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Chinese Medical Journal 2021年第19期134卷 2370-2372页

作者： Zhang Zhang Nan Liu Min chen Ran Peng hui-jiao chen Hong-Ying Zhang Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Pathology The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China

To the Editor:Lipomatous neoplasms with spindle cell components and atypical features are rare soft tissue *** lipomatous tumor(ALT)/well-differentiated liposarcoma(WDLPS)is one of the most common liposarcomas with MDM2(12q13–15)gene ***,recently,some studies have suggested that unique lipomatous tumors named“atypical spindle cell lipomatous tumor”(ASLT)and atypical pleomorphic lipomatous tumor(APLT)should be distinguished from WDLPS because they have a better prognosis.[1,2]ASLT and APLT are tumors with RB1 gene deletions and the same chromosomal alterations as classical spindle cell lipoma(SCL)/pleomorphic lipoma.[2]The latest edition of the“World Health Organization Classification of Tumors of Soft Tissue and Bone,fifth edition”formally introduced the names of ASLT/APLT[3];these tumors are rare among Chinese patients,and only a few small series of cases have been reported in Asia.

关键词： atypical neoplasms alterations

Orientated-assembly of rod-like silica particles based on sandwich structure from the superhydrophobic template and the superhydrophilic substrates

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Chinese Chemical Letters 2016年第12期27卷 1797-1800页

作者： Lun Wan chen-hui jiao Man-Bo Zhang Jing-Xia Wang Lei Jiang Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal University Technical Institute of Physics and Chemistry Chinese Academy of Sciences

The paper demonstrated a facile approach for the orientated assembly of the rod-like silica particles by sandwich structure from the combined effect of superhydrophobic template and the superhydrophilic substrates. The rod-like particles can be arranged in ring-like, square-like and etc from the confined effect of the template, which will produce an important insight for the oriented assembly ofanisotropic particles and the development of the novel functional materials and devices.

关键词： Anisotropic particles Rod-like silica Template-assisted Self-assembly Pattern

Primitive neuroectodermal tumor of the kidney with inferior vena cava tumor thrombus during pregnancy response to sorafenib

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Chinese Medical Journal 2010年第15期123卷 2155-2158页

作者： WU Yun-jian ZHU Yu-chun chen hui HUANG Ying WEI Qiang chen hui-jiao XIE Xi LI Xiang ZHOU Qiao YANG Yu-ru ZENG Hao Department of Urology West China Hospital Sichuan UniversityChengdu Sichuan 610041 China Department of Gynaecology and Obstetrics Second Affiliated West China Hospital Sichuan University Chengdu Sichuan 610041 China Department of Pathology West China Hospital Sichuan UniversityChengdu Sichuan 610041 China

Primitive neuroectodermal tumor （PNET） most often presents as a bone or soft tissue mass in the trunk or axial skeleton in adolescents and young adults.1 It is highly aggressive and rarely arises in the kidney.2 A combined therapy, consisting of surgical resection,chemotherapy and radiotherapy, is needed to treat this tumor but long-term survival remains poor.3,4 In the current study, we describe a case of 26-year-old woman （primigravida） who presented with a PNET of the right kidney with inferior vena cava （IVC） tumor thrombus.

关键词： primitive neuroectodermal tumor kidney pregnancy thrombus sorafenib

Synergistic myoprotection of L-arginine and adenosine in a canine model of global myocardial ischaemic reperfusion injury

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Chinese Medical Journal 2007年第22期120卷 1975-1981页

作者： DU Lei DIAN Ke chen hui-jiao AN Qi JIA Meng-xing YANG Ping-liang WANG Wei DENG Shuo-zeng LIU Jin Department of Anaesthesiology West China Hospital Sichuan University Chengdu 610041 China Department of Thoracic and Cardiovascular Surgery West China Hospital Sichuan University Chengdu 610041 China Department of Pathology West China Hospital Sichuan University Chengdu 610041 China

Background Endogenous nitric oxide and adenosine increase simultaneously to keep the balance of energy demand and supply when the oxygen supply is insufficient, which suggests that nitric oxide and adenosine might exert a synergistic myoprotection during tissue hypoxia. In this study, we tested this hypothesis utilizing a canine model of prolonged global myocardial ischaemic reperfusion injury. Methods In this double blind, controlled study, the hearts of 24 anaesthetized mongrel dogs were arrested for 2 hours with aortic cross clamping and blood cardioplegia. The treatment groups were those supplemented with 2 mmol/L L-arginine （ARG）, supplemented with 1 mmol/L adenosine （ADO）, ARG ＋ ADO supplemented with both, and no supplementation （control）（n=6 in each group）. Haemodynamics, biochemical indices, adenosine triphosphate （ATP） content and myeloperoxidase activities of myocardium were determined to evaluate myocardial injury. Statistical comparison was performed by two way ANOVA. Results Although the requirements for inotropic supports were higher, the cardiac outputs were lower in control group than in ARG, ADO and the combination groups. Plasma cardiac troponin I levels were higher and the areas of hydropic changes were larger in control group than in ARG and ADO groups. Combination of arginine and adenosine provided further myoprotection with respect to better cardiac performance, lower release of cardiac troponin I, and smaller areas of hydropic changes compared with ARG and ADO groups. ATP content was higher, but myeloperoxidase activities of myocardium were significantly lower in the combination group than in control, ARG and ADO groups （P〈0.05）. Conclusions Combination of L-arginine and adenosine provides synergistic myoprotection in a canine model of global myocardial ischaemia. Thus, the combination is recommended when the heart is exposed to a prolonged ischaemia during cardiac surgery.

关键词： nitric oxide adenosine myocardium injury, ischaemic reperfusion

Reproducibility of the Nottingham modification of the Scarff- Bloom-Richardson histological grading system and the complementary value of Ki-67 to this system

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Chinese Medical Journal 2010年第15期123卷 1976-1982页

作者： ZHANG Rui chen hui-jiao WEI Bing ZHANG Hong-ying PANG Zong-guo ZHU Hong ZHANG Zhang FU Jing BU Hong Department of Pathology West China Hospital Sichuan University Chengdu Sichuan 610041 China Depariment of Pathology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China

Background The reproducibility of the Nottingham modification of the Scarff-Bloom-Richardson （NSBR） histological grading system for invasive breast cancer （IBC） adopted by the World Health Organization （WHO） has previously not been studied in Chinese hospitals. The proliferation marker, Ki-67, has been widely applied in detecting IBC. The objective of this study was to assess the reproducibility of the NSBR system among Chinese pathologists and the complementary value that Ki-67 brings to this *** Four general pathologists graded 100 IBC cases independently, which had previously been graded by specialists in breast pathology. The interobserver reproducibility among four general pathologists and pairwise reproducibility between each of them and the specialists were assessed. The Ki-67 labeling index （Ki-67LI） was determined by immunohistochemistry, and its correlations with histological grade and survival were *** With respect to interobserver reproducibility, NSBR grading was fairly reproducible （kappa=0.34）; as for the components of NSBR grading, agreement was best for tubule formation （kappa=0.46）, intermediate for nuclear pleomorphism （kappa=0.42）, and poorest for mitotic count （kappa=0.28）. In terms of pairwise reproducibility, agreement was fair to substantial with NSBR grading （kappa=0.30-0.69） and nuclear pleomorphism （kappa=0.28-0.69）, moderate to substantial for tubule formation （kappa=0.51-0.78）, and slight to substantial for mitotic count （kappa=0.19-0.71）.There were characteristic Ki-67LI ranges for grades 1,2 and 3 tumors. Univariate analysis showed that Ki-67 was able to divide grade 2 patients into two different prognostic subgroups. Multivariate analysis of grade 2 patients with negative lymph node demonstrated that Ki-67 was an independent prognosticator for overall *** The reproducibility of grading by general pathologists could be enhanced. Specialization in breast pathology is essential for accurate grad

关键词： invasive breast cancer histological grading system reproducibility Ki-67 prognosis

Clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts

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Chinese Medical Journal 2007年第10期120卷 876-881页

作者： KE Qi Erbolat ZHANG Hong-ying BU Hong LI Sheng SHI Dan-ni YANG Guang-hua chen hui-jiao WEI Bing Department of Pathology West China Hospital Sichuan University Chengdu 610041 China Department of Pathology Kuitun Hospital Yili 833200 Xinjiang China Department of Pathology Langzhong Hospital Langzhong 637400 China Department of Pathology Luzhou Hospital Luzhou 646000 China

Background Pleomorphic hyalinizing angiectatic tumor （PHAT） of soft parts is a rare soft tissue tumor, which is generally considered low-grade. To distinguish the tumor from other soft tissue lesions, we analyzed the clinicopathologic and ultrastructural features, immunophenotypes, and flow cytometric DNA ploidy of PHAT in 9 cases. Methods PHAT specimens were collected from 9 patients with PHAT from 1990 to 2004. Each specimen was cut into pieces and stained with hematoxylin-eosin, phosphotungstic acid-hematoxylin, Prussian blue, and Masson trichrome, respectively. Immunohistochemical stains for vimentin, S-100 protein, CD34, CD31, CD99, VEGF, desmin, CDl17, α-SMA, and MIB-1 were performed with the Envision system. Flow cytometry was used in four specimens, two of which were observed by electron microscopy. Results In the 9 cases, the PHAT occurred at the lower extremity in 2 patients, inguinal in 2, waist in 1, forearm in 1, buttock in 1, foot in 1, and the chest wall in 1. All the lesions presented in the superficial subcutaneous tissues. Follow-up data were available in 7 of the patients, among whom 2 （28.6%） had recurrence after primary therapy. Microscopically, typical PHAT was characterized by sheet-like proliferation of spindle or pleomorphic cells and clusters of thin-walled hyalinized cstatic vessels. In some areas of the tumor, hemosiderin-laden spindle cells, numerous small single vessels, and myxoid extracellular matrix could be identified, indicating an ＂atypical PHAT＂. Mitotic figures were rare in all the cases In 5 of the 9 patients （55.6%）, the tumor was typical PHAT; and in the other 4 （44.4%）, typical and atypical PHAT coexisted. Immunohistochemically, the neoplastic cells were positive for vimentin, CD34, CD99, and VEGF, but negative for S-100 protein, desmin, SMA, and CD31. In all the cases, the MIB-1 proliferative activity of the neoplastic cells was lower than 2%. Ultrastructural analysis did not reveal any evidence of specific differentiat

关键词： pleomorphic hyalinizing angiectatic tumor soft tissue neoplasms

Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma

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Chinese Medical Journal 2005年第17期118卷 1451-1461页

作者： ZHANG Hong-ying YANG Guang-hua chen hui-jiao WEI Bing KE Qi GUO Hua YE Lü BU Hong YANG Ke ZHANG Yuan-heng Department of Pathology West China Hospital Sichuan University Chengdu 610041 China Department of Southwestern Petroleum College Nanchong 637001 China

Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells. The description of the course of the tumors differs somewhat, but it is generally considered as a benign lesion. We investigated the clinicopathologic features, immunophenotypes, and ultrastructural features of 13 patients with nonpsammomatous melanotic schwannoma （NPMS）.

关键词： melanotic schwannoma melanoma diagnosis, differential microscopy, electron pathology immunohistochemistry

Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf

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Journal of Environmental Sciences 2024年第3期137卷 500-514页

作者： Shan Cao Meng Wang jiao Pan Dengjie Luo Samavia Mubeen Caijin Wang jiao Yue Xia Wu Qijing Wu hui Zhang Canni chen Muzammal Rehman Sichen Xie Ru Li Peng chen Guangxi Key Laboratory of Agro-environment and Agric-products safety Key Laboratory of Plant Genetics and BreedingCollege of AgricultureGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Kenaf is considered to have great potential for remediation of heavy metals in ***,studies on molecular mechanisms of root Cd accumulation and tolerance are still *** this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd *** study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid *** with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding *** were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two *** biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation *** associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in *** genes might have played key roles in kenaf Cd tolerance and Cd ***,HcZIP2 was identified to be involved in Cd uptake and transport in *** findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf.

关键词： Kenaf Cd stress Physiological Transcriptome HcZIP2

Brain Pathology in COVID-19:Clinical Manifestations and Potential Mechanisms

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Neuroscience Bulletin 2024年第3期40卷 383-400页

作者： Zhixing Xu hui Wang Siya Jiang jiao Teng Dongxu Zhou Zhong chen chengping Wen Zhenghao Xu First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Afliated Lin’an People’s Hospital of Hangzhou Medical College First People’s Hospital of Hangzhou Lin’an DistrictLin’anHangzhou 311300China School of Life Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province College of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Laboratory of Rheumatology and Institute of TCM Clinical Basic Medicine College of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China

Neurological manifestations of coronavirus disease 2019(COVID-19)are less noticeable than the respiratory symptoms,but they may be associated with disability and mortality in *** though Omicron caused less severe disease than Delta,the incidence of neurological manifestations is *** than 30%of patients experienced“brain fog”,delirium,stroke,and cognitive impairment,and over half of these patients presented abnormal neuroimaging *** this review,we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with those in patients with influenza *** also illustrate the structure and cellular invasion mechanisms of SARS-CoV-2 and describe the pathway for central SARS-CoV-2 *** addition,we discuss direct damage and other pathological conditions caused by SARS-CoV-2,such as an aberrant interferon response,cytokine storm,lymphopenia,and hypercoagulation,to provide treatment *** review may offer new insights into preventing or treating brain damage in COVID-19.

关键词： COVID-19 SARS-CoV-2 Brain Neurological pathology

Buckling Properties of Water-Drop-Shaped Pressure Hulls with Various Shape Indices Under Hydrostatic External Pressure

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China Ocean Engineering 2024年第1期38卷 1-17页

作者： DING Xiao-de ZHANG Jian WANG Fang jiao hui-feng WANG Ming-lu School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Shanghai Engineering Research Center of Marine Renewable Energy College of Engineering Science and Technol-ogyShanghai Ocean UniversityShanghai 201306China China Ship Scientific Research Center Wuxi 214082China

The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater ***,this study conducted analytical,experimental and numerical investigation of the buckling properties of water-drop-shaped pressure hulls under hydrostatic pressure.A water-drop experiment was conducted to design water-drop-shaped pressure hulls with various shape *** critical loads for the water-drop-shaped pressure hulls were resolved by using Mushtari’s *** numerical simulations including linear buckling analysis and nonlinear buckling analysis including eigenmode imperfections were *** results indicated that the critical loads resolved by Mushtari's formula were in good agreement with the linear buckling loads from the numerical *** formula can be extended to estimate the buckling capacity of water-drop-shaped pressure *** addition,three groups of pressure hulls were fabricated by using stereolithography,a rapid prototyping ***,three groups of the pressure hulls were subjected to ultrasonic measurements,optical scanning,hydrostatic testing and numerical *** experimental results were consistent with the numerical *** results indicate that the sharp end of the water-drop-shaped pressure hulls exhibited instability compared with the blunt *** paper provides a new solution to the limitations of experimental studies on the water-drop-shaped pressure hulls as well as a new configuration and evaluation method for underwater observatories.

关键词： buckling pressure hull water drop underwater observatory