检索结果-南通市图书馆

Antibacterial and angiogenic dual-functional fibrous membrane dressing for infected wound healing

在线全文

学校读者我要写书评

暂无评论

Biomedical Engineering Communications 2024年第1期3卷 4-14页

作者： Chao Zhou che Zhao hao-Yu dai Tian-Jun Zhu jia-Pei Yao li chen Jing-Jing Wen jia ling Celestine Loh xin-Die Zhou Yong Huang School of Medical and Health Engineering Changzhou UniversityChangzhouJiangsu 213164China School of Aerospace and Mechanical Engineering Changzhou Institute of TechnologyChangzhouJiangsu 213032China Department of Orthopedics The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou Medical CenterNanjing Medical UniversityChangzhou 213000China Duke-NUS Graduate Medical School National University of SingaporeKent Ridge 169547Singapore

Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental *** full-thickness skin defects becomes especially challenging when infections and vascular injuries are *** wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound *** address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic ***:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic ***:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air *** not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo ***:These findings highlight the immense potential of this wound dressing material for future clinical applications.

关键词： electro spinning antibacterial polymer angiogenesis wound healing membrane dressing

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming Zhang Zhen-Fei Wang En-Tao li Chang-Fa Fan Ke Song Yuan-Guo li Run-Ze ye Fang-Xu li dai-Yun Zhu Jie Zhang Zhuang-Zhuang Shi Ming-Zhu Zhang liang-Jing li Shi-Jing Shen Song Jin Ya-Wei Zhang Wei-Guang Fu lin Zhao Wen-hao Wang Tie-cheng Wang You-Chun Wang jia-Fu jiang Yan-ling Hu Na jia Yu-Wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China life Sciences Institute Guangxi Medical UniversityNanning 530020China College of life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

linear correlations of formation enthalpies/bulk modules and atomic volumes observed in Pt-Zr compounds by ab initio calculation

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2013年第12期23卷 3704-3713页

作者：白雪李家好戴叶柳百新清华大学材料学院先进材料实验室北京100084 中国科学院上海应用物理研究所上海200240

118 kinds of Pt-Zr phases were established and investigated by considering various structures. Then the related physical properties, such as structural stability, lattice constants, formation enthalpies, elastic constants and bulk moduli, are obtained by ab initio calculations. Based on the calculated results of formation enthalpies, the ground-state convex hull is derived for the Pt-Zr system. The calculated physical data would provide a basis for further thermodynamic calculations and atomistic simulations. For these Pt-Zr compounds, it is found there are a positive linear correlation between the formation enthalpies and atomic volumes, and a negative linear correlation between the bulk modules and atomic volumes.

关键词： Pt-Zr system thermal properties elastic property ab initio calculations formation enthalpy bulk module atomic volume

CEPC Technical Design Report

在线全文

学校读者我要写书评

暂无评论

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha bai Yu bai Yang bai Vipul bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin che Yuzhi che Bin chen Danping chen Fuqing chen Fusan chen Gang chen Guoming chen Hua-xing chen Huirun chen Jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen Xiang chen Xiaoyu chen xin chen Xun chen Xurong chen ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun dai xinchen dai Xuwen dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Design of S-band photoinjector with high bunch charge and low emittance based on multi-objective genetic algorithm

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第3期34卷 93-105页

作者： Ze-Yi dai Yuan-Cun Nie Zi Hui Lan-xin liu Zi-Shuo liu jian-Hua Zhong jia-Bao Guan Ji-Ke Wang Yuan chen ye Zou hao-Hu li jian-Hua He The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

High-brightness electron beams are required to drive liNAC-based free-electron lasers(FELs)and storage-ring-based synchrotron radiation light *** bunch charge and RMS bunch length at the exit of the liNAC play a crucial role in the peak current;the minimum transverse emittance is mainly determined by the injector of the ***,a photoin-jector with a high bunch charge and low emittance that can simultaneously provide high-quality beams for 4th generation synchrotron radiation sources and FELs is *** design of a 1.6-cell S-band 2998-MHz RF gun and beam dynamics optimization of a relevant beamline are presented in this *** dynamics simulations were performed by combining ASTRA and the multi-objective genetic algorithm NSGA *** effects of the laser pulse shape,half-cell length of the RF gun,and RF parameters on the output beam quality were analyzed and *** normalized transverse emittance was optimized to be as low as 0.65 and 0.92 mm·mrad when the bunch charge was as high as 1 and 2 nC,***,the beam stability properties of the photoinjector,considering misalignment and RF jitter,were simulated and analyzed.

关键词： Electron linear accelerator Photoinjector Beam dynamics Multi-objective genetic algorithm

Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第47期27卷 8156-8165页

作者： jia-Yi liu Zhu-Yuan Ding Zi-Yi Zhou Sheng-Zhen dai Jie Zhang hao li Qiu Du ye-Yu Cai Quan-liangShang Yong-Heng Luo En-Hua Xiao Department of Radiology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Emergency Medicine First People's Hospital of Changde CityChangde 415000Hunan ProvinceChina Department of Urology Hunan Provincial People's HospitalFirst Affiliated Hospital of Hunan Normal UniversityChangsha 410005Hunan ProvinceChina

BACKGROUND Bile duct ligation(BDL)in animals is a classical method for mimicking cholestatic *** different surgical techniques have been described in rats and rabbits,mouse models can be more cost-effective and reproducible for investigating cholestatic *** resonance imaging(MRI)has made great advances for noninvasive assessment of liver *** comprehensive liver fibrotic features of BDL on MRI are ***,the utility of multiparameter MRI to detect liver fibrosis in a BDL mouse model has not been *** To evaluate the correlation between the pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse *** Twenty-eight healthy adult male balb/c mice were randomly divided into four groups:sham,week 2 BDL,week 4 BDL,and week 6 *** MRI sequences,included magnetic resonance cholangiopancreatography,T1-weighted,T2-weighted,T2 mapping,and pre-and post-enhanced T1 mapping,were performed after sham and BDL *** blood and liver tissue were collected after *** statistical analysis,Student’s t-test and Pearson’s correlation coefficient were *** Four mice died after BDL surgery;seven,six,five and six mice were included separately from the four *** intensities of liver parenchyma showed no difference on TI-and T2-weighted *** duct volume,ΔT1 value,T2 value,and the rate of liver fibrosis increased steadily in week 2 BDL,week 4 BDL and week 6 BDL groups compared with those in the sham group(Pline over *** correlations were found between bile duct volume(r=0.84),T2 value(r=0.78),ΔT1 value(r=0.62),and hepatic fibrosis rate(all P<0.01)in the BDL *** The BDL mouse model induces changes that can be observed on *** MRI parameters correlate with the hepatic fibrosis rate and allow for detec

关键词： liver Fibrosis Magnetic resonance imaging Pathology Animal model Bile duct ligation

Treatment strategies for mass burn casualties

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第5期122卷 525-529页

作者： CHAI jia-ke SHENG Zhi-yong YANG Hong-ming hao dai-feng SHEN Chuan-an jia Xiao-ming li Feng JING Sa li li-gen SONG Hui-feng jia Chi-yu TUO Xiao-ye SUN Tian-jun HU Quan Department of Burns and Plastic Surgery Burns Institute First Affiliated Hospital of General Hospital of PLA Beijing 100048 China

Background Mass burn casualties are always a great challenge to a medical team because a large number of seriously injured patients were sent in within a short time. Usually a high mortality is impending. Experiences gained from successful treatment of the victims may be useful in guiding the care of mass casualties in an armed conflict. Methods Thirty-five burn victims in a single batch, being transferred nonstop by air and highway from a distant province were admitted 48 hours post-injury. All patients were male with a mean age of （22.4±8.7） years. The burn extent ranged from 4% to 75% （（13.6±12.9）%） total body surface area. Among them, thirty-two patients were complicated by moderate and severe inhalation injury, and tracheostomy had been performed in 15 patients. Decompression incisions of burn eschar on extremities were done in 17 cases before transportation. All the thirty-five patients arrived at the destination smoothly via 4-hour airlift and road transportation. Among them, twenty-five patients were in critical condition. Results These thirty-five patients were evacuated 6 hours from the scene of the injury, and they were transferred to a local hospital for primary emergency care. The patients were in very poor condition when admitted to our hospital because of the severe injury with delayed and inadequate treatment. Examination of these patients at admission showed that one patient was suffering from sepsis and multiple organ dysfunction syndrome. Dysfunction of the heart, lung, liver, kidney, and coagulation were all found in the patients. Forty-eight operations were performed in the 23 patients during one month together with comprehensive treatment, and the function of various organs was ameliorated after appropriate treatment. All the 35 patients survived. Conclusions A well-organized team consisting of several cooperative groups with specified duties is very important. As a whole, the treatment protocol should be individualized, basing on the extent of

关键词： burns transportation of patients organization and administration mass casualties

Common mechanism of Citrus Grandis Exocarpium in treatment of chronic obstructive pulmonary disease and lung cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2021年第4期13卷 525-533页

作者： Wei Zhou Min Dong hao Wu Hui-lin li jia-le Xie Ru-yun Ma Wei-wei Su jian-ye dai School of Pharmacy Lanzhou UniversityLanzhou 730000China Department of Pulmonology Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM Guangdong Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

Objective:"Same treatment for different diseases"is a unique treatment strategy in traditional Chinese *** kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary disease(COPD)and lung *** Grandis Exocarpium(Huajuhong in Chinese,HJH),a famous herbal,is always applied by Chinese medicine practitioners to dispersion the lung to resolve phlegm based on"syndrome differentiation and treatment"***,the common mechanism for HJH’s treatment of COPD and lung cancer is not ***:In this study,based on network pharmacology and molecular docking technology,the common mechanism of HJH in the treatment of COPD and lung cancer was *** active ingredients and related targets of HJH were integrated from TCMSP,BATMAN-TAM,STP,and Pubchem *** standard names of these targets were united by Uni Prot *** of COPD and lung cancer were enriched through Gene Cards,NCBI(Gene),Therapeutic Target Database,and Dis Ge NET(v7.0)*** the intersection targets of HJH and diseases were *** STRING network and the Cytoscape 3.7.2 were used to construct PPI network,the DAVID database was used to perform GO and KEGG *** Cytoscape 3.6.1 was used to build"ingredient-target-signal pathway"***,Auto Dock 1.5.6 software was used to perform molecular docking of key proteins and ***:Eleven active ingredients in HJH were obtained by searching the database,corresponding to 184 HJH-COPD-lung cancer targets *** results of biological network analysis showed that naringenin,the active component in HJH,could mainly act on target proteins such as AKT1,*** through positive regulation of vasoconstriction and other biological processes,naringenin could regulate estrogen signaling pathway,VEGF signaling pathway,HIF-1 signaling pathway,Erb B signaling pathway,PI3K-Akt signaling pathway to play an important role in the treatment of both COPD and lung can

关键词： chronic obstructive pulmonary disease Citrus Grandis Exocarpium lung cancer mechanism molecular docking network pharmacology same treatment for different diseases

Characteristics of and strategies for patients with severe burn-blast combined injury

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第20期120卷 1783-1787页

作者： CHAI jia-ke SHENG Zhi-yong LU jiang-yang WEN Zhong-guang YANG Hong-ming jia Xiao-ming li li-gen CAO Wei-hong hao dai-feng SHEN Chuan-an TUO Xiao-ye liANG li-ming WANG Shu-jun Bums Institute First Hospital Affiliated to the General Hospital of People＇s Liberation Army Beijing 100037 China Department of Pathology First Hospital Affiliated to the General Hospital of People＇s Liberation Army Beijing 100037 China Department of Respiratory Medicine First Hospital Affiliated to the General Hospital of People＇s Liberation Army Beijing 100037 China

Background Severe burn-blast combined injury is a great challenge to medical teams for its high mortality. The aim of this study was to elucidate the clinical characteristics of the injury and to present our clinical experiences on the treatment of such cases.Methods Five patients with severe bum-blast combined injuries were admitted to our hospital 77 hours post-injury on June 7, 2005. The burn extent ranged from 80% to 97% （89.6%±7.2%） of TBSA （full-thickness burns 75%-92% （83.4%±7.3%））. All the patients were diagnosed as having blast injury and moderate or severe inhalation injury. Functions of the heart, liver, kidney, lung, pancreas and coagulation were observed. Autopsy samples of the heart, liver, and lungs were taken from the deceased. Comprehensive measures were taken during the treatment, including protection of organ dys function, use of antibiotics, early anticoagulant treatment, early closure of burn wounds, etc. All the data were analyzed statistically with t test.Results One patient died of septic shock 23 hours after admission （four days after injury）, the others survived. Dysfunction of the heart, liver, lungs, pancreas, and coagulation were found in all the patients on admission, and the functions were ameliorated after appropriate treatments.Conclusions Burn-blast combined injury may cause multiple organ dysfunctions, especially coagulopathy. Proper judgment of patients＇ condition, energetic anticoagulant treatment, early closure of burn wounds, rational use of antibiotics, nutritional support, intensive insulin treatment, timely and effective support and protection of organ function are the most important contributory factors in successful treatment of burn-blast combined injuries.

关键词： burn-blast combined injury treatment