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Freshening of the intermediate water of the south china {2. between the 1960s and the 1980s

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chinese Journal of oceanology and Limnology 2012年第6期30卷 1010-1015页

作者：刘长建王东晓陈举杜岩谢强 State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences south china {2. Marine Engineering Surveying Center State Oceanic Administration Graduate University of chinese academy of sciences Sanya institute of Deep-sea Science and Engineering Chinese Academy of Sciences

Variation in intermediate water salinity in the south china {2. (SCS) between the 1960s and 1980s was studied using historical hydrographic data. The results demonstrate that the water was significantly fresher in the 1980s than in the 1960s, indicating that vertical mixing at intermediate water depth was reduced in the 1980s. This was partially because of the change of the SCS meridional overturning circulation (MOC) connecting local intermediate water with deep water. Data assimilation showed a 0.5Sv (1 Sv=10 6m 3/s) reduction in the strength of the MOC, which is about one third of the mean SCS MOC. Because the SCS MOC is linked to the Pacific Ocean, such an interdecadal variation in the intermediate water SCS may reflect anthropogenic climate change in the world ocean.

关键词： decadal variability intermediate water meridional overturning circulation south china {2. (SCS)

Phase II study of novel orally PI3Kα/δinhibitor TQ-B352. in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua Wang Meiyun fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen chen Liping Su Hang Su yu Yang Xiaobao {2. Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B352.,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 2.,2.2.)comprised run-in stage and stage 2.R/R FL patients after≥2.lines therapies received oral 2. mg TQ-B352. once daily in a 2.-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 2. patients at run-in stage,second stage study was initiated and included 82.patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2.experienced POD2. at *** stage 2.ORR was 86.6%(71/82.95%CI,77.3-93.1%),with 2.(34.2.)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2.not estimable)*** overall survival(OS)was not reached by cutoff date;2.-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(2..0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B352. showed favorable efficacy and safety for R/R FL patients after≥2.lines prior therapies.

关键词： lymphoma assessed initiated

大亚湾拟菱形藻水华及其在生物群落中的生态地位

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海洋学报 2005年第1期27卷 114-119页

作者：陈菊芳齐雨藻徐宁江天久吕颂辉暨南大学水生态科学研究所广东广州510632

对2.00年4~5月藻类水华高发期大亚湾澳头海域的拟菱形藻进行逐日调查,并对其与浮游植物、浮游动物的相关关系进行分析.调查初期,整个生物群落的种类组成数量都相对贫乏;拟菱形藻数量急剧增长,最高的测站密度可达2.93×106 个/dm3.拟菱... 详细信息

对2.00年4~5月藻类水华高发期大亚湾澳头海域的拟菱形藻进行逐日调查,并对其与浮游植物、浮游动物的相关关系进行分析.调查初期,整个生物群落的种类组成数量都相对贫乏;拟菱形藻数量急剧增长,最高的测站密度可达2.93×106 个/dm3.拟菱形藻水华的组成种类有拟极细拟菱形藻和尖刺拟菱形藻两种,以尖刺拟菱形藻稍占优势.水华形成中其他种类硅藻和甲藻在种类组成和数量上也有一定程度的增加.分析表明,拟菱形藻在浮游植物群落的种间竞争中具有优势,并成为春季硅藻水华的最重要的组成者.桡足类等浮游动物对拟菱形藻的下行控制并不能明显抑制拟菱形藻的增长及水华的产生,这与其偏爱以其他种类藻类为食有关.以上因素外加拟菱形藻对环境的广泛适应性促使其在该水域成为最常见的赤潮生物之一.

关键词：拟菱形藻群落生态水华

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西施舌人工育苗及幼虫、稚贝生长研究

湛江海洋大学学报 2003年第4期23卷 14-19页

作者：吴进锋陈素文梁超愉张汉华陈健光陈瑞雯林俊明谢建文中国水产科学研究院南海水产研究所广东广州510300 广东省惠来县海洋与渔业局广东惠来515200

对西施舌 (Coelomactraantiquata)室内人工育苗进行了研究。结果表明 ,西施舌在广东的繁殖高峰期为 5～ 6月 ,用阴干加流水刺激的方法诱导亲贝排放精卵 ,其受精率和孵化率可达 98%左右。 1997年和 1999年两次育苗试验结果 :在盐度为 2.6... 详细信息

对西施舌 (Coelomactraantiquata)室内人工育苗进行了研究。结果表明 ,西施舌在广东的繁殖高峰期为 5～ 6月 ,用阴干加流水刺激的方法诱导亲贝排放精卵 ,其受精率和孵化率可达 98%左右。 1997年和 1999年两次育苗试验结果 :在盐度为 2.6 .0 0～ 32..0 0、水温为 2.3～ 2.6℃条件下 ,幼虫在培育密度为 1～ 2.L- 1时生长较好 ,经 9～ 10d培育 ,可进入附着变态期 ,其壳长生长速度为14 .1μm·d- 1。稚贝阶段在日流水量为育苗水体的 1.5～ 2..0倍时取得较好效果 ,其壳长生长速度为 112..4 μm·d- 1。

关键词：西施舌幼虫稚贝培育生长室内人工育苗双壳贝类

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浙江和安徽发现霍氏鼠耳蝠

动物学杂志 2024年第4期59卷 619-626页

作者：陈坤豪莫韵铮黄泽锋雍凡崔鹏方宏明赵凯吴毅王晓云余文华广州大学生命科学学院华南生物多样性研究保护与利用重点实验室广州510006 生态环境部南京环境科学研究所国家环境保护武夷山生态环境科学观测研究站国家环境保护生物多样性与生物安全重点实验室南京210042 安徽牯牛降国家级自然保护区石台管理站石台245100 安庆师范大学生命科学学院安庆246133

2.2.年3月及6月,本课题组在浙江省丽水市和安徽省池州市进行翼手目物种多样性资源调查期间,使用蝙蝠竖琴网及昆虫网采集到一批蝙蝠标本。其中10号(1♂,9♀)体型较小,头体长43.34~47.12.mm,前臂长34.37~37.87 mm。耳廓尖长,耳屏较短,其... 详细信息

2.2.年3月及6月,本课题组在浙江省丽水市和安徽省池州市进行翼手目物种多样性资源调查期间,使用蝙蝠竖琴网及昆虫网采集到一批蝙蝠标本。其中10号(1♂,9♀)体型较小,头体长43.34~47.12.mm,前臂长34.37~37.87 mm。耳廓尖长,耳屏较短,其长不及耳长一半;体毛柔软而浓密,背毛基部至毛尖呈黑色至深棕色,腹毛基部至毛尖呈深灰色至浅灰色;后足长8.2.~9.49 mm,胫骨长16.08~17.2. mm,后足较长,超过胫骨长之半;股间膜和翼膜呈棕色,且翼膜附着于踝关节以下的跖骨处。颅骨细弱,颅全长14.92.15.82.mm,脑颅宽7.46~8.04 mm,额骨处倾斜明显,脑颅稍膨大圆润,颅顶较平,颧弓较细。上述外形及头骨特征与霍氏鼠耳蝠(Myotis horsfieldii)相吻合。同时,基于细胞色素b基因(Cyt b)的系统发育学证据亦支持上述鉴定结果。本发现为霍氏鼠耳蝠在浙江省和安徽省翼手目分布新记录,丰富了该种的基础生物学资料,扩大了对其地理分布范围的认知。

关键词：翼手目(蝙蝠) 霍氏鼠耳蝠浙江省安徽省分布新记录

Three New Chromone Derivatives Produced by Phomopsis sp. HNY2.-2. from Acanthus ilicifolius Linn.

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chinese Journal of Chemistry 2017年第12期35卷 1889-1893页

作者： Bo Ding Zhiyuan Wang Guoping Xia Xishan Huang fang Xu Wenrui chen Zhigang She School of Chemistry Sun Yat-Sen University Guangzhou Guangdong 510275 China Guangdong Inspection and Quarantine Technology Center Guangdong Entry-Exit Inspection and Quarantine Bureau Guangzhou Guangdong 510623 China institute of Tumor Pharmacology College of Pharmacy Jinan University Guangzhou Guangdong 510632 China

Three new chromone derivatives, phomochromenones A-C （1-3）, and one known chaetocyclinone B （4） were obtained from the cultures ofPhomopsis sp. HNY2.-2. isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the south china {2.. Their structures were determined by the analysis of 1D NMR and 2. NMR as well as mass spectroscopic data. The absolute configurations of I and 2.were assigned by quantum chemi- cal calculations of the electronic circular dichroism （ECD） spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2.c] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines （PC-3 and DU145 cells） with the IC50 values of 8.13 and 3.59 μmol/L, respectively.

关键词： phomochromenones Phomopsis sp. absolution configurations electronic circular dichroism cytotoxicity

RNAi knockdown of PIK3CA preferentially inhibits invasion of mutant PIK3CA cells

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World Journal of Gastroenterology 2011年第32期17卷 3700-3708页

作者： Xin-Ke Zhou Sheng-Song Tang Gao Yi Min Hou Jin-Hui chen Bo Yang Ji-fang Liu Zhi-Min He Department of Pharmacology University of South China Hengyang 421001 Hunan Province China institute of Cancer Research Affiliated Tumor Hospital of Guangzhou Medical College Guangzhou 510095 Guangdong Province China Laboratory of Applied Marine Biology Southem China Sea Institute of Oceanology Chinese Academy of Science Guangzhou 510300 Guangdong Province China

AIM: To explore the effects of siRNA silencing of PIK3CA on proliferation, migration and invasion of gastric cancer cells and to investigate the underlying mechanisms. METHODS: The mutation of PIK3CA in exons 9 and 2. of gastric cancer cell lines HGC-2., SGC-7901, BGC-82., MGC-803 and MKN-45 was screened by polymerase chain reaction (PCR) followed by sequencing. BGC-82. cells harboring no mutations in either of the exons, and HGC-2. cells containing PIK3CA mutations were employed in the current study. siRNA targeting PIK3CA was chemically synthesized and was transfect- ed into these two cell lines in vitro . mRNA and protein expression of PIK3CA were detected by real-time PCR and Western blotting, respectively. We also measured phosphorylation of a serine/threonine protein kinase (Akt) using Western blotting. The proliferation, migration and invasion of these cells were examined separately by 3-(4,5-dimethylthiazol-2.yl)-2.5-diphenyltet-razolium bromide (MTT), wound healing and Transwell chambers assay. RESULTS: The siRNA directed against PIK3CA effectively led to inhibition of both endogenous mRNA and protein expression of PIK3CA, and thus significantly down-regulated phosphorylation of Akt (P 3CA resulted in an obvious reduction in tumor cell proliferation activity, migration and invasion potential (P 1). Intriguing, mutant HGC-2. cells exhibited stronger invasion ability than that shown by wild-type BGC-82. cells. Knockdown of PIK3CA in mutant HGC-2. cells contributed to a reduction in cell invasion to a greater extent than in non-mutant BGC-82. cells. CONCLUSION: siRNA mediated targeting of PIK3CA may specifically knockdown the expression of PIK3CA in gastric cancer cells, providing a potential implication for therapy of gastric cancer.

关键词： Gastric cancer Metastasis PIK3CA PI3K/ Akt pathway RNAi

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.chen C.H.chen Chao chen G.chen H.S.chen M.L.chen S.J.chen S.L.chen S.M.chen T.chen X.R.chen X.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.fang S.S.fang W.X.fang Y.fang Y.Q.fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central china Normal University Wuhan 430079China Central south University Changsha 410083China china Center of Advanced Science and Technology Beijing 100190China china University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China institute of Modern Physics Lanzhou 730000China institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(12.0)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2.ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2.1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.02._(stat.)±0.02._(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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智能井盖管理系统设计与实现

电子设计工程 2021年第16期29卷 36-40,45页

作者：李澥方子昂陈弘诺陈文荣于尚智广州大学华软软件学院广东广州510990

针对当今城市建设中井盖容易被盗、人工巡检不及时、运维成本高和易倾斜等安全隐患问题,设计了一款以低功耗为主旨,集数据采集、传输和处理于一体的智能井盖管理系统。该系统以STM8L051F3P6超低功耗微控制器为核心,用ADXL345倾斜角度传... 详细信息

针对当今城市建设中井盖容易被盗、人工巡检不及时、运维成本高和易倾斜等安全隐患问题,设计了一款以低功耗为主旨,集数据采集、传输和处理于一体的智能井盖管理系统。该系统以STM8L051F3P6超低功耗微控制器为核心,用ADXL345倾斜角度传感器精准采集井盖姿态数据,使用NB-IoT技术将数据传到管理平台,并通过智能井盖管理软件实现对井盖的实时监测和预警处理。测试结果表明,系统具有超低功耗、工作稳定、组网简单、实时性响应良好等特点,实现了井盖的智能化、网络化和可视化管理,提高了管理人员的工作效率,具有良好的应用推广价值。

关键词：智能井盖倾斜度角传感器 NB-IoT 超低功耗