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Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary Y.Jiang chen mao Xiao-bo Yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored yet.Objective:To investigate trial characteristics related to treatment effect estimates on CHM RCTs.Search strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July 2021.Inclusion criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one meta-analysis.Data extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included RCTs.They also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data analyses.The ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,respectively.Results:Ninety-one systematic reviews,comprising 1338 RCTs were identified.For binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect estimates.As for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30;95%CI:[0.18,0.43]),conducted at a single center

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

Molecular investigation into the transformation of recalcitrant dissolved organic sulfur in refinery sour water during stripping process

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Petroleum Science 2024年第3期21卷 2112-2119页

作者： Yu-Guo Li chen He Chun-mao chen Fan Liu Quan Shi State Key Laboratory of Heavy Oil Processing China University of Petroleum State Key Laboratory of Coal Mining and Clean Utilization PetroChina Ningxia Petrochemical Company

Refinery sour water primarily originates from the tops of towers in various units and coker condensate,and cannot be discharged directly to a wastewater treatment plant due to high levels of chemical oxygen demand(COD) and organic sulfur contents. Even after the recovery of H2S from the sour water by the stripping process, the effluent still contains a high concentration of dissolved organic sulfur(DOS), which can have a huge bad influence. While chemical composition of dissolved organic matter(DOM) in refinery wastewater has been extensively studied, the investigation of recalcitrant DOS from sour waters remains unclear. In the present study, chemical composition of sour water DOMs(especially DOS) was investigated using fluorescence spectroscopy(excitation-emission matrix, EEM) and mass spectrometry,including gas chromatography-mass spectrometry(GC-MS) and high-resolution Orbitrap MS. The GC-MS and EEM results showed that volatile and low-aromaticity compounds were effectively removed during the stripping process, while compounds with high hydrophilicity and humification degree were found to be more recalcitrant. The Orbitrap MS results showed that weak-polar oxygenated sulfur compounds were easier to be removed than oxygenated compounds. However, the effluent still contained significant amounts of sulfur-containing compounds with multiple sulfur atoms, particularly in the form of highly unsaturated and aromatic compounds. The Orbitrap MS/MS results of CHOS-containing compounds from the effluent indicate that the sulfur atoms may exist as sulfonates, disulfide bonds, thioethers. Understanding the composition and structure of sour water DOS is crucial for the development of effective treatment processes that can target polysulfide compounds and minimize their impact on the environment.

关键词： Molecular transformation Dissolved organic sulfur Stripping process Refinery sour water Orbitrap MS

Frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 374-379页

作者： Jie Cai Wen-Wen Fan Yun-Hui Zhong Cai-Lan Wen Xiao-Dan Wei Wan-chen Wei Wan-Yan Xiang Jin-mao chen Department of Ophthalmology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Digital and Intelligent Technology Transformation and Application Research Institute of Visual Function Tianjin 300000China Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina

AIM:To investigate the frequency and associated factors of accommodation and non-strabismic binocular vision dysfunction among medical university students.METHODS:Totally 158 student volunteers underwent routine vision examination in the optometry clinic of Guangxi Medical University.Their data were used to identify the different types of accommodation and nonstrabismic binocular vision dysfunction and to determine their frequency.Correlation analysis and logistic regression were used to examine the factors associated with these abnormalities.RESULTS:The results showed that 36.71%of the subjects had accommodation and non-strabismic binocular vision issues,with 8.86%being attributed to accommodation dysfunction and 27.85%to binocular abnormalities.Convergence insufficiency(CI)was the most common abnormality,accounting for 13.29%.Those with these abnormalities experienced higher levels of eyestrain(χ2=69.518,P<0.001).The linear correlations were observed between the difference of binocular spherical equivalent(SE)and the index of horizontal esotropia at a distance(r=0.231,P=0.004)and the asthenopia survey scale(ASS)score(r=0.346,P<0.001).Furthermore,the right eye's SE was inversely correlated with the convergence of positive and negative fusion images at close range(r=-0.321,P<0.001),the convergence of negative fusion images at close range(r=-0.294,P<0.001),the vergence facility(VF;r=-0.234,P=0.003),and the set of negative fusion images at far range(r=-0.237,P=0.003).Logistic regression analysis indicated that gender,age,and the difference in right and binocular SE did not influence the emergence of these abnormalities.CONCLUSION:Binocular vision abnormalities are more prevalent than accommodation dysfunction,with CI being the most frequent type.Greater binocular refractive disparity leads to more severe eyestrain symptoms.

关键词： optometry clinic non-strabismic binocular vision dysfunction college students convergence insufficiency

Dispersity Regulation in Photo-controlled Radical Polymerization by Merging Aryl Sulfonyl Chloride Initiators and Mixed Disulfide Agents

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Chemical Research in Chinese Universities 2023年第5期39卷 816-821页

作者： ZHANG Lu ZHANG Zexi chen mao Department of Macromolecular Science State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433P.R.China

On-demand regulation of molecular weight distribution(MWD)is crucial to influence the properties of polymers.In this work,we reported an organocatalyzed photo-controlled radical polymerization(photo-CRP)from the tosyl chloride initiator by combining two disulfides as chain transfer agents.This novel synthetic protocol allows facile access toward well-defined polymers with tunable MWDs and predetermined molecular weights.Experiments including structural characterization,kinetic investigation and chain-extension polymerization exhibited good chain-growth control for polymers of different dispersities.Given the easy accessibility of the initiating site(sulfonyl chloride)on many aromatic sources,this work presents a promising avenue to modify such substances with polymers of tailored MWDs,chain lengths and repeating units under metal-free and mild conditions driven by light.

关键词： Reversible deactivation radical polymerization Photo-controlled radical polymerization Organocatalyst Molecular weight distribution Polymer chemistry

Associations Between Specific Diets, Dietary Diversity, and Cognitive Frailty in Older Adults — China, 2002–2018

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China CDC weekly 2023年第39期5卷 872-876,I0005,I0006页

作者： Qingmei Huang Wenfang Zhong Ziting chen Zhihao Li Peidong Zhang Yujie Zhang Peiliang chen Qi Fu Weiqi Song Yuebin Lyu Xiaoming Shi chen mao Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou CityGuangdong ProvinceChina Southern Medical University High Performance Computing Center Guangzhou CityGuangdong ProvinceChina China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina.

Summary What is already known about this topic?The relationship between specific dietary patterns and dietary diversity with cognitive frailty continues to be a subject of ambiguity.What is added by this report?This research revealed that regular consumption of fruit,meat,bean products,garlic,and tea was connected to a decreased risk of cognitive frailty.Compared to participants with dietary diversity score(DDS)≤6 points,those with DDS of 9–10,11–12,and≥12 had a lower risk of cognitive frailty.

关键词： DDS ambiguity continue

三氟氯乙烯与甲基异丙烯基醚的光诱导共聚反应

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化学学报 2024年第2期82卷 126-131页

作者：易敬霖陈茂复旦大学高分子科学系聚合物分子工程国家重点实验室上海200433

氟聚合物综合性能优异,在诸多领域发挥了重要作用.三氟氯乙烯(chlorotrifluoroethylene,CTFE)与乙烯基醚共聚物被用于高性能涂料,但其较低的玻璃化转变温度对应用场景带来了局限.在本工作中,发展了CTFE与甲基异丙烯基醚(methyl isoprope... 详细信息

氟聚合物综合性能优异,在诸多领域发挥了重要作用.三氟氯乙烯(chlorotrifluoroethylene,CTFE)与乙烯基醚共聚物被用于高性能涂料,但其较低的玻璃化转变温度对应用场景带来了局限.在本工作中,发展了CTFE与甲基异丙烯基醚(methyl isopropenyl ether,MIE)的光照自由基共聚反应,在室温常压条件下合成了全新化学结构的氟烯烃与烯基醚共聚物.聚合反应过程符合一级动力学与交替共聚特征,通过控制链转移剂用量与MIE转化率可合成不同分子量的共聚物,表明该聚合反应具备一定的可控性,但共聚物分子量分布较宽、链末端保真度有限.在此基础上,本工作首次揭示了CTFE-MIE共聚物比CTFE-乙烯基乙醚共聚物的玻璃化转变温度提高了近50℃,有助于进一步开发高性能氟聚合物材料.

关键词：氟聚合物共聚物光照聚合可逆失活自由基聚合三氟氯乙烯

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older—China,1998-2018

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China CDC weekly 2023年第2期5卷 25-30,I0001-I0003页

作者： Jinhui Zhou Xiang Gao Yuan Wei chen chen Jun Wang Zhenwei Zhang Xinwei Li Lihong Ye Jiaming Ye Sixin Liu Xiaochang Zhang Feng Zhao Juan Zhang Virginia Byers Kraus Yuebin Lyu chen mao Xiaoming Shi China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Department of Nutrition and Food Hygiene School of Public HealthInstitute of NutritionFudan UniversityShanghaiChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchunJilinChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhouGuangdongChina Division of Non-communicable Disease and Aging Health Management Chinese Center for Disease Control and PreventionBeijingChina Duke Molecular Physiology Institute and Division of Rheumatology Department of MedicineDuke University School of MedicineDurhamNorth CarolinaUSA Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsuChina

Summary What is already known about this topic?Limited evidence on healthy longevity was provided in the world,and no studies investigated the fractions of healthy longevity attributed to modifiable factors.What is added by this report?Incidences of longevity and healthy longevity in China are provided.It reveals that the total weighted population attributable fractions for lifestyles and all modifiable factors were 32.8% and 83.7% for longevity,respectively,and 30.4% and 73.4% for healthy longevity,respectively.What are the implications for public health practice?China has a high potential for longevity and healthy longevity.Strategies may be targeted at education and residence in early life as well as healthy lifestyles,disease prevention,and functional optimization in late life.

关键词： prevention attributed education

共载雷帕霉素和光克洛的纳米药物复合可溶解微针治疗鲜红斑痣的实验研究

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四川大学学报（医学版） 2024年第2期55卷 433-440页

作者：郝颖徐润壕陈茂陈雨文四川大学华西医院心血管疾病研究所心脏结构与功能研究室成都610041 四川大学华西医院/四川大学华西护理学院成都610041

目的鲜红斑痣是一种先天性毛细血管畸形的皮肤疾病,本研究结合鲜红斑痣的生物学特性和微针经皮传输药物的优势,拟构建共载抗血管生成药物雷帕霉素(rapamycin, RPM)和光敏剂光克洛(photochlor, HPPH)的纳米药物复合可溶解微针(RPM-HPPH ... 详细信息

目的鲜红斑痣是一种先天性毛细血管畸形的皮肤疾病,本研究结合鲜红斑痣的生物学特性和微针经皮传输药物的优势,拟构建共载抗血管生成药物雷帕霉素(rapamycin, RPM)和光敏剂光克洛(photochlor, HPPH)的纳米药物复合可溶解微针(RPM-HPPH NP@HA MN)实现抗血管生成治疗与光动力协同治疗鲜红斑痣。方法首先通过乳化溶剂挥发法制备装载RPM和HPPH的纳米药物(RPM and HPPH co-loaded nanoparticles, RPM-HPPH NP),在660 nm激光照射下考察其活性氧(reactive oxygen species, ROS)产生能力,以小鼠血管内皮瘤细胞系EOMA为研究对象,通过荧光显微镜和流式细胞仪检测细胞摄取行为,MTT实验法检测在有、无660 nm激光照射下,RPM-HPPH NP对EOMA的细胞毒性作用(游离RPM为对照)。之后通过模板法将纳米药物与透明质酸(hyaluronic acid, HA)可溶解微针体系复合得到RPM-HPPH NP@HA MN,通过扫描电镜和电子万能试验机考察其形貌特征和力学性能,通过台盼蓝染色和HE染色实验评价RPMHPPH NP@HA MN对裸鼠皮肤的刺入能力。结果 RPM-HPPH NP粒径150 nm,在激光的照射下可产生大量的ROS。在细胞水平,RPM-HPPH NP可被EOMA摄取,且呈时间依赖性。无论是否光照,纳米药物RPM-HPPH NP的细胞毒性强于游离药物RPM;在光照条件下,RPM-HPPH NP展现出更强的细胞毒性作用,差异有统计学意义(P<0.05)。RPM-HPPH NP@HA MN针尖高度是600μm,单针力学性能为0.750 48 N。台盼蓝染色和HE染色实验表明微针按压可使皮肤表面产生孔道并穿透角质层。结论 RPM-HPPH NP@HA MN可将RPM-HPPH NP经皮传输至病灶组织,实现抗血管生成治疗与光动力协同治疗鲜红斑痣,为纳米药物复合微针体系的构建及鲜红斑痣的治疗研究提供新策略。

关键词：抗血管生成治疗光动力治疗可溶解微针鲜红斑痣

基于科学思维培养的初中化学教学探索--以“物质的酸碱性”教学为例

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化学教学 2024年第6期 41-44页

作者：陈懋海宁市斜桥中学浙江嘉兴314406

科学思维是义务教育化学学科核心素养的核心内容,情境和活动是发展科学思维的重要载体。以“物质的酸碱性”教学为例,创设真实的情境,引导学生参与酸碱指示剂、新型pH试纸的制作,把学科知识融合在活动中,在质疑、探究、推断中形成科学思... 详细信息

科学思维是义务教育化学学科核心素养的核心内容,情境和活动是发展科学思维的重要载体。以“物质的酸碱性”教学为例,创设真实的情境,引导学生参与酸碱指示剂、新型pH试纸的制作,把学科知识融合在活动中,在质疑、探究、推断中形成科学思维,促进学生的深度学习,实现核心素养在课堂教学中有效落地。

关键词：科学思维深度学习物质的酸碱性探究与实践