Atypical spindle cell lipomatous tumor/atypical pleomorphic lipomatous tumor and atypical mammary-type myofibroblastoma: clinicopathological, immunohistochemical, and multiplex fluorescence in situ hybridization analyses

作     者：Zhang Zhang Nan Liu Min Chen Ran Peng Hui-Jiao Chen Hong-Ying Zhang Zhang Zhang;Liu Nan;Chen Min;Peng Ran;Chen Hui-Jiao;Zhang Hong-Ying

作者机构：Department of PathologyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of PathologyThe First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第19期

页      面：2370-2372页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81972520 and 81472510) the Key R&D(Major Science and Technology Project)Project of Sichuan Science and Technology Department(No.2020YFS0270) the 135 Project for Disciplines of Excellence–Clinical Research Incubation Project,West China Hospital,Sichuan University(No.2018HXFH011) 

主　　题：atypical neoplasms alterations 

摘      要：To the Editor:Lipomatous neoplasms with spindle cell components and atypical features are rare soft tissue *** lipomatous tumor(ALT)/well-differentiated liposarcoma(WDLPS)is one of the most common liposarcomas with MDM2(12q13–15)gene ***,recently,some studies have suggested that unique lipomatous tumors named“atypical spindle cell lipomatous tumor(ASLT)and atypical pleomorphic lipomatous tumor(APLT)should be distinguished from WDLPS because they have a better prognosis.[1,2]ASLT and APLT are tumors with RB1 gene deletions and the same chromosomal alterations as classical spindle cell lipoma(SCL)/pleomorphic lipoma.[2]The latest edition of the“World Health Organization Classification of Tumors of Soft Tissue and Bone,fifth editionformally introduced the names of ASLT/APLT[3];these tumors are rare among Chinese patients,and only a few small series of cases have been reported in Asia.