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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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纳米碳对cN1b期甲状腺乳头状癌的手术效果与预后的影响

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岭南现代临床外科 2021年第6期21卷 640-644页

作者：闵耒陈伟春黄志恒香港大学深圳医院甲状腺外科广东深圳518053

目的目前研究普遍认为纳米碳对cN0期甲状腺乳头状癌手术有促进作用,而对c N1b期乳头状癌的作用仍不明。该研究探讨纳米碳在c N1b期乳头状癌手术中的应用。方法回顾香港大学深圳医院2017年1月至2019年6月收治侧颈淋巴转移(cN1b期)的甲状... 详细信息

目的目前研究普遍认为纳米碳对cN0期甲状腺乳头状癌手术有促进作用,而对c N1b期乳头状癌的作用仍不明。该研究探讨纳米碳在c N1b期乳头状癌手术中的应用。方法回顾香港大学深圳医院2017年1月至2019年6月收治侧颈淋巴转移(cN1b期)的甲状腺乳头状癌连续病人142例,手术方式为全甲状腺切除加侧颈淋巴结清扫术。其中77例术中注射纳米碳(纳米碳组),65例未注射(对照组)。对比分析术后侧颈淋巴结检出总数、转移数,术后放射碘治疗前血清刺激性甲状腺球蛋白(Tg),放射碘治疗后非刺激性Tg,术后甲状旁腺激素(PTH)、血钙等。结果纳米碳组与对照组手术时间无显著统计学差异(149±35 min vs.153±39 min,P=0.687),侧颈淋巴结检出总数两组无显著统计学差异(22.1±10.0 vs.21.1±10.7,P=0.583),转移淋巴结数同样无显著统计学差异(4.3±3.1 vs.4.0±3.7,P=0.574)。然而纳米碳组术后刺激性Tg显著高于对照组(2.59 ng/mL vs.0.67 ng/mL,P=0.046),放射碘治疗后抑制性Tg两组则无显著统计学差异(0.1 ng/mL vs.0.1 ng/mL,P=0.205)。纳米碳组术后第一天PTH显著低于对照组(8.1 pmol/L vs.13.6 pmol/L,P=0.044),而术后6个月甲状旁腺功能减退率则无统计学差异。结论术中注射纳米碳对c N1b期甲状腺乳头状侧颈淋巴结检出量、术后肿瘤指标均无改善作用,反而对术后短期甲状旁腺功能有潜在危害。c N1b期乳头状癌术中是否使用纳米碳应慎重考虑。

关键词：甲状腺肿瘤乳头状癌纳米颗粒颈淋巴清扫

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盐酸小檗碱对颅脑创伤模型小鼠双侧丘脑继发性损伤的神经保护作用

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中国现代神经疾病杂志 2017年第4期17卷 282-289页

作者：黄树宣朱飞奇裴中邓旭辉杨志朱瑾华陈淳淳林伟丰汕头大学医学院附属粤北人民医院神经内科韶关512026 广州医科大学附属第一医院神经内科邮政骗码510080 广东省深圳市罗湖区人民医院神经内科邮政编码518001 中山大学附属第一医院神经科广州510080

目的探讨盐酸小檗碱对颅脑创伤(TBI)模型小鼠双侧丘脑继发性损伤(炎症反应、氧化损伤和神经元缺失)的神经保护作用。方法采用自由落体撞击法制备颅脑创伤模型,盐酸小檗碱组小鼠予以盐酸小檗碱50 mg/(kg·d)灌胃21 d,TBI组予等量生理盐... 详细信息

目的探讨盐酸小檗碱对颅脑创伤(TBI)模型小鼠双侧丘脑继发性损伤(炎症反应、氧化损伤和神经元缺失)的神经保护作用。方法采用自由落体撞击法制备颅脑创伤模型,盐酸小檗碱组小鼠予以盐酸小檗碱50 mg/(kg·d)灌胃21 d,TBI组予等量生理盐水灌胃21 d,对照组不予自由落体撞击。免疫组织化学染色计数双侧丘脑诱导型一氧化氮合酶(i NOS)、环氧合酶-2(COX-2)、8-羟基脱氧鸟苷(8-OHd G)和神经元核抗原(Neu N)阳性神经元或胶质细胞数目,免疫荧光染色计数双侧丘脑胶质纤维酸性蛋白(GFAP)阳性星形胶质细胞和离子钙结合蛋白1(Iba1)阳性小胶质细胞数目。结果 3组小鼠颅脑创伤同侧丘脑i NOS(P=0.015)、COX-2(P=0.022)、8-OHd G(P=0.000)和Neu N(P=0.000)阳性神经元或胶质细胞数目以及GFAP阳性星形胶质细胞数目(P=0.024)和Iba1阳性小胶质细胞数目(P=0.000)差异均有统计学意义,其中,TBI组i NOS(P=0.005)、COX-2(P=0.011)和8-OHd G(P=0.000)阳性神经元或胶质细胞数目以及GFAP阳性星形胶质细胞数目(P=0.011)和Iba1阳性小胶质细胞数目(P=0.000)均高于对照组,而Neu N阳性神经元数目低于对照组(P=0.000);盐酸小檗碱组i NOS(P=0.031)、COX-2(P=0.024)和8-OHd G(P=0.008)阳性神经元或胶质细胞数目以及GFAP阳性星形胶质细胞数目(P=0.031)和Iba1阳性小胶质细胞数目(P=0.012)均低于TBI组,仅8-OHd G阳性神经元数目(P=0.014)和Iba1阳性小胶质细胞数目(P=0.024)仍高于对照组,而Neu N阳性神经元数目高于TBI组(P=0.016)、仍低于对照组(P=0.027)。3组小鼠颅脑创伤对侧丘脑仅COX-2(P=0.029)和8-OHd G(P=0.000)阳性神经元或胶质细胞数目差异有统计学意义,其中,TBI组COX-2(P=0.011)和8-OHd G(P=0.000)阳性神经元或胶质细胞数目高于对照组,盐酸小檗碱组COX-2(P=0.047)和8-OHd G(P=0.010)阳性神经元或胶质细胞数目低于TBI组,仅8-OHd G阳性神经元数目仍高于对照组(P=0.004)。结论颅脑创伤可以引起双侧丘脑继发性损伤,尤以同侧丘脑显著,对侧丘脑仅出现炎症反应和氧化损伤;盐酸小檗碱通过抑制颅脑创伤后双侧丘脑炎症反应和氧化损伤而发挥神经保护作用。

关键词：小檗碱颅脑损伤丘脑炎症氧化性应激神经元疾病模型动物

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鏈球菌溶血素“O”(SLO)的稳定性及血清类脂对抗SLO試驗的影响

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微生物学报 1965年第3期 374-381页

作者：舒浚陈維玲李連臣卫生部生物制品研究所

抗SLO试验中,血清效价随结合时间延长时常上升的现象,是草间等提出的,他们认为SLO的抗体结合抗原的速度很不相同。卽抗体有不同的亲和力。1961年Gooder又提出蛋白分解酶说,认为SLO中有链球菌的这种代谢产物,本身就不稳定。血清效价不稳... 详细信息

抗SLO试验中,血清效价随结合时间延长时常上升的现象,是草间等提出的,他们认为SLO的抗体结合抗原的速度很不相同。卽抗体有不同的亲和力。1961年Gooder又提出蛋白分解酶说,认为SLO中有链球菌的这种代谢产物,本身就不稳定。血清效价不稳定能影响诊断指标,造成误诊,需要探求原因,寻找合理的检验方法与条件。但是我们作的试验不能支持上述任何一种假说。得出的结果是血清类脂抑制SLO的作用,经过脱脂或控制结合时间与条件可以排除这种效价变动的现象,兹报告如下:

关键词：血清 SLO 类脂

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服装企业快速反应物流系统的探析

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山东纺织科技 2004年第5期45卷 47-49页

作者：徐晓春陈建伟青岛大学山东青岛266071

提出了快速反应物流概念 ,并阐述了快速反应物流的特征。论述了服装企业实行快速反应物流的现实意义。

关键词：服装企业物流系统物流概念快速反应实行对策探析

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Molecular transformation of dissolved organic matter in refinery wastewaters: Characterized by FT-ICR MS coupled with electrospray ionization and atmospheric pressure photoionization

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Petroleum Science 2023年第1期20卷 590-599页

作者： chen He wei-Ming chen chun-Mao chen Quan Shi State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Oil and Gas Pollution ControlChina University of PetroleumBeijing 102249China Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduSichuan 611756China

Dissolved organic matter(DOM)in refinery wastewater is an extremely complex mixture of various organic *** mass spectrometry,it is impossible to characterize all of the DOM molecules with only one ionization *** this study,negative-ion,electrospray ionization(ESI),positive-ion ESI,and positive-ion atmospheric pressure photoionization(APPI)were coupled with Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS)to analyze the molecular composition of DOM in a refinery wastewater stream during the treatment *** were obvious differences in the heteroatom composition,number of DOM constituents,and chemical properties in refinery wastewater under the three ionization *** CHO and CHOS compounds detected by(+)ESI,basic CHN and CHON compounds detected by(þ)ESI,and hydrocarbons detected by(+)APPI were analyzed to determine the molecular transformations that occurred during *** an anaerobic biological treatment process,acidic CHO and CHOS compounds with a high oxygen content were preferentially removed,and acidic CHO and CHOS compounds with a low oxygen content were *** an aerobic biological process,acidic CHO and CHOS compounds with a low oxygen content were preferentially removed,and acidic CHO and CHOS compounds with a high oxygen content were *** whole biological treatment process has a poor removal efficiency for CHN and CHON compounds,and *** activated carbon(AC)adsorption process removed different heteroatom compounds mainly with a low oxygen content for acidic and basic *** transformation mechanism of CHO and CHOS compounds in the biological treatment process was analyzed by the Kendrick mass defect(KMD)theory and a mass difference network *** the anaerobic process,large amounts of oxygenated CHO and CHOS compounds were degraded by decarboxylation,deoxydation,demethoxylation,and dehydration reactions,and converted to lower oxygen content *** the aerobic

关键词： Refinery wastewater DOM Molecular transformation ESI APPI FT-ICR MS

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铝粉含量及粒度对炸药驱动能力的影响

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科学技术与工程 2016年第31期16卷 179-182页

作者：李昆高立龙陈春燕李巍南海王晓峰西安近代化学研究所西安710065

通过一维平板加速试验方法,研究了铝粉含量及粒度对含铝浇注PBX炸药驱动能力的影响。测试分析了不同铝粉含量或粒度的炸药配方金属加速能力,并进行了工程验证试验。结果表明,在铝含量一定范围内,炸药驱动破片金属加速能力随着铝粉含量... 详细信息

通过一维平板加速试验方法,研究了铝粉含量及粒度对含铝浇注PBX炸药驱动能力的影响。测试分析了不同铝粉含量或粒度的炸药配方金属加速能力,并进行了工程验证试验。结果表明,在铝含量一定范围内,炸药驱动破片金属加速能力随着铝粉含量增加先增加后减小,铝粉含量存在一个最优配比;铝粉尺寸对能量释放有影响。

关键词：含铝炸药驱动能力破片速度粒度含量

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Statistical Measure for Risk-seeking Stochastic Wind Power Offering Strategies in Electricity Markets

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1437-1442页

作者： Dongliang Xiao Haoyong chen chun wei Xiaoqing Bai School of Electric Power South China University of TechnologyGuangzhou 510641China College of Information Engineering Zhejiang University of TechnologyHangzhouChina School of Electrical Engineering Guangxi UniversityNanningChina

This study proposes a statistical measure and a stochastic optimization model for generating risk-seeking wind power offering strategies in electricity markets. Inspired by the value at risk(VaR) to quantify risks in the worst-case scenarios of a profit distribution, a statistical measure is proposed to quantify potential high profits in the best-case scenarios of a profit distribution,which is referred to as value at best(VaB)in the best-case scenarios. Then, a stochastic optimization model based on VaB is developed for a risk-seeking wind power producer, which is formulated as a mixed-integer linear programming problem. By adjusting the parameters in the proposed model, the wind power producer can flexibly manage the potential high profits in the best-case scenarios from the probabilistic perspective. Finally, the proposed statistical measure and riskseeking stochastic optimization model are verified through case studies.

关键词： Electricity market risk-seeking statistical measure stochastic optimization wind power

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Wire Arc Additive Manufactured CuMn_(13)Al_(7)High-Manganese Aluminium Bronze

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Chinese Journal of Mechanical Engineering 2022年第5期35卷 382-392页

作者： chun Guo Baisong Hu Baoli wei Feng chen College of Mechanical Engineering Anhui Science and Technology UniversityBengbu 233000China

In this work,high-manganese aluminium bronze CuMn_(13)Al_(7)samples were prepared by arc additive manufacturing *** phase composition,microstructure,and crystal structure of the high-manganese aluminium bronze CuMn_(13)Al_(7)arc additive manufactured samples were analysed using direct-reading spectrometer,metallographic microscope,scanning electron microscope,and transmission electron *** micro-hardness tester,tensile tester,impact tester,and electrochemical workstation were also used to test the performance of the CuMn_(13)Al_(7)*** studying the microstructure and properties of the CuMn_(13)Al_(7)samples,it was found that preparation of the samples by the arc additive manufacturing technology ensured good forming quality,almost no defects,and good metallurgical bonding inside the *** metallographic structure(α+β+point phase)mainly comprises the following:the metallographic structure in the equiaxed grain region has an obvious grain boundaryα;the metallographic structure in the remelting region has no obvious grain boundaryα;the thermal influence on the metallographic structure produced a weaker grain boundaryαthan the equiaxed grain *** transverse and longitudinal cross sections of the sample had uniform microhardness distributions,and the average microhardness values were 190.5 HV0.1 and 192.7 HV0.1,*** sample also had excellent mechanical properties:yield strength of 301 MPa,tensile strength of 633 MPa,elongation of 43.5%,reduction of area by 58%,Charpy impact value of 68 J/cm^(2)at–20℃,and dynamic potential polarisation curve test ***,it was shown that the average corrosion potential of the sample was–284.5 mV,and the average corrosion current density was 4.1×10–3 mA/cm^(2).

关键词： CuMn_(13)Al_(7) High-manganese aluminium bronze Wire arc additive manufacturing Microstructure Mechanical properties

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New Amines and Activation Modes in Asymmetric Aminocatalysis

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Chinese Journal of Chemistry 2021年第7期39卷 1775-1786页

作者： Zhi-Chao chen wei Du Ying-chun chen Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China College of Pharmacy Third Military Medical UniversityShapingbaChongqing 400038China

Asymmetric aminocatalysis has become one of the most powerful strategies for the transformations of carbonyl substances over the past two ***,we describe the research from our laboratory that significantly expands the horizon of *** includes the development and application of cinchona-based primary amines,fruitful reactions based on HOMO-raising strategy,and the disclosure of amine/thiol double activation catalysis.

关键词： Organocatalysis Aminocatalysis Amine/thiol double catalysis Cycloaddition Domino reactions

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