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Simulation of jet-flow solid fraction during spray forming

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International Journal of Minerals,Metallurgy and Materials 2017年第6期24卷 657-669页

作者： Zi-qiang Pi Xin Lu Yuan Wu Lu-ning Wang cheng-chang Jia Xuan-hui Qu Wei zheng li-zhi Wu Qing-li Shao Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China Heye Special Steel Co. Ltd. Shijiazhuang 052165 China

A numerical model was developed to simulate the jet-flow solid fraction of W18Cr4 V high-speed steel during spray forming. The whole model comprises two submodels: one is an individual droplet model, which describes the motion and thermal behaviors of individual droplets on the basis of Newton's laws of motion and the convection heat transfer mechanism; the other is a droplet distribution model, which is used to calculate the droplet size distribution. After being verified, the model was used to analyze the effects of parameters, including the initial gas velocity, deposition distance, superheat degree, and the ratio of gas-to-metal mass flow rates, on the jet-flow solid fraction. Finally, an equation to predict the jet-flow solid fraction directly and conveniently according to the parameters was presented. The values predicted by the equation show good agreement with those calculated by the numerical model.

关键词： modeling steel spray forming solid fraction

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong li Ya-Nan Sun li Shi Min Wang Xi-cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu chang-Qing Zhao Zhen-lin Wang Hua-Bin li Feng liu Xiao-Bo Cui Sheng-Nan Ye zheng liu Yu Xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai liu Shao-Wei Gu Yu-cheng Yang Lei cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver cancer cell lines Huh-7

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Asian Pacific Journal of Tropical Medicine 2014年第10期7卷 780-786页

作者： chang-Jiang Lei Chun Yao Qing-Yun Pan Hao-cheng Long Lei li Shu-Ping zheng cheng Zeng Jian-Bin Huang Department of General Surgery the Second Affiliated Hospital of Jianghan University(Wuhan City Fifth Hospital) Wuhan Institute of Hematology the Second Affiliated Hospital of Jianghan University(Wuhan City Fifth Hospital) Integrated Department Branch of Jianqiao.Hanyang Affiliated Hospital of Wuhan University of Science and Technology Department of Pediatrics the Second Affiliated Hospital of Jianghan University(Wuhan City Fifth Hospital)

Objective:To build GPC3 gene short hairpin interference RNA(shRNA)slow virus *** expression of Huh-7 GPC3 gene in human liver cell line proliferation apoptosis and the effect of GPC3 gene influencing on liver cancer cell growth,and provide theoretical basis for genc therapy of liver ***:Hepatocellular carcinoma cell line Huh-7 wsa transfected by a RNA interference ***3 gene expression in a variety of liver cancer cell lines was detected by fluorescence quantitative *** GPC3 gene seqnences of small interfering RNA(siRNA)PGC-shRNA-GPC3 were *** expression cell linse of siRNA were screened and established with the heplp of liposomes(lipofectamine^(TM2000))as carrier transfcetion of human liver cell *** order to validate siRNA interference ***3 siRNA mRNA expression was detected after transfection by using RT-PCR and Western *** absorbance value of the cells of blank group,untransfection group and transfection group,the cell cycle and cell apoptosis were calculated,and effects of GPC3 gene nn Huh-7 cell proliferation and apoptosis were ***:In the liver cancer cell lines Huh-7 GPC3 gene showed high ***-shRNA-GPC3 recombinant plasmid was constructde successfully via sequencing *** recombinant plasmid transfected into liver cancer cell linse Huh-7can obviously inhibit GPC3 mRNA expression ***:The targeted GPC3 siRNA can effectively inhibit the expression of GPC3.

关键词： GPC3 gene Slow virus carrier liver cancer cell lines RNA interference

M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury

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Neural Regeneration Research 2022年第5期17卷 1072-1079页

作者： Shui-Sheng Yu Zi-Yu li Xin-Zhong Xu Fei Yao Yang Luo Yan-chang liu li cheng Mei-Ge zheng Jue-Hua Jing Department of Orthopedics The Second Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

After spinal cord injury(SCI),astrocytes gradually migrate to and surround the lesion,depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar,which limits the spread of inflammation but hinders axon ***,microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate a pro-inflammatory M1 phenotype or an anti-inflammatory M2 ***,the effect of microglia polarization on astrocytes is ***,we found that both microglia(CX3 CR1^(+))and astrocytes(GFAP^(+))gathered at the lesion border at 14 days post-injury(dpi).The microglia accumulated along the inner border of and in direct contact with the astrocytes.M1-type microglia(i NOS^(+)CX3 CR1^(+))were primarily observed at 3 and 7 dpi,while M2-type microglia(Arg1^(+)CX3 CR1^(+))were present at larger numbers at 7 and 14 *** growth factor-β1(TGFβ1)was highly expressed in M1 microglia in vitro,consistent with strong expression of TGFβ1 by microglia in vivo at 3 and 7 dpi,when they primarily exhibited an M1 ***,conditioned media from M1-type microglia induced astrocytes to secrete chondroitin sulfate proteoglycan in *** effect was eliminated by knocking down sex-determining region Y-box 9(SOX9)in astrocytes and could not be reversed by treatment with TGFβ*** together,our results suggest that microglia undergo M1 polarization and express high levels of TGFβ1 at 3 and 7 dpi,and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFβ1/SOX9 *** study was approved by the Institutional Animal Care and Use Committee of Anhui Medical University,China(approval ***20160052)on march 1,2016.

关键词： astrocytes astrocytic scar chondroitin sulfate proteoglycan M1/M2 polarization microglia sex-determining region Y-box 9 spinal cord injury transforming growth factor-β1

Cyanided Covalent Triazine Frameworks with Enhanced Adsorption Capability Toward Chloranil

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Journal of Wuhan University of Technology(Materials Science) 2023年第3期38卷 712-717页

作者：金英伟 XIE Peidong YANG Yuying RONG Gaoqi li Pingdeng HU Yeli cheng Bo zheng Qi 汪畅 Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China School of Environmental Ecology and Biological Engineering Wuhan Institute of TechnologyWuhan 430025China School of Chemistry and Chemical Engineering Wuhan University of Science and TechnologyWuhan 430081China Key Laboratory of Optoelectronic Chemical Materials and Devices Jianghan UniversityWuhan 430056China

Porous polymer(pyrrolopyrrole)was successfully prepared via domino-ring-formation *** chemical-physical properties of cyanided covalent triazine frameworks(CTF-CN)were characteriazed by fourier transform infrared spectra(FT-IR),scanning electron microscopy(SEM),nuclear magnetic resonance(NMR),specific surface area analyzer(BET)and thermogravimetric analysis(TGA),*** experimental results of adsorption of chloranil(TCBQ)in aqueous solution indicated that CTF-CN exhibited distinctive adsorption capacity toward TCBQ owing to its large specific surface ***,the adsorption equilibrium of as-prepared polymer was executed within 5 h and the calculated adsorption capacity was 499.76 mg/***,the adsorption kinetics could be well defined with the linear pseudo-second-order model,which implies that the chemical interaction are relative important in the course of TCBQ ***,the current studies verify that CTF-CN has unique rigid and nano-porous framework structure,which can be employed for the treatment of a series of harmful aromatic substances.

关键词： disinfection by-products(DBPs) adsorbent haloquinones covalent triazine frameworks

On High-Resolution Entropy-Consistent Flux with Slope limiter for Hyperbolic Conservation Laws

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Communications on Applied Mathematics and Computation 2023年第4期5卷 1616-1643页

作者： Xuan Ren Jianhu Feng Supei zheng Xiaohan cheng Yang li School of Sciences Chang’an UniversityXi’an710064ShaanxiChina Laboratory School of AstronauticsNorthwestern Polytechnical UniversityXi’an710072ShaanxiChina

This paper proposes a new version of the high-resolution entropy-consistent(EC-limited)flux for hyperbolic conservation laws based on a new minmod-type slope ***,we identify the numerical entropy production,a third-order differential term deduced from the previous work of Ismail and Roe[11].The corresponding dissipation term is added to the original Roe flux to achieve entropy *** new,resultant entropy-consistent(EC)flux has a general and explicit analytical form without any corrective factor,making it easy to compute and a less-expensive *** inequality constraints are imposed on the standard piece-wise quadratic reconstruction to enforce the pointwise values of bounded-type numerical *** design the new minmod slope limiter as combining two separate limiters for left and right *** propose the EC-limited flux by adding this reconstruction data method to the primitive variables rather than to the conservative variables of the EC flux to preserve the equilibrium of the primitive *** resulting fluxes are easily applied to general hyperbolic conservation laws while having attractive features:entropy-stable,robust,and *** illustrate the potential of these proposed fluxes,we show the applications to the Burgers equation and the Euler equations.

关键词： Hyperbolic conservation laws Entropy production Entropy-consistent(EC)flux Slope limiter High-resolution entropy-consistent(EC-limited)flux

Recent trends of study on esophageal variceal bleeding

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Chinese Medical Journal 2010年第18期123卷 2499-2501页

作者： cheng liu-fang and li chang-zheng Department of Gastroenterology and Hepatology Chinese People's Liberation Army General Hospital Beijing 100039 China

Esophageal variceal bleeding （EVB）, a severe complication and main mortality cause of portal hypertension, had reached a relatively mature stage in its research. The mortality rate of EVB within 5 days showed decrea... 详细信息

关键词：出血高血压门静脉基因

首批1型单纯疱疹病毒溶瘤活性测定国家候选标准品的研制

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药物分析杂志 2024年第4期44卷 663-670页

作者：秦玺胡金盼李永红史新昌丁有学毕华韩春梅郑红梅饶春明梁成罡中国食品药品检定研究院北京100050 厦门大学公共卫生和生命科学学院厦门361005

目的:研制首批1型单纯疱疹病毒(herpes simplex virus 1,HSV-1)溶瘤活性测定国家标准品。方法:按2020年版《中华人民共和国药典》三部相关要求,分别进行HSV-1溶瘤活性测定液体标准品和冻干标准品的制备和质量检测,并使用热加速试验进行... 详细信息

目的:研制首批1型单纯疱疹病毒(herpes simplex virus 1,HSV-1)溶瘤活性测定国家标准品。方法:按2020年版《中华人民共和国药典》三部相关要求,分别进行HSV-1溶瘤活性测定液体标准品和冻干标准品的制备和质量检测,并使用热加速试验进行稳定性考察,以U-2 OS细胞/CCK-8法分别在3家实验室对标准品的溶瘤活性进行协作标定。对比研究液体标准品和冻干标准品,选择其中更为适用的1种作为国家标准品。结果:制备的2种HSV-1溶瘤活性测定标准品的质量检测结果均符合要求,其中冻干标准品水分含量为1.09%,分装精度为0.15%。稳定性试验结果用阿伦尼乌斯公式计算,初步预测液体标准品溶瘤活性在-70℃下降低10%需7.7年;冻干标准品溶瘤活性在-70℃下降低10%需6.1×10^(5)年,其稳定性得到很大提高。3个实验室协作标定进行了共21次测定,液体标准品的溶瘤活性值几何均数为7.08×10^(4)U·mL^(-1),冻干标准品的溶瘤活性值几何均数为1.82×10^(4)U·支^(-1)。HSV-1标准品原液在冻干后溶瘤活性由7.08×10^(4)U·mL^(-1)下降至3.03×10^(4)U·mL^(-1),但因其溶瘤活性在预稀释100倍后仍然出现良好的S型量效关系曲线,并不影响它作为标准品使用的要求。将液体标准品作为样品,用冻干标准品作为标准品进行校准后,3家实验室结果的几何变异系数(GCV)由64.4%下降到29.2%,实验的精密度得到较大提高。结论:该批HSV-1溶瘤活性测定冻干标准品各项指标均符合相关要求,与液体标准品相比更适合作为国家标准品使用,其溶瘤活性赋值为1.82×10^(4)U·支^(-1)。

关键词： 1型单纯疱疹病毒(HSV-1) U-2 OS细胞/CCK-8法溶瘤活性标准品冻干稳定性

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design