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CircZFR promotes colorectal cancer progression via stabilizing BCLAF1.and regulating the miR-31.0}-5p/RTKN2.axis

Science china(Life {1.) 2024年第9期67卷 1881-1898页

作者： Jiaxin chen Huijuan Wang Jianbin Xu Engeng chen {2. Meng Jiawei Wang Haoyi Xiang Wei Zhou Ge Shan Zhenyu Ju Zhangfa Song Department of Colorectal Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Biological Treatment of Zhejiang Province Hangzhou 310016China Department of Pulmonary and Critical Care Medicine Regional medical center for National Institute of Respiratory DiseaseSir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative MedicineJinan UniversityGuangzhou 510632China Department of Breast Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Orthopedic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Aberrant expression of circular RNAs(circ RNAs)is frequently linked to colorectal cancer(CRC).Here,we identified circ ZFR as a promising biomarker for CRC diagnosis and *** ZFR was upregulated in CRC tissues and serum exosomes and its level was linked to cancer incidence,advanced-stages,and *** both in vitro and in vivo settings,circ ZFR promoted the growth and spread while suppressing apoptosis of *** with circ ZFR overexpression promoted the proliferation and migration of cocultured CRC ***,epithelial splicing regulatory protein 1.ESRP1.in CRC cells may enhance the production of circ ***2.associated transcription factor 1.BCLAF1.bound to circ ZFR,which prevented its ubiquitinated ***,circ ZFR sponged mi R-31.0}-5p to boost rhotekin 2.RTKN2.*** TCP1.CD-QDs nanocarrier was able to carry and deliver circ ZFR si RNA(si-circ ZFR)to the vasculature of CRC tissues and cells,which inhibited the growth of tumors in patient-derived xenograft(PDX)*** together,our results show that circ ZFR is an oncogenic circ RNA,which promotes the development and spread of CRC in a BCLAF1.and mi R-31.0}-5p-dependent *** ZFR is a possible serum biopsy marker for the diagnosis and a desirable target for further treatment of CRC.

关键词： circZFR exosome ESRP1 BCLAF1 miR-31.0}-5p nanoparticle(NP)

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Jiaohong pills attenuate neuroinflammation and amyloid-βprotein-induced cognitive deficits by modulating the mitogen-activated protein kinase/nuclear factor kappa-B pathway

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Animal Models and Experimental Medicine 2024年第3期7卷 222-233页

作者： Hong Zhang Weiyan Cai Lijinchuan Dong qing Yang Qi Li qingsen Ran Li {2. Yajie Wang Yujie Li Xiaogang Weng Xiaoxin Zhu Ying chen institute of {1. Materia Medica China Academy of Chinese Medical SciencesBeijingChina

Background:Jiaohong pills(JHP)consist of Pericarpium Zanthoxyli(PZ)and Radix Rehmanniae,two herbs that have been extensively investigated over many years due to their potential protective effects against cognitive decline and memory ***,the precise mechanisms underlying the beneficial effects remain ***,research studies were conducted to investigate and validate the therapeutic effects of JHP on Alzheimer's ***:BV-2.cell inflammation was induced by *** mice were administered amyloid-β(Aβ).Behavioral experiments were used to evaluate learning and memory *** levels of nitric oxide(NO),tumor necrosis factor-alpha(TNF-α),interleukin-1.(IL-1.),and interleukin-1.(IL-1.)were detected using enzymelinked immunosorbent assay(ELISA).The protein expressions of inducible nitric oxide synthase(iNOS)and the phosphorylation level of mitogen-activated protein kinase(MAPK)and nuclear factor kappa-B(NF-κB)were detected using Western *** staining was used to detect neuronal ***:The results demonstrated that an alcoholic extract of PZ significantly decreased the levels of NO,IL-1.,TNF-α,and iNOS;increased the expression level of IL-1.;and significantly decreased the phosphorylation levels of MAPK and NF-κ*** inhibitory effects were further confirmed in the AD mouse ***,JHP improved learning and memory function in AD mice,reduced neuronal damage,and enriched the Nissl bodies in the ***,IL-1.and TNF-αin the cortex were significantly downregulated after JHP administration,whereas IL-1.showed increased ***:It was found that JHP reduced neuroinflammatory response in AD mice by targeting the MAPK/NF-κB signaling pathway.

关键词： amyloid-β(Aβ)protein BV2 neuroinflammation Pericarpium Zanthoxyli Radix Rehmanniae

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A contrast of two typical LUCC processes and their driving forces in oases of arid areas: A case study of Sangong River Watershed at the northern foot of Tianshan Mountains

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Science china Earth {1. 2007年第S1期 65-75页

作者： TANG FaShu1.2. {1. Xi1. LUO GePing1. LIN qing1.2.& {2. HaiLong1.2.1.Xinjiang institute of Ecology and Geography, chinese academy of sciences, ürümqi 83001., china 2.Graduate University of chinese academy of sciences, Beijing 1.0049, china

Aerial photographs taken in 1.78 and 1.87, Landsat TM images in 1.98 as well as soil, hydrology and socio-economic data for the oases in Sangong River Watershed were processed by Remote Sensing (RS) and Geographic Information System (GIS). There are two typical agricultural land uses in oases, Farm-based Land Use with large-scale intensified agricultural activities (FLU) and Household Respon-sibility-based Land Use with small-scale activities (HRLU). The Index Model of Land Use/Land Cover Change (LUCC), Weighted Index Sum (WIS) and logistic stepwise regression model were estab-lished to contrast the two typical LUCC processes and their driving forces. The land use patterns were dominated by cropland and grassland for the entire region, and cropland, residential and industrial land were increasing stably. In the HRLU areas, woodland and grassland declined dramatically, but in the FLU areas, grassland decreased only by 1.0}0%, whereas woodland increased by 1..7%. LUCC was stronger in the earlier stage (1.78-1.87) than in the later stage (1.87-1.98) for the entire region. LUCC was more intense in the HRLU areas than in the FLU areas during the entire period (1.78-1.98). Policy was a key factor in the land use change, and water resources were a precondition in land use. Under the control of policy and water resources, the main human driving factors included population and economy, and the main natural restrictions were soil fertility and groundwater depth. Human driving factors controlled the land change in the HRLU areas, but natural restriction factors dominated in the FLU areas. In the mean time, intensification of LUCC in the region had some spatiotemporal implications with a fluctuation of impact factors.

关键词： oases land use driving forces Sangong River logistic

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后生遗传修饰及其对动物克隆的影响

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生物工程学报 2003年第1期19卷 9-12页

作者：李文雍郁卫东陈清轩中国科学院遗传与发育生物学研究所

近年来 ,不断有新的哺乳动物和两栖类动物被成功克隆 ,但这并不能掩盖克隆效率过低和克隆动物异常的现实 ,为了解决这一问题 ,人们对克隆机理进行了大量研究。高度分化的体细胞核在去核的卵质中去分化和再程序化不完全是导致动物克隆失... 详细信息

近年来 ,不断有新的哺乳动物和两栖类动物被成功克隆 ,但这并不能掩盖克隆效率过低和克隆动物异常的现实 ,为了解决这一问题 ,人们对克隆机理进行了大量研究。高度分化的体细胞核在去核的卵质中去分化和再程序化不完全是导致动物克隆失败的主要原因 ,而去分化和再程序化不完全主要是由于基因组去甲基化不充分和过早再甲基化引起克隆胚中甲基化水平比正常胚中偏高所至 ,这可引起一些重要基因的异常表达 ,尤其是印记基因。这些机制的研究对提高克隆效率有着重要意义。

关键词：后生遗传修复动物克隆再程序化甲基化基因组印记

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Detector performance of the Gamma-ray Transient Monitor onboard DRO-A satellite

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Science china(Physics,Mechanics & Astronomy) 2024年第11期67卷 75-90页

作者： Pei-Yi Feng Zheng-Hua An Da-Li Zhang chen-Wei Wang Chao Zheng Sheng Yang Shao-Lin Xiong Jia-Cong {1. Xin-Qiao Li Ke Gong Xiao-Jing {1. Min Gao Xiang-Yang Wen Ya-qing {1. Xiao-Yun Zhao Fan Zhang Xi-Lei Sun Hong Lu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The Gamma-ray Transient Monitor(GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A(DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 2. ke V to 1.MeV. The GTM was equipped with five Gamma-ray Transient Probe(GTP) detector modules utilizing a NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP uses a dedicated dual-channel coincident readout design. In this work, we first studied the impact of different coincidence times on the detection efficiency and ultimately selected a 0.5 μs time coincidence window for offline data processing. To test the performance of the GTPs and validate the Monte-Carlo-simulated energy response, we conducted comprehensive ground calibration tests using the Hard X-ray Calibration Facility(HXCF) and radioactive sources, including the energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively present the ground calibration results and validate the design and mass model of the GTP detector, thus providing the foundation for in-flight observations and scientific data analysis.

关键词： NaI(Tl)detector energy response ground calibration gamma-ray detector DRO-A satellite

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基于细菌视紫红质光子逻辑门的实验研究

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物理学报 2003年第11期52卷 2803-2806页

作者：冯晓强侯洵杨文正杨青陈烽中国科学院西安光学精密机械研究所瞬态光学技术国家重点实验室

研究了基于细菌视紫红质 (简称BR或菌紫质 )变种材料D96N的 3种光逻辑操作 .在 6 33nm激发光照射下 ,菌紫质分子会被激发到M态 ,处于M态的菌紫质对 4 1.0}m的紫光呈较大吸收 ,会抑制同时入射的紫光 .选择合适的紫光强度 ,通过CCD观测被... 详细信息

研究了基于细菌视紫红质 (简称BR或菌紫质 )变种材料D96N的 3种光逻辑操作 .在 6 33nm激发光照射下 ,菌紫质分子会被激发到M态 ,处于M态的菌紫质对 4 1.0}m的紫光呈较大吸收 ,会抑制同时入射的紫光 .选择合适的紫光强度 ,通过CCD观测被抑制的 4 1.0}m检测光透射强度分布 ,模拟了“非”、“或非”、“与非”几种基本的光子逻辑操作 .

关键词：细菌视紫红质光子逻辑门互补抑制非线性光学透射强度分布光致变色光学器件

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Features and trends of the environmental change in the arid areas in Central Asia

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Science china Earth {1. 2007年第S1期 142-148页

作者： ZHOU KeFa1.2. ZHANG {1.3, chen Xi1.& SUN Li1.1.Xinjiang {2. of Ecology and Geography, chinese academy of sciences, ürümqi 83001., china 2.Graduate University of chinese academy of sciences, Beijing 1.0049, china 3 {2. of Remote Sensing and Geographical Information System, Peking University, Beijing 1.0871. china

RS-monitoring index systems of ecological environment changes at a large scale, based on empirical data and trends in environmental change in Central Asia, are developed using NOAA and MODIS data. Moreover, with the help of mathematical statistics and GIS spatial analysis, the degrees, hazards and distribution extent of various possible ecological problems are discussed, environmental changes in Central Asia in 1.90 and 2.05 are separately evaluated, and dynamic changes in the environment in Central Asia over a 1.-year period are analyzed. The results reveal that during the 1.-year period from 1.90 to 2.05, areas of degenerated vegetation in Kazakhstan, Uzbekistan, Turkmenistan, Kirghizstan and Tadzhikistan were enlarged by 0.069×1.5 km2. 0.081.1.5 km2. 0.2.6×1.5 km2. 0.02.×1.5 km2.and 0.1.2.1.5 km2. respectively. The ecological environment in Central Asia was in the state of significant degeneration and even deterioration. This study proves that NOAA and MODIS data can be used to successfully monitor the environment and provide useful results.

关键词： Central Asia ecological environment vegetation coverage GIS RS

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Characteristics and origin of low-organicmatter carbonate source rocks in the Middle-Upper Ordovician, Tarim Basin, northwestern china

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Journal of Palaeogeography 2024年第3期13卷 594-619页

作者： Jun-qing {1. Fu-Jie Jiang Xiong-Qi Pang Hai-Jun Yang Kan-Yuan Shi Bo Pang Hong Pang Jian-Fa {1. Zhuo-Heng {1. Xin-Gang Zhang Song Wu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of Petroleum(Beijing)Beijing 102249China Beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research institute of Petroleum Exploration and Development PetroChina Tarim Oilfield CompanyKorla 841000Xinjiang Uygur Autonomous RegionChina Geological Survey of Canada Natural Resources CanadaCalgary T2L 2A7Canada

The continually-discovered large volumes of marine hydrocarbons indicate a huge exploration potential within the carbonate rocks of Ordovician in the Tarim Basin,northwestern *** Middle-Upper Ordovician(O2.3)carbonate source rocks are at a highly mature *** rocks presently contain a low amount of total organic carbon(TOC_(pd)≤0.5%)(TOC_(pd) means the present-day TOC).A mass balance approach is used to identify the source rocks that have expelled *** characteristics and origin of hydrocarbon expulsion from low-TOC_(pd) source rocks are studied,which are significant for oil exploration in the *** results showed that a low-TOC_(pd) O2.3 source rock having expelled hydrocarbons was type I and had a very narrow oil *** a high rock maturity and a high original TOC(TOCo)value exceeding 1.,nearly 80%of the generated hydrocarbons were *** content of gammacerane and C2. steranes in the oil and source rock extracts were relatively lean,with a V-shaped distribution of regular steranes,suggesting a possible genetic relation between the low-TOC_(pd) source rocks and the marine oil in the Tabei *** planktonic algae or acritarchs were the main hydrocarbon parent materials,distributed in the subsiding platform-slope *** matter was preserved under reducing conditions,and source rocks were formed with a favorable kerogen type and a moderate hydrocarbon generation *** study illustrates the hydrocarbon expulsion of low TOC_(pd) source rocks in northern Tarim Basin,which is greatly significant for analyzing the genesis of marine crude oil in Tarim Basin,and evaluating the distribution of marine source *** research method is theoretically significant for oil and gas exploration in the same type of highlymature carbonate paleobasins.

关键词： Carbonate source rock Mass balance approach Present-day TOC Genesis mechanism Tarim Basin

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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2.mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao Jiang Siyuan Zhao Dong Xie qing {2. Qi Zhao Hao Wu Jian Luo Lili Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2.as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2.in the endothelial-like differentiation of ligament *** acts via the HIF1. pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2.mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1.deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

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重庆温光型小麦雄性核不育系C49s小孢子发生和发育的细胞学研究

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四川大学学报（自然科学版） 2002年第S1期39卷 63-67页

作者：马欣荣邓光兵陈静张小萍余懋群余国东中国科学院成都生物研究所成都610041 重庆市作物所重庆402160

作者对重庆温光型小麦雄性核不育系“C4 9s”、普通小麦“6 9”及不育系“C4 9s 87”与普通小麦“94 6 4”的杂种F1.雄性器官进行切片观察 ,发现其雄配子发育从花粉母细胞减数分裂间期到二分孢子时期绒毡层差异不大 .在减数分裂前... 详细信息

作者对重庆温光型小麦雄性核不育系“C4 9s”、普通小麦“6 9”及不育系“C4 9s 87”与普通小麦“94 6 4”的杂种F1.雄性器官进行切片观察 ,发现其雄配子发育从花粉母细胞减数分裂间期到二分孢子时期绒毡层差异不大 .在减数分裂前期Ⅱ到中期Ⅱ ,不育系绒毡层细胞部分呈双核、三核增大细胞 ,部分出现核解体 ,而普通小麦“6 9”与“C4 9s 87/94 6 4”的杂种F1.中没有出现该现象 .不育系绒毡层细胞比可育系迟解体 .从单核早期开始 ,不育系小孢子发育不正常 ,表现为小孢子收缩变形 ,无核或有核细胞质稀薄 ,细胞核不能定向移动到萌发孔的对侧 .“C4 9s”败育的原因可能与绒毡层发育及液泡的动态性有关 .败育的高峰为单核期 .

关键词：温光型小麦雄性核不育细胞形态学花粉败育

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