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SARS-CoV-2 immunity in animal models

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Cellular & Molecular Immunology 2024年第2期21卷 119-133页

作者： zhao chen Yaochang yuan Qingtao Hu Airu Zhu Fenghua chen Shu Li Xin Guan chao Lv Tian Tang Yiyun He Jinling cheng Jie zheng Xiaoyu Hu jingxian zhao Jincun zhao jing Sun State Key Laboratory of Respiratory Disease National Clinical Research Centre for Respiratory DiseaseNational Centre for Respiratory MedicineGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510000China Guangzhou National Laboratory GuangzhouGuangdong 510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s Hospitalthe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen 518005China

The COVID-19 pandemic,which was caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has become a worldwide health crisis due to its ***-CoV-2 infection results in severe respiratory illness and can lead to significant complications in affected *** complications encompass symptoms such as coughing,respiratory distress,fever,infectious shock,acute respiratory distress syndrome(ARDS),and even multiple-organ *** models serve as crucial tools for investigating pathogenic mechanisms,immune responses,immune escape mechanisms,antiviral drug development,and vaccines against ***,various animal models for SARS-CoV-2 infection,such as nonhuman primates(NHPs),ferrets,hamsters,and many different mouse models,have been *** model possesses distinctive features and *** this review,we elucidate the immune response elicited by SARS-CoV-2 infection in patients and provide an overview of the characteristics of various animal models mainly used for SARS-CoV-2 infection,as well as the corresponding immune responses and applications of these models.A comparative analysis of transcriptomic alterations in the lungs from different animal models revealed that the K18-hACE2 and mouse-adapted virus mouse models exhibited the highest similarity with the deceased COVID-19 ***,we highlighted the current gaps in related research between animal model studies and clinical investigations,underscoring lingering scientific questions that demand further clarification.

关键词： COVID-19 SARS-CoV-2 animal models immune response

scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling

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Asian Journal of Andrology 2024年第1期26卷 46-56页

作者： Shi-Wei Liu Jia-Qiang Luo Liang-yu zhao Ning-jing Ou chao-Yang yu-xiang Zhang Hao-Wei Bai Hong-Fang Sun Jian-Xiong Zhang chen-cheng Yao Peng Li Ru-Hui Tian zheng Li Zi-Jue Zhu Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Lab of Reproductive Medicine Nanjing Medical UniversityNanjing 211166China Shanghai Key Lab of Reproductive Medicine Shanghai Jiao Tong University School of MedicineShanghai 200080China Department of Urology Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining *** single-cell RNA sequencing(scRNA-seq)analysis of the testis was performed to identify genes upregulated in *** scRNAseq analysis,we identified the spermatogonia upregulated gene origin recognition complex subunit 6(Orc6),which is involved in DNA replication and cell cycle regulation;its protein expression in the human and mouse testis was detected by western blot and *** explore the potential function of Orc6 in spermatogonia,the C18-4 cell line was transfected with control or Orc6 ***,5-ethynyl-2-deoxyuridine(EdU)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,flow cytometry,and western blot were used to evaluate its effects on proliferation and *** was revealed that ORC6 could promote proliferation and inhibit apoptosis of C18-4 *** RNA sequencing and bioinformatics analysis indicated that Orc6 was involved in the activation of wingless/integrated(Wnt)/β-catenin *** blot revealed that the expression ofβ-catenin protein and its phosphorylation(Ser675)were significantly decreased when silencing the expression of *** findings indicated that Orc6 was upregulated in spermatogonia,whereby it regulated proliferation and apoptosis by activating Wnt/β-catenin signaling.

关键词： cell proliferation ORCG scRNA-seq analysis spermatogonia Wnt/β-catenin signaling

Ultrafast laser-induced decomposition for selective activation of GaAs

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Light(Advanced Manufacturing) 2024年第2期5卷 87-94页

作者： Ke-Mi Xu chao Liu Lei Wang Feng-Chun Pang Xin-jing zhao xian-Bin Li Qi-Dai chen Wei-Qian zhao MIIT Key Laboratory of Complex-field Intelligent Exploration School of Optics and PhotonicsBeijing Institute of TechnologyBeijing100081China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

The manipulation of micro/nanostructures to customise their inherent material characteristics has garnered considerable *** this study,we present the selective activation of gallium arsenide(GaAs)via ultrafast laser-induced decomposition,which correlates with the emergence of ripples on the *** instigated a pronounced enrichment in the arsenic(As)concentration around the surface while inducing a depletion of gallium(Ga)at the structural *** simulations based on first principles exhibited a robust inclination towards the phase separation of GaAs,with the gasification of As-As pairs proving more facile than that of Ga-Ga pairs,particularly above the melting point of *** an illustrative application,a metal-semiconductor hybrid surface was confirmed,showing surface chemical bonding and surface-enhanced Raman scattering(SERS)through the reduction of silver ions on the laser-activated *** laser-induced selective activation holds promise for broader applications,including the controlled growth of Pd and the development of Au/Ag alloy-based platforms,and thereby opens innovative avenues for advancements in semiconductors,solar cell technologies,precision sensing,and detection methodologies.

关键词： Laser-induced activation Decomposition Laser-induced ripples Reduction SERS

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan Ming He Qing-Zhang zhao Wen-Hui Zhang chao-Xin Kan Jian-Ming Zhou Kang-Ning Li Xiao-Fei Wang Jian-cheng Liu zhao-Hua Peng Zhuo Liang Ai-Ling Li Jian zheng Qi-Wen Fan yun-Ju Li You-bao Wang Zhi-Hong Li Yang-Ping Shen Ding Nan Wei Nan yu-Qiang Zhang Jia-Ying-Hao Li Jun-Wen Tian Jiang-Lin Hou Chang-Xin Guo Zhi-cheng Zhang Ming-Hao Zhu yu-Wen chen yu-chen Jiang Tao Tian Jin-Long Ma Yi-Hui Liu jing-yu Dong Run-Long Liu Mei-yue-Nan Ma Yong-Shou chen Wei-Ping Liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

Detector performance of the Gamma-ray Transient Monitor onboard DRO-A satellite

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 75-90页

作者： Pei-Yi Feng zheng-Hua An Da-Li Zhang chen-Wei Wang chao zheng Sheng Yang Shao-Lin Xiong Jia-Cong Liu Xin-Qiao Li Ke Gong Xiao-jing Liu Min Gao xiang-Yang Wen Ya-Qing Liu Xiao-yun zhao Fan Zhang Xi-Lei Sun Hong Lu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The Gamma-ray Transient Monitor(GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A(DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 20 ke V to 1 MeV. The GTM was equipped with five Gamma-ray Transient Probe(GTP) detector modules utilizing a NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP uses a dedicated dual-channel coincident readout design. In this work, we first studied the impact of different coincidence times on the detection efficiency and ultimately selected a 0.5 μs time coincidence window for offline data processing. To test the performance of the GTPs and validate the Monte-Carlo-simulated energy response, we conducted comprehensive ground calibration tests using the Hard X-ray Calibration Facility(HXCF) and radioactive sources, including the energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively present the ground calibration results and validate the design and mass model of the GTP detector, thus providing the foundation for in-flight observations and scientific data analysis.

关键词： NaI(Tl)detector energy response ground calibration gamma-ray detector DRO-A satellite

Weighted cooperative routing for wireless mobile Ad-hoc network

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 16-21页

作者： zhao xian-jing zheng bao-yu chen chao Institute of Signal and Information Processing Nanjing University of Posts and Telecommunications Nanjing 210003 China

A novel weighted cooperative routing algorithm （WCRA） is proposed in this article, which was on the basis of a weighted metric with maximal remaining energy （MRE） of the relays and the maximal received SNR （MRS） of the nodes. Moreover, a cooperative routing protocol was implemented on the basis of WCRA. Then simulation is done on network simulation （NS-2） platform to compare the performances of MRS, MRE and WCRA with that of noncooperative destination-sequenced destination-sequenced distance-vector （DSDV） protocol. The simulative results show that WCRA obtains a performance tradeoff between MRE and MRS in terms of delivery ratio and network lifetime, which can effectively improve the network lifetime at an acceptable loss of delivery ratio.

关键词： weighted cooperative routing Ad-hoc networks,quality of service DSDV routing protocol

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang xiang‑Biao Qiu jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao chen Rui‑Rui Fan Kang Sun jing‑yu Tang Rong Zhang Han‑Tao jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie bao Ping Cao Qi‑Ping chen Zhen chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑yu Jiang Wei Jiang Zhi‑Jie Jiang zheng‑Yao Jin Ling Kang Bo Li chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑chao Ruan zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑cheng Wang zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang xian‑Peng Zhang yu‑Liang Zhang yue Zhang Zhi‑Yong Zhang Mao‑yuan zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao chen jing-yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu zheng-Yao Jin Xing-Zhu Cui Tian-xiang chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie bao Ping Cao Qi-Ping chen Zhen chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-chao Ruan zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-cheng Wang zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang xian-Peng Zhang yu-Liang Zhang yue Zhang Zhi-Yong Zhang Mao-yuan zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

The Design of GECAM Scientific Ground Segment

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Research in Astronomy and Astrophysics 2024年第10期24卷 1-10页

作者： Shijie zheng Liming Song xiang Ma Ping Wang Rui Qiao yue Huang Xiaoyun zhao Hongmei Zhang Xiaobo Li Mingyu Ge Gang chen Gongxing Sun Wenxi Peng Ce Cai Wei chen Yanqi Du Dongya Guo Bing Li chaoyang Li Jianhui Li Qingxin Li jing Liang Jiacong Liu Ge Ou Dongli Shi jingyan Shi Xinying Song Jin Wang Wenshuai Wang Hong Wu Shuo Xiao Wangchen Xue Min Yao Jianying Ye Kai Zhang Peng Zhang Xiaolu Zhang Yanqiu Zhang Guoying zhao Shiyi zhao chao zheng Shaolin Xiong Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Southwest Jiaotong University Chengdu 611756China xiangtan University Changsha 411105China Qufu Normal University Qufu 273165China

The Gravitational wave burst high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)is a dedicated mission for monitoring high-energy *** we report the design of the GECAM Scientific Ground Segment(GSGS)in terms of the scientific requirements,including the architecture,the external interfaces,the main function,and *** from the analysis and verification results during the commissioning phase,the GSGS functions well and is able to monitor the status of the payloads,adjust the parameters,develop the scientific observation plans,generate the scientific data products,analyze the data,***,the on-orbit operation and scientific researches of GECAM are guaranteed.

关键词： gravitational waves gamma-rays:general telescopes