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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan chen Qian WANG Yuan XING Yan-qing ZHENG Jun DUAN chen-chen chen lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

pH-sensitive KHA/CMC-Fe^(3+)@CS hydrogel loading and the drug release properties of riboflavin

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Particuology 2024年第3期86卷 13-23页

作者： Jie Song Xi Li Yuhua Niu lijun chen Zhiqiang Wei Yidan Li Youqian Wang Shaanxi University of Science&Technology Xi'an710021China

To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball method.The tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal stability.The stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were investigated.The results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

关键词： Potassium humate Hydrogel spheres pH-sensitive Drugsustained-release Drug release model

Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

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Food Science and Human Wellness 2024年第3期13卷 1258-1270页

作者： Qishan Wang Bin Liu Xianping Li Junying Zhao Zongshen Zhang Weicang Qiao Xinyue Wei lijun chen School of Bioengineering Dalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Sanyuan Foods Co.Ltd.Beijing 100163China

The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are limited.Herein,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral ovariectomy.After 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical testing.The results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid biosynthesis.Furthermore,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and microarchitecture.Mechanistically,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase 5b.Overall,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.

关键词： Dairy products Calcium Vitamin D Bone turnover markers Gut microbiota Postmenopausal osteoporosis

再生微粉与矿物掺合料对混凝土力学性能及微观结构的影响

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材料导报 2024年第5期38卷 178-183页

作者：陈立俊李滢陈文浩青海大学土木工程学院西宁810016 青海省建筑节能材料与工程安全重点实验室西宁810016

为了提高再生微粉在混凝土中的利用率,将单掺再生微粉的混凝土与复掺再生微粉、粉煤灰和硅灰的混凝土的力学性能及微观结构进行了对比研究。结果表明,单掺再生微粉和三者复掺对混凝土的抗压强度和孔结构有不同程度的影响,当掺量低于20%... 详细信息

为了提高再生微粉在混凝土中的利用率,将单掺再生微粉的混凝土与复掺再生微粉、粉煤灰和硅灰的混凝土的力学性能及微观结构进行了对比研究。结果表明,单掺再生微粉和三者复掺对混凝土的抗压强度和孔结构有不同程度的影响,当掺量低于20%时,单掺再生微粉的混凝土抗压强度高于同掺量时的复掺混凝土,孔隙率相比于复掺时也有所降低;而掺量高于20%时,复掺效果优于单掺,特别是当复掺掺量为30%时,混凝土28 d抗压强度相比单掺掺量为30%时提高了33.4%,总孔隙率和大孔占总孔隙的比例分别降低了4.4%和17.77%。这说明再生微粉的掺入量较大会给混凝土带来不利影响,但添加粉煤灰与硅灰后,它们可以发挥协同作用,从而改善混凝土的复合水泥基体强度和孔结构。

关键词：再生微粉混凝土微观结构力学性能孔结构协同作用

新中国城市蔬菜供应体系变迁的历史考察(1949-1965年)

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当代中国史研究 2024年第2期31卷 59-71,M0004页

作者：陈礼军广西大学马克思主义学院 530004

1949年后,特别是1953年“一五”计划实施前后,全国城市人口迅速增长,城市蔬菜供应成为新中国成立后必须解决的重大民生问题。党和政府先是做出了城市郊区农业生产应以蔬菜为中心的决策,采取了重视蔬菜储藏和建立有计划的蔬菜购销体制的... 详细信息

1949年后,特别是1953年“一五”计划实施前后,全国城市人口迅速增长,城市蔬菜供应成为新中国成立后必须解决的重大民生问题。党和政府先是做出了城市郊区农业生产应以蔬菜为中心的决策,采取了重视蔬菜储藏和建立有计划的蔬菜购销体制的措施,接着对城市蔬菜的统购包销制进行了调整;在三年经济困难时期,郊区的蔬菜生产和储藏得到了进一步的强化;在国民经济调整时期,经过实践、比较后,在集体经济基础上对城市蔬菜产销体制进行了改革。至此,新中国的城市蔬菜供应体系基本形成。不断调整的蔬菜产销体制在实践层面促进了党和政府对社会主义制度尤其是计划与市场问题的认识,为此后的改革和发展奠定了重要基础。

关键词：城市蔬菜供应工业化计划市场

Polycystic ovary syndrome: pathogenic mechanisms and nutritional therapeutic strategies

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Food Science and Human Wellness 2024年

作者： Yanyan Zhao Bin Liu Junying Zhao Yanpin Liu Hang Pan Yuying Yuan Xiaoyan Tian Weicang Qiao Zhenzhen Zhang lijun chen School of Public Health Shandong Second Medical University National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd. Beijing Engineering Research Center of Dairy Beijing Technical Innovation Center of Human Milk Research Beijing Sanyuan Foods Co.Ltd. Key Laboratory of Dairy Science Ministry of Education Food Science College Northeast Agricultural University

Polycystic ovary syndrome (PCOS) is the most common endocrine disease afflicting women of childbearing age. It is characterized by irregular menstruation， clinical or biochemical hyperandrogenemia， and polycystic ovary morphology. As a complex endocrine-metabolic syndrome， PCOS shares several endocrine-metabolic features with the metabolic syndrome (MS)， with insulin resistance at the core of their pathogenic mechanisms. PCOS and MS are interrelated and thus have similarities in treatment. Currently， the common treatment modalities for both are lifestyle intervention， medication， and surgery. More studies have shown that lifestyle intervention and regulation of intestinal flora are more effective and sustainable. However， progress towards treatment and cure is hampered by unclear etiology and mechanisms. This review aimed to summarize the relationship between PCOS and MS， the pathogenesis of metabolic disorders， and the current nutritional therapeutic strategies， especially lifestyle modifications and modulation of intestinal flora. Lifestyle interventions combined with the regulation of gut flora can be a new perspective for treatment. This perspective has a positive significance in the early diagnosis， adoption of personalized treatment plans， and prevention of complications in PCOS and MS. The need to prevent the occurrence of MS in patients with PCOS should be emphasized.

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巴渝接龙吹打乐的文化生态与传承策略

四川戏剧 2024年第2期 111-113页

作者：陈俐君四川文理学院音乐与演艺学院

乡村传统文化的生态建设和传承是进一步推进乡村振兴的重要环节。对于我国乡村现存的丰富文化,应当加强保护和传承,尽可能地将优秀的乡村传统文化融入新时代的发展当中。因此,在新时代乡村振兴战略背景之下,对作为巴渝地区代表性的非物... 详细信息

乡村传统文化的生态建设和传承是进一步推进乡村振兴的重要环节。对于我国乡村现存的丰富文化,应当加强保护和传承,尽可能地将优秀的乡村传统文化融入新时代的发展当中。因此,在新时代乡村振兴战略背景之下,对作为巴渝地区代表性的非物质文化遗产——巴渝接龙吹打乐的生态建设与传承策略的研究和探讨,有着较高的现实意义。

关键词：乡村振兴巴渝接龙吹打乐文化生态传承策略

台北“国家图书馆”藏王秉恩《息尘庵诗稿》稿本考述

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中华文化论坛 2024年第2期 180-192页

作者：陈立军成都中医药大学马克思主义学院四川成都610075

王秉恩是清末民初四川诗人,其唯一传世诗集《息尘庵诗稿》稿本现藏于台北“国家图书馆”。台北“国家图书馆”将之著录为著者手定底稿本,但通过对《息尘庵诗稿》稿本字迹、浮签和眉批等的分析研究,可知《息尘庵诗稿》是誊清稿本,也是未... 详细信息

王秉恩是清末民初四川诗人,其唯一传世诗集《息尘庵诗稿》稿本现藏于台北“国家图书馆”。台北“国家图书馆”将之著录为著者手定底稿本,但通过对《息尘庵诗稿》稿本字迹、浮签和眉批等的分析研究,可知《息尘庵诗稿》是誊清稿本,也是未完成的修订稿本。《息尘庵诗稿》以编年体编纂,《养云馆诗存》是其第一取材来源,比较二者的收诗内容,可知《息尘庵诗稿》存在内在性冲突,即诗集编年和文本修订之间的矛盾。《息尘庵诗稿》具有重要的文献价值可以弥补现有王秉恩传记载缺失、考订王秉恩生平及交游等。

关键词：王秉恩《息尘庵诗稿》《养云馆诗存》文献价值

Soil Phosphorus Composition and Phosphatase Activities along Altitudes of Alpine Tundra in Changbai Mountains,China

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Chinese Geographical Science 2016年第1期26卷 90-98页

作者： YANG Xiaozhu WEI Kai chen Zhenhua chen lijun State Key Laboratory of Forest and Soil Ecology Institute of Applied EcologyChinese Academy of SciencesShenyang 110164China University of Chinese Academy of Sciences Beijing 100049China

Alpine tundra ecosystems have specific vegetation and environmental conditions that may affect soil phosphorus(P) composition and phosphatase activities. However, these effects are poorly understood. This study used Na OH-EDTA extraction and solution31 P nuclear magnetic resonance(NMR) spectroscopy to determine soil P composition and phosphatase activities, including acid phosphomonoesterase(Ac P), phosphodiesterase(PD) and inorganic pyrophosphatase(IPP), in the alpine tundra of the Changbai Mountains at seven different altitudinal gradients(i.e., 2000 m, 2100 m, 2200 m, 2300 m, 2400 m, 2500 m, and 2600 m). The results show that total P(TP), organic P(OP), OP/TP, Na OH-EDTA extracted P and AcP, PD, and IPP activities over the altitude range of 2500–2600 m are significantly lower than those below 2400 m. The dominant extracted form of P is OP(73%–83%) with a large proportion of monoesters(65%–72%), whereas inorganic P is present in lower proportions(17%–27%). The activity of Ac P is significantly positively correlated with the contents of soil OP, total carbon(TC), total nitrogen(TN), and TP(P < 0.05), indicating that the Ac P is a more sensitive index for responding P nutrient storage than PD and IPP. Soil properties, P composition, and phosphatase activities decrease with increased altitude and soil p H. Our results indicate that the distribution of soil P composition and phosphatase activities along altitude and Ac P may play an important role in P hydrolysis as well as have the potential to be an indicator of soil quality.

关键词：磷酸酶活性高山冻原海拔梯度土壤磷长白山组成 NaOH溶液中国

Global cultivated land mapping at 30 m spatial resolution

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Science China Earth Sciences 2016年第12期59卷 2275-2284页

作者： CAO Xin chen XueHong ZHANG WeiWei LIAO AnPing chen lijun chen ZhiGang chen Jin State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University National Geomatics Center of China College of Geomatics Anhui University of Science and Technology

Cultivated land is one of the most important types of land cover in the global mapping of land cover, and its variation influences economic development, food security, and ecological environment protection. Existing products of global cultivated land mapping have a low resolution, and high spatial resolution products are in demand. This study uses global remote sensing image datasets in 2000/2010 with a spatial resolution of 30 m(Landsat TM/ETM+, HJ-1), MODIS 250 m NDVI time-serial data, and many types of reference data. An three-layer extraction method based on pixels, objects, and knowledge(POK) was adopted to ease cultivated land extraction in global-scale 30 m images, i.e., cultivated land classification based on pixel-scale multi-feature optimization, cultivated land automatic identification based on objects, and interactive object processing based on information service and priori knowledge. Global 30 m cultivated land mapping was accomplished for the two reference years(2000 and 2010), and statistical analysis was conducted on the data. Results showed that the total cultivated land area was 1.903 billion ha and 1.960 billion ha, respectively. Accuracy assessments showed that overall accuracy of global cultivated land mapping are higher than 92% for both the two reference years. The global cultivated land products in 2000/2010 developed in this research are superior to their international counterparts in terms of spatial resolution and classification accuracy. They also provide significant basic data on global food security, ecological environment supervision, and global change.

关键词： Cultivated land global 30 m resolution Remote sensing mapping NDVI time series