检索结果-南通市图书馆

High frequency of thrombocytopenia in patients with acute-on-chronic liver failure treated with linezolid

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 287-292页

作者： Yi-min zhang wei yu Ning Zhou jian-Zhou Li Li-chen xu Zhong-Yang Xie Ying-Feng Lu Lan-Juan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Department of Infectious Diseases the First Affiliated Hospital Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

BACKGROUND： linezolid is an effective antibiotic reagent for Gram-positive bacterial infection; its most common side effect is thrombocytopenia. However, the incidence of throm- bocytopenia in patients with acute-on-chronic liver failure （ACLF） who underwent linezolid therapy was unclear. The present study was to evaluate the incidence of thrombocyto- penia in ACLF and non-ACLF patients treated with linezolid and the risk factors of thrombocytopenia in these patients.

关键词： acute-on-chronic liver failure linezolid thrombocytopenia

高钾血症管理规范——多科室合作全流程管理模式

在线全文

学校读者我要写书评

暂无评论

中华肾脏病杂志 2024年第3期40卷 245-254页

作者：叶智明蔡建芳陈崴程虹何强李荣山李湘民廖新学毛志国毛慧娟谭宁徐钢詹红张浩张健余学清广东省人民医院肾内科广州510030 中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院肾内科北京100037 中山大学附属第一医院肾内科广州510080 首都医科大学附属北京安贞医院肾内科北京100011 浙江省人民医院肾内科杭州310014 山西省人民医院肾内科太原030000 中南大学湘雅医院急诊科长沙410013 中山大学附属第一医院心内科广州510080 海军军医大学第二附属医院肾内科上海200003 江苏省人民医院肾内科南京210029 广东省人民医院心内科广州510030 华中科技大学同济医学院附属同济医院肾内科武汉430030 中山大学附属第一医院急诊科广州510080 中南大学湘雅三医院肾内科长沙410013 北京协和医学院、中国医学科学院阜外医院、国家心血管病中心、心力衰竭中心、心衰重症监护病区北京100037

高钾血症是临床常见的离子代谢紊乱之一,国内外指南将血钾高于5.0 mmol/L定义为高钾血症。急性重度高钾血症可引起弛缓性麻痹、致死性心律失常,甚至心脏停搏等严重后果。肾素-血管紧张素-醛固酮系统抑制剂、β受体阻滞剂、保钾利尿剂的... 详细信息

高钾血症是临床常见的离子代谢紊乱之一,国内外指南将血钾高于5.0 mmol/L定义为高钾血症。急性重度高钾血症可引起弛缓性麻痹、致死性心律失常,甚至心脏停搏等严重后果。肾素-血管紧张素-醛固酮系统抑制剂、β受体阻滞剂、保钾利尿剂的应用,低钠高钾饮食以及相关合并症的存在均增加了高钾血症的发生。临床各科室均存在高钾血症风险人群,但缺乏医院多科室合作管理模式。为此,国内多位肾内科、心内科等领域专家讨论高钾血症医院多科室防治模式,制定了院内评估、预警、诊疗及管理规范流程,从而促进各科室更有效地参与院内高钾血症的诊疗以及慢性高钾血症的长期管理,提高全院高钾血症管理质量。

关键词：高钾血症跨部门合作组织和管理管理信息系统多科室合作全流程管理

Biodegradation of 2,6-ditert-butylphenol by immobilized microorga- nism strains

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2006年第2期18卷 369-372页

作者： zhang Ya-lei zhang Zhi-gang xu De-qiang QIANG Zhi-min LI Guang-ming ZHAO jian-fu Key Laboratory of Yangtze Water Environment of ministry of Education Tongji University Shanghai 200092 China School of Life Science Fudan University Shanghai 200433 China Department of Civil Architectural and Environmental Engineering University of Missouri-Rolla Rolla MO 65409 USA State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China

2,6-Ditert-butylphenol （2,6-DTBP） is a major organic contaminant presenting in acrylic fiber manufacturing wastewaters. This compound is of high bio-resistance due to its complex structure which consists of one phenol group and two highly branched tert-butyl groups. This research attempted to improve the biodegradation efficiency of 2,6-DTBP through various strain immobilization methods. The stratified immobilization can settle oxygen transmission in the single microorganism immobilization, and can realize two-process reaction in the single device by choosing two symbiotic microorganisms. Two effective strains, named F-1-4 and F-3-4, which were screened out in our previous work, were used to degrade 2,6-DTBP after being immobilized in calcium alginate gel. Results indicate that the substrate removal efficiency of various immobilization methods follows the order： stratified 〉 single F-3-4 〉 mixed ≈single F-1-4. The immobilized biodegradation capacity was higher than the free one. After an incubation time of 12 d, 91% of 2,6-DTBP could be degraded by the stratified immobilization method, compared to 79% achieved by the mixed immobilization method with an initial 2,6-DTBP concentration of 100 mg/L. The stratified immobilization satisfies the oxygen demand nature of the aerobic F-3-4 and the facultative F-1-4, thus yielding the highest degradation efficiency. Both the outer layer strain F-3-4 and the inner layer strain F-1-4 can grow actively on the substrate of 2,6-DTBP, as illustrated by SEM images. This study shows that the highly bio-refractory compound, 2,6-DTBP, can be effectively degraded using appropriately inunobilized microorganism strains.

关键词： biodegradation 2,6-ditert-butylphenol immobilization microorganism strains

Left jackknife position:a novel position for laparoscopic hepatectomy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第8期36卷 380-383页

作者： jian-Cong chen rong-Xin zhang min-Shan chen Li xu Jin-Bin chen Ke-Li Yang Yao-Jun zhang Zhong-Guo Zhou State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hepatobiliary Oncology Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Colorectal Cancer Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background: Laparoscopic hepatectomy for hepatocellular carcinoma(HCC) located in segment Ⅵ, Ⅶ, or Ⅷ of the liver is usually difficult because of poor operative exposure, due to the unique anatomical structure. In this study, we evaluated the practice of laparoscopic hepatectomy with the left jackknife position for patients with HCC located in segment Ⅵ, Ⅶ, or Ⅷ.Methods: A total of 10 patients were enrolled to undergo laparoscopic hepatectomy with the left jackknife *** located in segment Ⅵ, Ⅶ, or Ⅷ were assessed by preoperative dynamic computed tomography or magnetic resonance imaging. Operation time, intraoperative blood loss, postoperative fasting time, postoperative drainage time, major postoperative complications, and duration of postoperative hospital stay were ***: All surgeries were successfully completed. None of the patients required conversion to open surgery during the procedure, and no serious postoperative complications were *** median tumor size was 31 mm(range 23-41 mm) in diameter, the mean operation time was 166 ± 38 min, the mean intraoperative blood loss was220 ± 135 mL, and the median postoperative hospital stay was 4 days(range 2-7 days).Conclusions: For HCC located in segment Ⅵ, Ⅶ, or Ⅷ, laparoscopic hepatectomy with this novel position—the left jackknife position—is safe and effective during tumor resection by exposing a sufficient operating *** registration *** ID:

关键词： Laparoscopic hepatectomy Hepatocellular carcinoma Segment VI VII or VIII Left jackknife position

A fully automatic registration approach based on contour and SIFT for HJ-1 images

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2012年第10期55卷 1679-1687页

作者： NI XiLiang CAO ChunXiang DING lin jianG Tao zhang Hao JIA HuiCong LI GuangHe ZHAO jian chen wei JI wei xu min GAO Mengxu ZHENG Sheng TIAN rong LIU cheng LI Sha State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100049 China Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing 100101 China Shandong University of Science and Technology Qingdao 266510 China 5 Beijing University of Technology Beijing 100124 China Beijing University of Technology Bering 100124 China

To achieve a fully automatic registration between HJ-1 CCD images and HJ-1 infrared images is a difficult task as it must deal with the varying illuminations and resolutions of the images,different perspectives,and the local deformations within the *** this paper,aimed at those registration issues,a fully automatic registration approach based on contour and SIFT is *** registration technique performs a pre-registration process using contour feature matching algorithm that decides the overlapping region between a reference image and an input *** the coarse regions are obtained,it performs a fine registration process based on SIFT detector and a local adaptive matching *** the fine registration process,image blocking theory is used,which not only speeds up the features extraction and matching,but also makes the matching point pairs distributed uniformly in images,and further improves the accuracy of input image *** with visible images and infrared images from HJ-1A/B demonstrate the efficiency and the accuracy of the proposed technique for multisource remote sensing images registration.

关键词： automatic registration contour SIFT coarse matching fine registration local adaptive strategy

Hydrogen induced room-temperature ferromagnetism in Co-doped ZnO: first-principles and Monte Carlo study

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2014年第26期59卷 3232-3238页

作者： jian-min zhang Zhigao chen Kehua Zhong Guigui xu Zhigao Huang College of Physics and Energy Fujian Normal University Fujian Provincial Key Laboratory of Quantum Manipulation andNew Energy Materials

The structural stability, vibrational and magnetic properties of hydrogen doped ZnO:Co have been studied by first-principles calculations based on density functional theory. Bond-center(BC) sites were identified to be most stable sites for hydrogen, the corresponding vibrational frequencies including anharmonic contributions were calculated. Its magnetic properties were investigated as well. The calculated results reveal that hydrogen could induce the change of electronic transfer, leading to a decrease of magnetic moment. However, the magnetic coupling between Co atoms is greatly strengthen. The results simulated by Monte Carlo method indicate that hydrogen can induce the Curie temperature to increase from 200 to 300 K.

关键词：蒙特卡罗法钴掺杂第一性原理氧化锌铁磁性第一原理计算氢室温

A remote control training system for rat navigation in complicated environment

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第2期8卷 323-330页

作者： FENG Zhou-yan chen wei-dong YE xue-song zhang Shao-min ZHENG Xiao-jing wang Peng jianG Jun JIN lin xu Zhi-jian LIU Chun-qing LIU Fu-xin LUO jian-hong ZHUANG yue-ting ZHENG Xiao-xiang Qiushi Academy for Advanced Studies Zhejiang University Hangzhou 310027 China College of Biomedical Engineering and instrument Science Zhejiang University Hangzhou 310027 China College of Computer Science and Technology Zhefiang University Hangzhou 310027 China School of Medicine Zhejiang University Hangzhou 310006 China

A remote control system has been developed to deliver stimuli into the rat brain through a wireless micro-stimulator for animal behavior training. The system consists of the following main components： an integrated PC control program, a transmitter and a receiver based on Bluetooth （BT） modules, a stimulator controlled by C8051 microprocessor, as well as an operant chamber and an eight-arm radial maze. The micro-stimulator is featured with its changeable amplitude of pulse output for both constant-voltage and constant-current mode, which provides an easy way to set the proper suitable stimulation intensity for different training. The system has been used in behavior experiments for monitoring and recording bar-pressing in the operant chamber, controlling rat roaming in the eight-arm maze, as well as navigating rats through a 3D obstacle route. The results indicated that the system worked stably and that the stimulation was effective for different types of rat behavior controls. In addition, the results showed that stimulation in the whisker barrel region of rat primary somatosensory cortex （SI） acted like a cue. The animals can be trained to take different desired turns upon the association between the SI cue stimulation and the reward stimulation in the medial forehrain bundle （MFB）.

关键词： Remote control Brain Navigation Stimulator Reward stimulation Whisker

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第1期6卷 95-104页

作者： Ke wang wei chen Zheng zhang Yongqiang Deng jian-Qi Lian Peng Du Ding wei Yang zhang Xiu-xuan Sun Li Gong xu Yang Lei He Lei zhang Zhiwei Yang Jie-Jie Geng Ruo chen Hai zhang Bin wang yu-Meng Zhu gang Nan jian-Li jiang ling Li Jiao Wu Peng lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui zhang Jin-lin Miao Hong-Yong Cui min Huang Jun zhang ling Fu Xiang-min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe wang Chun-Fu wang Yacheng Lu Ying-Ying Liu Qing-Yi wang Huijie Bian Ping ZhuZhi-Nan chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Biotechnology Beijing 100071China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Tangdu Hospital Fourth Military Medical UniversityXi’an 710038China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Xi’an Jiaotong UniversityXi’an 710049China Sino Biological Inc. Beijing 100176China Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi’an 710032China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China

In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until ***-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike *** ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the *** the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its ***,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike *** loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 *** of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular *** loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type ***,virions are observed in lymphocytes of lung tissue from a COVID-19 *** T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by ***,CD147 mediates virus entering host cells by ***,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19.

关键词： ACE2 CD147 intestine

双胎早产儿支气管肺发育不良危险因素分析:一项多中心研究

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国当代儿科杂志 2024年第6期26卷 611-618页

作者：樊雨薇张伊佳温和梅晏红沈蔚丁月琴龙运峰张志钢李桂芳姜泓饶红萍邱建武魏贤张亚昱曾纪斌赵常亮许伟鹏王凡员丽杨秀芳李薇林霓阳陈倩夏昌顺钟鑫琪崔其亮广州医科大学附属第三医院新生儿科/广东省产科重大疾病重点实验室/广东省妇产疾病临床医学研究中心/粤港澳母胎医学高校联合实验室广东广州510150 北京大学第三医院儿科北京100191 四川锦欣妇女儿童医院新生儿科四川成都610011 贵州医科大学附属医院新生儿科贵州贵阳550001 厦门大学附属妇女儿童医院新生儿科福建厦门361003 南方医科大学附属东莞医院新生儿科广东东莞523000 邵阳学院附属第一医院新生儿科湖南邵阳422000 广东省第二人民医院新生儿科广东广州511000 沧州市人民医院新生儿科河北沧州061000 延安大学附属医院新生儿科陕西延安716000 惠州市中心人民医院新生儿科广东惠州516001 汕头大学医学院附属粤北人民医院新生儿科广东韶关512026 武汉科技大学附属孝感医院新生儿科湖北孝感432000 内蒙古医科大学附属医院新生儿科内蒙古呼和浩特010050 汕头大学医学院第二附属医院新生儿科广东汕头515041 包钢集团第三职工医院新生儿科内蒙古包头014010 暨南大学附属第一医院新生儿科广东广州510630 兰州大学第二医院甘肃兰州730000 新乡市中心医院新生儿科河南新乡453000 中山市人民医院新生儿科广东中山528400 东莞市滨海湾中心医院新生儿科广东东莞523808 汕头大学医学院第一附属医院新生儿科广东汕头515041

目的分析胎龄25%是双胎中仅一胎患BPD的危险因素(OR=3.370,95%CI:1.500~7.568,P<0.05),胎龄大是双胎均患BPD的保护因素(P<0.05)。对双胎中仅一胎为BPD组进行组内条件logistic回归分析,提示小于胎龄儿是双胎内个体发生BPD的危险因素(OR=... 详细信息

目的分析胎龄25%是双胎中仅一胎患BPD的危险因素(OR=3.370,95%CI:1.500~7.568,P<0.05),胎龄大是双胎均患BPD的保护因素(P<0.05)。对双胎中仅一胎为BPD组进行组内条件logistic回归分析,提示小于胎龄儿是双胎内个体发生BPD的危险因素(OR=5.017,95%CI:1.040~24.190,P<0.05)。结论双胎早产儿BPD的发生不仅与胎龄相关,也与双胎出生体重差异、小于胎龄儿密切相关。

关键词：支气管肺发育不良危险因素多中心研究双胎儿早产儿