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Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in china: A Cross-sectional Survey

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Biomedical and Environmental sciences 2024年第3期37卷 254-265页

作者： SHAN Xiao Yun ZOU Yan HUANG Li Chun JIANG Shan ZHOU Wei Wen QIN Qiu Lan liu Chang {1. LUO Xiao Yan LU Jia Xi MAO De Qian LI Min YANG Zhen Yu YANG Li {2. Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1.31. mothers(896 lactating and 41. non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 1.2.00µg/L and 1.9.95µg/L,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 2..04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

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Enhanced detection of freeze‒thaw induced landslides in Zhidoi county(Tibetan Plateau,china)with Google Earth Engine and image fusion

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Advances in Climate Change Research 2024年第3期15卷 476-489页

作者： Jia-Hui YANG Yan-chen GAO Lang JIA Wen-Juan WANG {1.-Bai WU Francis ZVOMUYA Miles DYCK Hai-Long HE College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Department of Soil Science University of Manitob1Winnipeg MB R3T 2N2Canada Department of Renewable Resources University of Albert1Edmonton AB T6G 2H1Canad

Freeze‒thaw induced landslides(FTILs)in grasslands on the Tibetan Plateau are a geological disaster leading to soil *** landslides reduce biodiversity and intensify landscape fragmentation,which in turn are strengthen by the persistent climate change and increased anthropogenic ***,conventional techniques for mapping FTILs on a regional scale are impractical due to their labor-intensive,costly,and time-consuming *** study focuses on improving FTILs detection by implementing image fusion-based Google Earth Engine(GEE)and a random forest *** of multiple data sources,including texture features,index features,spectral features,slope,and vertical‒vertical polarization data,allow automatic detection of the spatial distribution characteristics of FTILs in Zhidoi county,which is located within the qinghai‒Tibet Engineering Corridor(QTEC).We employed statistical techniques to elucidate the mechanisms influencing FTILs *** enhanced method identifies two schemes that achieve high accuracy using a smaller training sample(scheme A:94.1.;scheme D:94.5%)compared to other methods(scheme B:50.0%;scheme C:95.8%).This methodology is effective in generating accurate results using only~1.%of the training sample size necessitated by other *** spatial distribution patterns of FTILs generated for {1.{1. are similar to those obtained using various other training sample sources,with a primary concentration observed along the central region traversed by the *** results highlight the slope as the most crucial feature in the fusion images,accounting for 93%of FTILs occurring on gentle slopes ranging from 0°to 1.°.This study provides a theoretical framework and technological reference for the identification,monitoring,prevention and control of FTILs in *** developments hold the potential to benefit the management of grassland ecosystem,reduce economic losses,and promote grassland sustainability.

关键词： Permafrost degradation Random forest Thaw slump Spatial distribution Tibetan Plateau

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Fully sprayed MXene-based high-performance flexible piezoresistive sensor for image recognition

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Nano Materials Science 2024年第1期6卷 77-85页

作者： Zhi-Dong Zhang Xue-Feng Zhao qing-Chao Zhang Jie Liang Hui-Nan Zhang Tian-Sheng Zhang {1.-Yang Xue Key Laboratory of Instrumentation Science&Dynamic Measurement of Ministry of Education North University of ChinaTaiyuan030051People's Republic of China State Key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan UniversityShanghai200433People's Republic of China Shanxi Hosipital of Acupuncture and Moxibustion Taiyuan030006People's Republic of China

High-performance flexible pressure sensors provide comprehensive tactile perception and are applied in human activity monitoring,soft robotics,medical treatment,and human-computer ***,these flexible pressure sensors require extensive nano-architectural design and complicated manufacturing and are ***,a highly sensitive,flexible piezoresistive tactile sensor is designed and fabricated,consisting of three main parts:the randomly distributed microstructure on T-ZnOw/PDMS film as a top substrate,multilayer Ti_(3)C_(2.-MXene film as an intermediate conductive filler,and the few-layer Ti_(3)C_(2.-MXene nanosheetbased interdigital electrodes as the bottom *** MXene-based piezoresistive sensor with randomly distributed microstructure exhibits a high sensitivity over a broad pressure range(less than 1. kPa for 1.5 kPa^(-1.)and possesses an out-standing permanence of up to 5000 ***,a 1.-pixel sensor array is designed,and its potential applications in visualizing pressure distribution and an example of tactile feedback are *** fully sprayed MXene-based pressure sensor,with high sensitivity and excellent durability,can be widely used in,electronic skin,intelligent robots,and many other emerging technologies.

关键词： Piezoresistive sensor Ti_(3)C_(2.-MXene T-ZnOw/PDMS film Randomly distributed microstructure

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水稻抗稻瘟病基因Pi-d(t)~1.Pi-b、Pi-ta^2.聚合及分子标记选择

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生物工程学报 2004年第5期20卷 708-714页

作者：陈学伟李仕贵马玉清黎汉云周开达朱立煌中国科学院遗传与发育生物学研究所北京100101 四川农业大学水稻研究所成都611130

冈 4 6B(G4 6B)是水稻生产应用中的一个农艺性状十分优良的保持系 ,其主要的缺陷是稻瘟病抗性较弱 ,通过对地谷 ,BL 1.Pi 4号等三个分别含抗病基因Pi d(t) 1.、Pi b、Pi ta2.的稻瘟病抗性材料与G4 6B聚合杂交 ,并利用抗病基因连锁的分... 详细信息

冈 4 6B(G4 6B)是水稻生产应用中的一个农艺性状十分优良的保持系 ,其主要的缺陷是稻瘟病抗性较弱 ,通过对地谷 ,BL 1.Pi 4号等三个分别含抗病基因Pi d(t) 1.、Pi b、Pi ta2.的稻瘟病抗性材料与G4 6B聚合杂交 ,并利用抗病基因连锁的分子标记对杂交后代进行辅助选择 ,在聚合杂交的F2.及B1.1.群体中共获得了 1.株含Pi d(t) 1.、Pi b、Pi ta2.等三个抗稻瘟病基因的材料 ,其可能的基因型分别为 :三基因杂合体Pi d(t) 1.pi d(t) 1. Pi bpi b Pi ta2.pi ta2.4株 ,双基因杂合体 1.株 ,其中Pi d(t) 1.Pi d(t) 1. Pi bpi b Pi ta2.pi ta2.6株 ,Pi d(t) 1.pi d(t) 1. Pi bpi b Pi ta2.Pi ta2.3株 ,Pi d(t) 1.pi d(t) 1. Pi bPi b Pi ta2.pi ta2.1. ,双基因纯合体Pi d(t) 1.Pi d(t) 1. Pi bpi b Pi ta2.Pi ta2. 1. ,这一研究结果为进一步改良G4 6B的稻瘟病抗性奠定了基础 ,同时这一研究结果表明利用分子标记可快速、有效地实现多个抗病基因的聚合。

关键词：水稻稻瘟病抗病基因分子标记辅助选择育种

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Pharmacokinetics study of extended release formulations of buspirone hydrochloride in Beagle dogs

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沈阳药科大学学报 2008年第S1期25卷 98-99页

作者： CUI Meng-cun1.LI Jing-lai1.chen Yan{1.WANG Xiao-ying1.QIAO Jian-zhong1.ZHANG Zhen-qing1.RUAN Jin-xiu1.1.Beijing {{1. of Pharmacology and Toxicology,Beijing 1.0850,china {1.Beijng Wellso Pharmaceutical CO.,Ltd.,Beijing 1.{1.88,china)

Objective To evaluate the pharmacokinetics(PK)properties of extended release formulations of buspirone hydrochloride in Beagle *** A randomized,two period,two treatment,two sequence crossover bioequivalence study was designed;six healthy Beagle dogs were randomly divided into two groups,each group was orally given buspirone tablets or buspirone extended capsule containing 1. mg buspirone *** samples(about 1.mL)were collected in heparinized tubes before dosing and at 0.33,0.67,1.2.3,4,6,8,1.,1.0}1.,2. h after administration,and were then immediately centrifuged at 3000 rpm for 1. *** pharmacokinetics(PK)properties of the drugs were evaluated using the liquid chromatographic-tandem mass spectrometric(LC-MS/MS)*** The mean tmax was 4.7,0.8 h and Cmax values was 1.8,6.9 μg·L-1.respectively for the sustained-release test(capsule)and reference formulation(tablet).When compared to the tablets,the residence time of the sustained capsules was dramatically prolonged and Cmax was reduced(P1..The initial release speed was slow and *** bioavailability was similar to the common *** The sustained capsule had showed good pharmacokinetics property of sustained-release in the Beagle dogs.

关键词： pharmacokinetics buspirone sustained-release

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Comprehensive effects of traditional chinese medicine treatment on heart failure and changes in B-type natriuretic peptide levels: A meta-analysis

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World Journal of Clinical Cases 2024年第4期12卷 766-776页

作者： Li-Li Xia Shu-Yun Yang Jun-Yao Xu Han-qing {1. Zhu-Yuan Fang Hypertension Research institute Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210004Jiangsu ProvinceChina Department of General Practice Southeast University Affiliated Zhongda HospitalNanjing 210009Jiangsu ProvinceChina

BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and *** traditional chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are *** study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF *** encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established *** results offer crucial insights into the potential advantages and constraints of TCM in HF *** on TCM for HF treatment published since the establishment of the database were searched in four chinese and English databases,including {2. National Knowledge Infrastructure,Wanfang,VIP Information chinese Science and Technology Journal,and *** quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 ***,the quality of evidence was rated according to the GRADE *** A total of 1.98 RCTs were initially *** screening,1. RCTs were finally included in our study,which were published between 2.2. and *** RCTs involved 1.60 HF patients,including 832.in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 82. in the CWM group(CWM treatment).The course of treatments varied from 1.wk to 3 *** syndrome differentiation was analyzed in 1. of the included *** all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP *** meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0

关键词： Traditional chinese medicine Heart failure Comprehensive clinical outcomes Traditional chinese medicine syndrome score B-type natriuretic peptide level Meta-analysis©The Author(s)2.2..Published by Baishideng Publishing Group Inc.

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噬菌体抗体库的构建及抗乳腺癌细胞单链抗体的筛选

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生物工程学报 2004年第5期20卷 667-672页

作者：赵岩王清明付学奇陈吉中范国才陈惠鹏军事医学科学院放射医学研究所北京100850 吉林大学生命科学学院长春130023 军事医学科学院生物工程研究所北京100071

构建抗人乳腺癌细胞MCF 7的噬菌体单链抗体库 ,从中筛选MCF 7细胞特异性单链抗体。用MCF 7细胞免疫BALB C小鼠 ,取脾脏 ,提取总RNA ,用RT PCR技术扩增小鼠抗体重链 (VH)和轻链 (VL)可变区基因 ,经重叠PCR(SOE PCR) ,在体外将VH 和VL 连... 详细信息

构建抗人乳腺癌细胞MCF 7的噬菌体单链抗体库 ,从中筛选MCF 7细胞特异性单链抗体。用MCF 7细胞免疫BALB C小鼠 ,取脾脏 ,提取总RNA ,用RT PCR技术扩增小鼠抗体重链 (VH)和轻链 (VL)可变区基因 ,经重叠PCR(SOE PCR) ,在体外将VH 和VL 连接成单链抗体 (scFv)基因 ,并克隆到噬菌粒载体pCANTAB5E中 ,电转化至大肠杆菌TG1.经辅助噬菌体超感染 ,构建噬菌体单链抗体库。从该抗体库中筛选特异性识别MCF 7细胞的噬菌体单链抗体 ,将表面展示单链抗体的单克隆噬菌体转化大肠杆菌TOP1.进行可溶性表达。成功地构建了库容为 1.2. 1. 6 的抗MCF 7乳腺癌细胞的单链抗体库 ,初步筛选到了与MCF 7细胞特异性结合的scFv,Westernblot检测表明。

关键词：噬菌体抗体库人乳腺癌细胞 MCF-7 单链抗体表达

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基于细菌视紫红质薄膜的空间光调制器实验研究

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物理学报 2003年第3期52卷 761-766页

作者：杨文正杨青陈烽冯晓强侯洵中国科学院西安光学精密机械研究所瞬态光学技术国家重点实验室西安710068 西安交通大学电子科学与技术系西安710049

阐述了利用细菌视紫红质薄膜 (BR薄膜 )优良的非线性光学特性作为光寻址的空间光调制器的实验研究 .BR有两个重要的光敏中间态 (B态和M态 ) ,其吸收带 (B态吸收峰为 5 70nm ,M态吸收峰为 4 1.0}m)重叠区域较少 ,利用其正向 (B→M)和逆向... 详细信息

阐述了利用细菌视紫红质薄膜 (BR薄膜 )优良的非线性光学特性作为光寻址的空间光调制器的实验研究 .BR有两个重要的光敏中间态 (B态和M态 ) ,其吸收带 (B态吸收峰为 5 70nm ,M态吸收峰为 4 1.0}m)重叠区域较少 ,利用其正向 (B→M)和逆向 (M→B)光反应之间转化关系和B态与M态的差异吸收实现了相干光学图像到非相干光学图像的转换实验 .采用经基因改性的细菌视紫红质薄膜 (BRD96N)材料 ,使用 6 70nm相干光作为写入光 ,5 30nm非相干光作为读出光 ,得到了分辨率约为 2.0 0lines mm ,对比度约为 2..1.1.实验结果 .

关键词：实验研究光寻址空间光调制器细菌视紫红质薄膜 BR薄膜非线性光学特性相干光非相干光图像相互转换光学图像光学信息处理

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A novel alternative for pyrogen detection based on a transgenic cell line

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： qing He Chuan-Fei Yu Gang Wu Kai-Qin Wang Yong-Bo Ni Xiao Guo Zhi-Hao Fu Lan Wang De-Jiang Tan Hua Gao Can Wang Gang {1. Xu-Hong {1. Bo {1. Jun-Zhi Wang National institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1.transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

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Pt_(97.4)Mn_(2.6)/Co多层膜的磁性与磁光性质研究

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物理学报 2003年第2期52卷 492-497页

作者：周勋梁冰青王海陈良尧唐云俊王荫君中国科学院物理研究所磁学国家重点实验室复旦大学物理系上海200433

用磁控溅射法制备了Mn含量一定、不同PtMn层厚度的Pt97 4 Mn2. 6 Co磁性多层膜系列 ,通过x射线衍射对该多层膜系列进行结构分析 ;测定了不同PtMn层厚度系列样品的磁滞回线、有效垂直各向异性 ,分析了饱和磁化强度和有效垂直各向异性变... 详细信息

用磁控溅射法制备了Mn含量一定、不同PtMn层厚度的Pt97 4 Mn2. 6 Co磁性多层膜系列 ,通过x射线衍射对该多层膜系列进行结构分析 ;测定了不同PtMn层厚度系列样品的磁滞回线、有效垂直各向异性 ,分析了饱和磁化强度和有效垂直各向异性变化的原因 ;通过测定该多层膜体系的克尔谱 ,分析了一定波长下克尔角随PtMn层厚度变化的规律 .认为克尔角的变化是由于界面的合金化以及原子的极化减小所致 .

关键词： Pt97.3Mn2.6/Co多层膜磁性磁光磁控介质

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