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Boundary Layer Distributions and Cooling Rate of Cooling Sloping Plate Process

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Journal of Wuhan University of Technology(Materials Science) 2013年第4期28卷 701-705页

作者：赵占勇管仁国 WANG Xiang HUANG Hongqian chao runze DONG Lei LIU Chunming College of Materials and Metallurgy Northeastern University

According to the principle of grain refining and slurry preparation by cooling sloping plate process, the distributions of boundary layers during melt treatment by cooling sloping plate were studied, and mathematic model of cooling rate was established. The calculation value approximately agrees with the experimental result. Laminar flow and turbulent flow exist on sloping plate surface commonly. The thickness of velocity boundary layer and the critical transfer distance from laminar flow to turbulent flow increase with the decrease of initial flow velocity. The thickness of temperature boundary layer increases with the increment of flow distance and the decrease of initial flow velocity. The melt cooling rate and melt thickness have an inverse proportion relationship. The melt cooling rate increases along the plate direction gradually when the initial flow velocity is lower than 1 m/s, the melt cooling rate keeps nearly a constant when the initial flow velocity is 1 m/ s, when the initial flow velocity is higher than 1 m/s, the melt cooling rate decreases gradually. The melt cooling rate of cooling sloping plate process can reach 102-103 K/s and belongs to meta-rapid solidification scope.

关键词： semisolid grain refining sloping plate temperature boundary layer cooling rate

波浪环境下水下航行体高速倾斜出水流体动力与运动特性研究

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西北工业大学学报 2024年第4期42卷 616-624页

作者：李润泽张庆辉汪超刘勇锋李卓越杜鹏西北工业大学航海学院陕西西安710072 山西平阳重工机械有限责任公司山西侯马043099 中国船舶及海洋工程设计研究院上海200011 国家电网淮北供电公司安徽淮北235000 西安天和防务技术股份有限公司陕西西安710000

针对水下航行体跨水空交界面过程,基于CFD方法,结合VOF与DFBI模型,建立了复杂构型航行体穿越波浪环境的高精度数值模拟模型,实现了波浪环境下复杂构型航行体出水过程模拟,完成了造波和跨介质过程的模拟精度验证,得到了航行体出水过程中... 详细信息

针对水下航行体跨水空交界面过程,基于CFD方法,结合VOF与DFBI模型,建立了复杂构型航行体穿越波浪环境的高精度数值模拟模型,实现了波浪环境下复杂构型航行体出水过程模拟,完成了造波和跨介质过程的模拟精度验证,得到了航行体出水过程中的流体动力和运动特性,获得了波浪相位、运动方式等对航行体的受力和运动特性的影响规律,为跨介质无人航行体设计提供技术支撑。

关键词：水下航行体出水波浪数值模拟流体动力

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云网边端协同云控制研究进展及挑战

信息与控制 2024年第3期53卷 273-286页

作者：夏元清王晁高润泽詹玉峰孙中奇戴荔翟弟华北京理工大学自动化学院中原工学院

针对网络化控制系统通信与计算资源不足、云控制系统难以完全保证复杂任务实时控制的问题，在云控制系统研究基础上，云网边端协同云控制利用云控制平台层、网络传输层、边缘控制层、终端设备层各自优势，实现互联互通、相互协作、优化... 详细信息

针对网络化控制系统通信与计算资源不足、云控制系统难以完全保证复杂任务实时控制的问题，在云控制系统研究基础上，云网边端协同云控制利用云控制平台层、网络传输层、边缘控制层、终端设备层各自优势，实现互联互通、相互协作、优化运行，是复杂智能系统控制问题的理想解决方案。鉴于此，本文详细阐述了云网边端协同云控制的研究进展。首先，简要介绍了云网边端协同云控制的构成要素；其次，整理了云控制系统各方面的研究成果；最后，详细介绍云网边端协同云控制及其应用研究，并对未来的研究方向进行展望与讨论。

关键词：云网边端协同云控制云控制系统云计算动态云控制系统

大黄-黄连调控AMPK/ULK1/Beclin1通路改善db/db小鼠肝脏胰岛素抵抗的机制

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中国实验方剂学杂志 2024年第8期30卷 9-16页

作者：赵泓彰白敏汪湛东宋冰郭超刘馨鸿王琼杨润泽汪永锋张延英甘肃中医药大学兰州730000 甘肃省实验动物行业技术中心兰州730000

目的:探讨大黄-黄连通过调控腺苷酸活化蛋白激酶(AMPK)/UNC-51样激酶1(ULK1)/自噬关键分子苄氯素1(Beclin1)通路减轻db/db小鼠胰岛素抵抗的作用及其机制。方法:采用db/db小鼠,雄性6周龄db/db小鼠60只,随机分为模型组、二甲双胍组(0.26 g... 详细信息

目的:探讨大黄-黄连通过调控腺苷酸活化蛋白激酶(AMPK)/UNC-51样激酶1(ULK1)/自噬关键分子苄氯素1(Beclin1)通路减轻db/db小鼠胰岛素抵抗的作用及其机制。方法:采用db/db小鼠,雄性6周龄db/db小鼠60只,随机分为模型组、二甲双胍组(0.26 g·kg^(-1))、大黄-黄连低、中、高剂量组(2.25、4.5、9 g·kg^(-1));将同周龄db/m小鼠作为空白组,每组12只。连续灌胃给药干预8周,空白组和模型组每日给予等量蒸馏水灌胃,1次/d,观察小鼠生存状态并使用罗氏血糖设备检测空腹血糖(FBG);采用酶联免疫吸附测定法检测小鼠空腹血清胰岛素(FINS)并计算胰岛素抵抗指数(HOMA-IR);采用苏木素-伊红(HE)染色法观察小鼠肝脏病理变化;蛋白免疫印迹法(Western blot)检测肝脏组织中AMPK、Beclin1、自噬相关蛋白5(Atg5)及p62蛋白表达水平;免疫荧光检测肝脏组织中自噬相关蛋白1轻链3B(LC3B)、ULK1的蛋白表达水平;实时荧光定量聚合酶链式反应(Real-time PCR)检测AMPK、Beclin1、Atg5、ULK1、p62 mRNA表达水平。结果:与空白组比较,模型组体质量显著升高(P<0.01);FBG、FINS、HOMA-IR水平均有所改变(P<0.01);肝细胞结构紊乱;肝脏组织中AMPK、Beclin1、Atg5蛋白表达水平显著降低(P<0.01);p62蛋白表达水平显著升高(P<0.01);mRNA与蛋白表达水平基本一致。与模型组比较,二甲双胍组、大黄-黄连高、中剂量组体质量明显降低(P<0.05);FBG、FINS、HOMA-IR均有所下降(P<0.05,P<0.01);治疗后各组小鼠的肝脏结构损伤均有不同程度减轻;肝脏组织中AMPK、Beclin1、Atg5、LC3B和ULK1蛋白表达升高(P<0.05,P<0.01),p62蛋白表达下降(P<0.01);且mRNA与蛋白表达水平大致相同。结论:大黄-黄连可以有效改善肝脏胰岛素抵抗,调控AMPK自噬信号通路,减轻db/db小鼠胰岛素抵抗从而有效防治2型糖尿病的发生发展。

关键词：大黄-黄连肝损伤胰岛素抵抗肥胖型2型糖尿病腺苷酸活化蛋白激酶(AMPK)/UNC-51样激酶1(ULK1)/自噬关键分子苄氯素1(Beclin1)

An integrated thermoelectric-assisted photoelectrochemical system to boost water splitting

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Science Bulletin 2020年第14期65卷 1163-1169,M0003页

作者： Yuyang Kang runze Chen chao Zhen Lianzhou Wang Gang Liu Hui-Ming Cheng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandBrisbaneQLD 4072Australia Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua UniversityShenzhen 518055China Advanced Technology Institute University of SurreySurrey GU27XHUK

Common solar-driven photoelectrochemical(PEC) cells for water splitting were designed by using semiconducting photoactive materials as working photoelectrodes to capture sunlight. Due to the thermodynamic requirement of 1.23 eV and kinetic energy loss of about 0.6 eV, a photo-voltage of 1.8 V produced by PEC cells is generally required for spontaneous water splitting. Therefore, the minimum bandgap of1.8 eV is demanded for photoactive materials in single-photoelectrode PEC cells, and the bandgap of about 1 eV for back photoactive materials is appropriate in tandem PEC cells. All these PEC cells cannot effectively utilize the infrared light from 1250 to 2500 nm. In order to realize the full spectrum utilization of solar light, here, we develop a solar-driven PEC water splitting system integrated with a thermoelectric device. The key feature of this system is that the thermoelectric device produces a voltage as an additional bias for the PEC system by using the temperature difference between the incident infrared-light heated aqueous electrolyte in the PEC cell as the hot source and unirradiated external water as the cold source. Compared to a reference PEC system without the thermoelectric device, this system has a significantly improved overall water splitting activity of 1.6 times and may provide a strategy for accelerating the application of full spectrum solar light-driven PEC cells for hydrogen production.

关键词： Photoelectrochemical Water splitting Thermoelectric Hydrogen

Constructing CdSe QDs modified porous g-C_(3)N_(4)heterostructures for visible light photocatalytic hydrogen production

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Journal of Materials Science & Technology 2021年第36期95卷 167-171页

作者： Zheng Zhang Yuyang Kang Li-Chang Yin Ping Niu chao Zhen runze Chen Xiangdong Kang Fayu Wu Gang Liu School of Material and Metallurgy University of Science and Technology LiaoningAnshan 114051China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China

Constructing heterostructures with narrow-band-gap semiconductors is a promising strategy to extend light absorption range of graphitic carbon nitride(g-C_(3)N_(4))and simultaneously promote charge separation for its photocatalytic activity ***,its highly localized electronic states of g-C_(3)N_(4)hinder photo-carrier migration through bulk towards heterostructure interfaces,resulting in low charge carrier separation efficiency of solid bulk g-C_(3)N_(4)-based ***,porous g-C_(3)N_(4)(PCN)material with greatly shortened migration distance of photo-carriers from bulk to surface was used as an effective substrate to host Cd Se quantum dots to construct type II heterostructure of Cd Se/PCN for photocatalytic hydrogen *** homogeneous modification of the Cd Se quantum dots throughout the whole bulk of PCN together with proper band alignments between Cd Se and PCN enables the effective separation of photo-generated charge carriers in the ***,the Cd Se/PCN heterostructure photocatalyst gives the greatly enhanced photocatalytic hydrogen production activity of192.3μmol h^(-1),which is 4.4 and 8.1 times that of Cd Se and PCN,*** work provides a feasible strategy to construct carbon nitride-based heterostructure photocatalysts for boosting visible light driven water splitting performance.

关键词： Porous g-C_(3)N_(4) CdSe QDs Heterostructure Photocatalytic water splitting

上海市中老年女性绝经相关症状及绝经相关知识认知现状调查

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老年医学与保健 2024年第1期30卷 159-163页

作者：陈秀英陈曦黄润泽郭婷顾超邹世恩李斌复旦大学附属妇产科医院妇科上海200011

目的了解上海市40岁以上中老年女性绝经相关症状的发生情况及对绝经相关知识的认知现状,为加强绝经过渡期及绝经后期女性健康保健及管理工作提供参考。方法2021年1月—2021年12月,随机选择上海市年龄≥40岁的女性进行问卷调查,并以改良K... 详细信息

目的了解上海市40岁以上中老年女性绝经相关症状的发生情况及对绝经相关知识的认知现状,为加强绝经过渡期及绝经后期女性健康保健及管理工作提供参考。方法2021年1月—2021年12月,随机选择上海市年龄≥40岁的女性进行问卷调查,并以改良Kupperman评分量表评估其绝经相关症状发生情况。结果共收调查问卷5441份,其中有效问卷5200份,有效率95.57%。受调查人群平均年龄为(51.7±7.0)岁,平均身高(160.42±5.07)cm,平均体质量(58.94±8.01)kg,平均BMI(22.55±2.75)kg/m^(2)。出现绝经综合征者达77%,其中重度占10.15%,中度占34.37%,绝经综合征的主要症状报告率居前五位的依次为疲乏,易激动,肌肉、骨关节痛,失眠和头痛。23.03%~36.55%对绝经相关知识认识不清或存在错误认知,41.63%的调查对象不知道绝经激素治疗;46.31%调查对象不接受绝经激素治疗;48.23%不会推荐身边的适龄女性或者亲友进行绝经激素治疗;影响受调查人群接受激素治疗的主要原因中依次是不了解安全性和有效性(66.60%)与激素治疗的风险(45.94%)等。结论40岁以上女性中绝经综合征的报告率较高,但在一定程度上存在认知缺乏,尤其是对激素补充治疗;不了解安全性和有效性与激素治疗的风险是影响接受激素治疗的主要原因,加强科普宣教和健康管理非常重要。

关键词：中老年绝经过渡期绝经后期绝经综合征激素补充治疗

Dynamic human retinal pigment epithelium(RPE)and choroid architecture based on single-cell transcriptomic landscape analysis

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Genes & Diseases 2023年第6期10卷 2540-2556页

作者： Lulin Huang Lin Ye runze Li Shanshan Zhang chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Bo Gong Zheng Li Hongjie Yang Man Yu Yi Shi Changguan Wang Wei Chen Zhenglin Yang Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan 610072China Department of Ophthalmology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China School of Ophthalmology and Optometry Wenzhou Medical CollegeWenzhouZhejiang 325035China Department of Organ Transplant Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Ophthalmology Peking University Third HospitalBeijing 100730China

The retinal pigment epithelium(RPE)and choroid are located behind the human retina and have multiple functions in the human visual *** of the RPE and choroid cells and their gene expression profiles are fundamental for understanding retinal disease mechanisms and therapeutic ***,we sequenced the RNA of about 0.3 million single cells from human RPE and choroids across two regions and seven ages,revealing regional and age differences within the human RPE and ***–cell interactions highlight the broad connectivity networks between the RPE and different choroid cell ***,the transcription factors and their target genes change during *** coding of somatic variations increases during aging in the human RPE and choroid at the single-cell ***,we identified ELN as a candidate for improving RPE degeneration and choroidal structure during *** mapping of the molecular architecture of the human RPE and choroid improves our understanding of the human vision support system and offers potential insights into the intervention targets for retinal diseases.

关键词： Aging Choroid ELN Human RPE scRNA-seq

Deep Sc-RNA sequencing decoding the molecular dynamic architecture of the human retina

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Science China(Life Sciences) 2023年第3期66卷 496-515页

作者： Lulin Huang runze Li Lin Ye Shanshan Zhang Huaping Tian Mingyan Du chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Ling Zhong Hongjie Yang Man Yu Yi Shi Changguan Wang Houbin Zhang Wei Chen Zhenglin Yang The Key Laboratory for Human Disease Gene Study of Sichuan Province and the Department of Laboratory Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610075China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengdu 610075China Department of Ophthalmology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610075China School of Ophthalmology and Optometry Wenzhou Medical CollegeWenzhou 325035China Department of Organ Transplant Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610075China Department of Ophthalmology Peking University Third HospitalBejing 100730China

The human retina serves as a light detector and signals transmission *** insights into retinal disease mechanisms and therapeutic strategies require a deep understanding of healthy retina molecular ***,we sequenced the m RNA of over 0.6 million single cells from human retinas across six regions at nine different *** cell sub-types have been identified from the human mature retinas with unique *** revealed regional and age differences of gene expression profiles within the human ***-cell interaction analysis indicated a rich synaptic connection within the retinal *** expression regulon analysis revealed the specific expression of transcription factors and their regulated genes in human retina cell *** of the gene’s expression,such as DKK3,are elevated in aged retinas.A further functional investigation suggested that over expression of DKK3 could impact mitochondrial ***,decoding the molecular dynamic architecture of the human retina improves our understanding of the vision system.

关键词： deep Sc-RNA sequencing human retina aging