检索结果-南通市图书馆

Science China(Life Sciences) 2014年第12期57卷 1177-1182页

作者： yang Chao dai wei min chen Hai Xu wu Ben Yan Gastrointestinal Department of Southern Building General Hospital of Chinese PLA Department of Thoracic Surgery General Hospital of Chinese PLA Institute of Gerontology and Geriatrics General Hospital of Chinese PLA

Nuclear accidents and terrorism present a serious threat for mass *** or intended radiation exposure leads to radiation-induced gastrointestinal(GI)***,currently there are no approved medical countermeasures for GI ***,developing novel treatments for GI syndrome is *** stem cells(MSCs)derived from bone marrow are a subset of multipotent adult somatic stem cells that have the ability to undergo self-renewal,proliferation and pluripotent *** have advantages over other stem cells;they can be easily isolated from patients or donors,readily expanded ex vivo,and they possess reparative and immunomodulatory ***,MSCs have been shown to be powerful tools in gene therapy and can be effectively transduced with vectors containing therapeutic ***,the therapeutic potential of MSCs has been brought into the spotlight for the clinical treatment of GI *** this review,we discuss the possible role of MSCs in radiation-induced GI syndrome.

关键词： mesenchymal stem cells radiation-induced gastrointestinal syndrome treatment

Adjuvant percutaneous radiofrequency ablation of feeding artery of hepatocellular carcinoma before treatment

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第21期15卷 2638-2643页

作者： Yi-Bin Hou min-hua chen Kun Yan Jin-Yu wu wei yang Ultrasound Department Peking University School of Oncology Cancer Hospital & Institute No. 52 Fucheng Road Haidian District Beijing 100142 China

AIM:To evaluate the feasibility and efficacy of percutaneous radiofrequency ablation(RFA) of the feeding artery of hepatocellular carcinoma(HCC) in reducing the blood-flow-induced heat-sink effect of ***:A total of 154 HCC patients with 177 pathologically confirmed hypervascular lesions participated in the study and were randomly assigned into two ***-one patients with 75 HCCs(average tumor size,4.3 ± 1.1 cm) were included in group A,in which the feeding artery of HCC was identified by color Doppler flow imaging,and were ablated with multiple small overlapping RFA foci [percutaneous ablation of feeding artery(PAA)] before routine RFA treatment of the ***-three patients with 102 HCC(average tumor size,4.1 ± 1.0 cm) were included in group B,in which the tumors were treated routinely with ***-enhanced computed tomography was used as post-RFA imaging,when patients were followed-up for 1,3 and 6 ***:In group A,feeding arteries were blocked in 66(88%) HCC lesions,and the size of arteries decreased in nine(12%).The average number of punctures per HCC was 2.76 ± 1.12 in group A,and 3.36 ± 1.60 in group B(P = 0.01).The tumor necrosis rate at 1 mo post-RFA was 90.67%(68/75 lesions) in group A and 90.20%(92/102 lesions) in group *** recur-rence rate at 6 mo post-RFA was 17.33%(13/75) in group A and 31.37%(32/102) in group B(P = 0.04).CONCLUSION:PAA blocked effectively the feeding artery of *** of PAA and RFA significantly decreased post-RFA recurrence and provided an alternative treatment for hypervascular HCC.

关键词： Hepatocellular carcinoma Feeding artery Radiofrequency ablation Recurrence Color Dopplerflow imaging

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao hua Zhang Shui-Hong Zhou wei-Hong Jiang Yan Jiang Jing-wu Sun Qin-Tai yang Xue-Zhong Li Ya-Nan Sun Li Shi min Wang Xi-cheng Song Fu-Quan chen Xiao-Shu Zhang Hong-Quan wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-wei Cao Xu-Ping Xiao Xin wei Zhi-Hong Lin Feng-Hong chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu Xiao Cai wei huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-wei Gu Yu-cheng yang Lei cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

在线全文

学校读者我要写书评

暂无评论

锂电池产业中废氟磺酸资源化利用现状与展望

广州化工 2024年第15期52卷 5-7页

作者：吾石华江向阳秘西晨代伟浙江中硝康鹏化学有限公司浙江衢州324000 浙江师范大学浙江金华321004

梳理了废氟磺酸资源化利用现状,综述了以废氟磺酸为主要原料生产硫酸钾、氟化钾、硫酸铵、双氟磺酰亚胺锂、硫酸铵、白炭黑与石油防锈剂等产品的制备原理与生产工艺技术。锂电池产业中的废氟磺酸体量较大,迫切需要开发高效的资源化利用... 详细信息

梳理了废氟磺酸资源化利用现状,综述了以废氟磺酸为主要原料生产硫酸钾、氟化钾、硫酸铵、双氟磺酰亚胺锂、硫酸铵、白炭黑与石油防锈剂等产品的制备原理与生产工艺技术。锂电池产业中的废氟磺酸体量较大,迫切需要开发高效的资源化利用技术提升其附加值。此外,与废氟磺酸共存的杂质组分和含量差异极大,资源化利用废氟磺酸的同时需要建立产品的质量企业与行业标准,严格把控产品质量。

关键词：氟磺酸资源化高附加值现状

Radiofrequency ablation of hepatocellular carcinoma in difficult locations:Strategies and long-term outcomes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第5期21卷 1554-1566页

作者： wei yang Kun Yan Gong-Xiong wu wei wu ying Fu Jung-Chieh Lee Zhong-Yi Zhang Song Wang min-hua chen Department of Ultrasound Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education)Peking University Cancer Hospital and Institute Research Division Joslin Diabetes CenterHarvard Medical SchoolBostonMA 02215United States Department of Cardiovascular The Second Hospital Affiliated to Guangzhou Medical UniversityGuangzhou Institute of Cardiovascular Disease

AIM:To investigate the treatment strategies and longterm outcomes of radiofrequency ablation(RFA) of hepatocellular carcinoma(HCC) in difficult locations and to compare the results with non-difficult ***:From 2004 to 2012,a total of 470 HCC patients underwent ultrasound-guided percutaneous *** these HCC patients,382 with tumors located ≤ 5 mm from a major vessel/bile duct(n = 87),from peripheral important structures(n = 232) or from the liver capsule(n = 63) were regarded as difficult *** were 331 male patients and 51 female patients,with an average age of 55.3 ± 10.1 years old.A total of 235 and 147 patients had ChildPugh class A and class B liver function,*** average tumor size was 3.4 ± 1.2 *** treatment strategies were developed to treat these difficult *** the same period,88 HCC patients with tumors that were not in difficult locations served as the control *** the control group,74 patients were male,and 14 patients were female,with an average age of 57.4 ± 11.8 years *** these,62 patients and 26 patients had Child-Pugh class A and class B liver function,*** follow-up after RFA was performed to assess treatment *** results were generated from Kaplan-Meier estimates,and multivariate analysis was performed using the Cox regression ***:Early tumor necrosis rate in the difficult group was similar to that in the control group(97.6% vs 94.3%,P = 0.080).The complication rate in the difficult group was significantly higher than that in thecontrol group(4.9% vs 0.8%,P = 0.041).The followup period ranged from 6 to 116 mo,with an average of 28 ± 22.4 *** progression rate in the difficult group was significantly higher than that in the control group(12.7% vs 7.1%,P = 0.046).However,the 1-,3-,5-,and 7-year overall survival rates in the difficult group were not significantly different from those in the control group(84.3%,54.4%,41.2%,and 29.9% vs 92.5%,60.3%,43.2%,and

关键词： Radiofrequency ablation Ultrasound guidance Hepato

艾灸对慢性溃疡性结肠炎小鼠内脏高敏及结肠组织炎性反应的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

针刺研究 2024年第2期49卷 145-154页

作者：陈伟程斌余曙光吴巧凤成都中医药大学针灸推拿学院成都610075

目的:观察艾灸“足三里”对慢性溃疡性结肠炎(UC)小鼠结肠组织中肿瘤坏死因子-α(TNF-α)、肿瘤坏死因子受体1(TNF-R1)、P38丝裂原活化蛋白激酶(P38 MAPK)、瞬时感受器电位香草酸受体1(TRPV1)表达的影响,探讨艾灸改善慢性UC内脏高敏的... 详细信息

目的:观察艾灸“足三里”对慢性溃疡性结肠炎(UC)小鼠结肠组织中肿瘤坏死因子-α(TNF-α)、肿瘤坏死因子受体1(TNF-R1)、P38丝裂原活化蛋白激酶(P38 MAPK)、瞬时感受器电位香草酸受体1(TRPV1)表达的影响,探讨艾灸改善慢性UC内脏高敏的可能机制。方法:雄性C57BL/6J小鼠按体质量随机分为正常组、正常+艾灸组、模型组、模型+艾灸组,每组10只。以2.5%的葡聚糖硫酸钠循环3个周期饮用法建立慢性UC模型。正常+艾灸组和模型+艾灸组小鼠予以“足三里”艾灸,每次20 min,每周连续干预5 d,休息2 d,共4周。评价各组小鼠治疗前后的疾病活动指数(dai)评分;测定各组小鼠腹壁回撤反射(AWR)最小容量阈值以观察小鼠肠道敏感性;测量各组小鼠结肠长度;HE染色观察各组小鼠结肠组织病理变化;过碘酸雪夫染色检测各组小鼠结肠组织杯状细胞中的黏液素分泌;Masson染色观察各组小鼠肠道纤维化情况;免疫荧光染色法检测各组小鼠结肠组织类胰蛋白酶阳性细胞数(即肥大细胞数)及TNF-α表达水平;免疫组织化学法检测各组小鼠结肠组织TNF-R1、P38 MAPK、TRPV1表达水平。结果:艾灸治疗后,与正常组相比,模型组小鼠dai评分升高(Pdai评分降低(P<0.01),AWR最小容量阈值升高(P<0.001),结肠长度增加(P<0.001),炎性细胞浸润减少,黏膜肠腺结构完整性增加,黏液素分泌增多(P<0.01),胶原纤维减少(P<0.001),结肠组织中肥大细胞数量减少(P<0.001),TNF-α、TNF-R1、P38 MAPK、TRPV1表达水平均明显降低(P<0.001,P<0.01,P<0.05)。正常+艾灸组小鼠各项指标与正常组相比差异无统计学意义。结论:艾灸可减轻慢性UC小鼠内脏高敏,减轻肠道肥大细胞炎性浸润及纤维化损伤,该效应可能与艾灸下调结肠TNF-α、TNF-R1、P38 MAPK、TRPV1表达有关。

关键词：艾灸足三里慢性溃疡性结肠炎内脏高敏肿瘤坏死因子-α/肿瘤坏死因子受体1/P38丝裂原活化蛋白激酶/瞬时感受器电位香草酸受体1通路

Determination of Some Heavy-metal-ions Using a Sulfur Ion Modified BZ Oscillating System

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第9期17卷 1221-1224页

作者： hua chen wu yang Hong Xia dai Xiao Xia wei Jie QU Jin Zhang GAO College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070

A highly sensitive method is developed for the determination of trace amounts of some heavy metal ions in aqueous solution based on the classical Belousov-Zhabotinskii （BZ） oscillating chemical system. Introducing of S^2- ion makes the new oscillating system Ce（SO4）2 - KBrO3 - CH2（COOH）2 - Na2S - H2SO4 have to a high sensitivity for some heavy metal ions such as Ag^＋, Pb^2＋, Hg^2＋, Cd^2＋, Cu^2＋and Bi^3＋ with detection limits down to 10^-12 mol·L^- 1

关键词： BZ oscillating system kinetic determination heavy-metal-ion sulfur ion.

基于斑马鱼模型和网络药理学研究四方木皮的抗炎作用及其机制

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2024年第11期49卷 3070-3080页

作者：陈柳燕吴传梅梁潘韦金凤蓝婷婷郭敏李永华汝梅广西中医药大学药学院广西南宁530200 广西中医药大学广西高校中药民族药资源保护与利用重点实验室广西南宁530200 梧州市人民医院广西梧州543000

通过网络药理学-分子对接的方法,探讨四方木皮抗炎的作用机制,并用斑马鱼炎症模型进行验证。利用网络药理学预测四方木皮抗炎的有效成分、潜在核心靶点和信号通路。用脂多糖(LPS)诱导斑马鱼炎症模型,以细胞凋亡率和活性氧(ROS)生成率等... 详细信息

通过网络药理学-分子对接的方法,探讨四方木皮抗炎的作用机制,并用斑马鱼炎症模型进行验证。利用网络药理学预测四方木皮抗炎的有效成分、潜在核心靶点和信号通路。用脂多糖(LPS)诱导斑马鱼炎症模型,以细胞凋亡率和活性氧(ROS)生成率等指标来评价四方木皮水提物和70%乙醇提取物的抗炎活性,用q PCR验证预测的主要靶点。预测发现,四方木皮的潜在抗炎靶点有121个,PPI分析显示,四方木皮抗炎主要作用于信号传导和转录激活因子3 (signal transducer and activator of transcription 3,STAT3)、血管内皮生长因子A (vascular endothelial growth factor A,VEGFA)、表皮生长因子(epidermal growth factor,EGF)、肿瘤坏死因子(tumor necrosis factor,TNF)、肿瘤蛋白p53(tumor protein p53,TP53)、基质金属蛋白酶9(matrix metalloprotein 9,MMP9)、c-fos原癌蛋白(c-fos proto-oncogene protein,FOS)、环状素受体1(estrogen receptor 1,ESR1)、趋化因子8(c-x-c motif chemokine ligand 8,CXCL8)、白细胞分化抗原8(cluster of differentiation 8,CD8)等靶点;基因本体(Gene Ontology,GO)分析显示,生物过程主要作用于抑制细胞凋亡过程、基因表达的正调控、细胞增殖的正向调节;京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)分析表明,MAPK信号通路、PI3K-Akt信号途径、HIF-1信号通路等可能在四方木皮抗炎中起关键作用;分子对接显示,5种关键成分与核心靶点均具有较强的结合力。斑马鱼动物实验表明,四方木皮可显著抑制炎症导致的ROS形成,降低幼鱼体内细胞死亡,抑制了组织中炎症反应的增强。此外,与空白组相比,模型组中核因子(nuclear factor,NF)-κB、TP53、FOS、衔接蛋白复合物-1(adaptor protein complex-1,AP-1)、丝裂原活化蛋白激酶P38(mitogen-activated protein kinases P38,P38)的转录水平显著上调;与模型组相比,四方木皮水提物和70%乙醇提取物组的斑马鱼组织中NF-κB、TP53、FOS、AP-1、P38的m RNA表达明显下调。四方木皮通过多成分、多靶点发挥抗炎作用,且其抗炎作用可能与抑制MAPK信号通路有关。

关键词：四方木皮抗炎斑马鱼网络药理学分子对接

Differentiation of atypical hepatic hemangioma from liver metastases: Diagnostic performance of a novel type of color contrast enhanced ultrasound

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第9期26卷 960-972页

作者： Xiao-Feng wu Xiu-Mei Bai wei yang Yu Sun Hong Wang wei wu, min-hua chen Kun Yan Key Laboratory of Carcinogenesis and Translational Research(ministry of Education/Beijing) Department of UltrasoundPeking University Cancer Hospital&InstituteBeijing 100142China Key laboratory of Carcinogenesis and Translational Research(ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

BACKGROUND In clinical practice,the diagnosis is sometimes difficult with contrast-enhanced ultrasound(CEUS)when the case has an atypical perfusion *** parametric imaging(CPI)is an analysis software for CEUS with better detection of temporal differences in CEUS imaging using arbitrary *** measures the differences in arrival time of the contrast agent in lesions so that the perfusion features of atypical hemangioma and colorectal cancer(CRC)liver metastasis can be *** To evaluate the role of a novel type of CPI of CEUS in the differential diagnosis of atypical hemangioma from liver metastases in patients with a history of *** From January 2016 to July 2018,42 patients including 20 cases of atypical hemangioma and 22 cases of liver metastases from CRC were *** patients had a mean age of 60.5±9.3 years(range:39-75 years).All patients received ultrasound,CEUS and CPI *** and staff radiologists independently and retrospectively reviewed CEUS and CPI *** sets of criteria were assigned:(1)Routine CEUS alone;and(2)CEUS and *** diagnostic sensitivity,specificity,accuracy and receiver operating characteristic(ROC)curve of resident and staff radiologists were *** The following CPI features were significantly different between liver hemangioma and liver metastases analyzed by staff and resident radiologists:Peripheral nodular enhancement(65%-70.0%vs 4.5%-13.6%,P<0.001,P=0.001),mosaic/chaotic enhancement(5%-10%vs 68.2%-63.6%,P<0.001,P<0.001)and feeding artery(20%vs 59.1%-54.5%,P=0.010,P=0.021).CPI imaging offered significant improvements in detection rates compared with routine CEUS in both resident and staff *** resident radiologists,the specificity and accuracy of CEUS+CPI were significantly increased compared with that of CEUS(77.3%vs 45.5%,P=0.030;78.6%vs 50.0%,P=0.006).In addition,the area under the curve(AUC)of CEUS+CPI was significantly higher than that of CEUS(0.803 vs 0.757,

关键词： Color parametric imaging Contrast enhanced ultrasound Liver hemangioma Liver metastases

Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第9期19卷 693-699页

作者： ZHANG Jin-Jin chen Bao-Song dai huan-Qin REN Jin-wei ZHOU Li-wei wu Sheng-hua LIU Hong-wei State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Department of Biology National Museum of Natural ScienceTaichung 40453TaiwanChina

A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identification of fourteen secondary metabolites(1-14)including eight sesquiterpenoids(1-8)and six polyphenols(9-14).Compounds1-3 were sesquiterpenes with new structures which were elucidated based on NMR spectroscopy,high resolution mass spectrometry(HRMS)and electronic circular dichroism(ECD)*** the isolates were tested for their stimulation effects on glucose uptake in insulin-resistant HepG2 cells,and cellular antioxidant *** 9-12 were subjected to molecular docking experiment to primarily evaluate their anti-coronavirus(SARS-CoV-2)*** a result,compounds 9-12 were found to increase the glucose uptake of insulin-resistant HepG2 cells by 18.1%,62.7%,33.7%and 21.4%at the dose of 50μmol·L^(-1),*** 9-12 also showed good cellular antioxidant activities with CAA_(50)values of 12.23,23.11,5.31 and 16.04μmol·L^(-1),*** docking between COVID-19 M^(pro)and compounds 9-12 indicated potential SARS-CoV-2 inhibitory activity of these four *** work provides new insights for the potential role of the medicinal mushroom *** as drugs and functional foods.

关键词： Sanghuangporus sanghuang Sesquiterpenoids Polyphenols Glucose-uptake stimulation Cellular antioxidant activity Anti-coronavirus activity