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Application of nanoscale metal–organic frameworks in tumor immunotherapy

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Rare Metals 2024年第10期43卷 4867-4883页

作者： Xiao-Xuan Zeng Jing-Sheng Lu Dong-Wei Ma Yu-Ting Huang ling chen Gang Wang qing chen Ning Lin College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy, photodynamic therapy/immunotherapy, sonodynamic therapy/immunotherapy and so on. Nanoscale metal–organic frameworks(nMOFs) are widely used for drug delivery because of their rich and variable composition, high drug loading capacity and good biodegradability. Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies. This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers, supplementary agents and drug carriers, respectively, with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.

关键词： Drug delivery system Immunotherapy Metal–organic frameworks Tumor

Evaluation of 3D crustal seismic velocity models in southwest China:Model performance,limitation,and prospects

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Science China Earth Sciences 2024年第2期67卷 604-619页

作者： Xin WANG ling chen Qi-Fu chen Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Southwest China is a tectonically and seismically active region,witnessing strong deformation due to the collision between the Indian and Eurasian *** the subsurface velocity structure of this region is thus important in understanding the tectonics and geodynamic processes of continental collision and in mitigating seismic *** studies have provided various 3D seismic velocity models in southwest ***,discrepancies exist among these models,and less effort has been made to quantify the reliability and accuracy of these existing velocity *** this study,we use regional 3D waveform simulation to evaluate the performance of various regional crustal 3D velocity models in reproducing observed *** particularly focus on two recent earthquake sequence in the region,the 2021 Yunnan Yangbi MS_(6.4) earthquake sequence and the 2022 Sichuan Luding MS_(6.8) earthquake *** tested 3D velocity models include the Southwest China Community Velocity model V1.0,the Unified Seismic Tomography Models for Continental China Lithosphere V2.0,the adjoint full waveform tomography model of the crustal and upper mantle beneath Eastern Tibetan Plateau,and the shallow seismic structure model beneath continental *** results show that the tested 3D velocity models generally capture well long-period(<0.2 Hz)waveforms,indicating that the 3D models adequately resolve overall large-scale subsurface ***,the 3D synthetics show discrepancies in higher frequencies(0.05–0.3 Hz)and the performance of the 3D velocity models varies from region to region,suggesting that smaller scale heterogeneities are not well *** shallow velocity structures(<10 km)can improve the waveform fitting,emphasizing the importance of incorporating shallow structures in waveform *** full-waveform tomography model shows a slighter better performance than the other models,especially for the body-waves,highlighting the advantages

关键词： Southwest China Seismic tomography models Shallow Structures Waveform simulation Model evaluation

A novel framework for the carbon reduction performance of power grids:A case study of provincial power grids within the China Central Power Grid

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Frontiers of Engineering Management 2024年第3期11卷 455-468页

作者： Lei JIANG chen ling qing YANG Pietro BARTOCCI Shusong BA Shuangquan LIU China-EUInstituteforCleanandRenewableEnergy Huazhong University of Science and TechnologyWuhan 430074China StateKeyLaboratoryofCoalCombustion HuazhongUniversityof Science and TechnologyWuhan 430074China RISE Processum AB SE-89122ÖrnsköldsvikSweden HSBC Business School Peking UniversityShenzhen 518055China SystemOperationDepartment. YunnanPowerGridCo.LtdKunming 650011China

Power grids play a crucial role in connecting electricity suppliers and *** facilitate efficient power transmission and energy management,significantly contributing to the transition toward low-carbon practices across both upstream and downstream *** managing carbon reduction in the power industry is essential for enhancing carbon reduction efficiency and achieving dual-carbon *** studies have focused on the outcomes of carbon reduction efforts rather than the management ***,when power grids prioritize the process of carbon reduction in their management,they are more likely to achieve better *** address this gap,we propose an evaluation model for managing carbon reduction activities in power grids,comprising the carbon management efficiency(CME)module based on the maturity model and the carbon reduction efficiency(CRE)module based on the entropy *** CME module provides a scorecard corresponding to a detailed and continuous evaluation model for carbon management processes to calculate its ***,the CRE module relates carbon reduction results to the development direction of the government and power grid,allowing for effective adjustments and updates based on actual *** evaluation model was applied to provincial power grids within the China Central Power *** results reveal that despite some fluctuations in carbon reduction performance,provincial power grids within the China Central Power Grid have made continuous progress in carbon reduction *** to the synergy model,there is evidence suggesting that power grids are steadily improving their carbon reduction performance,and a more organized approach would lead to a greater degree of *** evaluation model applies to power grids,and its framework can be extended to other industries,providing a theoretical reference for evaluating their carbon reduction efforts.

关键词： power grid carbon reduction evaluation model maturity model synergy model

On the half-quantized Hall conductance of massive surface electrons in magnetic topological insulator films

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 127-136页

作者： Rui chen Shun-qing Shen Department of Physics The University of Hong KongHong Kong 999077China Department of Physics Hubei UniversityWuhan 430062China

In topological insulators,massive surface states resulting from local symmetry breaking were thought to exhibit a half-quantized Hall conductance,obtained from the low-energy effective model in an infinite Brillouin *** a lattice model,the surface band is composed of a combination of surface states and bulk *** massive surface states alone may not be enough to support an exact one-half quantized surface Hall conductance in a finite Brillouin zone and the whole surface band always gives an integer quantized Hall conductance as enforced by the TKNN *** explore this,we investigate the band structures of a lattice model describing the magnetic topological insulator film that supports the axion insulator,Chern insulator,and semi-magnetic topological insulator *** reveal that the gapped and gapless surface bands in the three phases are characterized by an integer-quantized Hall conductance and a half-quantized Hall conductance,*** propose an effective model to describe the three phases and show that the low-energy dispersion of the surface bands inherits from the surface Dirac *** gapped surface band manifests a nearly half-quantized Hall conductance at low energy near the center of Brillouin zone,but is compensated by another nearly half-quantized Hall conductance at high energy near the boundary of Brillouin zone because a single band can only have an integer-quantized Hall *** gapless band hosts a zero Hall conductance at low energy but is compensated by another half-quantized Hall conductance at high energy,and thus the half-quantized Hall conductance can only originate from the gapless ***,we calculate the layer-resolved Hall conductance of the *** conclusion suggests that the individual gapped surface band alone does not support the half-quantized surface Hall effect in a lattice model.

关键词： magnetic topological insulator Dirac equation half-quantized Hall conductance

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组合化学在催化领域中的应用

石油学报（石油加工） 2005年第3期21卷 34-38页

作者：陈庆龄中国石油化工股份有限公司上海石油化工研究院上海201208

从组合化学新概念出发,扼要地阐述组合催化技术及其研究方法,包括催化剂库的设计及优化、催化剂库的合成和筛选。重点列举了组合技术在多相催化中的应用实例,并探讨了组合化学技术在催化领域中应用的发展前景。

关键词：组合化学催化剂库高通量筛选

Prediction of suitable water content in granulation of sintering mixture based on Litster's model

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Journal of Iron and Steel Research International 2024年第3期31卷 552-560页

作者： Fang-lei Dai Xiao-hui Fan Xiao-xian Huang Xu-ling chen Min Gan Zhi-yun Ji Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Suitable water content plays a decisive role in the granulation of sintering ***,a method was proposed to predict the suitable water content for effective granulation on the basis of Litster's granulation *** granulation effectiveness of a sintering mixture was predicted by the model,with the allowance error of±10%.The effects of the water absorption properties,particle size composition and content of adhesive particles on the suitable water content were *** results showed that the allowable error of prediction was within±0.5%compared to the experimentally determined suitable water *** an increase in adhesive powder content of mixtures with higher water absorption,the suitable water content increased to achieve similar granulation ***,as the amount of concentrates increased,the suitable water content first increased and then remained *** influence of the water absorption characteristics of the adhesive particles on the suitable water content was less than that of their particle size composition in the mixture.

关键词： Adhesive particle Sintering mixture Granulation effectiveness Suitable water content

Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： ling-ling chen Ren-Fei Cao Hua Ke Zhi-Min chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China Engineering Technology Research Center for Environmental Protection Materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

Micro defects formation and dynamic response analysis of steel plate of quasi-cracking area subjected to explosive load

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Defence Technology（防务技术） 2024年第1期31卷 580-593页

作者： Zheng-qing Zhou Ze-chen Du Xiao Wang Hui-ling Jiang Qiang Zhou Yu-long Zhang Yu-zhe Liu Pei-ze Zhang Research Institute of Macro-Safety Science University of Science and TechnologyBeijing100083China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China School of Mechanical Engineering Nantong UniversityNantong226019China China North Industry Advanced Technology Generalization Institute Beijing100089China China Academy of Ordnance Science China

As the protective component,steel plate had attracted extensive attention because of frequently threats of explosive *** this paper,the evolution of microstructure and the mechanism of damage in the quasi-cracking area of steel plate subjected to explosive load were discussed and the relationships between micro defects and dynamic mechanical response were *** the explosion experiment,five observation points were selected equidistant from the quasi-cracking area of the section of the steel plate along the thickness direction,and the characteristics of micro defects at the observation points were analyzed by optical microscope(OM),scanning electron microscope(SEM) and electron backscattered diffraction(EBSD).The observation result shows that many slip bands(SBs) appeared,and the grain orientation changed obviously in the steel plate,the two were the main damage types of micro *** addition,cracks,peeling pits,grooves and other lager micro defects were appeared in the lower area of the *** stress parameters of the observation points were obtained through an effective numerical *** mechanism of damage generation and crack propagation in the quasicracking area were clarified by comparing the specific impulse of each observation point with the corresponding micro *** result shows that the generation and expansion of micro defects are related to the stress area(*** upper compression area,the neutral plane area,and the lower tension area).The micro defects gather and expand at the grain boundary,and will become macroscopic damage under the continuous action of tensile ***,the micro defects at the midpoint of the section of the steel plate in the direction away from the explosion center(*** horizontal direction) were also *** was found that the specific impulse at these positions were much smaller than that in the thickness direction,the micro defects were only SBs and a few micro cracks,and the those decrea

关键词： Explosive load Quasi-cracking area Micro defects Steel plate Dynamic response Numerical simulation

Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

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Acta Geochimica 2024年第3期43卷 441-458页

作者： qing-qing Zhang You-Wei chen Jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(<0.013)of quartz from granites suggest a mag-matic *** low Al/Ti and Ge/Ti ratios,accompanied by high Ti contents in quartz,suggest that the porphyritic biotite granite and biotite granite are characterized by rela-tively low levels of differentiation and high crystallization *** contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China