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Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

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Microsystems & Nanoengineering 2021年第1期7卷 1-19页

作者： An’an Sheng Long Lin Jia Zhu Jian Zhuang Jian Li lingqian chang Huanyu Cheng The Institute of Single Cell Engineering Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical Engineering Beihang University100191 BeijingChina Department of Stomatology Xiang’An Hospital of Xiamen University361100 XiamenChina School of Stomatology North China University of Science and Technology063210 TangshanChina Institute of Plastic Machinery and Plastic Engineering School of Mechanical and Electrical EngineeringBeijing University of Chemical Technology100029 BeijingChina Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16802USA.6 School of Biomedical EngineeringResearch and Engineering Center of Biomedical MaterialsAnhui Medical University230032 HefeiChina

Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few *** review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and *** first summarize the recent progress in this field by examining the available materials and fabrication techniques,device design principles,mechanisms,and biosafety aspects of micro/*** a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment,we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions,including oral cancer,eye wrinkles,keratitis,and *** with the identified key challenges,this review concludes with future directions as a small fraction of vast opportunities,calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.

关键词： treatment directions assessment

Single-molecule RNA capture-assisted droplet digital loop-mediated isothermal amplification for ultrasensitive and rapid detection of infectious pathogens

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Microsystems & Nanoengineering 2023年第5期9卷 151-160页

作者： Liying Jiang Xianghao Lan Linjiao Ren Zhiyuan Jin Xuchen Shan Mingzhu Yang lingqian chang School of Electrical and Information Engineering Zhengzhou University of Light Industry450002 ZhengzhouChina Academy for Quantum Science and Technology Zhengzhou University of Light Industry450002 ZhengzhouChina Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang University100191 BeijingChina School of Physics Beihang University100191 BeijingChina Beijing Research Institute of Mechanical Equipment 100143 BeijingChina

To minimize and control the transmission of infectious diseases,a sensitive,accurate,rapid,and robust assay strategy for application on-site screening is ***,we report single-molecule RNA capture-assisted digital RT-LAMP(SCADL)for point-of-care testing of infectious *** RNA was captured and enriched by specific capture probes and oligonucleotide probes conjugated to magnetic beads,replacing laborious RNA *** generation,amplification,and the recording of results are all integrated on a microfluidic *** assaying commercial standard samples,quantitative results precisely corresponded to the actual concentration of *** method provides a limit of detection of 10 copies mL−1 for the N gene within 1 h,greatly reducing the need for skilled personnel and precision *** ultrasensitivity,specificity,portability,rapidity and user-friendliness make SCADL a competitive candidate for the on-site screening of infectious diseases.

关键词： SCAD recording competitive

Highly integrated watch for noninvasive continual glucose monitoring

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Microsystems & Nanoengineering 2022年第1期8卷 331-339页

作者： Tianrui chang Hu Li Nianrong Zhang Xinran Jiang Xinge Yu Qingde Yang Zhiyuan Jin Hua Meng lingqian chang Key Laboratory of Biomechanics and Mechanobiology Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Biomedical Engineering City University of Hong KongHong KongChina General Surgery Department&Obesity and Metabolic Disease Center China-Japan Friendship HospitalBeijing 100029China Sense Future(HangZhou)Co. LtdHangzhou 311217China

This article reports a highly integrated watch for noninvasive continual blood glucose *** watch employs a Nafion-coated flexible electrochemical sensor patch fixed on the watchband to obtain interstitial fluid(ISF)transdermally at the *** reverse iontophoresis-based extraction method eliminates the pain and inconvenience that traditional fingerstick blood tests pose in diabetic patients’lives,making continual blood glucose monitoring practical and *** electronic modules,including a rechargeable power source and other modules for signal processing and wireless transmission,are integrated onto a watch face-sized printed circuit board(PCB),enabling comfortable wearing of this continual glucose ***-time blood glucose levels are displayed on the LED screen of the watch and can also be checked with the smartphone user *** 23 volunteers,the watch demonstrated 84.34%clinical accuracy in the Clarke error grid analysis(zones A+B).In the near future,commercial products could be developed based on this lab-made prototype to provide the public with noninvasive continual glucose monitoring.

关键词： Highly checked eliminate

Small-volume solution current-time behavior study for application in reverse iontophoresis-based non-invasive blood glucose monitoring

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Science China Chemistry 2011年第1期54卷 223-230页

作者： chang lingqian LIU ChunXiu HE YinZeng XIAO HongHui CAI XinXia State Key Laboratory of Transducer Technology Institute of Electronics Chinese Academy of Sciences Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100190 China

The reverse iontophoresis-based glucose monitoring circumstance is similar to the small-volume solution in which mass diffusion controls the current response of the electrochemical *** this study,the law of mass transfer in this type of solution was analyzed and a mathematic model was established to depict the current-time behavior of the fabricated planar electrode used in the non-invasive meter designed by ourselves.A small-volume glucose solution was directly constructed on the electrode to simulate the reverse iontophoresis-based sensing *** correctness of the model was demonstrated by *** assay was subsequently carried out to verify the practicality of the model in determination of blood *** results processed by the new method accurately traced the authentic value,confirming the advantage of the new method and the potential in clinical analysis.

关键词： non-invasive detection current.time behavior small-volume solution mass transfer semi-infinite diffusion mathematic model

Current research status of tumor cell biomarker detection

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Microsystems & Nanoengineering 2023年第5期9卷 17-34页

作者： Liying Jiang Xinyi Lin Fenghua Chen Xiaoyun Qin Yanxia Yan Linjiao Ren Hongyu Yu lingqian chang ang Wang School of Electrical and Information Engineering Zhengzhou University of Light IndustryZhengzhou 450002China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of Engineering Medicine Beihang UniversityBeijing 100083China

With the annual increases in the morbidity and mortality rates of tumors,the use of biomarkers for early diagnosis and real-time monitoring of tumor cells is of great *** used for tumor cell detection in body fluids include circulating tumor cells,nucleic acids,protein markers,and extracellular *** them,circulating tumor cells,circulating tumor DNA,and exosomes have high potential for the prediction,diagnosis,and prognosis of tumor diseases due to the large amount of valuable information on tumor characteristics and evolution;in addition,in situ monitoring of telomerase and miRNA in living cells has been the topic of extensive research to understand tumor development in real *** techniques,such as enzyme-linked immunosorbent assays,immunoblotting,and mass spectrometry,have been widely used for the detection of these *** them,the detection of tumor cell markers in body fluids based on electrochemical biosensors and fluorescence signal analysis is highly preferred because of its high sensitivity,rapid detection and portable ***,we summarize recent research progress in the detection of tumor cell biomarkers in body fluids using electrochemical and fluorescence biosensors,outline the current research status of in situ fluorescence monitoring and the analysis of tumor markers in living cells,and discuss the technical challenges for their practical clinical application to provide a reference for the development of new tumor marker detection methods.

关键词： diagnosis mortality diseases

Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer

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Bio-Design and Manufacturing 2023年第3期6卷 255-267页

作者： Yuqiong Wang An’an Sheng Xinran Jiang Shanshan Yang Long Lin Mingzhu Yang Fengshuo Zhu Yongyan Hu Jian Li lingqian chang Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Department of Stomatology Xiang’an Hospital of Xiamen UniversityXiamen 361000China Institute of Plastic Machinery and Plastic Engineering School of Mechanical and Electrical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Department of Biochemistry Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical CollegeBeijing 100005China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai 200011China Laboratory Animal Facility Peking University First HospitalBeijing 100034China

Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s *** lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic *** work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral *** ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin *** vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone *** proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C *** healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in *** as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral *** rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.

关键词： Recurrent oral ulcer Dissolvable microneedle Hyaluronic acid microneedle Multidrug Anti-inflammation Healing promoting effect

Micro/nano biomedical devices for point-of-care diagnosis of infectious respiratory diseases

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Medicine in Novel Technology and Devices 2022年第2期14卷 1-14页

作者： Yang Wang Huiren Xu Zaizai Dong Zhiying Wang Zhugen Yang Xinge Yu lingqian chang Key Laboratory for Biomechanics and Mechanobiology Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Biomedical Information and Engineering Hainan Medical UniversityHaikou471100China School of Water Energy and EnvironmentCranfield UniversityCranfieldMK430ALUnited Kingdom Department of Biomedical Engineering City University of Hong KongHong KongChina

Corona Virus Disease 2019(COVID-19)has developed into a global pandemic in the last two years,causing significant impacts on our daily life in many *** and accurate detection of COVID-19 is of great importance to both treatments and pandemic *** now,a variety of point-of-care testing(POCT)approaches devices,including nucleic acid-based test and immunological detection,have been developed and some of them has been rapidly ruled out for clinical diagnosis of COVID-19 due to the requirement of mass *** this review,we provide a summary and commentary on the methods and biomedical devices innovated or renovated for the quick and early diagnosis of *** particular,some of micro and nano devices with miniaturized structures,showing outstanding analytical performances such as ultra-sensitivity,rapidness,accuracy and low cost,are discussed in this *** also provide our insights on the further implementation of biomedical devices using advanced micro and nano technologies to meet the demand of point-of-care diagnosis and home testing to facilitate pandemic *** general,our paper provides a comprehensive overview of the latest advances on the POCT device for diagnosis of COVID-19,which may provide insightful knowledge for researcher to further develop novel diagnostic technologies for rapid and on-site detection of pathogens including SARS-CoV-2.

关键词： COVID-19 Point-of-care testing Micro/nano devices

Low-Cost and Scalable Platform with Multiplexed Microwell Array Biochip for Rapid Diagnosis of COVID-19

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Research 2021年第1期2021卷 94-102页

作者： Yang Wang Kaiju Li Gaolian Xu Chuan Chen Guiqin Song Zaizai Dong Long Lin Yu Wang Zhiyong Xu Mingxia Yu Xinge Yu Binwu Ying Yubo Fan lingqian chang Jia Geng Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and MechanobiologySchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Laboratory Medicine State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Nano Biomedical Research Centre School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Wuhan Chain Medical Labs WuhanHubei 430011China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Biomedical Engineering City University of Hong KongChina

Sensitive detection of SARS-CoV-2 is of great importance for inhibiting the current pandemic of ***,we report a simple yet efficient platform integrating a portable and low-cost custom-made detector and a novel microwell array biochip for rapid and accurate detection of *** instrument exhibits expedited amplification speed that enables colorimetric read-out within 25 minutes.A polymeric chip with a laser-engraved microwell array was developed to process the reaction between the primers and the respiratory swab RNA extracts,based on reverse transcriptase loop-mediated isothermal amplification(RT-LAMP).To achieve clinically acceptable performance,we synthesized a group of six primers to identify the conserved regions of the ORF1ab gene of *** trials were conducted with 87 PCR-positive and 43 PCRnegative patient *** platform demonstrated both high sensitivity(95.40%)and high specificity(95.35%),showing potentials for rapid and user-friendly diagnosis of COVID-19 among many other infectious pathogens.

关键词： instrument diagnosis specificity

On-chip multiplexed single-cell patterning and controllable intracellular delivery

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Microsystems & Nanoengineering 2020年第1期6卷 1222-1232页

作者： Zaizai Dong Yanli Jiao Bingteng Xie Yongcun Hao Pan Wang Yuanyuan Liu Junfeng Shi Chandani Chitrakar Stephen Black Yu-Chieh Wang LJames Lee Mo Li Yubo Fan lingqian chang School of Biological Science and Medical Engineering Beihang University100083 BeijingChina Institute of Nanotechnology for Single Cell Analysis(INSCA) Beijing Advanced Innovation Center for Biomedical EngineeringBeihang University100083 BeijingChina College of Agricultural and Life Sciences University of FloridaGainesvilleFL 32611USA Center for Reproductive Medicine Peking University Third Hospital100191 BeijingChina Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical University710072 Xi’anChina Chemical and Biomolecular Engineering Department Ohio State UniversityColumbusOH 43209USA Department of Biomedical Engineering University of North TexasDentonTX 76207USA Department of Pharmaceutical Sciences University of North Texas Health Science CenterFort WorthTX 76107USA

Conventional electroporation approaches show limitations in the delivery of macromolecules in vitro and in *** limitations include low efficiency,noticeable cell damage and nonuniform delivery of ***,we present a simple 3D electroporation platform that enables massively parallel single-cell manipulation and the intracellular delivery of macromolecules and small molecules.A pyramid pit micropore array chip was fabricated based on a silicon wet-etching method.A controllable vacuum system was adopted to trap a single cell on each *** this chip,safe single-cell electroporation was performed at low *** of various sizes ranging from oligonucleotides(molecular beacons,22 bp)to plasmid DNA(CRISPR-Cas9 expression vectors,>9 kb)were delivered into targeted cells with a significantly higher transfection efficiency than that of multiple benchmark methods(e.g.,commercial electroporation devices and Lipofectamine).The delivered dose of the chemotherapeutic drug could be controlled by adjusting the applied *** using CRISPR-Cas9 transfection with this system,the p62 gene and CXCR7 gene were knocked out in tumor cells,which effectively inhibited their cellular ***,this vacuum-assisted micropore array platform provides a simple,efficient,high-throughput intracellular delivery method that may facilitate on-chip cell manipulation,intracellular investigation and cancer therapy.

关键词： inhibited vacuum limitations