physics Letters 2012年第12期29卷 219-222页

作者： QI Ning JIA Yan-Lin LIU Hui-qun YI Dan-qing chen Zhi-Quan Hubei Nuclear Solid Physics Key Laboratory Department of PhysicsWuhan UniversityWuhan 430072 school of Materials Science and Engineering Central South UniversityChangsha 410083

The effect of isochronal annealing on the deformation-induced defects in pure Cu and Cu-Ni-Si alloys is studied by positron annihilation *** the cold-rolled Cu,annealing up to 900℃ causes a gradual recovery of the deformation-induced defects and monotonous decrease of the *** indicates that its hardening is mainly related with defects such as ***,for the hot-rolled and quenched Cu-Ni-Si alloy,although there is a partial recovery of defects after annealing below 500℃,formation of additional defects is observed after annealing above 500℃.The hardness of Cu-Ni-Si alloy has a maximum value after annealing at 500℃,which suggests that the hardening of Cu-Ni-Si alloy is not due to defects,but primarily due to the precipitation formed during *** annealing of the Cu-Ni-Si alloy above 500℃ results in over-aging effect and the precipitates lose coherence with the host matrix,which leads to positron trapping by vacancy clusters in the incoherent interface region.

关键词： alloy annealing positron

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Uncovering the dynamic evolution of nucleotidebinding site-leucine-rich repeat(NBS-LRR) genes in Brassicaceae

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Journal of Integrative Plant Biology 2016年第2期58卷 165-177页

作者： Yan-Mei Zhang Zhu-qing Shao Qiang Wang Yue-Yu Hang Jia-Yu Xue Bin Wang Jian-qun chen State Key Laboratory of Pharmaceutical Biotechnology Center of Plant Genetics and Molecular EvolutionSchool of Life SciencesNanjing University Institute of Botany Jiangsu Province and Chinese Academy of Sciences

Plant genomes harbor dozens to hundreds of nucleotide-binding site-leucine-rich repeat （NBS-LRR） genes; however, the long-term evolutionary history of these resistance genes has not been fully understood, This study focuses on five Brassicaceae genomes and the Carica papaya genome to explore changes in NBS-LRR genes that have taken place in this Rosid II lineage during the past 72 million years. Various numbers of NBS-LRR genes were identified from Arabidopsis lyrata （198）, A. thaliana （165）, Brassica rapa （204）, Capsella rubella （127）, Thellungiella salsuginea （88）, and C. papaya （51）. In each genome, the identified NBS-LRR genes were found to be unevenly distributed among chromosomes and most of them were clustered together. Phylogenetic analysis revealed that, before and after Brassicaceae speciation events, both toll/interleukin-1 receptor-NBS-LRR （TNL） genes and non-toll/interleukin-1 receptor-NBS-LRR （nTNL） genes exhibited a pattern of first expansion and then contraction, suggesting that both subclasses of NBS-LRR genes were responding to pathogen pressures synchronically. Further, by examining the gain/loss of TNL and nTNL genes at different evolutionary nodes, this study revealed that both events often occurred more drastically in TNL genes. Finally, the phylogeny of nTNL genes suggested that this NBS-LRR subclass is composed of two separate ancient gene types： RPW8-NBS-LRR and Coiled-coiI-N BS-LRR.

关键词： Dynamic evolution nucleotide-binding site-leucine-rich repeat gene phylogenetic relationship plant disease resistance

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Differences in anti-inflammatory effects between two specifications of Scutellariae Radix in LPS-induced macrophages in vitro

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Chinese Journal of Natural Medicines 2017年第7期15卷 515-524页

作者： chen Qian-Yu WANG Chao-qun YANG Zhi-Wei TANG Qi TAN Huan-Ran WANG Xuan CAI Shao-qing Department of Chemical Biology School of Pharmaceutical Science Peking University Beijing 100191 China State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China Department of Pharmacology Peking University Beijing 100191 China

Scutellariae Radix(SR), the root of Scutellaria baicalensis Georgi, is used as an antipyretic drug and has been demonstrated to have anti-inflammatory activity. SR is divided into two specifications, "Ku Qin"(KQ) and "Zi Qin"(ZQ), for use against different symptoms(upper energizer heat or lower portion of the triple energizer), according to the theory of traditional Chinese medicine(TCM). However, differences in the efficacies of these two specifications have not been determined. In the present study, we aimed to characterize the differences in the anti-inflammatory activities between KQ and ZQ and to explore how their differences are manifested in lipopolysaccharide(LPS)-induced macrophages. Our results showed that, in RAW264.7 cells(a mouse macrophage cell line derived from ascites), KQ and ZQ displayed anti-inflammatory effects by inhibiting the release of nitric oxide(NO), inducible NOS(iNOS), and nuclear factor-κB(NF-κB) in a dose-dependent manner without distinction. In NR8383 cells(a rat alveolar macrophage cell line), KQ and ZQ displayed similar effects on NO, iNOS, and NF-κB as seen in RAW264.7 cells, but KQ showed a higher inhibition rate for NO and i NOS than that shown by ZQ at the same concentration. These results indicated that there were differences in efficacy between KQ and ZQ in treating lung inflammation. Our findings provided an experimental evidence supporting the different uses of KQ and ZQ in clinic, as noted in ancient herbal records.

关键词： Scutellaria baicalensis "Ku Qin" "Zi Qin" Anti-inflammatory activity Efficacy differences RAW264.7 cells NR8383 cells

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A novel herbivorous wood-borer insect outbreak triggers die-offs of a foundation plant species in coastal ecosystems

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Ecosystem Health and Sustainability 2020年第1期6卷 39-44,38页

作者： Zhonghua Ning Cong chen Tian Xie qing Wang Xu Ma Haochen Sui Baoshan cui school of Environment State Key Joint Laboratory of Environmental Simulation and Pollution ControlBeijing Normal UniversityBeijingChina Yellow River Estuary Wetland Ecosystem Observation and Research Station Ministry of EducationShandongChina Research and Development Center for Watershed Environmental Eco-Engineering Advanced Institute of Natural ScienceBeijing Normal University at ZhuhaiZhuhaiChina

Introduction:Understanding the trophic interactions between plants and herbivorous insects is essential for managing the ecosystem health and sustainability in the context of climate change and anthropogenic *** Tamarix chinensis is a foundation plant species of salt marshes in northern china,which provides a variety of ecological functions and services in coastal ecosystems such as withstanding storm tide,conserving biodiversity,and preventing shoreline ***:However,through long-term field observations,for the first time,we found that the health of this population has been suffering from the potential outbreak of a novel wood-borer insect(Zeuzera leuconotum Butler)under multiple stresses,contributing substantially to the degradation of the coastal salt *** and Conclusion:Therefore,there is urgent need and great significance to investigate the potential impact of this herbivorous wood-borer insects on health and sustainability of plant community in coastal ecosystems for in-depth understanding its degradation mechanisms.

关键词： Die-off foundation species(Tamarix chinensis) insect herbivory wood-borer pest control salt marsh coastal ecosystem

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3D Max建模在医学物理学课程中的应用案例分析

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大学物理 2024年第1期43卷 26-30,63页

作者：黄翠莺李发波陈晓青郑海波福建医科大学文理艺术学院福建福州350122

医学物理学课程中的抽象概念模型和复杂数学公式推导向来是教学过程中的重点和难点.如何将其空间结构和动态过程进行直观的呈现是提升授课效果的关键.本研究通过调查问卷筛选了杨氏双缝干涉、简谐振动方程、眼睛屈光不正和矫正三个案例... 详细信息

医学物理学课程中的抽象概念模型和复杂数学公式推导向来是教学过程中的重点和难点.如何将其空间结构和动态过程进行直观的呈现是提升授课效果的关键.本研究通过调查问卷筛选了杨氏双缝干涉、简谐振动方程、眼睛屈光不正和矫正三个案例,运用3D Max构建其三维动态模型,并对相应的课堂教学进行设计.以此辅助虚拟实验教学,可丰富抽象物理过程的表现形式,创新课堂知识呈现方式,为更新医学物理学教学模式、深化课程改革提供参考.

关键词： 3D Max 三维动态模型医学物理教学改革

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长江上游保护区干流江安-重庆段禁渔初期鱼类时空分布特点

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水生生物学报 2024年第4期48卷 558-567页

作者：田盼盼李祥艳邓华堂王导群刘绍平陈大庆段辛斌王珂田辉伍中国水产科学研究院长江水产研究所/国家农业科学重庆观测实验站武汉430223 西南大学生命科学学院重庆400715

为掌握“长江十年禁渔”初期长江上游保护区干流江安-重庆江段鱼类资源时空分布特征,研究在开展鱼类资源调查的同时,利用SIMRADEK80分裂波束科研回声探测仪于2020年12月和2021年5月在江安-重庆江段开展水声探测。水声学探测结果表明,江... 详细信息

为掌握“长江十年禁渔”初期长江上游保护区干流江安-重庆江段鱼类资源时空分布特征,研究在开展鱼类资源调查的同时,利用SIMRADEK80分裂波束科研回声探测仪于2020年12月和2021年5月在江安-重庆江段开展水声探测。水声学探测结果表明,江安-重庆江段2020年12月和2021年5月鱼类平均密度分别为25.31和41.23 ind./1000 m^(3),鱼类目标强度均值分别为–55.81和–52.79 dB,无显著差异,估算鱼类平均体长分别为17.97和24.36 cm。在水平方向上,两次调查鱼类都主要分布在重庆-江津江段,两次水声学探测的鱼类密度在垂直方向上呈现出一定差异,2020年12月表现为下层>中层>上层,2021年5月表现为上层>中层>下层。此次鱼类资源调查共发现了鱼类12科62种,其中瓦氏黄颡鱼、光泽黄颡鱼、蒙古鲌和贝氏䱗等小型鱼类的数量占比达到50.21%,与水声学结果一致。研究初步探究了保护区内鱼类在不同时段的空间分布规律,评估了禁捕初期长江上游鱼类分布特征,为长江“十年禁渔”生态效果评估提供基础数据参考。

关键词：鱼类资源水声学时空分布禁渔长江上游保护区

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