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Unmanned autonomous air-to-air refueling intelligent docking technology

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Chinese Journal of Aeronautics 2024年第5期37卷 1-5页

作者： Peng lin Yakun HE Yuanze chen Chinese Aeronautical Establishment Beijing 100029China

Unmanned autonomous Air-to-Air Refueling(AAR)capability is the key guarantee to support the distant-field,high-intensity and durable operations of the penetration counterair combat *** the future,the long-range unmanned reconnaissance and attack platform can reach the maximum flight range requirement through *** present,large transport aircraft platforms in China are still equipped with probe-and-drogue systems,and the refueling mode is gradually changing from manned to unmanned autonomous *** docking process is the riskiest and most important part,and there are strict safety,precision,and efficiency requirements for refueling operation,especially during close-distance docking and formation maintenance *** this paper,five issues that need to be solved to achieve autonomous AAR docking are *** this basis,five key technology development needs are proposed to solve these engineering ***,some prospects are given.

关键词： Air-to-air refueling Probe-and-drogue Unmanned aerial vehicles Docking Perception Collaborative control

Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes

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Genomics, Proteomics & Bioinformatics 2024年第3期22卷 29-41页

作者： Fei Qi Junjie chen Yue chen Jianfeng Sun Yiting lin Zipeng chen Philipp Kapranov State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Institute of Genomics School of MedicineHuaqiao UniversityXiamen 361021China Botnar Research Centre University of OxfordOxfordOX37LDUnited Kingdom

Accurate identification of the correct,biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA molecules and plays pivotal roles in many essential biological ***,a plethora of approaches have been developed to predict,identify,or solve RNA structures based on various computational,molecular,genetic,chemical,or physicochemical *** computational approaches hold distinct advantages over all other strategies in terms of the ease of implementation,time,speed,cost,and throughput,but they strongly underperform in terms of accuracy that significantly limits their broader ***,the advantages of these methods led to a steady development of multiple in silico RNA secondary structure prediction approaches including recent deep learning-based ***,we compared the accuracy of predictions of biologically relevant secondary structures of dozens of self-cleaving ribozyme sequences using seven in silico RNA folding prediction tools with tasks of varying *** found that while many programs performed well in relatively simple tasks,their performance varied significantly in more complex RNA folding ***,in general,a modern deep learning method outperformed the other programs in the complex tasks in predicting the RNA secondary structures,at least based on the specific class of sequences tested,suggesting that it may represent the future of RNA structure prediction algorithms.

关键词： RNA secondary structure RNA secondary structure prediction Ribozyme Deep learning Pseudoknot

Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression

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Current Medical Science 2024年第1期44卷 144-155页

作者： lin WANG Qing-guang chen Hao LU Department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic *** the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains *** study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and *** Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were *** sequencing was utilized to analyze differential gene expression and identify potential therapeutic *** vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 *** viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and *** expression levels were determined by Western blotting *** investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein *** The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in

关键词： Jianpi Qinghua formula diabetic cardiomyopathy AP-1 transcription factor apoptosis inflammation

Intra-Oceanic Subduction Termination and Reinitiation of the Eastern Neo-Tethys in Myanmar

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Journal of Earth Science 2024年第3期35卷 1053-1058页

作者： Yi chen Qinghua Zhang lin chen Kaihui Shi Kyaing Sein State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Myanmar Geosciences Society Hlaing University CampusYangon 11062Myanmar

Subduction initiation and termination represent the birth and death of a subduction zone and are inevitable elements of terrestrial plate *** evidence demonstrates that subduction zone processes did not operate continuously and might involve multiple initiation and termination stages(Stern,2004),characterized by sustained subduction-zone death and *** geological and numerical studies focus on subduction initiation processes/mechanisms(see reviews in Yang,2022);however,subduction termination is often studied numerically at continental margins(Gerya,2022).How subduction termination proceeds in intra-oceanic settings remains enigmatic due to lacking geological records.

关键词： Eastern terrestrial continental

Self-Driven Photo-Polarized Water Molecule-Triggered Graphene-Based Photodetector

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Research 2024年第2期2023卷 273-283页

作者： Shisheng lin Chang Liu Xin chen Yi Zhang Hongtao lin Xutao Yu Yujiao Bo Yanghua Lu College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027P.R.China Hangzhou Gelanfeng Technology Co.Ltd Hangzhou 310051P.R.China State Key Laboratory of Modern Optical Instrumentation Zhejang UniversityHangzhou 310027P.R.China Key Laboratory of Wide Bandgap Semiconductor Materials and Devices HCSemitek CorporationYiwu 322009P.R.China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100P.R.China

Flowing water can be used as an energy source for generators,providing a major part of the energy for daily ***,water is rarely used for information or electronic ***,we present the feasibility of a polarized liquid-triggered photodetector in which polarized water is sandwiched between graphene and a *** to the polarization and depolarization processes of water molecules driven by photogenerated carriers,a photo-sensitive current can be repeatedly produced,resulting in a high-performance *** response wavelength of the photodetector can be fine-tuned as a result of the free choice of semiconductors as there is no requirement of lattice match between graphene and the *** zero voltage bias,the responsivity and specific detectivity of Gr/NaCl(0.5 M)W/N-GaN reach values of 130.7 mA/W and 2.3×10^(9)Jones under 350 nm illumination,***,using a polar liquid photodetector can successfully read the photoplethysmography signals to produce accurate oxygen blood saturation and heart *** with the commercial pulse oximetry sensor,the average errors of oxygen saturation and heart rate in the designed photoplethysmography sensor are~1.9%and~2.1%,*** study reveals that water can be used as a high-performance photodetector in informative industries.

关键词： polarization polarized saturation

Immune checkpoint inhibitor-associated gastritis:Patterns and management

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World Journal of Gastroenterology 2024年第14期30卷 1941-1948页

作者： Jing lin Zhong-Qiao lin Shi-cheng Zheng Yu chen Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina Phase I Clinical Trial Ward Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina

Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various ***-related adverse events(irAEs)are defined as adverse effects resulting from ICI *** irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of *** irAE gastritis is rarely reported,it may lead to serious complications such as ***,irAE gastritis is often difficult to identify early due to its diverse *** steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains *** addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be *** this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.

关键词： Immunotherapy Immune checkpoint inhibitor Immune-related adverse events Immune checkpoint inhibitor-related gastritis

Efficient Spin-Flip between Charge-Transfer States for High-Performance Electroluminescence, without an Intermediate Locally Excited State

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Research 2024年第1期2023卷 339-349页

作者： Donghai Zhang Shanshan Jiang Xiaodong Tao Fulin lin lingyi Meng Xu-lin chen Can-Zhong Lu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China FuzhouFujian 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamenFujian 361021China University of Chinese Academy of Sciences Beijing 100049China

Thermally activated delayed fluorescence(TADF)materials with both high photoluminescence quantum yield(PLQY)and fast reverse intersystem crossing(RISC)are strongly desired to realize efficient and stable organic light-emitting diodes(OLEDs).Control of excited-state dynamics via molecular design plays a central role in optimizing the PLQY and RISC rate of TADF materials but remains ***,3 TADF emitters possessing similar molecular structures,similar high PLQYs(89.5%to 96.3%),and approximate energy levels of the lowest excited singlet states(S_(1)),but significantly different spin-flipping RISC rates(0.03×10^(6) s^(−1) vs.2.26×10^(6) s^(−1))and exciton lifetime(297.1 to 332.8μs vs.6.0μs)were systematically synthesized to deeply investigate the feasibility of spin-flip between charge-transfer excited states(^(3)CT–^(1)CT)transition.

关键词： transition lifetime desired

Parallel Computing Based Solution for Reliability-constrained Distribution Network Planning

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1147-1158页

作者： Yaqi Sun Wenchuan Wu Yi lin Hai Huang Hao chen State Key Laboratory of Power Systems Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua UniversityChengduChina State Grid Fujian Electric Power Co.Ltd. FuzhouChina

The main goal of distribution network(DN)expan-sion planning is essentially to achieve minimal investment con-strained by specified reliability *** reliability-constrained distribution network planning(RcDNP)problem can be cast as an instance of mixed-integer linear programming(MILP)which involves ultra-heavy computation burden espe-cially for large-scale *** this paper,we propose a parallel computing based solution method for the RcDNP *** RcDNP is decomposed into a backbone grid and several lateral grid problems with ***,a parallelizable aug-mented Lagrangian algorithm with acceleration method is devel-oped to solve the coordination planning *** lateral grid problems are solved in parallel through coordinating with the backbone grid planning ***-Seidel iteration is adopted on the subset of the convex hull of the feasible region constructed by *** mild conditions,the opti-mality and convergence of the proposed method are *** tests show that the proposed method can significant-ly reduce the solution time and make the RcDNP applicable for real-worldproblems.

关键词： Distribution network expansion planning reliability parallel computing

Stochastic Economic Dispatch Based Optimal Market Clearing Strategy Considering Flexible Ramping Products Under Wind Power Uncertainties

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1525-1535页

作者： Haoyong chen Jianping Huang Zhenjia lin Fanqi Huang Mengshi Li School of Electric Power South China University of TechnologyGuangzhou510641China Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina

High penetration level of renewable energy has brought great challenges to operation of power systems,and use of flexible resources(FRs)is becoming increasingly *** of power systems can be improved by changing generation arrangements,but the interests of some market participants may be harmed in the *** study proposes a stochastic economic dispatch model with trading of flexible ramping products(FRPs).To calculate changes in revenue and reasonably compensate units that provide FRs,multisegmented marginal bidding for energy is simulated by linearizing generation cost,and an optimal market clearing strategy for FRPs is developed according to changes in clearing energy and marginal clearing ***,the correlation between prediction errors of wind speeds among different wind farms is determined based on a joint distribution function modeled by the copula function,and quasi-Monte Carlo simulation(QMC)is used to generate wind power ***,numerical simulations of modified IEEE-30 and IEEE-118 bus systems is performed with minimum comprehensive cost as the objective *** verifies the proposed model could effectively deal with wind variability and uncertainty,stabilize the marginal clearing price of the electricity market,and ensure fairness in the market.

关键词： Flexible ramping product marginal clearing price risk cost stochastic economic dispatch wind power correlation