检索结果-南通市图书馆

耐药菌的环境分布、传播及新型抗菌技术研究进展

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

环境化学 2024年第1期43卷 1-13页

作者：欧阳富成曹慧明陈博磊李准洁李智梁勇南方医科大学第一临床医学院广州510515 持久性有毒污染物环境与健康危害湖北省重点实验室环境与健康学院江汉大学武汉430056 中部战区总医院骨科武汉430070

抗生素的广泛使用导致细菌耐药性增加、多重耐药菌菌群数量急剧增多,严重威胁着人类生命健康.环境中耐药菌(ARB)及耐药基因(ARGs)的存在给临床治疗耐药菌感染带来了巨大挑战.有关医院中常见耐药致病菌的研究已有很多,尚缺乏环境中耐药... 详细信息

抗生素的广泛使用导致细菌耐药性增加、多重耐药菌菌群数量急剧增多,严重威胁着人类生命健康.环境中耐药菌(ARB)及耐药基因(ARGs)的存在给临床治疗耐药菌感染带来了巨大挑战.有关医院中常见耐药致病菌的研究已有很多,尚缺乏环境中耐药菌的分布、传播及新型耐药菌抗菌技术等的相关研究.本文综述了耐药菌的环境分布特征及其传播机制,概述了新型抗菌技术及其应用,最后展望了有关环境耐药菌研究的未来发展方向.

关键词：耐药菌环境分布传播抗菌技术展望

Self-adaptive hydrogel for breast cancer therapy via accurate tumor elimination and on-demand adipose tissue regeneration

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第1期35卷 371-378页

作者： Ran Tian Xinyu Qiu Wenyun Mu bolei Cai Zhongning Liu Shiyu Liu Xin chen School of Chemical Engineering and Technology Department of Chemical EngineeringShaanxi Key Laboratory of Energy Chemical Process IntensificationXi'an Jiao Tong UniversityXi'an 710049China School of Stomatology State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral DiseasesDepartment of Preventive DentistryThe Fourth Military Medical UniversityXi'an 710032China School of Stomatology State Key Laboratory of Military StomatologyDepartment of Oral and Maxillofacial SurgeryThe Fourth Military Medical UniversityXi'an 710032China Department of Prosthodontics Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China School of Stomatology State Key Laboratory of Military StomatologyNational Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringThe Fourth Military Medical UniversityXi'an 710032China

The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer ***,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection *** hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed *** bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose ***,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.

关键词： Smart hydrogel with self-adaptable size Breast cancer therapy Dual responsive cargoes release Selective tumor elimination On-demand adipose tissue regeneration Effective bacteria inhibition

Development of a Completely New PFOS Alternative with Lower Surface Tension for Minimizing the Environmental Burden

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2023年第3期39卷 408-414页

作者： ZHOU Zhen GUO Rui chen bolei WANG Ling CAO Huiming WEI Cuiyun HU Ming ZHAN Yuhang LI Shutao WANG Yawei LIANG Yong Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances School of Environment and HealthJianghan UniversityWuhan430056P.R.China Hubei Hengxin Chemical Co. Ltd.Yingcheng432400P.R.China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085P.R.China

Improving the technical performance of related industrial products is an efficient strategy to reducing the application quantities and environmental burden for toxic chemicals.A novel polyfluoroalkyl surfactant potassium 1,1,2,2,3,3,4,4-octafluoro-4-(perfluorobutoxy)butane-1-sulfonate(F404)was synthesized by a commercializable *** had a surface tension(γ)of 18.2 mN/m at the critical micelle concentration(CMC,1.04 g/L),significantly lower than that of perfluorooctane sulfonate(PFOS,ca.33.0 mN/m,0.72 g/L),and exhibited remarkable suppression of chromium-fog at a dose half that of *** half maximal inhibitory concentration(IC_(50))values in HepG2 cells and the lethal concentration of 50%(LC_(50))in zebrafish embryos after 72 hpf indicated a lower toxicity for F404 in comparison to *** a UV/sulphite system,89.3%of F404 were decomposed after 3 h,representing a defluorination efficiency of 43%.The cleavage of the ether C—O bond during the decomposition would be expected to form a short chain·C_(4)F_(9) as the position of the ether C—O in the F404 fluorocarbon chains is C4—*** ether unit is introduced in the perfluoroalkyl chain to improve water solubility,biocompatibility and degradation,thereby minimizing the environmental burden.

关键词： Perfluorooctane sulfonate(PFOS) Surface tension Chromium-fog inhibitor Perfluoropolyether

From Environmental Toxicants to Antibacterial Agents:BPA Analogues Selectively Inhibit the Growth of Gram-Positive Bacteria by Disturbing Biosynthesis of the Cell Wall

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environment & Health 2023年第4期1卷 291-299页

作者： Huiming Cao Zhunjie Li bolei chen Jing Wang Zhen Zhou Zhi Li Yun Qian Yong Liang Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances School of Environment and HealthJianghan UniversityWuhan 430056P.R.China Department of Orthopedics General Hospital of Central Theater Command of Chinese People’s Liberation ArmyWuhan 430070P.R.China Department of Biomedical Engineering Florida International UniversityMiamiFlorida 33174United States

Remarkable antibacterial activity of BPA analogues especially for tetrabromobi-sphenol A against Staphylococcus aureus 25923(Sa25923)and methicillin-resistant Staphylococcus aureus(MRSA)has been reported in our previous ***,the toxic effects of the compounds as environmental contaminants on the endocrine system limited their applications in the field of medicine and *** the abuse of antibiotics has led to the emergence of multiple super-resistant bacteria,we considered that structural modifications based on the BPA structure will be available for molecular designing of potential antimicrobial agents without drug *** this study,to further improve the antibacterial activity and reduce the biological toxicity,we performed the computational models to evaluate the binding affinities of BPA analogues to the potential target DltA protein in the biosynthesis of cell wall.A series of synthesized achiral analogues ofα,α,α′-tris(4-hydroxyphenyl)-1-ethyl-4-isopropylbenzene(α,α,α′-TEIB)exhibited low minimum inhibitory concentration against Sa25923 and MRSA(2 or 1μg mL−1).Especially,the analogue A4 did not induce the drug-resistant mutants for all tested Gram-positive bacterial strains and exhibited relatively lower cytotoxicity in HepG2 *** developed classification model based on the light gradient boosting algorithm showed the superior performances on the internal robustness and generalization ability for the ligand-based virtual screening of bisphenol and polyphenol antimicrobial ***,our findings suggest that the molecular structure ofα,α,α′-TEIB is promising as a scaffold,which is expected to achieve a breakthrough in the development of antibiotics which can prevent the invasion of MRSA and other super bacteria.

关键词： Environmental toxicants Antibacterial agents BPA analogues Lipoteichoic acid Virtual screening Machine learning

Intermediate phase assisted sequential deposition of reverse-graded quasi-2D alternating cation perovskites for MA-free perovskite solar cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

InfoMat 2023年第3期5卷 134-149页

作者： Shaofu Wang Yumin Liu Junjie Zou Junjun Jin Yun Jiang Tao Zeng Wenyan Zhao Rong-Xiang He bolei chen Yu chen Shuoxue Jin Hong-Xiang Li Zhipeng Xie Chang-An Wang Weiwei Sun Qiang Cao Xing-Zhong Zhao School of Materials Science and Engineering National Engineering Research Center for Domestic&Building CeramicsJingdezhen Ceramic UniversityJingdezhenthe People Republic of China School of Physics and Technology Institute of Technological SciencesKey Laboratory of Artificial Micro/Nano StructuresMinistry of EducationWuhan UniversityWuhanthe People Republic of China Institute for Interdisciplinary Research(IIR) Key Laboratory of Optoelectronic Chemical Materials and DevicesMinistry of EducationJianghan UniversityWuhanthe People Republic of China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijingthe People Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduthe People Republic of China College of Aerospace Science and Engineering National University of Defense TechnologyChangshathe People Republic of China

One-step deposition approaches have been widely applied and developed in the fabrication of quasi-2D ***,the regulation of quantum wells(QWs)and crystalline orientation is difficult and complicated when using this *** deposition is another widespread synthetic approach for preparing perovskite films and perovskite dimension *** this article,δ-CsPbI_(3)intermediate phase assisted sequential(IPAS)deposition is successfully carried out to fabricate MA-free quasi-2D ACI *** amount of theδ-CsPbI_(3)intermediate phase in the PbI2 layer and the concentration of GAI molecule in the IPA solution both play important roles in the production of MA-free quasi-2D ACI perovskite *** n value of the MA-free quasi-2D ACI perovskites can be adjusted,which affects the photovoltaic performance and device *** with one-step deposition,the MA-free quasi-2D ACI perovskites prepared via IPAS deposition have opposite reverse-graded QW distribution and improved vertical orientation,leading to a remarkable PEC of up to 18.86%and allowing the preparation of unpackaged devices with prominent working stability(80%,400 h).The underlying mechanism and crystallization pathway of IPAS deposition confirm that sequential deposition has unique superiority in regulating the QW distribution and crystalline orientation of quasi-2D perovskites.

关键词： intermediate phase quantum well distribution quasi-2D perovskite sequential deposition solar cells

D-氨基酸在细菌生理中的结构性能和调节功能的研究进展

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微生物学报 2018年第12期58卷 2078-2086页

作者：纪芳陈博磊梁勇江汉大学医学院湖北武汉430056 江汉大学交叉学科研究院湖北武汉430056 江汉大学环境与健康研究院湖北武汉430056

除最小的甘氨酸外,所有的氨基酸(amino acid,AA)都有手性,以D-氨基酸(DAA)或L-氨基酸(LAA)形式存在。DAA广泛存在于各类生物中,尤其是细菌。DAA虽没有参与蛋白质合成,但DAA尤其是非典型DAA在细菌生理中具有很多特殊功能。在结构性能方面... 详细信息

除最小的甘氨酸外,所有的氨基酸(amino acid,AA)都有手性,以D-氨基酸(DAA)或L-氨基酸(LAA)形式存在。DAA广泛存在于各类生物中,尤其是细菌。DAA虽没有参与蛋白质合成,但DAA尤其是非典型DAA在细菌生理中具有很多特殊功能。在结构性能方面,DAA是细菌细胞壁肽聚糖的重要组分,并参与组成某些非核糖体合成途径产生的生物多肽,少数细菌能产生含有D-Glu的γ-聚谷氨酸。对细胞个体而言,DAA能调节细菌表面电荷和自溶素活性,抑制细菌芽胞萌发,调节稳定期细胞壁的重塑及调节病原菌的毒力等。对细菌群落而言,DAA对生物膜的解聚和细菌生态也具有调控作用。此外,某些DAA还能直接作为营养支持某些细菌的生长,而有的DAA则具有抑菌作用。本文主要综述了DAA在细菌生理过程中发挥多项功能的研究进展。

关键词： D-氨基酸非典型D型氨基酸细菌细胞壁生物膜细菌生理活动的调节

3D Printing Challenges in Enabling Rapid Response to Public Health Emergencies

在线全文

学校读者我要写书评

暂无评论

The Innovation 2020年第3期1卷 1-2页

作者： Dingyi Wang Junpeng Zhang Qian Liu bolei chen Yong Liang Ligang Hu Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances&Institute of Environment and Health Jianghan UniversityWuhan 430056China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310000China

The coronavirus disease 2019(COVID-19)epidemic has become a global public health emergency over last *** of September 14th,over 28,000,000 confirmed cases and 917,000 deaths have been reported from all over the world.1 Its large-scale outbreak and pandemic cause an extreme shortage of personal protective equipment(PPE)andmedical supplies such as face masks,testing kits,nasopharyngeal swabs,and medical ventilators in the early stage,which consequently leads to the collapse of local medical systems.2 It turns out that measures like lockdown and travel bans are themost effective strategies in response to an epidemic at an early stage with insufficient knowledge.3 However,those physical isolation measures will inevitably result in work stoppages and have a great impact on industrial *** supply of raw materials and components,and the production and transportation of final products are greatly restricted under a global supply chain.4 This further aggravates the shortage of anti-epidemic supplies and so the vicious cycle begins.

关键词： measures travel protective

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Profile of *** chen

Science China(Life Sciences) 2024年第10期67卷 2062-2063页

作者： chen, Songlin Yellow Sea Fisheries Res Inst Qingdao Peoples R China

For decades,*** has been engaged in fish germplasm preservation,sex control and research focusing on molecular breeding for disease *** discovered the first sex-specific molecular marker of fish(chen et al.,2007),deciphered the first fish genome(Chinese tongue sole)in China,revealed the sex determination mechanism in fish(chen et al.,2014),and created molecular sex control *** also discovered the molecular mechanism of metamorphosis in flatfish(Shao et al.,2017)and developed China's first fish disease-resistant breeding gene chip,“YUXIN No.1”.

关键词： technology breeding

在线全文

学校读者我要写书评

暂无评论

基于树莓派和神经计算棒的智能家居机器人

单片机与嵌入式系统应用 2019年第7期19卷 56-59,64页

作者：陈铂垒中南民族大学计算机科学学院

利用树莓派、Intel二代神经计算棒、Arduino mega2560设计了一种基于科大讯飞语音识别API和ROS机器人操作系统的智能家居机器人。利用OpenVINO软件平台对神经网络进行优化和视觉推理,使机器人更加智能化。本文主要介绍了智能家居机器人... 详细信息

利用树莓派、Intel二代神经计算棒、Arduino mega2560设计了一种基于科大讯飞语音识别API和ROS机器人操作系统的智能家居机器人。利用OpenVINO软件平台对神经网络进行优化和视觉推理,使机器人更加智能化。本文主要介绍了智能家居机器人系统的整体设计、硬件组成、软件设计和算法实现等。经过测试,本文设计的智能家居机器人灵活性好、机动性强,能够较好地实现人机交互和家电控制。

关键词：树莓派 Intel二代神经计算棒 Arduino mega2560 ROS OpenVINO