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A novel linear microprobe array for the fabrication of neural microelectrodes

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Science China(Technological Sciences) 2015年第2期58卷 346-351页

作者： ZHAO Shan Shan PEI Wei Hua ZHAO Hui WANG Yi jun chen San yuan chen yuan Fang zhang He GUO Dong Mei GUI Qiang chen hong Da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Institute for Neural Computation University of California San Diego

A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from *** LMPA leverages the properties of conventional microwire with additional features of naturally formed regular *** the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the *** fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo *** SNR of the spikes recorded was 6.

关键词： LMPA regular spacing cleavage fracture V-groove

Exposure to Radon and Kidney Cancer:A Systematic Review and Meta-analysis of Observational Epidemiological Studies

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Biomedical and Environmental Sciences 2018年第11期31卷 805-815页

作者： chen Bin yuan Tan Wei WANG Ai Qing zhang hong FANG Li jun WU Qian Qian zhang hong Bo TAO Sha Sha TIAN Hai Lin School of Public Health Medical College of Soochow UniversitySuzhou 215123JiangsuChina Suzhou Gusu District Center For Disease Prevention and Control Suzhou 215123JiangsuChina Experimental Center of Medical College Soochow UniversitySuzhou 215123JiangsuChina Suzhou Xiangcheng District For Maternal and Child Care Service Centre Suzhou 215123JiangsuChina Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Dis eases School of Public HealthSoochow UniversitySuzhou 215123JiangsuChina

Objective To evaluate the possible association between radon exposure and kidney cancer. Methods We performed a systematic review and a meta-analysis based on random effect models to provide a pooled association measure. Results We subjected 8 studies(overall relative risks and 95% confidence intervals: 1.01, 0.72 to 1.43, I2= 64.4%) to meta-analysis. Subgroup analysis revealed a marginally significant association between radon exposure and kidney cancer in studies conducted in Europe. Two population-based studies provided no evidence for the increased risk of kidney cancer in the general population. Conclusion The association between radon and kidney cancer remains unclear but cannot be excluded because of its biological plausibility and the limited number and quality of existing studies. Additional data from the general population and well-designed miner cohort studies are needed to reveal the real relationship between radon exposure and kidney cancer.

关键词： Radon Kidney Systematic review Meta-analysis

CHADS2 versus CHA2DS2-VASc score in assessing the stroke and throm-boembolism risk stratification in patients with atrial fibrillation:a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2013年第3期10卷 258-266页

作者： Jia-yuan chen Ai-Dong zhang hong-Yan Lu jun Guo Fei-Fei Wang Zi-cheng Li Department of Cardiology the First Affiliated Hospital of Jinan University Guangzhou Guangdong 510630 China

Objective To perform a systematic review and meta-analysis of the predictive abilities of CHADS2 and CHA2DS2-VASc in stroke and thromboembolism risk stratification of atrial fibrillation (AF) patients. Methods We searched PubMed and EMBASE for Eng-lish-language literature on comparisons of the diagnostic performance between CHADS2 and CHA2DS2-VASc in predicting stroke, or sys-temic embolism, in AF. We then assessed the quality of the included studies and pooled the C-statistics and 95%confidence intervals (95%CI). Results Eight studies were included. It was unsuitable to perform a direct meta-analysis because of high heterogeneity. When analyzed as a continuous variable, the C-statistic ranged from 0.60 to 0.80 (median 0.683) for CHADS2 and 0.64-0.79 (median 0.673) for CHA2DS2-VASc. When analyzed as a continuous variable in anticoagulation patients, the subgroup analysis showed that the pooled C-statistic (95%CI) was 0.660 (0.655-0.665) for CHADS2 and 0.667 (0.651-0.683) for CHA2DS2-VASc (no significant difference). For non-anticoagulation patients, the pooled C-statistic (95%CI) was 0.685 (0.666-0.705) for CHADS2 and 0.675 (0.656-0.694) for CHA2DS2-VASc (no significant differ-ence). The average ratio of endpoint events in the low-risk group of CHA2DS2-VASc was less than CHADS2 (0.41%vs. 0.94%, P<0.05). The average proportion of the moderate-risk group of CHA2DS2-VASc was lower than CHADS2 (11.12%vs. 30.75%, P<0.05). Conclu-sions The C-statistic suggests a similar clinical utility of the CHADS2 and CHA2DS2-VASc scores in predicting stroke and thromboem-bolism, but CHA2DS2-VASc has the important advantage of identifying extremely low-risk patients with atrial fibrillation, as well as classi-fying a lower proportion of patients as moderate risk.

关键词： Atrial fibrillation CHA2DS2-VASc CHADS2 Meta-analysis Prediction Stroke

Fabrication of porous Zn_(2)TiO_(4)-ZnO microtubes and analysis of their acetone gas sensing properties

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Rare Metals 2021年第6期40卷 1528-1535页

作者： Xiao-Yan chen Xin-Zhen Wang feng-jun Liu Guo-Song zhang Xiao-Jie Song Jian Tian hong-Zhi Cui School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Shandong Province Key Laboratory of Mine Mechanical Engineering Shandong University of Science and TechnologyQingdao 266590China

Porous Zn2 Ti04-ZnO microtubes have been successfully fabricated using chemical precipitation followed by a calcination process using a carbon fiber *** porous Zn_(2)TiO_(4)-ZnO micro tubes with a diameter of~4μm consisted of Zn_(2)TiO_(4) and ZnO *** displayed worm-like pore *** fibers played an important role during the porous Zn_(2)TiO_(4)-ZnO microtube formation *** porous and hollow structure of Zn_(2)TiO_(4)-ZnO provided abundant active sensing sites and channels for gas adsorption and *** porous Zn_(2)TiO_(4)-ZnO microtubes exhibited improved gas sensing properties for acetone when compared with pure *** Zn_(2)TiO_(4)-ZnO sensor response was 33.4 for 100μg·ml^(-1) acetone at the optimum operating temperature(370℃).This was~2.7 times higher than that of pure ***,the as-prepared porous Zn_(2)TiO_(4)-ZnO microtubes displayed sufficient long-term acetone stability and *** showed the potential application for acetone *** enhanced Zn_(2)TiO_(4)-ZnO gas sensing properties are due to the unique heterogeneous and porous structure,which was analyzed using the porous and band structure.

关键词： Zn_(2)TiO_(4) Zinc oxide Porous Heterostructure Sensors

网络药理学方法联合体外实验初探金水六君煎辅助放化疗治疗恶性黑色素瘤的分子机制

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沈阳药科大学学报 2024年第3期41卷 330-342页

作者：洪学敏彭圆张翀杨莉陈娟平湖北中医药大学基础医学院湖北武汉430065

目的网络药理学方法联合体外实验初步探索金水六君煎辅助放化疗治疗恶性黑色素瘤(malignant melanoma,MM)的分子机制。方法在TCMSP数据库中获取金水六君煎的活性成分及靶点,以“malignant melanoma”为关键词在GeneCards、TTD、OMIM数... 详细信息

目的网络药理学方法联合体外实验初步探索金水六君煎辅助放化疗治疗恶性黑色素瘤(malignant melanoma,MM)的分子机制。方法在TCMSP数据库中获取金水六君煎的活性成分及靶点,以“malignant melanoma”为关键词在GeneCards、TTD、OMIM数据库中获得MM相关靶点,得到金水六君煎有效成分-MM交集靶点;通过STRING数据库获取蛋白质互作(PPI)网络,利用Metascape数据库进行基因本体论分析(GO)和基因组的京都基因与基因组百科全书富集分析(KEGG)并在AutoDockTools软件中进行分子对接;MTT法检测金水六君煎含药血清对小鼠B16黑色素瘤细胞增殖活性影响;蛋白免疫印迹法(Western blotting)检测金水六君煎含药血清对P38、p-P38、JNK、p-JNK、Beclin1、P62、LC3蛋白表达调控;透射电镜观察金水六君煎含药血清对B16细胞自噬影响。结果共获得金水六君煎相关靶点248个,MM相关靶点2147个,交集靶点149个。GO显示主要生物过程是DNA结合转录因子、激酶结合、细胞因子受体结合等;KEGG显示主要是癌症通路和MAPK信号通路,网络拓扑分析显示金水六君煎治疗MM的主要有效活性成分是槲皮素、山奈酚、柚皮素等,主要核心靶点为AKT1、TP53、jun等;核心靶点与有效活性成分分子对接显示结合活性较好。MTT结果显示,与空白组比较,金水六君煎含药血清能有效抑制B16细胞的增殖且呈浓度依赖性。Western blotting实验表明,较空白组,中高剂量组能下调B16细胞中p-P38、p-JNK、P62蛋白表达,上调LC3Ⅱ、LC3Ⅱ/LC3Ⅰ、Beclin1蛋白表达。透射电镜下显示金水六君煎含药血清能促进B16细胞中自噬体生成,减少黑素体生成。结论金水六君煎的有效成分和药物靶点很多,其治疗MM的作用靶点与通路众多,分子机制可能是通过下调p-P38、p-JNK、P62的蛋白表达,上调Beclin1、LC3Ⅱ/LC3Ⅰ的蛋白表达,抑制P38通路和JNK通路的激活,从而抑制B16细胞增殖;同时促进细胞凋亡,激活细胞自噬,发挥抑癌作用。

关键词：网络药理学金水六君煎恶性黑色素瘤增殖自噬分子机制

基于不同生育时期干旱对花生抗旱性的综合评定

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花生学报 2024年第2期53卷 31-38,46页

作者：陈雷杨明达贺群岭李帅王宏青张枫叶张梦圆吴继华商丘市农林科学院河南商丘476000 商丘市经济作物技术推广中心河南商丘476000

在防雨棚人工控水条件下,采用盆栽试验模拟花生不同生育时期干旱胁迫,调查产量和农艺性状等抗旱性指标,利用抗旱系数法和多性状隶属函数方法分析、鉴定9个商花系列花生品种的抗旱性。结果表明,在苗期、花针期及全生育期干旱条件下,花生... 详细信息

在防雨棚人工控水条件下,采用盆栽试验模拟花生不同生育时期干旱胁迫,调查产量和农艺性状等抗旱性指标,利用抗旱系数法和多性状隶属函数方法分析、鉴定9个商花系列花生品种的抗旱性。结果表明,在苗期、花针期及全生育期干旱条件下,花生产量的下降幅度分别为9.91%~46.86%、16.80%~86.62%和63.99%~97.29%。干旱时期不同,通过抗旱系数法和抗旱性综合评价值(D)筛选出的抗旱品种存在差异。综合不同生育时期干旱,利用平均抗旱系数和平均综合D值筛选出强抗旱品种为商花21号、商花33号和商花43号。不同生育时期干旱条件下,去根生物量、结果枝数和单株果质量的隶属函数值均与抗旱系数呈显著或极显著相关关系,可作为鉴定花生品种抗旱性的指标。研究结果可为区域推广商花系列抗旱新品种及筛选优异抗旱种质资源提供理论参考。

关键词：花生品种筛选抗旱性抗旱指标

Impurity-induced formation of bilayered graphene on copper by chemical vapor deposition

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Nano Research 2016年第9期9卷 2803-2810页

作者： jun Li Jianing Zhuang chengmin Shen yuan Tian Yande Que Ruisong Ma Jinbo Pan Yanfang zhang Yeliang Wang Shixuan Du feng Ding hong-jun Gao Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Textiles and Clothing Hong Kong Polytechnic UniversityKowloonHong KongChina Beijing Key Laboratory for Nanomaterials and Nanodevices Beijing 100190China

High-quality single-layered and bilayered graphene (SLG and BLG) was synthesized on copper foil surfaces by controllable chemical vapor deposition (CVD). Impurity nanoparticles formed on the copper foil surface by hightemperature annealing were found to play a crucial role in the growth of BLG. Analysis of energy-dispersive spectrometry (EDS) data indicated that these nanoparticles consisted of silicon and aluminum. According to the inverted wedding cake model, these nanoparticles served as nucleation centers for BLG growth and the free space between a nanoparticle and graphene served as the center of C injection for the continuous growth of the adlayer beneath the top layer. By combining phase-field theory simulations, we confirmed the mechanism of BLG growth and revealed more details about it in comparison with SLG growth. For the first time, this study led to a complete understanding of the BLG growth mechanism from nucleation to continuous growth in the CVD process, and it has opened a door to the thickness-controllable synthesis of graphene. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

关键词： graphene chemical vapor deposition (CVD) bilayer growth mechanism

Nonlinear Electrical Behaviour of the ***2O3 System

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Chinese Physics Letters 2000年第7期17卷 530-531页

作者： WANG Jin-feng chen hong-cun zhang Xing-Hua zhang De-jun Zhong WEI-LIE Department of Physics Shandong UniversityJi'nan 250100

The Sb2O3-doped TiO2 varistors were obtained by conventional ceramic processing. The 0.75mol%Sb2O3 99.25 mol%TiO2 varistor has a nonlinear coefficient α = 7 and a minimum breakdown electrical field of 6 V/mm. The nonlinear electrical behaviour of ***2O3 ceramics was explained by the introduction of defects in the crystal lattice that are responsible for the formation of Schottky potential barriers at grain boundaries.

关键词： ceramics ceramic electrical

Carbon nanotube supported PtOx nanoparticles with hybrid chemical states for efficient hydrogen evolution

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Journal of Energy Chemistry 2021年第7期30卷 364-369页

作者： Kun feng Hechuang Zheng Duo zhang Guotao yuan Lo-Yueh Chang Yufeng chen jun Zhong Institute of Functional Nano and Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123JiangsuChina State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123JiangsuChina

Efficient electrocatalysts for hydrogen evolution reaction(HER) in alkaline solution are highly required for water *** we design an ultra-small PtOx nanoparticle with hybrid Pt chemical states on carbon nanotubes as highly efficient alkaline HER catalyst,which shows a low overpotential of 19.4 mV at 10 mA cm^(-2),a high mass activity of 5.56 A mg_(Pt)^(-1) at 0.1 V, and a stable durability for at least 20 *** HER performance is better than that of the benchmark 20 wt% Pt/C while the Pt content in the catalyst is only about one tenth of that in Pt/*** also represents one of the best catalysts ever reported for HER in alkaline *** radiation X-ray absorption spectroscopy reveals that the efficient and stable alkaline HER performance can be attributed to the favorable design of hybrid chemical states of Pt with carbon nanotubes,which exhibits abundant surface Pt-O as active catalytic sites and forms stable Pt-C interfacial interaction to both anchor the NPs and improve the synergistic effect between catalyst and substrate.

关键词： Electrochemical HER Carbon nanotubes Hybrid chemical states Ultra-small nanoparticle Interfacial interaction