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Recurrence patterns of advanced non-small cell lung cancer treated with gefitinib

Chinese Medical Journal 2013年第12期126卷 2235-2241页

作者： chen min-jiang zhong wei zhang li zhao jing li long-yun wang meng-zhao Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Background Gefitinib is widely used in the treatment of advanced non-small cell lung cancer （NSCLC）.However,only a small number of reports have described initial failure sites in patients treated with *** aim of this study was to investigate survival,recurrence sites,and treatment after recurrence in these *** A retrospective review was conducted of all patients with stage Ⅲ/Ⅳ NSCLC treated with gefitinib in Peking Union Medical College Hospital from October 2002 to September *** characteristics,initial failure sites,associated clinical factors,and subsequent therapy were included in the analysis of prognostic *** A total of 316 patients were identified The median progress free survival （PFS） and overall survival （OS） times were 238 days and 468 days,*** median survival time after progression was 145 *** sites of initial failure were lung （62.34%）,bone （17.72%）,central nerve system （CNS,16.14%）,liver （9.49%）,and others （7.19%）.Patients with single-site progression or multi-site progression were 81.01% and 18.99%,***-free survival time was associated with lung and bone ***,the median survival time after progression was lower in patients with multi-site progression and liver *** initial failure sites displayed no relationship with survival,including CNS *** therapy may affect survival after *** patients receiving continuous epidermal growth factor receptor tyrosine kinase inhibitor （EGFR-TKI） therapy,chemotherapy,radiotherapy,and retreatment with EGFR-TKIs,survival time after progression was prolonged compared with the best supportive *** Our data suggest that patients receiving gefltinib should be closely monitored regarding lung metastasis during *** metastases and multi-site progression were poor prognostic *** failure with gefltinib,patients may benefit from radiotherapy,chemotherapy,continuo

关键词： non-small cell lung cancer recurrence gefitinib

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long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases

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Journal of Geriatric Cardiology 2019年第4期16卷 338-343页

作者： chen-Xi jiang Jian-Gang wang Rui-Dong QI wei wang li-Jian GAO jing-Hua zhao Chun-Xiao zhang meng-chen ZHOU Xin TU Mei-Sheng SHANG Yan YAO Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Cardiovascular Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Center for Coronary Heart Disease Department of CardiologyCardiovascular Institute & Fuwai HospitalCAMS & PUMCNational Center for Heart DiseaseBeijingChina College of life Science and Technology Huazhong University of Science and TechnologyWuhanChina

Objective To assess long-term survival and late cardiovascular events in patients with atrial myxoma after surgical intervention. Methods Retrospective analysis of 403 patients undergoing resection of atrial myxoma from January 2002 to December 2016 was conducted with a median follow-up period of 4.5 (range: 0.5?15) years. Results The cross-clamp time and cardiopulmonary bypass times were 41.1 ± 21.4 and 65.2 ± 27.3 min,respectively. A diagnosis of myxoma was histopathologically confirmed in all cases. The early in-hospital mortality rate was 0.7%(n = 3). During the follow-up period,tumor recurrence occurred in six patients and cerebral infarction in nine. There were 48 (11.9%) patients with late onset atrial fibrillation (AF). By multivariate analysis,age (HR = 1.05,95% CI: 1.02–1.09,P lity. Conclusions Atrial myxoma can be resected with good long-term survival. Late onset AF is common after surgery in patients with atrial myxoma. Advanced age,left atrial diameter,and mitral valve surgery were independent predictors of outcomes.

关键词： Atrial fibrillation Atrial myxoma Embolism Survival

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Measurement of the ^(232)Th(n,f)cross section in the 1-200 MeV range at the CSNS Back-n

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Nuclear Science and Techniques 2023年第8期34卷 142-153页

作者： Zhi-Zhou Ren Yi-wei Yang Yong-Hao chen Rong liu Bang-Jiao Ye Jie Wen Hai-Rui Guo Zi-Jie Han Qi-Ping chen zhong-wei Wen wei-li Sun Han Yi Xing-Yan liu Tao Ye jiang-Bo Bai Qi An Jie Bao Yu Bao Ping Cao Hao-Lei chen Zhen chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-long Gao min-Hao Gu Chang-Cai Han Guo-Zhu He Yong-cheng He Yang Hong Yi-wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu jiang wei jiang Zhi-Jie jiang Han-Tao jing ling Kang Bo li Chao li Jia-Wen li Qiang li Xiao li Yang li Jie liu Shu-Bin liu Ze long Guang-Yuan Luan Chang-Jun Ning meng-chen Niu Bin-Bin Qi Jie Ren Xi-Chao Ruan zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan jing-Yu Tang Xin-Yi Tang Bin-Bin Tian li-Jiao wang Peng-cheng wang zhao-Hui wang Xiao-Guang Wu Xuan Wu li-Kun Xie Xiao-yun Yang li Yu Tao Yu Yong-Ji Yu Guo-Hui zhang lin-Hao zhang Qi-wei zhang Xian-Peng zhang Yu-liang zhang Zhi-Yong zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230027China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China

The ^(232)Th(n,f)cross section is very important in basic nuclear physics and applications based on the Th/U fuel *** the time-of-flight method and a multi-cell fast-fission ionization chamber,a novel measurement of the^(232)Th(n,f)cross sec-tion relative to^(235)U in the 1–200 MeV range was performed at the China Spallation Neutron Source Back-n white neutron source(Back-n).The fission event-neutron energy spectra of^(232)Th and^(235)U fission cells were measured in the single-bunch *** 232Th/235U fission cross-sectional ratios were obtained,and the measurement uncertainties were 2.5–3.7%for energies in the 2–20 MeV range and 3.6–6.2%for energies in the 20–200 MeV ***^(232)Th(n,f)cross section was obtained by introducing the standard cross section of^(235)U(n,f).The results were compared with those of previous theoreti-cal calculations,measurements,and *** measured 232Th fission cross section agreed with the main evaluation results in terms of the experimental uncertainty,and 232Th fission resonances were observed in the 1–3 MeV *** present results provide^(232)Th(n,f)cross-sectional data for the evaluation and design of Th/U cycle nuclear systems.

关键词： 232Th(n f)cross section Fast-fission ionization chamber Back-n white neutron source

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Back-n white neutron source at CSNS and its applications

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Nuclear Science and Techniques 2021年第1期32卷 95-104页

作者： jing-Yu Tang Qi An jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei chen Qi-Ping chen Yong-Hao chen Zhen chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-long Gao min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He Yang Hong Yi-wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu jiang wei jiang Zhi-Jie jiang Han-Tao jing ling Kang Bo li Chao li Jia-Wen li Qiang li Xiao li Yang li Jie liu Rong liu Shu-Bin liu Xing-Yan liu Ze long Guang-Yuan Luan Chang-Jun Ning meng-chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian li-Jiao wang Peng-cheng wang zhao-Hui wang zhong-wei Wen Xiao-Guang Wu Xuan Wu li-Kun Xie Xiao-yun Yang Yi-wei Yang Han Yi li Yu Tao Yu Yong-Ji Yu Guo-Hui zhang lin-Hao zhang Qi-wei zhang Xian-Peng zhang Yu-liang zhang Zhi-Yong zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China The CSNS Back-n Collaboration

Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March *** Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the *** addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the *** with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional *** article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn.

关键词： White neutron source Nuclear data measurements Experimental setups Neutron applications

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑Jiao wang Xiang‑Biao Qiu jing‑Wen li wei Xu Tao li Ze‑Bin lin Chang‑Jun Ning Yong‑Hao chen Rui‑Rui Fan Kang Sun jing‑Yu Tang Rong zhang Han‑Tao jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen Zhen chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He Yang Hong Yi‑wei Hu Han‑Xiong Huang wei‑Hua Jia Hao‑Yu jiang wei jiang Zhi‑Jie jiang Zheng‑Yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑cheng wang zhao‑Hui wang zhong‑wei Wen Xiao‑Guang Wu Xuan Wu li‑Kun Xie Yi‑wei Yang Han Yi Yong‑Ji Yu Guo‑Hui zhang lin‑Hao zhang Mo‑Han zhang Qi‑wei zhang Xian‑Peng zhang Yu‑liang zhang Yue zhang Zhi‑Yong zhang Mao‑Yuan zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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Insight-HXMT observations of the first binary neutron star merger GW170817

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Science China(Physics,Mechanics & Astronomy) 2018年第3期61卷 26-33页

作者： TiPei li Shaolin Xiong ShuangNan zhang FangJun Lu liming Song XueLei Cao Zhi Chang Gang chen li chen TianXiang chen Yong chen YiBao chen YuPeng chen wei Cui weiwei Cui jingKang Deng Yongwei Dong YuanYuan Du minXue Fu GuanHua Gao He Gao min Gao mingYu Ge YuDong Gu Ju Guan chengcheng Guo Dawei Han wei Hu Yue Huang Jia Huo ShuMei Jia LuHua jiang weiChun jiang jing Jin YongJie Jin Bing li chengKui li Gang li MaoShun li wei li Xian li XiaoBo li XuFang li YanGuo li ZiJian li Zhengwei li XiaoHua liang JinYuan liao CongZhan liu GuoQing liu Hongwei liu ShaoZhen liu Xiaojing liu Yuan liu YiNong liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai liang Sun Yin Tan lian Tao WenHui Tao Youli Tuo GuoFeng wang HuanYu wang Juan wang WenShuai wang YuSa wang XiangYang Wen BoBing WU Mei Wu Guangcheng Xiao He Xu YuPeng Xu linli Yan Jiawei Yang Sheng Yang YanJi Yang AiMei zhang ChunLei zhang chengMo zhang Fan zhang HongMei zhang Juan zhang Qiang zhang Shu zhang Tong zhang wei zhang WanChang zhang Wenzhao zhang Yi zhang Yue zhang YiFei zhang YongJie zhang zhao zhang Ziliang zhang HaiSheng zhao Jianling zhao XiaoFan zhao ShiJie Zheng Yue Zhu YuXuan Zhu Changlin Zou Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Physics Tsinghua University Beijing 100084 China University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100049 China Department of Astronomy Beijing Normal University Beijing 100088 China Department of Engineering Physics Tsinghua University Beijing 100084 China

Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced liGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.

关键词： GW170817 BNS merger gravitational wave electromagnetic counterpart

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Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 2-19页

作者： Shuang-Nan zhang TiPei li FangJun Lu liming Song YuPeng X u CongZhan liu Yong chen XueLei Cao QingCui Bu Zhi Chang Gang chen li chen TianXiang chen YiBao chen YuPeng chen wei Cui weiwei Cui jingKang Deng Yongwei Dong Yuan Yuan Du minXue Fu GuanHua Gao He Gao min Gao mingYu Ge YuDong Gu Ju Guan Can Gungor chengcheng Guo Dawei Han wei Hu Yue Huang Jia Huo ShuMei Jia LuHua jiang weiChun jiang jing Jin YongJie Jin Bing li chengKui li Gang li MaoShun li wei li Xian li XiaoBo li XuFang li YanGuo li ZiJian li Zhengwei li XiaoHua liang JinYuan liao GuoQing liu Hongwei liu ShaoZhen liu Xiaojing liu Yuan liu YiNong liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai Rencheng Shang GuoHong Shen liang Sun Ying Tan lian Tao Youli Tuo chen wang ChunQin wang GuoFeng wang HuanYu wang Juan wang WenShuai wang YuSa wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu Guangcheng Xiao Shaolin Xiong linli Yan Jiawei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei zhang ChunLei zhang chengMo zhang Fan zhang HongMei zhang Juan zhang Qiang zhang ShenYi zhangs Shu zhang Tong zhang WanChang zhang wei zhang Wenzhao zhang Yi zhang YiFei zhang YongJie zhang Yue zhang zhao zhang Zhi zhang Ziliang zhang HaiSheng zhao XiaoFan zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu Renlin Zhuang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China

As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be *** we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.

关键词： X-and γ-ray telescopes and instrumentation neutron stars black holes X-ray binaries γ-ray bursts

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Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5919-5930页

作者： lin wang Jia-Bao Cao Bin-Bin Xia Yue-Juan li Xuan zhang Guo-Xin Mo Rui-Juan wang Si-Qi Guo Yu-Qing zhang Kun Xiao Guang-Fa Zhu Peng-Fei liu li-cheng Song Xi-Hui Ma Ping-Chao Xiang jiang wang Yu-Hong liu Fei Xie Xu-Dong zhang Xiang-Xin li Wan-Lu Sun Yan Cao Kai-Fei wang Wen-Hui zhang wei-Chao zhao Peng Yan Ji-Chao chen Yu-wei Yang zhong-Kuo Yu jing-Si Tang li Xiao Jie-min Zhou li-Xin Xie Jun wang College of Pulmonary&Critical Care Medicine 8th Medical Center of Chinese PLA General HospitalBeijing 100091China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Faculty of Biological Science and Technology Baotou Teacher’s CollegeBaotou 014030China Department of Respiratory Medicine PLA Strategic Support Force Medical CenterBeijing 100101China Department of Respiratory and Critical Care Medicine Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China Respiratory Research Institute Department of Pulmonary&Critical Care MedicineBeijing Key Laboratory of OTIRthe 8th Medical Center of Chinese PLA General HospitalBeijing 100091China Shougang hospital of Peking University Beijing 100144China Department of Respiratory Medicine Beijing Changping HospitalBeijing 102200China Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Pulmonary research institute Senior Department of Respiratory and Critical Care Medicinethe 8th medical center of Chinese PLA general hospitalBeijing 100091China College of Pulmonary&Critical Care Medicine Chinese PLA General HospitalBeijing 100853China China Aerospace Science&Industry Corporation 731 hospital Beijing 100074China Department of Respiratory and Critical Care Medicine Aerospace Center HospitalBeijing 100049China Vision Medicals Center for Infectious Diseases Guangzhou 510700China

The Omicron variant of the severe acute respiratory syndrome coronavirus 2(SARS‑CoV‑2)infected a substantial proportion of Chinese population,and understanding the factors underlying the severity of the disease and fatality is valuable for future prevention and clinical *** recruited 64 patients with invasive ventilation for COVID-19 and performed metatranscriptomic sequencing to profile host transcriptomic profiles,plus viral,bacterial,and fungal content,as well as virulence factors and examined their relationships to 28-day mortality were *** addition,the bronchoalveolar lavage fluid(BALF)samples from invasive ventilated hospital/community-acquired pneumonia patients(HAP/CAP)sampled in 2019 were included for *** analysis revealed that all Omicron strains belong to BA.5 and BF.7 sub-lineages,with no difference in 28-day mortality between *** to HAP/CAP cohort,invasive ventilated COVID-19 patients have distinct host transcriptomic and microbial signatures in the lower respiratory tract;and in the COVID-19 non-survivors,we found significantly lower gene expressions in pathways related viral processes and positive regulation of protein localization to plasma membrane,higher abundance of opportunistic pathogens including bacterial Alloprevotella,Caulobacter,Escherichia-Shigella,Ralstonia and fungal Aspergillus sydowii and Penicillium *** analysis further revealed significant associations between host immune responses and microbial compositions,besides synergy within viral,bacterial,and fungal *** study presents the relationships of lower respiratory tract microbiome and transcriptome in invasive ventilated COVID-19 patients,providing the basis for future clinical treatment and reduction of fatality.

关键词： patients mortality prevention

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Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-Hua Sun Jian-wei zhao Xue-Heng zhang li-Na Sheng Zhi-Yu Sun Isao Tanihata Satoru Terashima Yong Zheng li-Hua Zhu li-min Duan liu-Chun He Rong-jiang Hu Guang-Shuai li Wen-Jian lin wei-Ping lin Chuan-Ye liu zhong liu chen-Gui Lu Xin-Wen Ma li-Jun Mao Yi Tian Feng wang meng wang Shi-Tao wang Jia-Wen Xia Xiao-Dong Xu Hu-Shan Xu Zhi-Guo Xu Jian-cheng Yang Da-Yu Yin You-Jin Yuan Wen-long Zhan Yu-Hu zhang Xiao-Hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang li li‑Jiao wang jing‑Yu Tang Xiang‑Biao Qiu Zhen chen Mao‑Yuan zhao Chang‑Jun Ning Kai Pan wei Xu Tao li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen Yong‑Hao chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He Yang Hong Yi‑wei Hu Han‑Xiong Huang wei jiang Zhi‑Jie jiang Zheng‑Yao Jin ling Kang Bo li Gong li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑cheng wang Peng‑cheng wang zhao‑Hui wang zhong‑wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui zhang Hang‑Chang zhang lin‑Hao zhang Qi‑wei zhang Xian‑Peng zhang Yu‑liang zhang Yue zhang Zhi‑Yong zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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