Long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases

作     者：Chen-Xi JIANG Jian-Gang WANG Rui-Dong QI Wei WANG Li-Jian GAO Jing-Hua ZHAO Chun-Xiao ZHANG Meng-Chen ZHOU Xin TU Mei-Sheng SHANG Yan YAO 

作者机构：Department of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Cardiovascular SurgeryBeijing Anzhen HospitalCapital Medical UniversityBeijingChina Center for Coronary Heart DiseaseDepartment of CardiologyCardiovascular Institute & Fuwai HospitalCAMS & PUMCNational Center for Heart DiseaseBeijingChina College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2019年第16卷第4期

页      面：338-343页

核心收录：

学科分类：10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China (No.81670294 & No.81200141 & No.81470430 & No.81770320 & No. 81570291) the Beijing Novel Program (No.2011081 & Z131103000413116) 

主　　题：Atrial fibrillation Atrial myxoma Embolism Survival 

摘      要：Objective To assess long-term survival and late cardiovascular events in patients with atrial myxoma after surgical intervention. Methods Retrospective analysis of 403 patients undergoing resection of atrial myxoma from January 2002 to December 2016 was conducted with a median follow-up period of 4.5 (range: 0.5?15) years. Results The cross-clamp time and cardiopulmonary bypass times were 41.1 ± 21.4 and 65.2 ± 27.3 min,respectively. A diagnosis of myxoma was histopathologically confirmed in all cases. The early in-hospital mortality rate was 0.7%(n = 3). During the follow-up period,tumor recurrence occurred in six patients and cerebral infarction in nine. There were 48 (11.9%) patients with late onset atrial fibrillation (AF). By multivariate analysis,age (HR = 1.05,95% CI: 1.02–1.09,P 0.001),left atrial diameter (HR = 1.23,95% CI: 1.08–1.36,P = 0.012),and mitral valve surgery (HR = 1.17,95% CI: 1.05–1.29,P = 0.027) were independent predictors of late onset AF. Twenty-one (5.2%) patients died during the follow-up period. Advanced age (HR = 1.07,95% CI: 1.04–1.10,P = 0.003) and multiple surgical procedures (HR = 1.18,95% CI: 1.06–1.29,P = 0.012) were significantly associated with overall mortality. Conclusions Atrial myxoma can be resected with good long-term survival. Late onset AF is common after surgery in patients with atrial myxoma. Advanced age,left atrial diameter,and mitral valve surgery were independent predictors of outcomes.