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Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020

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Chinese Medical Journal 2021年第7期134卷 783-791页

作者： Wei Cao hong-da chen Yi-Wen Yu Ni Li Wan-Qing chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

Background:Cancer is one of the leading causes of death globally,but its burden is not *** 2020 has newly updated the estimates of cancer *** study summarizes the most recent changing profiles of cancer burden worldwide and in China and compares the cancer data of China with those of other ***:We conducted a descriptive secondary analysis of the GLOBOCAN 2020 *** depict the changing global profile of the leading cancer types in 2020 compared with 2018,we extracted the numbers of cases and deaths in 2018 from GLOBOCAN *** also obtained cancer incidence and mortality from the 2015 National Cancer Registry Report in China when sorting the leading cancer types by new cases and *** the leading cancer types according to sex in China,we summarized the estimated numbers of incidence and mortality,and calculated China’s percentage of the global new cases and ***:Breast cancer displaced lung cancer to become the most leading diagnosed cancer worldwide in ***,liver,stomach,breast,and colon cancers were the top five leading causes of cancer-related death,among which liver cancer changed from the third-highest cancer mortality in 2018 to the second-highest in *** accounted for 24%of newly diagnosed cases and 30%of the cancer-related deaths worldwide in *** the 185 countries included in the database,China’s age-standardized incidence rate(204.8 per 100,000)ranked 65th and the age-standardized mortality rate(129.4 per 100,000)ranked *** two rates were above the global *** cancer remained the most common cancer type and the leading cause of cancer death in ***,breast cancer became the most frequent cancer type among women if the incidence was stratified by *** of colorectal cancer and breast cancer increased *** leading causes of cancer death varied minimally in ranking from 2015 to 2020 in *** cancers,including stomach,colorectal,liver,and es

关键词： Cancer incidence Cancer mortality Changing profile China GLOBOCAN 2020 Worldwide

Divergent detection rates of fecal immunochemical test and questionnaire-based risk assessment for detecting proximal and distal advanced colorectal adenomas

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Chinese Medical Journal 2021年第5期134卷 605-607页

作者： hong-da chen Ming Lu Yu-Han Zhang Min dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

To the Editor:Fecal immunochemical tests(FTTs)are immunoassays that are designed to detect human hemoglobin to indicate the occurrence of colonic neopla-sia,which have been widely used in global colorectal cancer(CRC)screening *** diagnostic studies demonstrated that strong gradient in site-specific sensitivity existed with typically higher rate for advanced adenoma located in distal colon/rectum than that in the proximal parts,which may be explained by the colonic transition time affecting the degradation of hemoglobin,and the shape of adenoma(pedunculated,flat,and sessile)in different anatomic regions.

关键词： adenoma colorectal proximal

Fabrication of Dry Electrode for Recording Bio-potentials

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Chinese Physics Letters 2011年第1期28卷 47-49页

作者： WANG Yu GUO Kai PEI Wei-Hua GUI Qiang LI Xiao-Qian chen hong-da YANG Jian-hong Institute of Microelectronics School of Physical Science and Technology Lanzhou University Lanzhou 730000 State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing 100083

Development of minimally invasive dry electrodes for recording biopotentials is presented. The detailed fabrication process is outlined. A dry electrode is formed by a number of microneedles. The lengths of the microneedles are about 150μm and the diameters are about 50μm. The tips of the microneedles are sharp enough to penetrate into the skin. The silver/silver chloride is grown on microneedle arrays and demonstrates good character. The electrocardiogram shows that the dry electrode is suitable for recording biopotentials.

关键词： Instrumentation and measurement Medical physics Biological physics

Colorectal cancer incidence and mortality:the current status,temporal trends and their attributable risk factors in 60 countries in 2000–2019

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Chinese Medical Journal 2021年第16期134卷 1941-1951页

作者： Bin Lu Na Li chen-Yu Luo Jie Cai Ming Lu Yu-Han Zhang hong-da chen Min dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Prevention Hunan Cancer HospitalChangshaHunan 410006China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China.

Background:Globally,colorectal cancer(CRC)imposes a substantial burden on healthcare systems and confers considerable medical *** aimed to evaluate the global and regional burden in epidemiological trends and factors associated with the incidence and mortality of ***:We used data from the GLOBOCAN database to estimate CRC incidence and mortality worldwide in 2020 and their association with the human development index(HDI).Trends of age-standardized rates of incidence and mortality in 60 countries(2000–2019)were evaluated by Joinpoint regression analysis using data of Global Burden of Disease *** association between exposure to country-level lifestyle,metabolic and socioeconomic factors obtained from the World Health Organization Global Health Observatory and World Bank dataBank data and CRC incidence and mortality was determined by multivariable linear ***:CRC incidence and mortality varied greatly in the 60 selected countries,and much higher incidence and mortality were observed in countries with higher HDIs,and vice *** 2000 to 2019,significant increases of incidence and mortality were observed for 33 countries(average annual percent changes[AAPCs],0.24–3.82)and 18 countries(AAPCs,0.41–2.22),respectively.A stronger increase in incidence was observed among males(AAPCs,0.36–4.54)and individuals<50 years(AAPCs,0.56–3.86).Notably,15 countries showed significant decreases in both incidence(AAPCs,0.24 to2.19)and mortality(AAPCs,0.84 to2.74).A significant increase of incidence among individuals<50 years was observed in 30 countries(AAPCs,0.28–3.62).Countries with higher incidence were more likely to have a higher prevalence of alcohol drinking,higher level of cholesterol level,higher level of unemployment,and a poorer healthcare ***:Some high-HDI countries showed decreasing trends in CRC incidence and mortality,whereas developing countries that previously had low disease burden showed significantly increas

关键词： Colorectal cancer burden Trend Incidence Mortality Risk factor GLOBOCAN Global Burden of Disease

Head-to-head comparison of the test performance of selfadministered qualitative vs. laboratory-based quantitative fecal immunochemical tests in detecting colorectal neoplasm

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Chinese Medical Journal 2021年第11期134卷 1335-1344页

作者： Ming Lu Yu-Han Zhang Bin Lu Jie Cai cheng-cheng Liu hong-da chen Min dai Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Background:Fecal immunochemical tests(FITs)are the most widely used non-invasive tests in colorectal cancer(CRC)***,evidence about the direct comparison of the test performance of the self-administered qualitative a laboratory-based quantitative FITs in a CRC screening setting is ***:Based on a CRC screening trial(TARGET-C),we included 3144 pre-colonoscopy fecal samples,including 24 CRCs,230 advanced adenomas,622 non-advanced adenomas,and 2268 participants without significant findings at *** selfadministered qualitative FITs(Pupu tube)with positivity thresholds of 8.0,14.4,or 20.8 mg hemoglobin(Hb)/g preset by the manufacturer and one laboratory-based quantitative FIT(OC-Sensor)with a positivity threshold of 20 mg Hb/g recommended by the manufacturer were tested by trained staff in the central *** diagnostic performance of the FITs for detecting colorectal neoplasms was compared in the different scenarios using the preset and adjusted thresholds(for the quantitative FIT).Results:At the thresholds preset by the manufacturers,apart from the qualitative FIT-3,significantly higher sensitivities for detecting advanced adenoma were observed for the qualitative FIT-1(33.9%[95%CI:28.7–39.4%])and qualitative FIT-2(22.2%[95%CI:17.7–27.2%])compared to the quantitative FIT(11.7%[95%CI:8.4–15.8%]),while at a cost of significantly lower ***,such difference was not observed for detecting *** scenarios of adjusting the positivity thresholds of the quantitative FIT to yield comparable specificity or comparable positivity rate to the three qualitative FITs accordingly,there were no significant differences in terms of sensitivity,specificity,positive/negative predictive values and positive/negative likelihood ratios for detecting CRC or advanced adenoma between the two types of FITs,which was further evidenced in ROC ***:Although the self-administered qualitative and the laboratory-based quantitat

关键词： Fecal immunochemical test Test performance Colorectal neoplasm Screening

A novel linear microprobe array for the fabrication of neural microelectrodes

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Science China(Technological Sciences) 2015年第2期58卷 346-351页

作者： ZHAO Shan Shan PEI Wei Hua ZHAO Hui WANG Yi Jun chen San Yuan chen Yuan Fang ZHANG He GUO Dong Mei GUI Qiang chen hong da State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Institute for Neural Computation University of California San Diego

A novel linear microprobe array(LMPA)has been developed by a conventional microfabrication method from *** LMPA leverages the properties of conventional microwire with additional features of naturally formed regular *** the help of periodic microprobe arrays and double-side V-grooves fabricated in advance between each pair of the two microprobes’rear ends,the number of microprobe units for assembly in one array can be flexibly chosen by cleavage fracture from the *** fabrication method was demonstrated and the prototype device was assessed by electrochemical impedance spectroscopy(EIS)and in vivo *** SNR of the spikes recorded was 6.

关键词： LMPA regular spacing cleavage fracture V-groove

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北京艺术中心项目的规划统筹及管控传导

建筑技术 2024年第12期55卷 1413-1415页

作者：恽爽于润东陈宏达王康吴良良北京清华同衡规划设计研究院有限公司北京100085 北京城市副中心投资建设集团有限公司北京101117 北京建工集团有限责任公司北京100055

基于北京城市副中心绿心片区规划,对北京艺术中心、图书馆和博物馆三大建筑进行了整体统筹和管控传导。规划涵盖三大建筑的选址布局、定位规模、征集整合、方案比选、实施保障等内容,并在北京艺术中心建设的前中期发挥了相应的责任担当... 详细信息

基于北京城市副中心绿心片区规划,对北京艺术中心、图书馆和博物馆三大建筑进行了整体统筹和管控传导。规划涵盖三大建筑的选址布局、定位规模、征集整合、方案比选、实施保障等内容,并在北京艺术中心建设的前中期发挥了相应的责任担当和使命作用。

关键词：规划统筹管控传导方案比选

Light Extraction Enhancement of GaN LED with a Two-Dimensional Photonic Crystal Slab

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Chinese Physics Letters 2011年第5期28卷 161-163页

作者： LIU hong-Wei KAN Qiang WANG Chun-Xia HU Hai-Yang XU Xing-Sheng chen hong-da School of Electronics and Information Engineering Tianjin Polytechnic UniversityTianjin 300160 Institute of Semiconductors Chinese Academy of SciencesBeijing 100083

Light extraction effects ora photonic crystal slab with a micrometer scale lattice constant are studied.A GaN light emitting diode(LED)with a photonic crystal slab is *** light extraction effects and the enhancement mechanism are *** theoretical analysis,it is found that the characteristics of LED light emission are modulated by the photonic crystal *** results show that the LED light emission intensity is enhanced by 38%due to guide mode extracting by the photonic crystal.

关键词： GaN Crystal light

Risk factors for gastric cancer:a large-scale,population-based case-control study

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Chinese Medical Journal 2021年第16期134卷 1952-1958页

作者： Rui Zhang He Li Ni Li Ju-Fang Shi Jiang Li hong-da chen Yi-Wen Yu Chao Qin Jian-Song Ren Wan-Qing chen Jie He Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College/Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and ImplementBeijing 100021China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

Background:Early detection of gastric cancer(GC)has been the topic of major efforts in *** study aimed to explore the risk factors associated with GC and to provide evidence for the selection of a high-risk population of ***:Based on the cancer screening cohort of the National Cancer Screening Program in Urban China,GC patients diagnosed by endoscopy and pathological examinations constituted the case group,and controls were 1:3 matched by sex and age(±5 years)*** variables were selected by univariable analysis of factors such as body mass index(BMI),dietary habits,lifestyle,stomach disease history,and family history of GC;and multivariable logistic regression was used to analyze the influencing factors of GC and to calculate the odds ratio(OR)of related factors and its 95%confidence interval(CI).Results:A total of 215 GC cases and 645 matched healthy controls were included in the final analysis,with a median age of 61 years for the case and control *** analysis showed that high educational level(above primary school)(OR=0.362,95%CI=0.219–0.599,P<0.001),overweight/obesity(BMI≥24 kg/m2;OR=0.489,95%CI=0.329–0.726,P<0.001),cigarette smoking(OR=3.069,95%CI=1.700–5.540,P<0.001),alcohol consumption(OR=1.661,95%CI=1.028–2.683,P=0.038),history of stomach disease(OR=6.917,95%CI=4.594–10.416,P<0.001),and family history of GC in first-degree relatives(OR=4.291,95%CI=1.661–11.084,P=0.003)were significantly correlated with the occurrence of *** analyses by age and gender indicated that GC risk was still increased in the presence of a history of stomach disease.A history of chronic gastritis,gastric ulcer,or gastric polyposis was positively associated with GC,with adjusted ORs of 4.155(95%CI=2.711–6.368),1.839(95%CI=1.028–3.288),and 2.752(95%CI=1.197–6.326).Conclusions:Subjects who smoke,drink,with history of stomach disease and family history of GC in first-degree relatives are the high-risk populations for ***,attention shou

关键词： Risk factors Gastric cancer Case-control study Cancer screening